Conformational change of Syntaxin-3b in regulating SNARE complex assembly in the ribbon synapses

Name: Work Video:
Duration: 3 min 30 s
Claire Gething; Joshua Ferrar; Bishal Misra; Giovanni Howells; Alexa L. Andrzejewski; Mark E. Bowen; Ucheor B. Choi
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'SNAP-25': [23], 'plasma': [26, 51], 'membrane': [27, 47, 52], 'synaptobrevin': [29], 'vesicle.': [33, 56], 'The': [34], 'formation': [35, 152], 'SNARE': [38, 63, 99, 117, 150, 174], 'complex': [39, 64, 100, 151, 175], 'progressively': [40], 'zippers': [41], 'towards': [42], 'membranes,': [44], 'which': [45], 'drives': [46], 'fusion': [48], 'between': [49], 'However,': [57], 'underlying': [59], 'molecular': [60], 'mechanism': [61], 'regulation': [65], 'is': [66, 106, 146, 153], 'unclear.': [67], 'In': [68], 'this': [69], 'study,': [70], 'we': [71, 178], 'investigated': [72], 'syntaxin-3b': [74, 95, 105, 129, 145, 162, 187], 'isoform': [75], 'found': [76, 103], 'in': [77, 108, 196], 'retinal': [79], 'ribbon': [80, 198], 'synapses': [81], 'using': [82], 'single-molecule': [83], 'fluorescence': [84], 'resonance': [85], 'energy': [86], 'transfer': [87], '(smFRET)': [88], 'to': [89, 135, 148, 172], 'monitor': [90], 'conformational': [92, 170, 184], 'changes': [93], 'that': [96, 104], 'modulate': [97], 'formation.': [101], 'We': [102], 'predominantly': [107], 'a': [109, 120, 169, 180], 'self-inhibiting': [110], 'closed': [111], 'conformation,': [112, 133], 'inefficiently': [113], 'forming': [114], 'ternary': [116], 'complex.': [118], 'Conversely,': [119], 'phosphomimetic': [121], 'mutation': [122, 160], '(T14E)': [123], 'at': [124], 'N-terminal': [126], 'region': [127], 'promoted': [130], 'open': [132, 138], 'similar': [134], 'constitutively': [137], 'form': [139], 'LE': [142], 'mutant.': [143], 'When': [144], 'bound': [147], 'Munc18-1,': [149], 'almost': [154], 'completely': [155], 'blocked.': [156], 'Surprisingly,': [157], 'T14E': [159], 'partially': [163], 'abolishes': [164], 'Munc18-1': [165], 'regulation,': [166], 'acting': [167], 'as': [168], 'switch': [171], 'trigger': [173], 'assembly.': [176], 'Thus,': [177], 'suggest': [179], 'model': [181], 'where': [182], 'change': [185], 'induced': [188], 'by': [189], 'phosphorylation': [190], 'initiates': [191], 'neurotransmitters': [195], 'synapses.': [199]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4281723594', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 1}], 'updated_date': '2024-12-10T04:32:20.480480', 'created_date': '2022-06-13'}
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