Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2903701123', 'doi': 'https://doi.org/10.1007/s11523-018-0612-z', 'title': 'Liquid-Biopsy-Based Identification of EGFR T790M Mutation-Mediated Resistance to Afatinib Treatment in Patients with Advanced EGFR Mutation-Positive NSCLC, and Subsequent Response to Osimertinib', 'display_name': 'Liquid-Biopsy-Based Identification of EGFR T790M Mutation-Mediated Resistance to Afatinib Treatment in Patients with Advanced EGFR Mutation-Positive NSCLC, and Subsequent Response to Osimertinib', 'publication_year': 2018, 'publication_date': '2018-12-12', 'ids': {'openalex': 'https://openalex.org/W2903701123', 'doi': 'https://doi.org/10.1007/s11523-018-0612-z', 'mag': '2903701123', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30539501', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6403194'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s11523-018-0612-z', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007/s11523-018-0612-z.pdf', 'source': {'id': 'https://openalex.org/S163958984', 'display_name': 'Targeted Oncology', 'issn_l': '1776-2596', 'issn': ['1776-2596', '1776-260X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320330', 'host_organization_name': 'Adis, Springer Healthcare', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320330'], 'host_organization_lineage_names': ['Springer Nature', 'Adis, Springer Healthcare'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://link.springer.com/content/pdf/10.1007/s11523-018-0612-z.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5012226414', 'display_name': 'Maximilian J. Hochmair', 'orcid': 'https://orcid.org/0000-0002-8673-2450'}, 'institutions': [{'id': 'https://openalex.org/I4210107853', 'display_name': 'Ludwig Boltzmann Institute for COPD And Respiratory Epidemiology', 'ror': 'https://ror.org/01tf5aq62', 'country_code': 'AT', 'type': 'facility', 'lineage': ['https://openalex.org/I2799334681', 'https://openalex.org/I4210107853']}, {'id': 'https://openalex.org/I4210139931', 'display_name': 'Otto Wagner Hospital', 'ror': 'https://ror.org/041jk5w53', 'country_code': 'AT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210117134', 'https://openalex.org/I4210139931']}], 'countries': ['AT'], 'is_corresponding': True, 'raw_author_name': 'Maximilian J. Hochmair', 'raw_affiliation_strings': ['Department of Respiratory and Critical Care Medicine and Ludwig Boltzmann Institute for COPD and Respiratory Epidemiology, Otto Wagner Hospital, Sanatoriumstrasse 2, 1140, Vienna, Austria'], 'affiliations': [{'raw_affiliation_string': 'Department of Respiratory and Critical Care Medicine and Ludwig Boltzmann Institute for COPD and Respiratory Epidemiology, Otto Wagner Hospital, Sanatoriumstrasse 2, 1140, Vienna, Austria', 'institution_ids': ['https://openalex.org/I4210107853', 'https://openalex.org/I4210139931']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033620486', 'display_name': 'Anna Buder', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210092129', 'display_name': 'Comprehensive Cancer Center Vienna', 'ror': 'https://ror.org/00df3z122', 'country_code': 'AT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802328216', 'https://openalex.org/I4210092129']}, {'id': 'https://openalex.org/I76134821', 'display_name': 'Medical University of Vienna', 'ror': 'https://ror.org/05n3x4p02', 'country_code': 'AT', 'type': 'education', 'lineage': ['https://openalex.org/I76134821']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Anna Buder', 'raw_affiliation_strings': ['Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria'], 'affiliations': [{'raw_affiliation_string': 'Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria', 'institution_ids': ['https://openalex.org/I4210092129', 'https://openalex.org/I76134821']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086358486', 'display_name': 'Sophia Schwab', 'orcid': 'https://orcid.org/0000-0002-8554-9443'}, 'institutions': [{'id': 'https://openalex.org/I4210107853', 'display_name': 'Ludwig Boltzmann Institute for COPD And Respiratory Epidemiology', 'ror': 'https://ror.org/01tf5aq62', 'country_code': 'AT', 'type': 'facility', 'lineage': ['https://openalex.org/I2799334681', 'https://openalex.org/I4210107853']}, {'id': 'https://openalex.org/I4210139931', 'display_name': 'Otto Wagner Hospital', 'ror': 'https://ror.org/041jk5w53', 'country_code': 