Title: Is γ-secretase a multienzyme complex for membrane protein degradation?
Abstract: The β- and γ-secretases cleave the amyloid protein precursor (APP) to release the amyloid protein (Aβ). While the β-secretase has now been identified, the γ-secretase remains an enigma. A number of mutations in the presenilins (PS) and APP have been shown to alter the cleavage specificity of γ-secretase. However, the relationship between PS and γ-secretase remains unclear. This article presents some models of γ-secretase and suggests that the simplest interpretation of current data is that γ-secretase is a complex of several proteases located in the lumen of secretory vesicles.
Publication Year: 2002
Publication Date: 2002-07-01
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 11
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