Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4234241458', 'doi': 'https://doi.org/10.21203/rs.3.rs-28626/v1', 'title': 'Activated Hepatic Stellate Cells Induce Infiltration and Formation of CD163+ Macrophages via CCL2/CCR2 Pathway', 'display_name': 'Activated Hepatic Stellate Cells Induce Infiltration and Formation of CD163+ Macrophages via CCL2/CCR2 Pathway', 'publication_year': 2020, 'publication_date': '2020-05-17', 'ids': {'openalex': 'https://openalex.org/W4234241458', 'doi': 'https://doi.org/10.21203/rs.3.rs-28626/v1'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.21203/rs.3.rs-28626/v1', 'pdf_url': 'https://www.researchsquare.com/article/rs-28626/v1.pdf?c=1631848888000', 'source': {'id': 'https://openalex.org/S4306402450', 'display_name': 'Research Square (Research Square)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210096694', 'host_organization_name': 'Research Square (United States)', 'host_organization_lineage': ['https://openalex.org/I4210096694'], 'host_organization_lineage_names': ['Research Square (United States)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.researchsquare.com/article/rs-28626/v1.pdf?c=1631848888000', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100523308', 'display_name': 'Sujuan Xi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210146956', 'display_name': 'Third Affiliated Hospital of Sun Yat-sen University', 'ror': 'https://ror.org/04tm3k558', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146956']}, {'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Sujuan Xi', 'raw_affiliation_strings': ['Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China. Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou, Guangdong 510080, China. The'], 'affiliations': [{'raw_affiliation_string': 'Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China. Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou, Guangdong 510080, China. The', 'institution_ids': ['https://openalex.org/I4210146956', 'https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037750945', 'display_name': 'Xiaoyan Zheng', 'orcid': 'https://orcid.org/0000-0002-2997-9756'}, 'institutions': [{'id': 'https://openalex.org/I4210146956', 'display_name': 'Third Affiliated Hospital of Sun Yat-sen University', 'ror': 'https://ror.org/04tm3k558', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146956']}, {'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaoyan Zheng', 'raw_affiliation_strings': ['Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China', 'institution_ids': ['https://openalex.org/I4210146956', 'https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091216176', 'display_name': 'Yuming Jiang', 'orcid': 'https://orcid.org/0000-0001-6184-3931'}, 'institutions': [{'id': 'https://openalex.org/I58200834', 'display_name': 'Southern Medical University', 'ror': 'https://ror.org/01vjw4z39', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I58200834']}, {'id': 'https://openalex.org/I4210103346', 'display_name': 'Nanfang Hospital', 'ror': 'https://ror.org/01eq10738', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210103346']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yuming Jiang', 'raw_affiliation_strings': ['Department of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Department of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, China', 'institution_ids': ['https://openalex.org/I58200834', 'https://openalex.org/I4210103346']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063263180', 'display_name': 'Yuankai Wu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210146956', 'display_name': 'Third Affiliated Hospital of Sun Yat-sen University', 'ror': 'https://ror.org/04tm3k558', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146956']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yuankai Wu', 'raw_affiliation_strings': ['Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210146956']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081688615', 'display_name': 'Jiao Gong', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210146956', 'display_name': 'Third Affiliated Hospital of Sun Yat-sen University', 'ror': 'https://ror.org/04tm3k558', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146956']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jiao Gong', 'raw_affiliation_strings': ['Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China. Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou, Guangdong 510080, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China. Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou, Guangdong 510080, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210146956']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036106779', 'display_name': 'Yusheng Jie', 'orcid': 'https://orcid.org/0000-0003-3756-0653'}, 'institutions': [{'id': 'https://openalex.org/I4210146956', 'display_name': 'Third Affiliated Hospital of Sun Yat-sen University', 'ror': 'https://ror.org/04tm3k558', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146956']}, {'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yusheng Jie', 'raw_affiliation_strings': ['Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China. Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou, Guangdong 510080, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China. Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou, Guangdong 510080, China', 'institution_ids': ['https://openalex.org/I4210146956', 'https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057939990', 'display_name': 'Xiangyong Li', 'orcid': 'https://orcid.org/0000-0003-1131-5123'}, 'institutions': [{'id': 'https://openalex.org/I4210146956', 'display_name': 'Third Affiliated Hospital of Sun Yat-sen University', 'ror': 'https://ror.org/04tm3k558', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146956']}, {'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiangyong Li', 'raw_affiliation_strings': ['Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China', 'institution_ids': ['https://openalex.org/I4210146956', 'https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090688671', 'display_name': 'Jing Cao', 'orcid': 'https://orcid.org/0000-0002-0268-6005'}, 'institutions': [{'id': 'https://openalex.org/I4210146956', 'display_name': 'Third Affiliated Hospital of Sun Yat-sen University', 'ror': 'https://ror.org/04tm3k558', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146956']}, {'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jing Cao', 'raw_affiliation_strings': ['Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China. Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou, Guangdong 510080, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China. Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou, Guangdong 510080, China', 'institution_ids': ['https://openalex.org/I4210146956', 'https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039778506', 'display_name': 'Liuping Sha', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210146956', 'display_name': 'Third Affiliated Hospital of Sun Yat-sen University', 'ror': 'https://ror.org/04tm3k558', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146956']}, {'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Liuping Sha', 'raw_affiliation_strings': ['Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China', 'institution_ids': ['https://openalex.org/I4210146956', 'https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100402853', 'display_name': 'Min Zhang', 'orcid': 'https://orcid.org/0000-0001-8327-6405'}, 'institutions': [{'id': 'https://openalex.org/I4210146956', 'display_name': 'Third Affiliated Hospital of Sun Yat-sen University', 'ror': 'https://ror.org/04tm3k558', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146956']}, {'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Min Zhang', 'raw_affiliation_strings': ['Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China. Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou, Guangdong 510080, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China. Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou, Guangdong 510080, China', 'institution_ids': ['https://openalex.org/I4210146956', 'https://openalex.org/I157773358']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5008182583', 'display_name': 'Yutian Chong', 'orcid': 'https://orcid.org/0000-0001-8215-4393'}, 'institutions': [{'id': 'https://openalex.org/I4210146956', 'display_name': 'Third Affiliated Hospital of Sun Yat-sen University', 'ror': 'https://ror.org/04tm3k558', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146956']}, {'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Yutian Chong', 'raw_affiliation_strings': ['Third Affiliated Hospital of Sun Yat-Sen University'], 'affiliations': [{'raw_affiliation_string': 'Third Affiliated Hospital of Sun Yat-Sen University', 'institution_ids': ['https://openalex.org/I4210146956', 'https://openalex.org/I157773358']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5008182583'], 'corresponding_institution_ids': ['https://openalex.org/I4210146956', 'https://openalex.org/I157773358'], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.713098, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 61, 'max': 69}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10966', 'display_name': 'Liver physiology and pathology', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10966', 'display_name': 'Liver physiology and pathology', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10351', 'display_name': 'Liver Disease Diagnosis and Treatment', 'score': 0.9831, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12672', 'display_name': 'Phagocytosis and Immune Regulation', 'score': 0.9816, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cd163', 'display_name': 