Publication Information

{'id': 'https://openalex.org/W4226003420', 'doi': 'https://doi.org/10.3390/ijms222413600', 'title': 'Conformational Models of APP Processing by Gamma Secretase Based on Analysis of Pathogenic Mutations', 'display_name': 'Conformational Models of APP Processing by Gamma Secretase Based on Analysis of Pathogenic Mutations', 'publication_year': 2021, 'publication_date': '2021-12-18', 'ids': {'openalex': 'https://openalex.org/W4226003420', 'doi': 'https://doi.org/10.3390/ijms222413600', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/34948396'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ijms222413600', 'pdf_url': 'https://www.mdpi.com/1422-0067/22/24/13600/pdf?version=1639997166', 'source': {'id': 'https://openalex.org/S10623703', 'display_name': 'International Journal of Molecular Sciences', 'issn_l': '1422-0067', 'issn': ['1422-0067', '1661-6596'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/1422-0067/22/24/13600/pdf?version=1639997166', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5048649101', 'display_name': 'Meewhi Kim', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4388891891', 'display_name': 'Southwestern Medical Center', 'ror': 'https://ror.org/05d80e146', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I4388891891']}, {'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Meewhi Kim', 'raw_affiliation_strings': ['Department of Physiology, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA', 'institution_ids': ['https://openalex.org/I4388891891', 'https://openalex.org/I867280407', 'https://openalex.org/I867280407']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5074668880', 'display_name': 'Ilya Bezprozvanny', 'orcid': 'https://orcid.org/0000-0001-7006-6951'}, 'institutions': [{'id': 'https://openalex.org/I212220629', 'display_name': 'Peter the Great St. Petersburg Polytechnic University', 'ror': 'https://ror.org/02x91aj62', 'country_code': 'RU', 'type': 'education', 'lineage': ['https://openalex.org/I212220629']}, {'id': 'https://openalex.org/I137534880', 'display_name': 'Southern Federal University', 'ror': 'https://ror.org/01tv9ph92', 'country_code': 'RU', 'type': 'education', 'lineage': ['https://openalex.org/I137534880']}, {'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}, {'id': 'https://openalex.org/I4388891891', 'display_name': 'Southwestern Medical Center', 'ror': 'https://ror.org/05d80e146', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I4388891891']}], 'countries': ['RU', 'US'], 'is_corresponding': True, 'raw_author_name': 'Ilya Bezprozvanny', 'raw_affiliation_strings': ['Department of Physiology, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA', 'Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnical University, 195251 St. Petersburg, Russia', 'Laboratory of Synaptic Biology, Southern Federal University, 344006 Rostov-on-Don, Russia'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnical University, 195251 St. Petersburg, Russia', 'institution_ids': ['https://openalex.org/I212220629']}, {'raw_affiliation_string': 'Laboratory of Synaptic Biology, Southern Federal University, 344006 Rostov-on-Don, Russia', 'institution_ids': ['https://openalex.org/I137534880']}, {'raw_affiliation_string': 'Department of Physiology, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA', 'institution_ids': ['https://openalex.org/I867280407', 'https://openalex.org/I867280407', 'https://openalex.org/I4388891891']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5048649101', 'https://openalex.org/A5074668880'], 'corresponding_institution_ids': ['https://openalex.org/I4388891891', 'https://openalex.org/I867280407', 'https://openalex.org/I212220629', 'https://openalex.org/I137534880', 'https://openalex.org/I867280407', 'https://openalex.org/I4388891891'], 'apc_list': {'value': 2300, 'currency': 'CHF', 'value_usd': 2490, 'provenance': 'doaj'}, 'apc_paid': {'value': 2300, 'currency': 'CHF', 'value_usd': 2490, 'provenance': 'doaj'}, 'fwci': 1.161, 'has_fulltext': False, 'cited_by_count': 8, 'citation_normalized_percentile': {'value': 0.754601, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 84, 'max': 86}, 'biblio': {'volume': '22', 'issue': '24', 'first_page': '13600', 'last_page': '13600'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11335', 'display_name': 'Prion Diseases and Protein Misfolding', 'score': 0.9718, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11305', 'display_name': 'Amyloidosis: Diagnosis, Treatment, Outcomes', 'score': 0.9685, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/conformational-change', 'display_name': 'Conformational change', 'score': 0.42936653}], 'concepts': [{'id': 'https://openalex.org/C175344181', 'wikidata': 'https://www.wikidata.org/wiki/Q907198', 'display_name': 'Presenilin', 'level': 4, 'score': 0.8651913}, {'id': 