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2784, 2839, 3013, 3035, 3055, 3060, 3080, 3143, 3183, 3255, 3372, 3396, 3420, 3468, 3499, 3513, 3535, 3549, 3574, 3685, 3692, 3714, 3752, 3781, 3797, 3887, 3893, 3900, 3944], 'photodynamic': [23, 593, 1063, 1216, 1286, 1310, 1365, 1382, 1600, 1621, 2391, 2438, 2635, 2922, 3239, 3250, 3639, 3720], 'action': [24, 1064, 1287, 1311, 1327, 3495], 'internalizable': [26], 'conjugates': [27, 636, 749, 1223, 1240, 1262, 1280, 1351, 1702, 1715, 1721, 1741, 2375, 2586, 2596, 2645, 2845, 2926, 2973, 2986, 3027, 3119, 3127, 3140, 3223, 3243, 3253, 3392, 3487, 3498, 3529, 3699, 3733, 3773, 3778, 3830, 3943, 3971], 'containing': [28, 1224, 1654, 1871, 1990, 2090, 2130, 2155, 2241, 2661, 2782, 2830, 2877, 3141, 3393, 3402, 3616], 'chlorin': [29, 658, 712, 737, 885, 889, 1017, 1320, 1385, 1569, 2018, 2054, 2276, 2299, 2647, 2777, 2780, 2854, 2988, 3029, 3136, 3165, 3436, 3445, 3501, 3531, 3687], 'e6': [30, 659, 886, 890, 1018, 1302, 1321, 1386, 2019, 2055, 2266, 2277, 2300, 2648, 2778, 2781, 2855, 3030, 3437, 3446, 3502, 3688, 3847], 'Tamara': [31, 34, 265, 268], 'V.': [32, 35, 80, 83, 266, 269, 314, 317], 'Akhlynina,': [33, 267], 'Akhlynina': [36, 270, 2029, 2508], 'Biophysical': [37, 163, 223, 271, 397, 457], 'Laboratory,': [38, 71, 164, 224, 272, 305, 398, 458], 'Russian': [39, 165, 202, 225, 273, 399, 436, 459], 'Institute': [40, 125, 143, 166, 203, 226, 274, 359, 377, 400, 437, 460], 'Agricultural': [42, 168, 205, 228, 276, 402, 439, 462], 'Biotechnology,': [43, 169, 206, 229, 277, 403, 440, 463], 'Moscow,': [44, 93, 114, 170, 180, 207, 230, 240, 250, 278, 327, 348, 404, 414, 441, 464, 474, 484, 2950], 'RussiaSearch': [45, 94, 115, 181, 208, 279, 328, 349, 415, 442], 'for': [46, 64, 74, 95, 116, 126, 134, 144, 152, 182, 209, 259, 280, 298, 308, 329, 350, 360, 368, 378, 386, 416, 443, 493, 710, 793, 853, 1009, 1065, 1071, 1114, 1215, 1274, 1617, 2136, 2141, 2176, 2202, 2582, 2649, 2673, 2817, 3018, 3047, 3340, 3424, 3435, 3444, 3460, 3464, 3520, 3677, 3680, 3768, 3882, 3910, 3914, 3972], 'more': [47, 75, 96, 117, 135, 153, 183, 210, 260, 281, 309, 330, 351, 369, 387, 417, 444, 494, 703, 715, 2930, 3905], 'papers': [48, 76, 97, 118, 136, 154, 184, 211, 261, 282, 310, 331, 352, 370, 388, 418, 445, 495], 'by': [49, 77, 98, 119, 137, 155, 185, 212, 262, 283, 311, 332, 353, 371, 389, 419, 446, 496, 585, 780, 873, 935, 1125, 1246, 1331, 1387, 1495, 1575, 1692, 1808, 1822, 1836, 1943, 1957, 1971, 2150, 2209, 2221, 2260, 2428, 2472, 2500, 2571, 2749, 2967, 2980, 3192, 3305, 3312, 3327, 3757, 3789, 3804], 'this': [50, 78, 99, 120, 138, 156, 186, 213, 263, 284, 312, 333, 354, 372, 390, 420, 447, 497, 560, 631, 1376, 3295, 3814], 'authorDavid': [51, 285], 'A.': [52, 55, 158, 161, 286, 289, 392, 395, 2183], 'Jans,': [53, 287], 'David': [54, 288], 'Jans': [56, 290], 'John': [57, 291], 'Curtin': [58, 292], 'School': [59, 293], 'Medical': [61, 127, 130, 145, 148, 295, 361, 364, 379, 382], 'Research,': [62, 296], 'Division': [63, 297], 'Biochemistry': [65, 299], 'Molecular': [67, 195, 301, 429], 'Biology,': [68, 302], 'Nuclear': [69, 303, 3696], 'Signalling': [70, 304], 'Canberra,': [72, 306], 'AustraliaSearch': [73, 307], 'authorNatalia': [79, 313], 'Statsyuk,': [81, 315], 'Natalia': [82, 316], 'Statsyuk': [84, 318], 'Department': [85, 106, 172, 232, 319, 340, 406, 466], 'Biophysics,': [87, 108, 174, 234, 243, 321, 342, 408, 468, 477], 'Biological': [88, 109, 175, 235, 244, 322, 343, 409, 469, 478], 'Faculty,': [89, 110, 176, 236, 245, 323, 344, 410, 470, 479], 'Moscow': [90, 111, 177, 237, 246, 324, 345, 411, 471, 480], 'State': [91, 112, 178, 238, 247, 325, 346, 412, 472, 481], 'University,': [92, 113, 131, 149, 179, 239, 248, 326, 347, 365, 383, 413, 473, 482], 'authorIrina': [100, 334], 'Y.': [101, 104, 335, 338], 'Balashova,': [102, 336], 'Irina': [103, 337], 'Balashova': [105, 339], 'authorGabor': [121, 355], 'Toth,': [122, 356], 'Gabor': [123, 357], 'Toth': [124, 358], 'Chemistry,': [128, 146, 362, 380], 'Szeged': [129, 147, 363, 381], 'Szeged,': [132, 150, 366, 384], 'HungarySearch': [133, 151, 367, 385], 'authorImre': [139, 373], 'Pavo,': [140, 374], 'Imre': [141, 375], 'Pavo': [142, 376], 'authorAndrey': [157, 391], 'Rosenkranz,': [159, 393], 'Andrey': [160, 394], 'Rosenkranz': [162, 396], 'Russia': [171, 231, 405, 465], 'authorBoris': [187, 421], 'S.': [188, 191, 215, 220, 422, 425, 449, 454], 'Naroditsky,': [189, 423], 'Boris': [190, 424], 'Naroditsky': [192, 426], 'Laboratory': [193, 427], 'Diagnostics': [196, 430], 'Genetic': [198, 432], 'Engineering': [199, 433], 'Micro-organisms,': [201, 435], 'authorAlexander': [214, 448], 'Sobolev,': [216, 450], 'Corresponding': [217, 451], 'Author': [218, 452], 'Alexander': [219, 453], 'Sobolev': [221, 455], '[email protected]': [222, 456], 'RussiaDepartment': [241, 475], '119899': [249, 483], 'Russia.': [251, 485], 'Fax:': [252, 