'AT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210117134', 'https://openalex.org/I4210139931']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Sophia Schwab', 'raw_affiliation_strings': ['Department of Respiratory and Critical Care Medicine and Ludwig Boltzmann Institute for COPD and Respiratory Epidemiology, Otto Wagner Hospital, Sanatoriumstrasse 2, 1140, Vienna, Austria'], 'affiliations': [{'raw_affiliation_string': 'Department of Respiratory and Critical Care Medicine and Ludwig Boltzmann Institute for COPD and Respiratory Epidemiology, Otto Wagner Hospital, Sanatoriumstrasse 2, 1140, Vienna, Austria', 'institution_ids': ['https://openalex.org/I4210107853', 'https://openalex.org/I4210139931']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062210485', 'display_name': 'Otto Chris Burghuber', 'orcid': 'https://orcid.org/0000-0002-8419-621X'}, 'institutions': [{'id': 'https://openalex.org/I4210107853', 'display_name': 'Ludwig Boltzmann Institute for COPD And Respiratory Epidemiology', 'ror': 'https://ror.org/01tf5aq62', 'country_code': 'AT', 'type': 'facility', 'lineage': ['https://openalex.org/I2799334681', 'https://openalex.org/I4210107853']}, {'id': 'https://openalex.org/I4210139931', 'display_name': 'Otto Wagner Hospital', 'ror': 'https://ror.org/041jk5w53', 'country_code': 'AT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210117134', 'https://openalex.org/I4210139931']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Otto C. Burghuber', 'raw_affiliation_strings': ['Department of Respiratory and Critical Care Medicine and Ludwig Boltzmann Institute for COPD and Respiratory Epidemiology, Otto Wagner Hospital, Sanatoriumstrasse 2, 1140, Vienna, Austria'], 'affiliations': [{'raw_affiliation_string': 'Department of Respiratory and Critical Care Medicine and Ludwig Boltzmann Institute for COPD and Respiratory Epidemiology, Otto Wagner Hospital, Sanatoriumstrasse 2, 1140, Vienna, Austria', 'institution_ids': ['https://openalex.org/I4210107853', 'https://openalex.org/I4210139931']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014530467', 'display_name': 'Helmut Prosch', 'orcid': 'https://orcid.org/0000-0002-6119-6364'}, 'institutions': [{'id': 'https://openalex.org/I4210092129', 'display_name': 'Comprehensive Cancer Center Vienna', 'ror': 'https://ror.org/00df3z122', 'country_code': 'AT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802328216', 'https://openalex.org/I4210092129']}, {'id': 'https://openalex.org/I76134821', 'display_name': 'Medical University of Vienna', 'ror': 'https://ror.org/05n3x4p02', 'country_code': 'AT', 'type': 'education', 'lineage': ['https://openalex.org/I76134821']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Helmut Prosch', 'raw_affiliation_strings': ['Department of Radiology, Comprehensive Cancer Center, Medical University of Vienna, Währingergürtel 18-22, 1090, Vienna, Austria'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiology, Comprehensive Cancer Center, Medical University of Vienna, Währingergürtel 18-22, 1090, Vienna, Austria', 'institution_ids': ['https://openalex.org/I4210092129', 'https://openalex.org/I76134821']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019003637', 'display_name': 'Wolfgang Hilbe', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210093545', 'display_name': 'Wilhelminen Hospital', 'ror': 'https://ror.org/00qcsrr17', 'country_code': 'AT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210093545', 'https://openalex.org/I4210117134']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Wolfgang Hilbe', 'raw_affiliation_strings': ['Department of Internal Medicine 1, Wilhelminen Hospital, Montleartstraße 37, 1160, Vienna, Austria'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine 1, Wilhelminen Hospital, Montleartstraße 37, 1160, Vienna, Austria', 'institution_ids': ['https://openalex.org/I4210093545']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058525887', 'display_name': 'A. Cseh', 'orcid': 'https://orcid.org/0000-0002-9815-2453'}, 'institutions': [{'id': 'https://openalex.org/I4210119669', 'display_name': 'Boehringer Ingelheim (Austria)', 'ror': 'https://ror.org/026vtvm28', 'country_code': 'AT', 'type': 'company', 'lineage': ['https://openalex.org/I1330995197', 'https://openalex.org/I4210119669']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Agnieszka Cseh', 'raw_affiliation_strings': ['Boehringer