Title: Relevance of somatostatin receptor expression in pancreatic neuroendocrine tumors for treatment with somatostatin analogues
Abstract: The overexpression of somatostatin receptors (SSTR), a family of G-protein-coupled receptors comprising five distinct subtypes (characterized SSTR1 – 5), mediates the function of somatostatin and characterises neuroendocrine tumors (NETs). Treatment with somatostatin still represents the cornerstone of pancreatic NETs. This approach decreases not only problems related to the secretory activity of the tumors and may relieve symptoms but also decrease the proliferative activity of the tumors. With the advent of new somatostatin analouges targeted to all SSTR subtypes except for SSTR 4 it appears crucial to characterize the expression pattern of SSTR subtypes to define, whether these new analogues may be of additional therapeutic benefit. Thus, the aim of the present study was to investigate the expression pattern of SSTR subtypes in a series of pancreatic NETs.
Publication Year: 2014
Publication Date: 2014-03-06
Language: en
Type: article
Indexed In: ['crossref']
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