486], '(7': [253, 256, 487, 490], '095)': [254, 257, 488, 491], '977-0947;': [255, 489], '939-1115.Search': [258, 492], 'author': [264, 498], 'First': [499], 'published:': [500], '08': [501], 'November': [502], '1999': [503, 804], 'https://doi.org/10.1002/(SICI)1097-0215(19990531)81:5<734::AID-IJC12>3.0.CO;2-JCitations:': [504], '28AboutSectionsPDF': [505], 'ToolsRequest': [506], 'permissionExport': [507], 'citationAdd': [508], 'favoritesTrack': [510], 'citation': [511], 'ShareShare': [512], 'Give': [513], 'accessShare': [514, 517], 'full': [515], 'text': [516], 'full-text': [518, 533, 557], 'accessPlease': [519], 'review': [520], 'our': [521, 1544, 2572, 3758], 'Terms': [522, 545], 'Conditions': [524, 547], 'Use': [526], 'check': [528], 'box': [529], 'below': [530, 553], 'share': [532, 555], 'version': [534, 558], 'article.I': [536], 'have': [537, 891, 952, 1467, 1614, 2899, 3276, 3285], 'read': [538], 'accept': [540], 'the': [541, 551, 615, 624, 641, 656, 661, 672, 679, 692, 708, 733, 745, 755, 758, 765, 778, 818, 828, 907, 921, 924, 956, 969, 978, 999, 1025, 1059, 1090, 1154, 1156, 1166, 1190, 1204, 1247, 1258, 1271, 1296, 1309, 1363, 1381, 1388, 1394, 1412, 1423, 1434, 1440, 1444, 1452, 1459, 1471, 1483, 1487, 1504, 1541, 1557, 1565, 1573, 1582, 1588, 1592, 1599, 1605, 1676, 1713, 1720, 1729, 1733, 1739, 1779, 1784, 1793, 1818, 1914, 1919, 1928, 1953, 2024, 2171, 2235, 2297, 2304, 2308, 2374, 2397, 2404, 2437, 2480, 2489, 2537, 2543, 2580, 2592, 2623, 2682, 2720, 2741, 2761, 2800, 2804, 2820, 2847, 2857, 2861, 2909, 2916, 2972, 2975, 2983, 3065, 3087, 3101, 3103, 3112, 3134, 3146, 3170, 3173, 3188, 3198, 3209, 3229, 3232, 3249, 3257, 3265, 3288, 3299, 3313, 3322, 3351, 3356, 3367, 3387, 3413, 3442, 3558, 3581, 3609, 3627, 3633, 3637, 3652, 3675, 3729, 3795, 3798, 3810, 3819, 3822, 3828, 3837, 3840, 3851, 3949, 3962], 'Wiley': [542], 'Online': [543], 'Library': [544], 'UseShareable': [549], 'LinkUse': [550], 'link': [552, 2296], 'a': [556, 571, 811, 848, 949, 1033, 1496, 1526, 1576, 1641, 1704, 1872, 1991, 2049, 2107, 2164, 2194, 2242, 2441, 2451, 2557, 2631, 2688, 2705, 2890, 2942, 3038, 3048, 3403, 3538, 3622, 3703, 3744], 'article': [561], 'your': [563], 'friends': [564], 'colleagues.': [566], 'Learn': [567], 'more.Copy': [568], 'URL': [569], 'Share': [570], 'linkShare': [572], 'onFacebookTwitterLinked': [573], 'InRedditWechat': [574], 'Abstract': [575], 'Photosensitizers,': [576], 'molecules': [577, 2233], 'that': [578, 617, 720, 729, 776, 815, 842, 1001, 1014, 1151, 1203, 1299, 1317, 1338, 1362, 1525, 1562, 2436, 2608, 3287, 3434, 3459], 'produce': [579], 'active': [580], 'oxygen': [581, 839, 1116, 1133, 2413, 2462, 2469, 2496, 3710, 3933], 'species': [582, 2463, 2470, 3711, 3934], 'upon': [583, 3706], 'activation': [584, 2474], 'visible': [586, 831], 'light,': [587], 'are': [588, 620, 869, 1006, 1057, 1107, 1165, 1196, 3224, 3602], 'currently': [589], 'being': [590, 3381], 'used': [591, 634, 742, 1222, 1405, 1450, 1480, 2294, 2416, 2486, 2616, 2901, 2997, 3139, 3717], 'in': [592, 652, 777, 786, 822, 878, 897, 900, 911, 915, 938, 1041, 1186, 1189, 1257, 1422, 1485, 1530, 1597, 1609, 1640, 1648, 1724, 1768, 1811, 1814, 1906, 1946, 1949, 2039, 2087, 2111, 2127, 2256, 2284, 2307, 2340, 2362, 2393, 2453, 2588, 2655, 2681, 2760, 2767, 2803, 2824, 2856, 2860, 2902, 2921, 2974, 2982, 3007, 3064, 3078, 3086, 3169, 3194, 3235, 3476, 3510, 3557, 3572, 3580, 3722, 3734, 3824, 3850, 3922, 3948, 3977], 'therapy': [594, 808], '(PDT)': [595, 809], 'treat': [597], 'cancer': [598, 813], 'other': [600, 627, 1088], 'conditions,': [601], 'where': [602, 3765], 'limitations': [603, 922], 'include': [604, 1549], 'normal': [605, 901], 'cells': [606, 768, 862, 902, 937, 1043, 1188, 1249, 1635, 1699, 2424, 2768, 2814, 2821, 2864, 3052, 3426, 3452, 3546, 3562, 3585, 3648, 3679, 3736, 3858, 3947, 3954], 'tissue': [608, 824], 'damage': [609, 1040, 1369], 'associated': [611], 'side': [612, 971], 'effects,': [613], 'fact': [616], 'cytotoxic': [618, 837], 'effects': [619, 972], 'largely': [621], 'restricted': [622], 'plasma': [625, 1026], 'peripheral': [628, 1054, 1324], 'membranes.': [629], 'In': [630, 754, 1082, 1218], 'study,': [632], 'we': [633, 951, 1221, 1404, 1466, 3138], 'insulin-containing': [635], 'which': [638, 1187, 1465, 1486, 1552, 1798, 1824, 1933, 1959, 3164, 3275, 3430, 3701], 'variants': [639], 'simian-virus-SV40': [642], 'large-tumor': [643], 'antigen': [644, 1419], '(T-ag)': [645, 1420], 'signal': [648, 1415], '(NLS)': [649, 1416], 'were': [650, 664, 741, 1241, 1636, 2068, 2188, 2254, 2367, 2376, 2642, 2756, 2822, 2865, 2939, 2996, 3005, 3053, 3062, 3094, 3120, 3150, 3178, 3190, 3508, 3518, 3547, 3555, 3774, 3955], 'linked': [651, 1432, 2070, 2354, 3180], 'order': [653, 3195], 'target': [655, 1042, 1214], 'photosensitizer': [657, 959, 1005, 1121, 1181, 1392, 2452, 2561, 2619, 3135, 3750], 'nucleus.': [662, 