Ingelheim RCV GmbH & Co. KG, Doktor-Boehringer-Gasse 5-11, 1120, Vienna, Austria'], 'affiliations': [{'raw_affiliation_string': 'Boehringer Ingelheim RCV GmbH & Co. KG, Doktor-Boehringer-Gasse 5-11, 1120, Vienna, Austria', 'institution_ids': ['https://openalex.org/I4210119669']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053977534', 'display_name': 'Richard R. Fritz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210119669', 'display_name': 'Boehringer Ingelheim (Austria)', 'ror': 'https://ror.org/026vtvm28', 'country_code': 'AT', 'type': 'company', 'lineage': ['https://openalex.org/I1330995197', 'https://openalex.org/I4210119669']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Richard Fritz', 'raw_affiliation_strings': ['Boehringer Ingelheim RCV GmbH & Co. KG, Doktor-Boehringer-Gasse 5-11, 1120, Vienna, Austria'], 'affiliations': [{'raw_affiliation_string': 'Boehringer Ingelheim RCV GmbH & Co. KG, Doktor-Boehringer-Gasse 5-11, 1120, Vienna, Austria', 'institution_ids': ['https://openalex.org/I4210119669']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5030453966', 'display_name': 'Martin Filipits', 'orcid': 'https://orcid.org/0000-0003-2847-4534'}, 'institutions': [{'id': 'https://openalex.org/I4210092129', 'display_name': 'Comprehensive Cancer Center Vienna', 'ror': 'https://ror.org/00df3z122', 'country_code': 'AT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802328216', 'https://openalex.org/I4210092129']}, {'id': 'https://openalex.org/I76134821', 'display_name': 'Medical University of Vienna', 'ror': 'https://ror.org/05n3x4p02', 'country_code': 'AT', 'type': 'education', 'lineage': ['https://openalex.org/I76134821']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Martin Filipits', 'raw_affiliation_strings': ['Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria'], 'affiliations': [{'raw_affiliation_string': 'Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria', 'institution_ids': ['https://openalex.org/I4210092129', 'https://openalex.org/I76134821']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 6, 'corresponding_author_ids': ['https://openalex.org/A5012226414'], 'corresponding_institution_ids': ['https://openalex.org/I4210107853', 'https://openalex.org/I4210139931'], 'apc_list': {'value': 3390, 'currency': 'EUR', 'value_usd': 4390, 'provenance': 'doaj'}, 'apc_paid': {'value': 3390, 'currency': 'EUR', 'value_usd': 4390, 'provenance': 'doaj'}, 'fwci': 13.75, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 99, 'citation_normalized_percentile': {'value': 0.903319, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '14', 'issue': '1', 'first_page': '75', 'last_page': '83'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10417', 'display_name': 'Advancements in Lung Cancer Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10417', 'display_name': 'Advancements in Lung Cancer Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10952', 'display_name': 'mTOR Signaling in Growth and Disease', 'score': 0.988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12318', 'display_name': 'Chemistry and Pharmacology of Quinazoline Compounds', 'score': 0.9869, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/afatinib', 'display_name': 'Afatinib', 'score': 0.98689187}, {'id': 'https://openalex.org/keywords/t790m', 'display_name': 'T790M', 'score': 0.96818435}, {'id': 'https://openalex.org/keywords/osimertinib', 'display_name': 'Osimertinib', 'score': 0.94892764}, {'id': 'https://openalex.org/keywords/resistance-mutation', 'display_name': 'Resistance mutation', 'score': 0.6208481}, {'id': 'https://openalex.org/keywords/egfr-mutations', 'display_name': 'EGFR Mutations', 'score': 0.583222}], 'concepts': [{'id': 'https://openalex.org/C2780586478', 'wikidata': 'https://www.wikidata.org/wiki/Q4688818', 'display_name': 'Afatinib', 'level': 5, 'score': 0.98689187}, {'id': 'https://openalex.org/C2777930144', 'wikidata': 'https://www.wikidata.org/wiki/Q25100112', 'display_name': 'T790M', 'level': 5, 'score': 0.96818435}, {'id': 'https://openalex.org/C2777626846', 'wikidata': 'https://www.wikidata.org/wiki/Q21506464', 'display_name': 'Osimertinib', 'level': 5, 'score': 0.94892764}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.869685}, {'id': 'https://openalex.org/C182707283', 'wikidata': 'https://www.wikidata.org/wiki/Q7315622', 'display_name': 'Resistance mutation', 