Title: The Pilocarpine Model of Chronic Temporal Lobe Epilepsy in Rats
Abstract: Objective:To characterize the acute and chronic behavioral and histologic effects of sustained seizures induced by pilocarpine in rats. Methods:After status epilepticus, the surviving animals were continuously monitored during 24 h for 120 days,using a video system, then we examined the morphology of the brains by light microscopy. Results:First spontaneous recurrent seizures accurred between 4 and 42 days after status epilepticus. The mean “seizure silent period” lasted for(14.5±3.6)days. During the chronic phase, spontaneous recurrent seizures were observed 2~4 times per animal per week, and the structural damage of the brain distributed mainly in the temporal lobe. Conclusion:structural brain damage promoted by pilocarpine induced status epilepticus may underlie spontaneous recurrent seizures, and such mechanisms may be involved in the etiology of some forms of epilepsy in humans.
Publication Year: 2000
Publication Date: 2000-01-01
Language: en
Type: article
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