1395], 'NLSs': [663, 730, 1563, 1589], 'included': [665, 1421, 1451], 'either': [666, 1428, 2591, 2700, 3153, 3957], 'as': [667, 1032, 1075, 1211, 1429, 1516, 1658, 1682, 1766, 1904, 2498, 2747, 2998, 3161, 3724, 3726, 3755], 'peptides': [668, 1430, 1735, 2061, 3177, 3233, 3394], 'coupled': [669], 'co-valently': [670, 1431], 'carrier': [673, 1435, 1445, 2232, 2306, 2318], 'bovine': [674, 1275, 1847, 1980], 'serum': [675, 1276, 1848, 1981], 'albumin,': [676], 'or': [677, 1038, 1437, 2251, 2357, 2597, 2646, 2713, 2779, 2849, 2853, 2874, 2894, 2979, 2987, 3028, 3042, 3070, 3155, 3463, 3530, 3564, 3739, 3779, 3940, 3966], 'within': [678, 1029, 1270, 3294, 3793, 3809], 'coding': [680, 1441], 'sequence': [681, 1442, 3269], 'β-galactosidase': [683, 695, 1884, 2003, 2237, 2252, 3653], 'fusion': [684, 696, 1869, 1988, 2238, 3157, 3611], 'proteins.': [685], 'The': [686, 1118, 1285, 1373, 1447, 1716, 2060, 2205, 2231, 2795, 2863, 2994, 3221, 3606, 3641, 3866], 'most': [687], 'potent': [688], 'photosensitizing': [689, 734, 771, 1566, 2626], 'conjugate': [690, 1303, 2206, 3607, 3841], 'was': [691, 773, 1291, 1314, 1342, 1378, 1493, 1547, 1673, 1690, 1696, 2015, 2097, 2148, 2160, 2207, 2267, 2292, 2331, 2415, 2695, 2738, 2960, 3072, 3109, 3364, 3431, 3455, 3566, 3643, 3689, 3716, 3889, 3901], 'NLS-containing': [693, 759, 2236, 3176, 3242], 'T-ag': [694, 1448, 1780, 1800, 1826, 1875, 1891, 1915, 1935, 1961, 1994, 2245, 3147, 3258, 3266, 3281, 3302, 3346, 3617], 'protein': [697, 1870, 1989, 2239, 3158, 3612], '(P10)-(chlorin': [698], 'e6)-insulin,': [699, 3682], 'exhibiting': [700], 'an': [701, 722, 1212, 1332, 2409, 2454, 3337, 3657, 3660], 'EC50': [702, 1574, 3416, 3443, 3642, 3661, 3676, 3825], 'than': [704, 707, 716, 719, 775, 1298, 1316, 3433, 3458, 3906, 3913], '2400-fold': [705], 'lower': [706, 718, 2917, 3432, 3669], 'value': [709, 3662], 'free': [711, 1319, 1335, 3500, 3686, 3834], 'e6,': [713, 1570, 3137, 3166, 3532], '15-fold': [717], 'NLS-deficient': [723], 'β-galactosidase-(chlorin': [724, 2229, 3595, 3683], 'e6)-insulin': [725, 1279, 1290, 1844, 1858, 1865, 1899, 2010, 2227, 3462, 3466, 3684, 3791, 3806, 3843, 3862, 3912, 3916, 3939, 3942, 3964, 3969], 'construct,': [726], 'thus': [727, 1500], 'demonstrating': [728], 'can': [731, 846, 2614], 'increase': [732, 744, 977, 1564, 1591], 'activity': [735, 772, 1366, 1383, 1567, 1840, 1975, 2392, 2636, 2923, 3240, 3251, 3363, 3484, 3721], 'e6.': [738, 2989], 'Attenuated': [739], 'adenoviruses': [740, 785, 1585, 1608], 'through': [750, 983, 1348, 2378, 2622], 'its': [751], 'endosomal-membrane-disrupting': [752], 'activity.': [753, 1601, 3640], 'case': [756, 1259, 3066, 3088, 3171, 3559, 3582], 'P10-conjugate,': [760], 'co-incubation': [761], 'adenovirus': [763, 1666], 'increased': [764, 1364], 'proportion': [766], 'whose': [769], 'higher': [774, 1292, 1315, 2910, 3457, 3908], 'cytoplasm': [779, 2765, 3799, 3811, 3852], '2.5-fold.': [781], 'This': [782, 2484, 3332, 3741], 'use': [783, 1398, 1606], 'conjunction': [787, 1610], 'photosensitizers': [789, 821, 835, 843, 934, 1066, 1613], 'has': [790, 1127, 1182, 2522, 2568], 'clear': [791, 1615], 'implications': [792, 1616], 'achieving': [794, 1618], 'efficient': [795, 1010, 1619, 3341], 'cell-type-specific': [796, 1620], 'PDT.': [797], 'Int.': [798], 'J.': [799], 'Cancer': [800], '81:734–740,': [801], '1999.': [802], '©': [803], 'Wiley-Liss,': [805], 'Inc.': [806], 'Photodynamic': [807, 1326, 3483, 3494], 'is': [810, 918, 975, 1013, 1533, 1722, 1742, 1792, 1817, 1927, 1952, 2426, 2434, 2440, 2485, 2515, 2556, 2629, 3743], 'novel': [812], 'treatment': [814, 852], 'depends': [816], 'on': [817, 1411, 1675, 2212, 2963, 3448, 3488, 3503, 3646], 'retention': [819], 'tumor': [823, 829, 898, 936], 'irradiation': [826, 2888, 2981, 3672, 3945], 'light.': [832], 'Upon': [833], 'activation,': [834, 2914], 'generate': [836], 'reactive': [838, 1115, 2412, 2461, 2495, 3709, 3932], 'species,': [840, 2414, 2497], 'meaning': [841], 'PDT': [845, 917], 'be': [847, 929, 964, 1110, 1208, 1244, 1329, 2606, 2615, 2928, 3904], 'particularly': [849], 'useful': [850, 1210], 'alternative': [851], 'drug-resistant': [854], 'tumors': [855], '(Canti': [856], 'et': [857, 864, 881, 904, 991, 1049, 1100, 1104, 1139, 1143, 1199, 1236, 1264, 1282, 1358, 1661, 1685, 2030, 2328, 2370, 2418, 2505, 2509, 2546, 2565, 2576, 2638, 2730, 2751, 2809, 2906, 2933, 2955, 3001, 3762, 3854, 3897], 'al.,': [858, 865, 882, 905, 992, 1050, 1101, 1105, 1140, 1144, 1200, 1237, 1265, 1283, 1359, 1662, 1686, 2031, 2329, 2371, 2419, 2506, 2510, 2547, 2566, 2577, 2639, 2731, 2810, 2907, 2934, 2956, 3002, 3763, 3855, 3898], '1995)': [859, 2250, 2578], 'radio-resistant': [861], '(Lofgren': [863], '1995).': [866, 1238, 1284, 1477, 1513, 1663, 1830, 1842, 1889, 1965, 1977, 2008, 2264, 2420, 2640, 3331], 'Since': [867], 'porphyrins': [868], 'taken': [870, 953], 'up': [871], 