'level': 5, 'score': 0.6208481}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.54987997}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5446583}, {'id': 'https://openalex.org/C2776256026', 'wikidata': 'https://www.wikidata.org/wiki/Q47912', 'display_name': 'Lung cancer', 'level': 2, 'score': 0.5049885}, {'id': 'https://openalex.org/C2779438470', 'wikidata': 'https://www.wikidata.org/wiki/Q424401', 'display_name': 'Epidermal growth factor receptor', 'level': 3, 'score': 0.48505253}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.4648399}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.37305933}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.33040622}, {'id': 'https://openalex.org/C2780580887', 'wikidata': 'https://www.wikidata.org/wiki/Q417824', 'display_name': 'Gefitinib', 'level': 4, 'score': 0.28735107}, {'id': 'https://openalex.org/C2778087573', 'wikidata': 'https://www.wikidata.org/wiki/Q418369', 'display_name': 'Erlotinib', 'level': 4, 'score': 0.27026218}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.103815705}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.07359767}, {'id': 'https://openalex.org/C156719811', 'wikidata': 'https://www.wikidata.org/wiki/Q28774', 'display_name': 'Reverse transcriptase', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000178', 'descriptor_name': 'Acrylamides', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000077716', 'descriptor_name': 'Afatinib', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000814', 'descriptor_name': 'Aniline Compounds', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000073890', 'descriptor_name': 'Liquid Biopsy', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000178', 'descriptor_name': 'Acrylamides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077192', 'descriptor_name': 'Adenocarcinoma of Lung', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077192', 'descriptor_name': 'Adenocarcinoma of Lung', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D000077192', 'descriptor_name': 'Adenocarcinoma of Lung', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000077192', 'descriptor_name': 'Adenocarcinoma of Lung', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077716', 'descriptor_name': 'Afatinib', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000814', 'descriptor_name': 'Aniline Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005500', 'descriptor_name': 'Follow-Up Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000073890', 'descriptor_name': 'Liquid Biopsy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012189', 'descriptor_name': 'Retrospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015996', 'descriptor_name': 'Survival Rate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s11523-018-0612-z', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007/s11523-018-0612-z.pdf', 'source': {'id': 'https://openalex.org/S163958984', 'display_name': 'Targeted Oncology', 'issn_l': '1776-2596', 'issn': ['1776-2596', '1776-260X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320330', 'host_organization_name': 'Adis, Springer Healthcare', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320330'], 'host_organization_lineage_names': ['Springer Nature', 'Adis, Springer Healthcare'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403194', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30539501', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s11523-018-0612-z', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007/s11523-018-0612-z.pdf', 'source': {'id': 'https://openalex.org/S163958984', 'display_name': 'Targeted Oncology', 'issn_l': '1776-2596', 'issn': ['1776-2596', '1776-260X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320330', 'host_organization_name': 'Adis, Springer Healthcare', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320330'], 'host_organization_lineage_names': ['Springer Nature', 'Adis, Springer Healthcare'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.84, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 25, 'referenced_works': ['https://openalex.org/W1980497534', 'https://openalex.org/W2074791509', 'https://openalex.org/W2154149901', 'https://openalex.org/W2163351155', 'https://openalex.org/W2292347930', 'https://openalex.org/W2328294134', 'https://openalex.org/W2339311613', 'https://openalex.org/W2468983064', 