Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4220994100', 'doi': 'https://doi.org/10.1101/2022.03.05.483126', 'title': 'SNARE assembly enlightened by cryo-EM structures of a synaptobrevin-Munc18-1-syntaxin-1 complex', 'display_name': 'SNARE assembly enlightened by cryo-EM structures of a synaptobrevin-Munc18-1-syntaxin-1 complex', 'publication_year': 2022, 'publication_date': '2022-03-06', 'ids': {'openalex': 'https://openalex.org/W4220994100', 'doi': 'https://doi.org/10.1101/2022.03.05.483126'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2022.03.05.483126', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2022/03/06/2022.03.05.483126.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.biorxiv.org/content/biorxiv/early/2022/03/06/2022.03.05.483126.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5042289367', 'display_name': 'Karolina P. Stepien', 'orcid': 'https://orcid.org/0000-0003-0373-8919'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Karolina P. Stepien', 'raw_affiliation_strings': ['Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390', 'Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas 75390', 'Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, 7590'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390', 'institution_ids': ['https://openalex.org/I867280407']}, {'raw_affiliation_string': 'Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, 7590', 'institution_ids': ['https://openalex.org/I867280407']}, {'raw_affiliation_string': 'Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas 75390', 'institution_ids': ['https://openalex.org/I867280407']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079500303', 'display_name': 'Junjie Xu', 'orcid': 'https://orcid.org/0000-0003-2914-9514'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Junjie Xu', 'raw_affiliation_strings': ['Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390', 'Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas 75390', 'Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, 7590'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, 7590', 'institution_ids': ['https://openalex.org/I867280407']}, {'raw_affiliation_string': 'Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390', 'institution_ids': ['https://openalex.org/I867280407']}, {'raw_affiliation_string': 'Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas 75390', 'institution_ids': ['https://openalex.org/I867280407']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100768037', 'display_name': 'Xuewu Zhang', 'orcid': 'https://orcid.org/0000-0002-3634-6711'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xuewu Zhang', 'raw_affiliation_strings': ['Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas 75390', 'Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, 7590'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, 7590', 'institution_ids': ['https://openalex.org/I867280407']}, {'raw_affiliation_string': 'Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas 75390', 'institution_ids': ['https://openalex.org/I867280407']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014221058', 'display_name': 'Xiao‐chen Bai', 'orcid': 'https://orcid.org/0000-0002-4234-5686'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Xiaochen Bai', 'raw_affiliation_strings': ['Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas 75390', 'Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, 75390'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, 75390', 'institution_ids': ['https://openalex.org/I867280407']}, {'raw_affiliation_string': 'Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas 75390', 'institution_ids': ['https://openalex.org/I867280407']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5065106268', 'display_name': 'Josep Rizo', 'orcid': 'https://orcid.org/0000-0003-1773-8311'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Josep Rizo', 'raw_affiliation_strings': ['Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390', 'Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas 75390', 'Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, 7590'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390', 'institution_ids': ['https://openalex.org/I867280407']}, {'raw_affiliation_string': 'Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, 7590', 'institution_ids': ['https://openalex.org/I867280407']}, {'raw_affiliation_string': 'Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas 75390', 'institution_ids': ['https://openalex.org/I867280407']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5014221058', 'https://openalex.org/A5065106268'], 'corresponding_institution_ids': ['https://openalex.org/I867280407', 'https://openalex.org/I867280407'], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.645221, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 76, 'max': 80}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13415', 'display_name': 'Calcium signaling and nucleotide metabolism', 'score': 0.9926, 'subfield': {'id': 'https://openalex.org/subfields/1314', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10407', 'display_name': 'Lipid Membrane Structure and Behavior', 'score': 0.9912, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/synaptobrevin', 'display_name': 'Synaptobrevin', 'score': 0.9146689}, {'id': 'https://openalex.org/keywords/snare-complex', 'display_name': 'SNARE complex', 'score': 0.84589773}], 'concepts': [{'id': 'https://openalex.org/C2777029164', 'wikidata': 'https://www.wikidata.org/wiki/Q82452579', 'display_name': 'Synaptobrevin', 'level': 5, 'score': 