'non-selectively': [872], 'all': [874, 1815, 1950, 2789], 'cell': [875, 1085, 1091, 1136, 1194, 1272, 1678, 2534, 2964, 2992, 3107, 3376], 'types': [876], 'studied': [877], 'vitro': [879], '(Henderson': [880], '1983),': [883], 'e.g.,': [884], 'mono-L-aspartyl': [888, 1162], 'been': [892, 1128, 1183, 2523, 2569, 2900, 3277], 'shown': [893, 1129, 1468, 1810, 1945, 2499, 2524, 2570, 3225, 3278, 3286], 'accumulate': [895], 'both': [896, 1313, 3747, 3794], '(Aizawa': [903], '1987),': [906], 'lack': [908], 'selectivity': [910], 'terms': [912], 'cytotoxicity': [914], 'conventional': [916], 'one': [919], 'approach.': [925], 'Although': [926], 'there': [927, 2959], 'may': [928, 1206], 'some': [930], 'preferential': [931], 'uptake': [932, 1339], 'situ,': [939], 'apart': [940, 1152], 'from': [941, 1153, 1368, 1535, 2021, 2448, 2554, 2600, 2612, 2788, 3891], 'cell-specific': [942, 3129], '(Reddy,': [944, 1080], '1997;': [945, 993], 'see': [947, 995, 2065, 3885], 'below),': [948], 'strategy': [950], 'enable': [955], 'dose': [957, 2911, 2918], 'administered': [960], 'patients': [962], 'reduced': [965, 1355], 'hence': [967], 'minimize': [968], 'harmful': [970], 'PDT,': [974], 'effectiveness': [979], 'tumor-cell': [981, 1011], 'killing': [982, 1012], 'targeted': [984, 3130], 'hypersensitive': [987], 'subcellular': [988, 2529, 2562, 2620, 3730, 3749, 3769], 'sites': [989, 1158, 2490, 3928], '(Akhlynina': [990, 1099, 1138, 1235, 1263, 1281, 1357, 1660, 2417, 2545, 2564, 2575, 2637, 2905, 2932, 2954, 3000, 3761, 3896], 'below).': [996, 2692], 'One': [997], 'reasons': [1000], 'large': [1002], 'doses': [1003, 2898, 2937, 3670], 'normally': [1007], 'required': [1008], 'porphyrins,': [1015], 'including': [1016, 2536, 3350], 'hematoporphyrin': [1020], 'derivatives,': [1021], 'localize': [1022], 'predominantly': [1023], 'at': [1024, 1352, 1503, 1638, 1703, 2048, 2106, 2134, 2144, 2174, 2193, 2200, 2431, 2652, 2676, 2892, 3021, 3083, 3316, 3409, 3523, 3576, 3626, 3975], 'membrane': [1027], 'mitochondria,': [1030, 2539], 'and,': [1031, 3168], 'result,': [1034], 'primarily': [1035], 'induce': [1036, 1131], 'plasma-membrane': [1037], 'mitochondrial': [1039], '(Roberts': [1044, 1168], 'Berns,': [1046, 1170], '1989;': [1047], 'Bachor': [1048, 1103, 1142], '1991).': [1051, 2467, 3856], 'Plasma': [1052], 'intracellular': [1055, 1213, 1371, 2429, 2492], 'membranes': [1056, 1086], 'also': [1058, 1479, 2630], 'predominant': [1060], 'targets': [1061, 1113], 'conjugated': [1067, 2016, 2116], 'agents': [1069], 'specific': [1070, 1227, 1233, 1253, 1406, 2793], 'target-cell-surface': [1072], 'determinants,': [1073], 'such': [1074, 1515], 'antibodies': [1076], 'low-density': [1078], 'lipoproteins': [1079], '1997).': [1081, 2935, 3003], 'contrast': [1083], 'organelles,': [1089], 'nucleus': [1092, 1273, 2544, 2762, 2805, 3796], '(Wiseman': [1093], 'Halliwell,': [1095], '1996)': [1096], 'lysosomes': [1098, 1167], '1995;': [1102, 1141, 2548, 2728, 2807], '1991)': [1106], 'known': [1108, 2435], 'very': [1111], 'sensitive': [1112], 'species.': [1117], 'into': [1122, 1252, 1393, 1439, 2423, 2527], 'lysosomes,': [1123, 1256], 'followed': [1124], 'photo-activation,': [1126], 'singlet': [1132], 'production': [1134, 2459, 2493, 2553, 2599, 2611, 2694, 3783, 3930], 'death': [1137], '1991),': [1145], 'while': [1146, 1308, 1344, 1581, 3100, 3203, 3310, 3651], 'transmission': [1147], 'electron': [1148], 'microscopy': [1149, 2702, 2717], 'indicates,': [1150], 'mitochondrion,': [1155], 'primary': [1157], 'photofrin': [1160], 'chlorin-e6-induced': [1163], 'destruction': [1164], '1989).': [1171], 'Cell-cycle': [1172], 'dependence': [1173], 'photosensitization': [1175, 1341, 1356], 'respect': [1177], 'lysosomally': [1179], 'localized': [1180, 3849], 'shown,': [1184], 'however,': [1185], 'stationary': [1191], 'phase': [1192], 'growth': [1195], 'insensitive': [1197], '(Strauss': [1198], '1995),': [1201, 1266, 1360, 1804, 1939, 2032, 2511, 2567, 3309, 3615, 3764], 'implying': [1202], 'lysosome': [1205], 'not': [1207, 3219], 'generally': [1209], 'action.': [1217], 'earlier': [1219, 2903, 3759, 3894], 'experiments,': [1220], 'ligands': [1225], 'cellular': [1228, 1254], 'receptors': [1229], 'effect': [1231, 2439, 2962], 'cell-type': [1232], 'targeting': [1234, 1408, 1594, 3343, 3697], 'These': [1239], 'able': [1242], 'endocytosed': [1245], 'receptor-expressing': [1248], 'transported': [1251], 'compartments:': [1255], 'concanavalin-A-chlorin-e6': [1261], 'near': [1268, 1295], 'albumin': [1277], '(BSA)-(chlorin': [1278], 'BSA-(chlorin': [1289, 2073, 2085], '(selective': [1293, 1304], 'photodamage': [1294, 1305], 'nucleus)': [1297], 'concanavalin-A-chlorin': [1301], 'lysosomes),': [1307], '(photodamage': [1322], 'membranes).': [1325], 'could': [1328], 'competed': [1330], 'excess': [1333], 'ligand,': [1336], 'indicating': [1337, 1361], 'receptor-specific,': [1343], 