'https://openalex.org/C118892022', 'wikidata': 'https://www.wikidata.org/wiki/Q7834587', 'display_name': 'Transmembrane domain', 'level': 3, 'score': 0.82246363}, {'id': 'https://openalex.org/C24530287', 'wikidata': 'https://www.wikidata.org/wiki/Q424204', 'display_name': 'Transmembrane protein', 'level': 3, 'score': 0.7044479}, {'id': 'https://openalex.org/C31705614', 'wikidata': 'https://www.wikidata.org/wiki/Q423510', 'display_name': 'Amyloid precursor protein', 'level': 4, 'score': 0.7041904}, {'id': 'https://openalex.org/C36103677', 'wikidata': 'https://www.wikidata.org/wiki/Q4749551', 'display_name': 'Amyloid precursor protein secretase', 'level': 5, 'score': 0.658806}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.50989234}, {'id': 'https://openalex.org/C104292427', 'wikidata': 'https://www.wikidata.org/wiki/Q899781', 'display_name': 'Protein subunit', 'level': 3, 'score': 0.4549737}, {'id': 'https://openalex.org/C2777339483', 'wikidata': 'https://www.wikidata.org/wiki/Q647203', 'display_name': 'Conformational change', 'level': 2, 'score': 0.42936653}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.41211998}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.38730463}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.35894293}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.33187467}, {'id': 'https://openalex.org/C502032728', 'wikidata': 'https://www.wikidata.org/wiki/Q11081', 'display_name': "Alzheimer's disease", 'level': 3, 'score': 0.24538633}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.13823214}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.12918073}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.12796125}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.110895514}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.065674394}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D053829', 'descriptor_name': 'Amyloid Precursor Protein Secretases', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D016564', 'descriptor_name': 'Amyloid beta-Protein Precursor', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053764', 'descriptor_name': 'Presenilin-1', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D053766', 'descriptor_name': 'Presenilin-2', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072417', 'descriptor_name': 'Protein Domains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055550', 'descriptor_name': 'Protein Stability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ijms222413600', 'pdf_url': 'https://www.mdpi.com/1422-0067/22/24/13600/pdf?version=1639997166', 'source': {'id': 'https://openalex.org/S10623703', 'display_name': 'International Journal of Molecular Sciences', 'issn_l': '1422-0067', 'issn': ['1422-0067', '1661-6596'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/38c5cd8844a64b39a9c057512840c7cd', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709358', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.20944/preprints202111.0564.v1', 'pdf_url': 'https://www.preprints.org/manuscript/202111.0564/v1/download', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/34948396', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ijms222413600', 'pdf_url': 'https://www.mdpi.com/1422-0067/22/24/13600/pdf?version=1639997166', 'source': {'id': 'https://openalex.org/S10623703', 'display_name': 'International Journal of Molecular Sciences', 'issn_l': '1422-0067', 'issn': ['1422-0067', '1661-6596'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320324099', 'funder_display_name': 'Russian Science Foundation', 'award_id': '19-15-00184'}, {'funder': 'https://openalex.org/F4320337337', 'funder_display_name': 'National Institute on Aging', 'award_id': 'R56AG071310'}, {'funder': 'https://openalex.org/F4320337337', 'funder_display_name': 'National Institute on Aging', 'award_id': 'R01AG055577'}], 'datasets': [], 'versions': [], 'referenced_works_count': 36, 'referenced_works': ['https://openalex.org/W1572225000', 'https://openalex.org/W1585083630', 'https://openalex.org/W1596429639', 'https://openalex.org/W1989654750', 'https://openalex.org/W2005184232', 'https://openalex.org/W2013306109', 'https://openalex.org/W2019437260', 'https://openalex.org/W2030182984', 'https://openalex.org/W2050386832', 'https://openalex.org/W2082429191', 'https://openalex.org/W2093682315', 'https://openalex.org/W2096410114', 'https://openalex.org/W2118935254', 'https://openalex.org/W2120396539', 'https://openalex.org/W2129085204', 'https://openalex.org/W2154297075', 'https://openalex.org/W2158854213', 'https://openalex.org/W2162980545', 'https://openalex.org/W2163895781', 'https://openalex.org/W2166461214', 'https://openalex.org/W2168334242', 'https://openalex.org/W2306696647', 'https://openalex.org/W2325208507', 'https://openalex.org/W2326435909', 'https://openalex.org/W2329336071', 