0.9146689}, {'id': 'https://openalex.org/C2778256703', 'wikidata': 'https://www.wikidata.org/wiki/Q390407', 'display_name': 'Syntaxin', 'level': 4, 'score': 0.847304}, {'id': 'https://openalex.org/C2908790754', 'wikidata': 'https://www.wikidata.org/wiki/Q279694', 'display_name': 'SNARE complex', 'level': 4, 'score': 0.84589773}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.46341106}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.38843474}, {'id': 'https://openalex.org/C148785051', 'wikidata': 'https://www.wikidata.org/wiki/Q671136', 'display_name': 'Synaptic vesicle', 'level': 4, 'score': 0.34300146}, {'id': 'https://openalex.org/C103038307', 'wikidata': 'https://www.wikidata.org/wiki/Q6556360', 'display_name': 'Lipid bilayer fusion', 'level': 3, 'score': 0.21439764}, {'id': 'https://openalex.org/C144647389', 'wikidata': 'https://www.wikidata.org/wiki/Q423042', 'display_name': 'Membrane protein', 'level': 3, 'score': 0.15243003}, {'id': 'https://openalex.org/C130316041', 'wikidata': 'https://www.wikidata.org/wiki/Q189206', 'display_name': 'Vesicle', 'level': 3, 'score': 0.12015808}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.10527715}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.079330236}], 'mesh': [], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2022.03.05.483126', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2022/03/06/2022.03.05.483126.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1126/sciadv.abo5272', 'pdf_url': 'https://www.science.org/doi/pdf/10.1126/sciadv.abo5272?download=true', 'source': None, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2022.03.05.483126', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2022/03/06/2022.03.05.483126.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W1497380575', 'https://openalex.org/W1570845414', 'https://openalex.org/W1600427108', 'https://openalex.org/W1807494075', 'https://openalex.org/W1822005186', 'https://openalex.org/W1822252127', 'https://openalex.org/W1840564118', 'https://openalex.org/W1966364658', 'https://openalex.org/W1971016259', 'https://openalex.org/W1999213641', 'https://openalex.org/W2013703566', 'https://openalex.org/W2052469181', 'https://openalex.org/W2052999464', 'https://openalex.org/W2058751269', 'https://openalex.org/W2060384627', 'https://openalex.org/W2061342956', 'https://openalex.org/W2063487710', 'https://openalex.org/W2067354100', 'https://openalex.org/W2076789610', 'https://openalex.org/W2086919645', 'https://openalex.org/W2101097180', 'https://openalex.org/W2122970793', 'https://openalex.org/W2153569460', 'https://openalex.org/W2170349574', 'https://openalex.org/W2403577250', 'https://openalex.org/W2464112691', 'https://openalex.org/W2581328787', 'https://openalex.org/W2587405972', 'https://openalex.org/W2611650009', 'https://openalex.org/W2743096680', 'https://openalex.org/W2769789189', 'https://openalex.org/W2801919855', 'https://openalex.org/W2910833885', 'https://openalex.org/W2917060214', 'https://openalex.org/W2941374900', 'https://openalex.org/W2951496883', 'https://openalex.org/W2974428906', 'https://openalex.org/W3008624462', 'https://openalex.org/W3041477429', 'https://openalex.org/W3093300511', 'https://openalex.org/W3096985586', 'https://openalex.org/W4200627843'], 'related_works': ['https://openalex.org/W4389889961', 'https://openalex.org/W4310518166', 'https://openalex.org/W4299395602', 'https://openalex.org/W4283257555', 'https://openalex.org/W4281723594', 'https://openalex.org/W4220994100', 'https://openalex.org/W2789573010', 'https://openalex.org/W2023907596', 'https://openalex.org/W2008400247', 'https://openalex.org/W1992294030'], 'abstract_inverted_index': {'Abstract': [0], 'Munc18-1': [1, 56, 143], 'forms': [2], 'a': [3, 21, 112], 'template': [4], 'to': [5, 20, 38, 58, 98, 119], 'recruit': [6], 'and': [7, 35, 61, 71, 90, 108], 'organize': [8], 'assembly': [9, 46, 106, 140], 'of': [10, 24, 43, 55, 67, 75, 87, 101, 136], 'the': [11, 32, 41, 76, 85, 88, 133], 'SNARE': [12, 33, 44, 92, 104, 121, 138], 'complex': [13, 45, 105, 122, 139], 'that': [14], 'triggers': [15], 'neurotransmitter': [16], 'release,': [17], 'binding': [18, 37], 'first': [19], 'closed': [22], 'conformation': [23], 'syntaxin-1': [25, 60, 69, 77, 89], 'where': [26], 'its': [27], 'N-terminal': [28, 78], 'region': [29, 79], 'interacts': [30], 'with': [31], 'motif,': [34], 'later': [36], 'synaptobrevin.': [39, 62], 'However,': [40], 'mechanism': [42, 135], 'remains': [47], 'unclear.': [48], 'Here': [49], 'we': [50], 'report': [51], 'two': [52], 'cryo-EM': [53], 'structures': [54, 64, 128], 'bound': [57], 'cross-linked': [59], 'The': [63], 'allow': [65], 'visualization': [66], 'how': [68, 73], 'opens': [70], 'reveal': [72, 129], 'part': [74], 'can': [80], 'help': [81], 'nucleate': [82], 'interactions': [83, 116], 'between': [84], 'N-termini': [86], 'synaptobrevin': [91], 'motifs': [93], 'while': [94], 'their': [95], 'C-termini': [96], 'bind': [97], 'distal': [99], 'sites': [100], 'Munc18-1.': [102], 'Mutagenesis,': [103], 'assays': [107], 'reconstitution': [109], 'experiments': [110], 'support': [111], 'model': [113], 'whereby': [114], 'these': [115], 'are': [117], 'critical': [118], 'initiate': [120], 'assembly.': [123], 'One': [124], 'Sentence': [125], 'Summary': [126], 'Cryo-EM': [127], 'key': [130], 'insights': [131], 'into': [132], 'molecular': [134], 'neuronal': [137], 'templated': [141], 'by': [142]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4220994100', 'counts_by_year': [{'year': 2022, 'cited_by_count': 3}], 'updated_date': '2024-12-12T03:18:50.693152', 'created_date': '2022-04-03'}