'prevention': [1345], 'endocytosis': [1347], 'incubation': [1349, 2968, 3046, 3936], 'low': [1353], 'temperature': [1354], 'resulted': [1367], 'sites.': [1372], 'goal': [1374], 'study': [1377], 'directed': [1389], 'We': [1396, 1478, 3244, 3284], 'made': [1397, 2757], '2': [1400, 1910, 2662, 3829], 'new': [1401], 'components:': [1402], 'first,': [1403], 'based': [1410], 'simian-virus-SV40-large-tumor': [1418], 'insulin-': [1424], 'chlorin-e6-containing': [1426, 1714, 3486, 3497], 'conjugates,': [1427, 2405, 2783, 3175, 3202], 'BSA,': [1436, 1846, 1979, 2664], 'incorporated': [1438], 'β-galactosidase.': [1446, 1851, 1984], 'sequences': [1449, 1731, 3230], 'NLS': [1453, 1734, 1773, 1785, 1839, 1920, 1974, 3259, 3338, 3405], '(amino': [1454, 3260, 3270], 'acids': [1455, 1463, 1788, 1877, 1886, 1893, 1923, 1996, 2005, 2247, 3261, 3271, 3348, 3619], '126–132)': [1456, 1789, 1924, 3262], 'together': [1457, 1700, 1727, 3227, 3263], 'N-terminal': [1460, 1880, 1999, 3267], 'flanking': [1461, 3268, 3296], 'amino': [1462, 1787, 1876, 1885, 1892, 1922, 1995, 2004, 2246, 3347, 3618], '(111–125),': [1464], 'import': [1473, 1802, 1828, 1937, 1963, 3304], 'rate': [1474, 3300], '50-fold': [1475, 3307], '(Jans,': [1476, 1512, 1803, 1829, 1841, 1888, 1938, 1964, 1976, 2007, 2249, 2263, 2727, 2806, 3308, 3330, 3614], 'derivatives': [1481, 3144], 'latter': [1484], 'cyclin-dependent-kinase': [1488], '(cdk)': [1489], 'site': [1490, 1505, 1794, 1819, 1929, 1954, 2398, 3291, 3318, 3358, 3629], 'Thr124': [1491, 1806, 1941], 'residue': [1492, 3625], 'replaced': [1494], 'non-phosphorylatable': [1497, 3623], 'alanine': [1498, 3624], 'residue,': [1499], 'preventing': [1501], 'phosphorylation': [1502, 1797, 1821, 1932, 1956, 3290, 3311], 'consequently': [1507], 'inhibition': [1508], 'transport': [1511, 1532, 3326], 'Ligands': [1514], 'insulin': [1517, 2095, 3142, 3167, 3835], 'proceed': [1518], 'endosomes': [1520], 'after': [1521, 2518, 2602, 3122, 3213, 3386, 3784, 3935], 'receptor-mediated': [1522], 'endocytosis,': [1523], 'so': [1524], 'potentially': [1527], 'limiting': [1528], 'step': [1529, 3215], 'escape': [1534], 'these': [1536, 3892], 'vesicle': [1537], 'structures': [1538], 'access': [1540], 'cytosol.': [1542], 'Accordingly,': [1543], 'second': [1545], 'innovation': [1546], 'attenuated': [1550], 'adenoviruses,': [1551], 'possess': [1553], 'endosomolytic': [1554], 'function,': [1555], 'conjugates.': [1558], 'Results': [1559], 'demonstrated': [1560, 3756], 'clearly': [1561], 'maximally': [1571], 'reducing': [1572], 'factor': [1577], 'over': [1579], '2000-fold,': [1580], 'inclusion': [1583], 'synergized': [1586], 'efficiency,': [1595], 'consequence': [1598], 'Our': [1602], 'results': [1603, 2581, 3767], 'nuclear-targeting': [1612], 'therapy.': [1622], 'MATERIAL': [1623], 'AND': [1624], 'METHODS': [1625], 'Cell': [1626, 3479], 'culture': [1627], 'PLC/PRF/5': [1628, 3068, 3369, 3425, 3489, 3561, 3647, 3678, 3735, 3857, 3953], 'human': [1629, 3370, 3490], 'hepatoma': [1630, 3371, 3491], 'C6': [1632, 3090, 3373, 3449, 3504, 3584], 'rat': [1633, 3374, 3450], 'glioma': [1634, 3375, 3451, 3505], 'cultured': [1637, 1674], '37°C': [1639, 2135, 2175, 3022, 3524, 3976], 'humidified': [1642], 'incubator': [1643], '5%': [1645], 'CO2': [1646], 'atmosphere': [1647], 'RPMI-1640': [1649, 2656, 2825, 2869], 'medium': [1650, 2456, 2657, 2684, 2826, 2859, 2870], '(Serva,': [1651], 'Heidelberg,': [1652], 'Germany)': [1653], '10%': [1655], 'heat-inactivated': [1656], 'FCS': [1657], 'described': [1659, 1683, 1743, 1767, 1905, 2748, 2999], 'Adenovirus': [1664, 1695], 'Human': [1665], 'serotype': [1667], '5,': [1668], 'strain': [1669], 'dl312': [1670], '(Ad5': [1671], 'dl312)': [1672], '293': [1677], 'line': [1679], 'purified': [1681, 2208, 2259, 2377], '(Sobolev': [1684, 2327, 2369], '1998).': [1687], 'Virion': [1688], 'concentration': [1689, 1705, 2166, 3104], 'determined': [1691], 'spectrophotometric': [1693], 'analysis.': [1694], 'incubated': [1697, 2173, 2199, 2643, 2670, 2840, 3014, 3519, 3956], '3.7': [1707], '×': [1708, 3592], '1010': [1709], 'virions/ml.': [1710], 'Synthesis': [1711, 1737, 3125], 'basic': [1717], 'outline': [1718], 'summarized': [1723], 'Table': [1725, 1745, 2066, 3236, 3273, 3360], 'I,': [1726], 'amino-acid': [1730, 1781, 1916], 'used.': [1736], 'different': [1740, 2533, 2925], 'below.': [1744], 'I.': [1746, 3237], 'OUTLINE': [1747], 'OF': [1748, 1760], 'THE': [1749, 1757, 1761], 'CONJUGATES': [1750], 'USED': [1751, 1763], 'IN': [1752], 'THIS': [1753], 'STUDY,': [1754], 'TOGETHER': [1755], 'WITH': [1756], 'AMINO-ACID': [1758], 'SEQUENCES': [1759], 'NLS-PEPTIDES/SEQUENCES': [1762], 'Conjugate11': [1764], 'Prepared': [1765, 1903], '“Material': [1769, 1907, 3182, 3713, 3886], 'Methods”.': [1771, 1909], 'Carrier': [1772], 'peptide/protein': [1774], 'sequence22': [1775], 'Numbers': [1776, 1911], 'refer': [1777, 1912], 'sequence,': [1782, 