'CD163', 'score': 0.8751608}, {'id': 'https://openalex.org/keywords/hepatic-stellate-cell', 'display_name': 'Hepatic stellate cell', 'score': 0.7838781}, {'id': 'https://openalex.org/keywords/hepatic-fibrosis', 'display_name': 'Hepatic fibrosis', 'score': 0.6886353}, {'id': 'https://openalex.org/keywords/ccr2', 'display_name': 'CCR2', 'score': 0.68604475}, {'id': 'https://openalex.org/keywords/infiltration', 'display_name': 'Infiltration (HVAC)', 'score': 0.44169253}], 'concepts': [{'id': 'https://openalex.org/C2775858924', 'wikidata': 'https://www.wikidata.org/wiki/Q18034009', 'display_name': 'CD163', 'level': 4, 'score': 0.8751608}, {'id': 'https://openalex.org/C176891718', 'wikidata': 'https://www.wikidata.org/wiki/Q1997459', 'display_name': 'Hepatic stellate cell', 'level': 2, 'score': 0.7838781}, {'id': 'https://openalex.org/C2780559512', 'wikidata': 'https://www.wikidata.org/wiki/Q605709', 'display_name': 'Fibrosis', 'level': 2, 'score': 0.6949405}, {'id': 'https://openalex.org/C2993667909', 'wikidata': 'https://www.wikidata.org/wiki/Q147778', 'display_name': 'Hepatic fibrosis', 'level': 3, 'score': 0.6886353}, {'id': 'https://openalex.org/C206615009', 'wikidata': 'https://www.wikidata.org/wiki/Q4035572', 'display_name': 'CCR2', 'level': 5, 'score': 0.68604475}, {'id': 'https://openalex.org/C101666144', 'wikidata': 'https://www.wikidata.org/wiki/Q2587862', 'display_name': 'CCL2', 'level': 4, 'score': 0.68280137}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.509022}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.4616837}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.45601135}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.45536226}, {'id': 'https://openalex.org/C153400128', 'wikidata': 'https://www.wikidata.org/wiki/Q3150731', 'display_name': 'Infiltration (HVAC)', 'level': 2, 'score': 0.44169253}, {'id': 'https://openalex.org/C2779244956', 'wikidata': 'https://www.wikidata.org/wiki/Q184204', 'display_name': 'Macrophage', 'level': 3, 'score': 0.42345244}, {'id': 'https://openalex.org/C13373296', 'wikidata': 'https://www.wikidata.org/wiki/Q421866', 'display_name': 'Chemokine', 'level': 3, 'score': 0.39256945}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.37417525}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.36862123}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.35025275}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.2869084}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.1332162}, {'id': 'https://openalex.org/C12823836', 'wikidata': 'https://www.wikidata.org/wiki/Q24720618', 'display_name': 'Chemokine receptor', 'level': 4, 'score': 0.0985333}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.058231086}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C97355855', 'wikidata': 'https://www.wikidata.org/wiki/Q11473', 'display_name': 'Thermodynamics', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.21203/rs.3.rs-28626/v1', 'pdf_url': 'https://www.researchsquare.com/article/rs-28626/v1.pdf?c=1631848888000', 'source': {'id': 'https://openalex.org/S4306402450', 'display_name': 'Research Square (Research Square)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210096694', 'host_organization_name': 'Research Square (United States)', 'host_organization_lineage': ['https://openalex.org/I4210096694'], 'host_organization_lineage_names': ['Research Square (United States)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.21203/rs.3.rs-28626/v1', 'pdf_url': 'https://www.researchsquare.com/article/rs-28626/v1.pdf?c=1631848888000', 'source': {'id': 'https://openalex.org/S4306402450', 'display_name': 'Research Square (Research Square)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210096694', 'host_organization_name': 'Research Square (United States)', 'host_organization_lineage': ['https://openalex.org/I4210096694'], 'host_organization_lineage_names': ['Research Square (United States)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.51}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 23, 'referenced_works': ['https://openalex.org/W1968858038', 'https://openalex.org/W1989646523', 'https://openalex.org/W1990225108', 'https://openalex.org/W2019694067', 'https://openalex.org/W2046208657', 'https://openalex.org/W2055348159', 'https://openalex.org/W2091600198', 'https://openalex.org/W2108851732', 'https://openalex.org/W2111161262', 'https://openalex.org/W2146524990', 'https://openalex.org/W2147425799', 'https://openalex.org/W2167796978', 'https://openalex.org/W2594491387', 'https://openalex.org/W2613180696', 'https://openalex.org/W2783093140', 'https://openalex.org/W2794450803', 'https://openalex.org/W2803367030', 'https://openalex.org/W2884310345', 'https://openalex.org/W2893835498', 'https://openalex.org/W2904680828', 'https://openalex.org/W2915396415', 'https://openalex.org/W4233620093', 'https://openalex.org/W4250007760'], 'related_works': ['https://openalex.org/W4245493393', 