Title: Epileptogenesis after status epilepticus reflects age‐ and model‐dependent plasticity
Abstract: Annals of NeurologyVolume 48, Issue 4 p. 580-589 Original Article Epileptogenesis after status epilepticus reflects age- and model-dependent plasticity Raman Sankar MD, PhD, Corresponding Author Raman Sankar MD, PhD Department of Neurology, University of California at Los Angeles School of Medicine, Los Angeles, CA Department of Pediatrics, University of California at Los Angeles School of Medicine, Los Angeles, CA Neurology Service, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CAPediatric Neurology (22-474 MDCC), Box 951752, UCLA School of Medicine, Los Angeles, CA 90095–1752Search for more papers by this authorDon Shin BS, Don Shin BS Department of Pediatrics, University of California at Los Angeles School of Medicine, Los Angeles, CA Neurology Service, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CASearch for more papers by this authorAndrey M. Mazarati MD, PhD, Andrey M. Mazarati MD, PhD Department of Neurology, University of California at Los Angeles School of Medicine, Los Angeles, CA Neurology Service, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CASearch for more papers by this authorHantao Liu MD, Hantao Liu MD Department of Neurology, University of California at Los Angeles School of Medicine, Los Angeles, CA Neurology Service, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CASearch for more papers by this authorHiroshi Katsumori MD, PhD, Hiroshi Katsumori MD, PhD Department of Neurology, University of California at Los Angeles School of Medicine, Los Angeles, CA Neurology Service, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CASearch for more papers by this authorRosario Lezama BS, Rosario Lezama BS Neurology Service, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CASearch for more papers by this authorClaude G. Wasterlain MD, Claude G. Wasterlain MD Department of Neurology, University of California at Los Angeles School of Medicine, Los Angeles, CA Neurology Service, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CASearch for more papers by this author Raman Sankar MD, PhD, Corresponding Author Raman Sankar MD, PhD Department of Neurology, University of California at Los Angeles School of Medicine, Los Angeles, CA Department of Pediatrics, University of California at Los Angeles School of Medicine, Los Angeles, CA Neurology Service, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CAPediatric Neurology (22-474 MDCC), Box 951752, UCLA School of Medicine, Los Angeles, CA 90095–1752Search for more papers by this authorDon Shin BS, Don Shin BS Department of Pediatrics, University of California at Los Angeles School of Medicine, Los Angeles, CA Neurology Service, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CASearch for more papers by this authorAndrey M. Mazarati MD, PhD, Andrey M. Mazarati MD, PhD Department of Neurology, University of California at Los Angeles School of Medicine, Los Angeles, CA Neurology Service, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CASearch for more papers by this authorHantao Liu MD, Hantao Liu MD Department of Neurology, University of California at Los Angeles School of Medicine, Los Angeles, CA Neurology Service, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CASearch for more papers by this authorHiroshi Katsumori MD, PhD, Hiroshi Katsumori MD, PhD Department of Neurology, University of California at Los Angeles School of Medicine, Los Angeles, CA Neurology Service, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CASearch for more papers by this authorRosario Lezama BS, Rosario Lezama BS Neurology Service, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CASearch for more papers by this authorClaude G. Wasterlain MD, Claude G. Wasterlain MD Department of Neurology, University of California at Los Angeles School of Medicine, Los Angeles, CA Neurology Service, Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CASearch for more papers by this author First published: 13 April 2001 https://doi.org/10.1002/1531-8249(200010)48:4<580::AID-ANA4>3.0.CO;2-BCitations: 109AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Although epilepsy often begins in childhood, factors that contribute to the development of epilepsy as a consequence of status epilepticus (SE) during early development are poorly understood. We investigated animal models in which seizure-induced epileptogenicity could be studied. Rats undergoing self-sustaining SE induced by perforant path stimulation (PPS) at the ages of postnatal day 21 (P21) and P35 were compared with those subjected to SE by lithium and pilocarpine (LiPC). Although only one animal subjected to PPS at P21 developed chronic spontaneous seizures by several months of observation, all the animals subjected to PPS at P35 became epileptic. In the LiPC model, however, most of the rat pups subjected to SE at P21 became epileptic. Animals with spontaneous seizures showed increased inhibition in the dentate gyrus, a characteristic of the epileptic brain, with evidence of mossy fiber synaptic reorganization. Examination of circuit recruitment by c-Jun immunohistochemistry showed activation restricted to the hippocampus in P21 animals subjected to PPS, although extensive activation of hippocampal and extrahippocampal structures was seen in pups subjected to PPS-induced self-sustaining SE at P35 or LiPC SE at P21. These results demonstrate that the appearance of epilepsy as a consequence of SE is influenced by the type of insult as well as by age-dependent circuit recruitment. Ann Neurol 2000;48:580–589 Citing Literature Volume48, Issue4October 2000Pages 580-589 RelatedInformation
Publication Year: 2000
Publication Date: 2000-10-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 11
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