1917], '(T-ag': [1786, 1921], 'underlined.': [1790, 1925], 'Ser112': [1791, 1926], 'CKII': [1796, 1931, 3352], 'enhances': [1799, 1934], '(substituted': [1807, 1942], 'Ala,': [1809, 1944], 'bold': [1812, 1947], 'type,': [1813, 1948], 'cases)': [1816, 1951], 'cdc2': [1823, 1958, 3315], 'inhibits': [1825, 1960], 'Substitution': [1831, 1966], 'Lys128': [1833, 1968], '(bold': [1834, 1969], 'type)': [1835, 1970], 'Thr': [1837, 1972], 'abolishes': [1838, 1973], 'BSA-P101Lys-(chlorin': [1843, 2009, 3461, 3590, 3790, 3842, 3861, 3911, 3938], 'BSA33': [1845], 'albumin;': [1849, 1982], 'β-Gal,': [1850, 1983], 'P101Lys:': [1852], 'NH2-Cys-Gly-Pro-Gly-Ser112-': [1853], 'Asp-Asp-Glu-Ala-Ala-Ala-Asp-Ala-Gln-His-Ala-Ala124-': [1854], 'Pro-Pro-Lys-Lys128-Lys-Arg-Lys-': [1855], 'Val132-Gly-Tyr-COOH': [1856], 'BSA-P101Thr-(chlorin': [1857, 2012, 3465, 3805, 3915, 3941, 3968], 'BSA': [1859, 2014, 2052, 2831, 2878, 3154], 'P101Thr:': [1860], 'NH2-Cys-Gly-Pro-Gly-Ser112-Asp-Asp-Glu-Ala-': [1861], 'Ala-Ala-Asp-Ala-Gln-His-Ala-Ala124-Pro-Pro-Lys-': [1862], 'Thr128-Lys-Arg-Lys-Val132-Gly-Tyr-COOH': [1863], 'P10-(chlorin': [1864, 2226, 3598, 3681], 'P1044': [1866], 'P10,': [1867, 1986, 2240], 'T-ag-β-galactosidase': [1868, 1987, 3610], 'variant': [1873, 1992, 2243], '111–135': [1878, 1997, 2248, 3620], 'fused': [1879, 1998], 'Escherichia': [1882, 2001], 'coli': [1883, 2002], '9–1023': [1887, 2006], 'Includes': [1890], '111–135:': [1894], 'Ser-Ser112-Asp-Asp-Glu-Ala-Thr-Ala-Asp-Ala-Gln-His-Ala-': [1895], 'Ala124-Pro-Pro-Lys-Lys128-': [1896], 'Lys-Arg-Lys-Val-Glu-Asp-Pro135': [1897], 'β-Gal-(chlorin': [1898], 'β-Gal': [1900], 'none': [1901], '1': [1902, 3015, 3514], '3': [1978], '4': [1985], 'e6)-insulin.': [2013, 2230, 3599], 'isolated': [2020], 'leaves': [2022], 'nettle': [2025], '(Urtica': [2026], 'dioica': [2027], 'L.;': [2028], 'using': [2033, 2075, 2272, 2590, 2687, 2704, 2719, 2740, 2941, 3037, 3074, 3096, 3111, 3152, 3366, 3537, 3608, 3737, 3776], 'cyclo-hexyl-3(2-morpholinoethyl)carbodiimide': [2034], 'metho-4-toluene': [2035], 'sulfonate': [2036], '(CMCS,': [2037], 'Serva)': [2038], '10': [2040, 2285, 2310, 2834, 2881, 3050, 3544], 'mM': [2041, 2092, 2132, 2157, 2286, 2311, 2342, 2345, 2666, 2835, 2882], 'Na-phosphate': [2042, 2287, 2312, 2381], 'buffer,': [2043, 2288, 2313], 'pH': [2044, 2289, 2314, 2347, 2385, 2668, 2837, 2884], '7.5': [2045, 2348], '(buffer': [2046, 2349], 'A)': [2047], 'ratio': [2050, 2108, 2195, 2337, 2797, 3869], 'CMCS': [2057, 2273, 2281, 2291, 2323], '1:30:300.': [2059], '(P101Lys': [2062], 'P101Thr,': [2064], 'I)': [2067, 3274], 'then': [2069, 2115, 2140, 2161, 2179, 2352, 2679, 2696, 2866, 3033, 3533], 'individually': [2071], 'e6)': [2074, 2086], '3-maleimidobenzoyl-N-hydroxysuccinimide': [2076], 'ester': [2077], '(MBS,': [2078], 'Sigma,': [2079], 'St.': [2080], 'Louis,': [2081], 'MO)-activated': [2082], 'NH2-groups': [2083], 'buffer': [2088, 2112, 2128, 2153, 2182, 2363, 2382], 'A': [2089, 2113, 2129, 2154], '0.5': [2091, 2131, 2156], 'EDTA.': [2093, 2158], 'Bovine': [2094], '(Sigma)': [2096, 3077, 3571], 'reacted': [2098, 2269, 2332], 'separately': [2099], 'sulpho-succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate': [2101], '(sulfo-SMCC,': [2102], 'Pierce,': [2103], 'Rockford,': [2104], 'IL)': [2105], '1:1.5': [2110], 'dithiothreitol-pre-treated': [2118], 'BSA-chlorin': [2119], 'e6)-peptide': [2120], '(ratio': [2121, 2274, 2316, 2359], '15:1)': [2123, 2361], 'under': [2124, 2190], 'anaerobic': [2125, 2191], 'conditions': [2126, 2192], 'EDTA': [2133], '30': [2137, 2177], 'min': [2138, 2675], '18': [2142, 2203, 2650, 3019, 3384, 3521, 3973], 'hr': [2143, 2651, 3020, 3385, 3522, 3974], '4°C.': [2145], 'Excess': [2146, 3833], 'sulfo-SMCC': [2147], 'removed': [2149, 2368], 'dialysis': [2151, 2379], 'against': [2152, 2181, 2380], 'Dithiothreitol': [2159], 'added': [2162], 'final': [2165], '50': [2168, 3419], 'mM,': [2169, 2384], 'mixture': [2172], 'min,': [2178], 'dialyzed': [2180], 'Sulfo-SMCC-insulin': [2184], 'HS-BSA-(chlorin': [2186], 'e6)-P101Lys': [2187], 'mixed': [2189], '15:1': [2197], '4°C': [2201], 'hr.': [2204], 'column': [2210, 3206], 'chromatography': [2211, 2262, 3207], 'Sephacryl': [2213], 'S-300': [2214], '(Pharmacia,': [2215], 'Uppsala,': [2216], 'Sweden)': [2217], 'ultimately': [2219], 'analyzed': [2220], 'SDS-polyacrylamide': [2222], 'gel': [2223], 'electrophoresis': [2224], '(PAGE).': [2225], '[either': [2234], 'itself]': [2253], 'expressed': [2255], 'bacteria': [2257], 'affinity': [2261], 'Chlorin': [2265, 3846], 'initially': [2268], '1,6-diaminohexane': [2271, 2279], '1:100:100)': [2283], '7.0.': [2290], 'subsequently': [2293], 'modified': [2298], '(“aminochlorin': [2301], 'e6”)': [2302], 'P10/β-galactosidase': [2305], 'same': [2309, 2683, 2858], '7.0': [2315], '“aminochlorin': [2320], 'e6”': [2321], '1:30:300).': [2325], 'Citraconic-insulin': [2326], '1998)': [2330, 