'https://openalex.org/W3129029989', 'https://openalex.org/W3038928394', 'https://openalex.org/W3028957131', 'https://openalex.org/W2776126594', 'https://openalex.org/W2361918928', 'https://openalex.org/W2356869055', 'https://openalex.org/W2318211403', 'https://openalex.org/W2124077207', 'https://openalex.org/W2040434262'], 'abstract_inverted_index': {'Abstract': [0], 'Background:': [1], 'Growing': [2], 'evidence': [3], 'indicates': [4], 'that': [5, 182], 'activated': [6], 'hepatic': [7, 83, 183], 'stellate': [8], 'cells': [9], '(aHSCs)': [10], 'play': [11], 'unexpected': [12], 'roles': [13], 'in': [14, 66, 122, 138, 154, 189, 210], 'regulating': [15], 'immune': [16], 'cells’': [17], 'function': [18, 49], 'during': [19, 52, 158, 327], 'liver': [20, 53, 62, 159, 193, 331], 'fibrosis.': [21, 54, 79], 'Macrophages': [22], 'feature': [23], 'with': [24, 58, 129, 213, 233, 274, 312, 335], 'inducible': [25], 'plasticity': [26], 'according': [27], 'to': [28, 74, 111, 175], 'the': [29, 43, 46, 76, 92, 104, 116, 127, 134, 215, 234, 242, 275, 295, 328], 'circumstances': [30], 'while': [31, 266], 'patrol': [32], 'for': [33], 'potential': [34], 'pathogens.': [35], 'However,': [36], 'studies': [37], 'seldom': [38], 'investigate': [39], 'whether': [40, 113, 147], 'and': [41, 48, 85, 91, 97, 106, 132, 142, 165, 247, 300, 333, 343], 'how': [42], 'aHSCs': [44, 105, 114, 139], 'regulate': [45], 'phenotype': [47], 'of': [50, 61, 78, 82, 118, 136, 192, 220, 244, 261, 277, 297, 320, 330], 'macrophages': [51, 109, 121, 185, 216, 251, 304, 342], 'Methods:': [55], '96': [56], 'patients': [57], 'different': [59, 190], 'stages': [60, 191], 'fibrosis': [63, 98, 194, 278, 332, 336], 'were': [64, 87, 100, 310], 'involved': [65], 'our': [67, 177], 'study.': [68], 'Metavir': [69], 'score': [70, 272], 'system': [71, 174], 'was': [72], 'used': [73, 162], 'evaluate': [75], 'degree': [77], 'The': [80, 318], 'expression': [81, 117, 243, 296, 319], 'CCL2': [84, 137, 164, 270, 292], 'CD163': [86, 119, 221, 245, 298, 324], 'detected': [88], 'by': [89, 140], 'immunohistochemistry,': [90], 'relationship': [93], 'among': [94], 'CD163,': [95], 'CCL2,': [96, 262], 'scores': [99], 'explored.': [101], 'We': [102, 180, 253], 'co-cultured': [103, 212], 'THP-1-derived': [107], 'M0-type': [108], '(M0MФ)': [110], 'observe': [112], 'modulate': [115], 'on': [120, 250, 303], 'vitro.': [123], 'Furthermore,': [124], 'we': [125, 161, 171, 237], 'treated': [126], 'M0MФ': [128], 'aHSCs’': [130, 255], 'supernatant': [131, 240, 256], 'investigated': [133], 'production': [135], 'ELISA': [141], 'immunofluorescence': [143], 'assay.': [144], 'To': [145], 'explore': [146], 'CCL2/CCR2': [148, 350], 'axis': [149], 'plays': [150], 'a': [151, 258], 'crucial': [152], 'role': [153], 'macrophage': [155, 322], 'phenotypic': [156, 347], 'changes': [157], 'fibrosis,': [160], 'recombinant': [163], 'its': [166], 'specific': [167], 'receptor': [168], 'antagonist.': [169], 'Moreover,': [170], 'employed': [172], 'LX2': [173, 313], 'confirm': [176], 'results.': [178], 'Results:': [179], 'found': [181, 238], 'M2': [184, 321, 346], '(CD163+)': [186], 'infiltration': [187], 'increased': [188, 264, 273, 325], '(F0-1:': [195], '34.95±18.12;': [196], 'F2-3:': [197], '77.57±32.48;': [198], 'F4:': [199, 289], '99.62±40.84,': [200], 'F0-1': [201], 'vs.': [202, 206, 223, 230], 'F2-3,': [203], 'P<0.001;': [204], 'F2-3': [205], 'F4,': [207], 'P=0.074).': [208], 'After': [209], 'vitro': [211], 'aHSCs,': [214], 'expressed': [217], 'higher': [218], 'levels': [219], '(29.5±6.1%': [222], '2.7±1.1%)': [224], 'as': [225, 227], 'well': [226], 'CD206': [228, 248, 301], '(28.0±4.2%': [229], '2.4±1.2%)': [231], 'compared': [232], 'control.': [235], 'Then': [236], 'aHSC': [239], 'up-regulated': [241, 294], '(26.1±2.8%)': [246], '(25.8±3.8%)': [249], 'independently.': [252], 'noted': [254], 'contained': [257], 'high': [259], 'level': [260], 'which': [263], 'dramatically': [265], 'TGF-β': [267], 'stimulation.': [268], 'Meanwhile,': [269], 'staining': [271], 'progress': [276, 329], '(': [279], 'N:': [280], '23.26±13.85;': [281], 'F1:': [282], '4': [283], '8.56±19.18;': [284], 'F2:': [285], '58.25±16.24;': [286], 'F3:': [287], '81.32±18.48;': [288], '110.93±24.75).': [290], 'Intriguingly,': [291], 'significantly': [293, 326], '(27.6±7.0%)': [299], '(26.5±5.1%)': [302], 'besides': [305], 'inducing': [306], 'their': [307, 345], 'aggregation.': [308], 'Results': [309], 'confirmed': [311], 'co-culture': [314], 'system.': [315], 'Conclusions:': [316], '(1)': [317], 'marker': [323], 'associated': [334], 'severity.': [337], '(2)': [338], 'AHSCs': [339], 'can': [340], 'recruit': [341], 'induce': [344], 'transformation': [348], 'through': [349], 'pathway.': [351]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4234241458', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}], 'updated_date': '2024-12-24T04:51:49.939160', 'created_date': '2022-05-12'}