'https://openalex.org/W2407468727', 'https://openalex.org/W2412965878', 'https://openalex.org/W2462793879', 'https://openalex.org/W2557653052', 'https://openalex.org/W2566006671', 'https://openalex.org/W2598340935', 'https://openalex.org/W2765275788', 'https://openalex.org/W2908723002', 'https://openalex.org/W3036672623', 'https://openalex.org/W3198052269', 'https://openalex.org/W4231640017'], 'related_works': ['https://openalex.org/W4232664324', 'https://openalex.org/W2329847864', 'https://openalex.org/W2194208597', 'https://openalex.org/W2136736966', 'https://openalex.org/W2120860069', 'https://openalex.org/W2076444547', 'https://openalex.org/W2071727701', 'https://openalex.org/W2050586736', 'https://openalex.org/W2005249952', 'https://openalex.org/W1973130935'], 'abstract_inverted_index': {'Proteolytic': [0], 'processing': [1, 254, 262, 281, 313], 'of': [2, 14, 20, 31, 46, 50, 71, 87, 97, 125, 133, 159, 184, 202, 220, 227, 242, 255, 275, 297, 311, 325, 338], 'amyloid': [3], 'precursor': [4], 'protein': [5, 208], '(APP)': [6], 'plays': [7], 'a': [8, 47, 143, 162, 187], 'critical': [9], 'role': [10, 45], 'in': [11, 57, 63, 77, 100, 110, 121, 147, 174, 194, 263, 282], 'the': [12, 29, 44, 69, 88, 111, 122, 155, 165, 175, 180, 195, 200, 206, 217, 224, 243, 251, 273, 335, 339], 'pathogenesis': [13], 'Alzheimer’s': [15], 'disease': [16], '(AD).': [17], 'Sequential': [18], 'cleavage': [19], 'APP': [21, 89, 101, 112, 140, 160, 185, 248, 261, 280, 312], 'by': [22, 268, 290, 332], 'β': [23], 'and': [24, 34, 68, 75, 93, 102, 151, 222, 300], 'γ': [25, 244, 340], 'secretases': [26], 'leads': [27, 249], 'to': [28, 117, 250, 287], 'generation': [30], 'Aβ40': [32], '(non-amyloidogenic)': [33], 'Aβ42': [35, 73, 326], '(amyloidogenic)': [36], 'peptides.': [37], 'Presenilin-1': [38], '(PS1)': [39], 'or': [40, 60], 'presenilin-2': [41], '(PS2)': [42], 'play': [43], 'catalytic': [48], 'subunit': [49], 'γ-secretase.': [51], 'Multiple': [52], 'familial': [53], 'AD': [54], '(FAD)': [55], 'mutations': [56, 99, 109, 204, 215], 'APP,': [58], 'PS1,': [59], 'PS2': [61], 'result': [62], 'an': [64, 119], 'increased': [65], 'Aβ42:Aβ40': [66], 'ratio': [67], 'accumulation': [70], 'toxic': [72], 'oligomers': [74], 'plaques': [76], 'patient': [78], 'brains.': [79], 'In': [80, 153, 178, 278], 'this': [81], 'study,': [82], 'we': [83, 137, 211, 233], 'perform': [84], 'molecular': [85], 'modeling': [86], 'complex': [90, 144, 246, 342], 'with': [91, 145, 164, 189, 247, 307, 343], 'γ-secretase': [92, 135, 146], 'analyze': [94], 'potential': [95, 149], 'effects': [96, 201], 'FAD': [98, 108], 'PS1.': [103], 'We': [104], 'noticed': [105], 'that': [106, 139, 168, 213, 235, 260, 322], 'all': [107], 'transmembrane': [113, 157, 170, 182, 190], 'domain': [114, 158, 167, 171, 183, 191], 'are': [115, 305], 'predicted': [116], 'cause': [118], 'increase': [120, 216], 'local': [123, 207], 'disorder': [124, 209], 'its': [126], 'secondary': [127], 'structure.': [128, 177, 197], 'Based': [129, 229], 'on': [130, 205, 230], 'structural': [131], 'analysis': [132], 'known': [134], 'structures,': [136], 'propose': [138, 234], 'can': [141], 'form': [142], '2': [148], 'conformations—M1': [150], 'M2.': [152], 'conformation,': [154, 179, 237, 241], 'M1': [156, 240, 264], 'forms': [161, 186], 'contact': [163, 188], 'perimembrane': [166], 'follows': [169], '6': [172], '(TM6)': [173], 'PS1': [176, 196], 'M2': [181, 221, 236, 283, 336], '7': [192], '(TM7)': [193], 'By': [198], 'analyzing': [199], 'PS1-FAD': [203], 'index,': [210], 'discovered': [212], 'these': [214, 231], 'conformational': [218, 225], 'flexibility': [219, 226], 'reduce': [223], 'M1.': [228], 'results,': [232], 'but': [238], 'not': [239], 'secretase': [245, 341], 'amyloidogenic': [252], '(Aβ42-generating)': [253], 'APP.': [256, 344], 'Our': [257, 318], 'model': [258], 'predicts': [259], 'conformation': [265, 284, 337], 'is': [266, 285], 'favored': [267, 289], 'curved': [269], 'membranes,': [270, 293], 'such': [271, 294], 'as': [272, 295], 'membranes': [274, 296], 'early': [276], 'endosomes.': [277], 'contrast,': [279], 'likely': [286], 'be': [288, 329], 'relatively': [291], 'flat': [292], 'late': [298], 'endosomes': [299], 'plasma': [301], 'membranes.': [302], 'These': [303], 'predictions': [304], 'consistent': [306], 'published': [308], 'biochemical': [309], 'analyses': [310], 'at': [314], 'different': [315], 'subcellular': [316], 'locations.': [317], 'results': [319], 'also': [320], 'suggest': [321], 'specific': [323], 'inhibitors': [324], 'production': [327], 'could': [328], 'potentially': [330], 'developed': [331], 'selectively': [333], 'targeting': [334]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4226003420', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 1}], 'updated_date': '2024-12-18T11:05:03.363774', 'created_date': '2022-05-05'}