'https://openalex.org/W2479380037', 'https://openalex.org/W2508624127', 'https://openalex.org/W2517226402', 'https://openalex.org/W2550326170', 'https://openalex.org/W2560717039', 'https://openalex.org/W2591118779', 'https://openalex.org/W2734942005', 'https://openalex.org/W2760639821', 'https://openalex.org/W2761725905', 'https://openalex.org/W2770828094', 'https://openalex.org/W2783694051', 'https://openalex.org/W2787639107', 'https://openalex.org/W2790958665', 'https://openalex.org/W2891909134', 'https://openalex.org/W2896248377', 'https://openalex.org/W2896513927', 'https://openalex.org/W2953884587'], 'related_works': ['https://openalex.org/W4362609540', 'https://openalex.org/W4252148494', 'https://openalex.org/W3131089254', 'https://openalex.org/W3002825748', 'https://openalex.org/W2981698511', 'https://openalex.org/W2903782160', 'https://openalex.org/W2903701123', 'https://openalex.org/W2901732362', 'https://openalex.org/W2887887720', 'https://openalex.org/W2767471949'], 'abstract_inverted_index': {'Acquired': [0], 'epidermal': [1], 'growth': [2], 'factor': [3], 'receptor': [4], '(EGFR)': [5], 'T790M': [6, 85, 114, 152, 201, 204], 'mutation': [7, 38, 115, 153, 205], 'is': [8, 39, 64, 206], 'the': [9, 41, 47, 81, 104, 138, 151], 'primary': [10], 'resistance': [11, 45, 212], 'mechanism': [12, 209], 'to': [13, 46, 77, 102, 107, 213], 'first-generation': [14], 'EGFR': [15, 23, 54, 60, 84, 94, 113, 128, 224], 'tyrosine': [16], 'kinase': [17], 'inhibitors': [18], '(TKIs)': [19], 'used': [20], 'in': [21, 32, 87, 137, 156, 167, 223, 230], 'advanced,': [22], 'mutation-positive': [24, 95], 'non-small-cell': [25], 'lung': [26], 'cancer': [27], '(NSCLC).': [28], 'Available': [29], 'data,': [30], 'predominantly': [31, 88], 'Asian': [33], 'patients,': [34], 'suggest': [35], 'that': [36], 'this': [37, 109], 'also': [40], 'major': [42, 208], 'cause': [43], 'of': [44, 83, 169, 184, 200, 210], 'irreversible': [48], 'ErbB': [49], 'family': [50], 'blocker,': [51], 'afatinib.': [52, 214], 'For': [53], 'T790M-positive': [55, 129, 174, 225], 'patients': [56, 90, 130, 134, 158, 172, 226], 'who': [57, 97], 'progress': [58], 'on': [59, 71, 99], 'TKI': [61], 'therapy,': [62], 'osimertinib': [63, 72, 177], 'an': [65, 187], 'effective': [66], 'treatment': [67], 'option.': [68], 'However,': [69], 'data': [70], 'use': [73, 229], 'after': [74, 117, 179, 220], 'afatinib': [75, 118, 136, 149, 221], 'are,': [76], 'date,': [78], 'scarce.To': [79], 'identify': [80], 'prevalence': [82], 'mutations': [86], 'Caucasian': [89], 'with': [91, 173], 'stage': [92], 'IV': [93], 'NSCLC': [96], 'progressed': [98], 'afatinib,': [100], 'and': [101, 125, 145, 162, 227], 'investigate': [103], 'subsequent': [105], 'response': [106, 189, 218], 'osimertinib.In': [108], 'single-center,': [110], 'retrospective': [111], 'analysis,': [112], 'status': [116], 'failure': [119, 222], 'was': [120, 154, 198], 'assessed': [121], 'using': [122], 'liquid': [123], 'biopsy': [124, 161], 'tissue': [126, 163], 'rebiopsy.': [127], 'subsequently': [131], 'received': [132, 135, 176], 'osimertinib.Sixty-seven': [133], 'first-,': [139], 'second-,': [140], 'or': [141], 'third-line': [142], '(80.6%,': [143], '14.9%,': [144], '4.5%,': [146], 'respectively).': [147], 'After': [148], 'failure,': [150], 'identified': [155], '49': [157], '(73.1%).': [159], 'Liquid': [160], 'rebiopsy': [164], 'were': [165], 'concordant': [166], '79.4%': [168], 'cases.': [170], 'All': [171], 'tumors': [175], '(73.5%': [178], 'first-line': [180], 'afatinib);': [181], '37': [182], '(75.5%)': [183], 'these': [185], 'had': [186], 'objective': [188], '(complete': [190], 'response:': [191, 194], '22.4%;': [192], 'partial': [193], '53.1%).': [195], 'Response': [196], 'rate': [197], 'independent': [199], 'copy': [202], 'number.EGFR': [203], 'a': [207], 'acquired': [211], 'Osimertinib': [215], 'confers': [216], 'high': [217], 'rates': [219], 'its': [228], 'sequence': [231], 'potentially': [232], 'allows': [233], 'extended': [234], 'chemotherapy-free': [235], 'treatment.': [236]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2903701123', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 15}, {'year': 2022, 'cited_by_count': 15}, {'year': 2021, 'cited_by_count': 26}, {'year': 2020, 'cited_by_count': 22}, {'year': 2019, 'cited_by_count': 17}], 'updated_date': '2024-09-13T14:09:31.253001', 'created_date': '2018-12-22'}