2372], 'N-succinimidyl': [2334], '3-[2-pyridyldithio]propionate': [2335], '(Sigma;': [2336], '1:6)': [2339], '25': [2341, 2665], 'HEPES,': [2343, 2667, 2883], '150': [2344], 'NaCl,': [2346], 'B),': [2350], 'citraconic-insulin-pyridyldithiopropionate': [2353], 'P10-chlorin-e6': [2356], 'β-galactosidase-chlorin-e6': [2358], 'B.': [2364], 'Citraconic': [2365], 'groups': [2366], '(10': [2383], '7.0).': [2386], 'Visualization': [2387], 'quantitation': [2389], 'situ': [2394, 3723], 'To': [2395], 'visualize': [2396, 2488], 'chlorin-e6': [2400, 2473], 'photoactivation': [2401], 'due': [2402, 3406], '2′,7′-dichlorofluorescin': [2406], 'diacetate': [2407], '(DCFD),': [2408], 'indicator': [2410, 2559, 2633, 3746], 'DCFD': [2421, 2521, 2555, 2601, 2613, 2672, 3780], 'penetrates': [2422], 'de-acetylated': [2427], 'esterases': [2430], '37°C.': [2432], 'It': [2433, 2604], 'photo-oxidation': [2442], 'biosubstrates': [2444], '(also': [2445], 'DCFD)': [2446], 'resulting': [2447], 'illumination': [2449], 'aerated': [2455], 'subsequent': [2458, 3879], '(Spikes': [2464], 'Bommer,': [2466], 'Reactive': [2468], 'generated': [2471, 3775], 'react': [2475], '2′,7′-dichlorofluorescin,': [2477], 'yield': [2479, 2792], 'fluorescent': [2481, 3704], 'derivative': [2482], '2′,7′-dichlorofluorescein.': [2483], 'ourselves': [2501], 'others': [2503], '(Suematsu': [2504], '1991;': [2507], 'especially': [2512], 'if': [2513], 'analysis': [2514, 2734], 'performed': [2516, 2587, 2739, 3121], 'immediately': [2517, 2698], 'photo-irradiation,': [2519], 'since': [2520, 2609], 'penetrate': [2526], 'various': [2528, 2842, 3024, 3222, 3526], 'compartments': [2530, 2541], 'many': [2532], 'types,': [2535], 'cytosol,': [2538], 'endocytotic': [2540], 'Sarvazyan,': [2549], '1996).': [2550, 2732, 2811], 'That': [2551], '2′,7′-dichlorofluorescein': [2552, 2598, 2610, 2693, 3782, 3787, 3802, 3878], 'true': [2558], 'location': [2563, 2621], 'own': [2573], 'experiments': [2574, 3760, 3895], 'comparing': [2579], 'insulin-BSA-chlorin-e6': [2585, 3772], 'parallel,': [2589], 'fluorescence': [2593, 2759, 2786, 3876], 'FITC-labelled': [2595, 3777], 'photo-activation.': [2603, 3785], 'should': [2605], 'stressed': [2607], 'determine': [2618, 3728], 'detection': [2624], 'activity,': [2627, 3754], 'it': [2628], 'quantitative': [2632], 'Cells': [2641, 3004, 3507], '37°C,': [2653, 2677], 'washed': [2654, 2680, 2823, 2867, 3034, 3534], '(without': [2658], 'phenol': [2659, 2875], 'red,': [2660, 2876], 'mg/ml': [2663], '7.5),': [2669], 'irradiated': [2686, 3036, 3536], 'slide': [2689, 3039, 3539], 'projector': [2690, 3040, 3540], '(see': [2691, 3181, 3359, 3427, 3712, 3831], 'visualized': [2697], 'employing': [2699], 'video-intensified': [2701], '(VIM)': [2703], 'cooled': [2706], 'CCD': [2707], 'camera': [2708], '(AT200,': [2709], 'Photometrics,': [2710], 'Tucson,': [2711], 'AZ)': [2712], 'confocal': [2714], 'laser': [2715], 'scanning': [2716], '(CLSM)': [2718], 'BioRad': [2721], '(Hercules,': [2722], 'CA)': [2723], 'MRC-600': [2724], 'CLSM': [2725, 2736, 3738], 'system': [2726], 'Xiao': [2729, 2750, 2808], 'Image': [2733, 2743], 'files': [2737], 'NIH': [2742], 'public': [2744], 'domain': [2745], 'software': [2746], 'al.': [2752], '(1996).': [2753], 'Equivalent': [2754], 'measurements': [2755], '(Fn),': [2763], '(Fc)': [2766, 3875], 'treated': [2769, 3859], 'without': [2772, 2827, 2871, 3254], '(background': [2773], 'fluorescence)': [2774], 'pre-treatment': [2775], 'background': [2785, 3883], 'subtracted': [2787], 'values': [2790, 3417, 3826], 'fluorescence.': [2794], 'nuclear/cytoplasmic': [2796], '(Fn/c)': [2798], 'represents': [2799], 'fold': [2801], 'accumulation': [2802, 3838], 'Irradiation': [2812], 'After': [2815, 3045, 3543], 'plating': [2816, 3011], '24': [2818], 'hr,': [2819], 'sodium': [2828, 2872], 'bicarbonate,': [2829], '(2': [2832, 2879], 'mg/ml),': [2833, 2880], 'HEPES': [2836], '7.2,': [2838, 2885], 'concentrations': [2843, 3025, 3527], '(in': [2846, 3031], 'presence': [2848, 3950], 'absence': [2850, 2976, 2984], 'insulin)': [2852], 'dark.': [2862], 'bicarbonate': [2873], 'prior': [2886], 'slide-projector': [2891], '12.3': [2893], '96': [2895, 3043], 'kJ/m2.': [2896], 'Both': [2897], 'work': [2904], '1997),': [2908, 2958], 'giving': [2912], 'maximal': [2913, 3323], 'permitting': [2919], 'differences': [2920], 'discerned': [2929], 'easily': [2931], 'Light': [2936], '(polychromatic)': [2938], 'measured': [2940, 3082, 3365], 'fluence': [2943], 'meter': [2944], 'ILD-2M': [2945], '(Institute': [2946], 'Physical': [2948], 'Measurements,': [2949], 'Russia).': [2951], 'As': [2952], 'reported': [2953], '1995,': [2957], 'no': [2961], 'viability': [2965, 2993, 3480], 'induced': [2966], 'any': [2970], 'irradiation,': [2978], 'Determination': [2990], 'assays': [2995], 'plated': [3006, 3509], '35-mm': [3008, 3511], 'dishes': [3009], '(70%': [3010], 'efficiency),': [3012], 'day': [3016, 3515], 'later': [3017, 3516], 'triplicate),': [3032], '(12.3': [3041, 3673], 'kJ/m2).': [3044, 3542], 'further': [3049], 'days,': [3051, 3545], 'fixed': [3054, 3548], 'stained': [3056, 3550], 'methylene': [3058, 3552], 'blue': [3059], 'colonies': [3061, 3554], 'counted,': [3063, 3556], 'cells,': [3069], 'dye': [3071, 3565], 'extracted': [3073, 3567], '1%': [3075, 3569], 'N-lauroyl-sarcosine': [3076, 3570], 'PBS': [3079, 3573], 'absorbance': [3081, 3575], '630': [3084, 3577], 'nm,': [3085], 'cells.': [3091, 3506], 'Standard': [3092, 3600], 'deviations': [3093, 3601], 'calculated': [3095, 3110, 3890], 'Microsoft': [3097], 'Excel': [3098], '5.0,': [3099], 'EC50,': [3102], 'inducing': [3105], '50%': [3106], 'death,': [3108], 'least-square': [3113], 'method.': [3114], 'Electrophoresis': [3115], 'Molecular-weight': [3116], 'estimations': [3117], 'SDS-PAGE.': [3123], 'RESULTS': [3124], 'For': [3128], 'NLS.': [3148], 'Conjugates': [3149], 'constructed': [3151], 'β-galactosidase/β-galactosidase': [3156], 'T-ag-β-gal-protein': [3159], '(P10)': [3160], 'carriers': [3162], 'BSA-containing': [3174], 'successively': [3179], 'Methods”).': [3184], 'All': [3185], 'steps': [3186], 'conjugation': [3189, 3217], 'monitored': [3191], 'SDS-PAGE': [3193], 'estimate': [3197], 'molecular': [3199, 3204, 3211], 'weights': [3200, 3212], 'sieve': [3205], 'confirmed': [3208], 'increasing': [3210], 'each': [3214], '(data': [3218], 'shown).': [3220], 'schematically,': [3226], 'used,': [3234], 'Enhanced': [3238], 'set': [3245], 'out': [3246, 3383], 'compare': [3248], '111–125—see': [3272], 'transport.': [3283], 'casein-kinase-II(CKII)': [3289], '(serine': [3292], '112)': [3293], 'region': [3297], 'increases': [3298], 'about': [3306, 3328], 'cdk': [3314, 3357, 3628], 'another': [3317], '(threonine': [3319], '124)': [3320], 'reduces': [3321], 'level': [3324], '70%': [3329], 'enabled': [3333], 'us': [3334], 'design': [3336], 'optimized': [3339], '(P101Lys)': [3344], 'spanning': [3345], '111–132,': [3349], 'site,': [3353], 'but': [3354, 3401], 'lacking': [3355, 3656], 'I).': [3361], 'Photosensitizing': [3362], 'insulin-receptor-bearing': [3368], 'lines,': [3377], 'photo-activation': [3378], '(96': [3379, 3541], 'kJ/m2)': [3380], 'carried': [3382], 'addition': [3388], 'conjugate.': [3390], 'BSA-based': [3391], 'P101Lys': [3395, 3634], 'P101Thr': [3397], '(identical': [3398], 'P101Lys,': [3400], 'non-functional': [3404], 'threonine': [3408], 'position': [3410], '128': [3411], 'NLS)': [3414], 'gave': [3415], '104': [3421], 'nM,': [3422], 'respectively,': [3423], 'Fig.': [3428, 3472], '1a),': [3429], '(350': [3438], 'nM—Fig.': [3439], '1b).': [3440, 3667], 'Similarly,': [3441], 'alone': [3447, 3848], '(>1000': [3453], 'nM)': [3454], 'much': [3456], '(28': [3467], '74': [3469], 'nM': [3470, 3645, 3665, 3694, 3960], 'respectively;': [3471], '1c).': [3473], 'Figure': [3474, 3920], '1Open': [3475], 'figure': [3477, 3923], 'viewerPowerPoint': [3478, 3924], 'curves:': [3481], '(a,b)': [3482, 3965], 'cells;': [3492], '(c)': [3493, 3970], 'dishes,': [3512], 'they': [3517], 'blue;': [3553], '(a,b),': [3563], 'nm': [3578], 'measured,': [3579], '(c).': [3586], '□,': [3587], 'BSA-P101Thr-(chlorin-e6)-insulin;': [3588], '█,': [3589], 'e6)-insulin;': [3591, 3596], 'chlorin-e6-free;': [3593], '○,': [3594], '•,': [3597], 'indicated': [3603], '(error': [3604], 'bars).': [3605], 'P10': [3613], 'threonine,': [3630], 'comparable': [3631], 'peptide,': [3635], 'showed': [3636, 3863], 'highest': [3638], '0.13': [3644], '(Fig.': [3649, 3666, 3800, 3812, 3844], '1b),': [3650], 'conjugate,': [3654], 'completely': [3655], 'NLS,': [3658], 'exhibited': [3659], '2.0': [3664], 'At': [3668], 'kJ/m2),': [3674], '17,': [3690], '319': [3691], '11500': [3693], 'respectively.': [3695], 'DCFD,': [3700], 'yields': [3702], 'product': [3705], 'interaction': [3707], 'Methods”)': [3715], 'measure': [3719], 'well': [3725], 'distribution': [3731, 3926], 'VIM.': [3740], 'approach': [3742], 'valid': [3745], 'identical': [3766], 'Whereas': [3786], 'produced': [3788, 3803], 'accumulated': [3792, 3807], '2a),': [3801], 'mainly': [3808], '2c),': [3813], 'differential': [3815], 'presumably': [3817], 'representing': [3818], 'basis': [3820], 'difference': [3823], 'above).': [3832], 'inhibited': [3836], '2b).': [3845], '(Bachor': [3853], 'accumulation.': [3865], 'Fn/c': [3867], '[the': [3868], '(Fn)': [3872], 'cytoplasmic': [3874], 'correction': [3881], 'fluorescence;': [3884], 'Methods”]': [3888], '1997)': [3899], 'found': [3902], '85%': [3907], '(0.88)': [3909], '(Fn/c': [3917], '0.48).': [3919], '2Open': [3921], 'Intracellular': [3925], 'DCFD.': [3952], '100': [3959], 'BSA-P1010Lys-(chlorin': [3963]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4238345585', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-09-19T17:10:19.331232', 'created_date': '2022-05-12'}