27-Hydroxycholesterol Binds GPER and Induces Progression of Estrogen Receptor-Negative Breast Cancer

Name: Work Video:
Duration: 3 min 30 s
Paola Avena; Ivan Casaburi; Lucia Zavaglia; Marta C. Nocito; Davide La Padula; Vittoria Rago; Jing Dong; Peter Thomas; Chieko Mineo; Rosa Sirianni; Philip W. Shaul
{'id': 'https://openalex.org/W4220654221', 'doi': 'https://doi.org/10.3390/cancers14061521', 'title': '27-Hydroxycholesterol Binds GPER and Induces Progression of Estrogen Receptor-Negative Breast Cancer', 'display_name': '27-Hydroxycholesterol Binds GPER and Induces Progression of Estrogen Receptor-Negative Breast Cancer', 'publication_year': 2022, 'publication_date': '2022-03-16', 'ids': {'openalex': 'https://openalex.org/W4220654221', 'doi': 'https://doi.org/10.3390/cancers14061521', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/35326671'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/cancers14061521', 'pdf_url': 'https://www.mdpi.com/2072-6694/14/6/1521/pdf?version=1648017047', 'source': {'id': 'https://openalex.org/S168415115', 'display_name': 'Cancers', 'issn_l': '2072-6694', 'issn': ['2072-6694'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/2072-6694/14/6/1521/pdf?version=1648017047', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5027686769', 'display_name': 'Paola Avena', 'orcid': 'https://orcid.org/0000-0001-6387-1848'}, 'institutions': [{'id': 'https://openalex.org/I45204951', 'display_name': 'University of Calabria', 'ror': 'https://ror.org/02rc97e94', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45204951']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Paola Avena', 'raw_affiliation_strings': ['Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy', 'institution_ids': ['https://openalex.org/I45204951']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113558904', 'display_name': 'Ivan Casaburi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45204951', 'display_name': 'University of Calabria', 'ror': 'https://ror.org/02rc97e94', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45204951']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Ivan Casaburi', 'raw_affiliation_strings': ['Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy', 'institution_ids': ['https://openalex.org/I45204951']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049001722', 'display_name': 'Lucia Zavaglia', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45204951', 'display_name': 'University of Calabria', 'ror': 'https://ror.org/02rc97e94', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45204951']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Lucia Zavaglia', 'raw_affiliation_strings': ['Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy', 'institution_ids': ['https://openalex.org/I45204951']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029155022', 'display_name': 'Marta C. Nocito', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45204951', 'display_name': 'University of Calabria', 'ror': 'https://ror.org/02rc97e94', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45204951']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Marta C. Nocito', 'raw_affiliation_strings': ['Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy', 'institution_ids': ['https://openalex.org/I45204951']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063741832', 'display_name': 'Davide La Padula', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45204951', 'display_name': 'University of Calabria', 'ror': 'https://ror.org/02rc97e94', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45204951']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Davide La Padula', 'raw_affiliation_strings': ['Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy', 'institution_ids': ['https://openalex.org/I45204951']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028328541', 'display_name': 'Vittoria Rago', 'orcid': 'https://orcid.org/0000-0003-3971-7378'}, 'institutions': [{'id': 'https://openalex.org/I45204951', 'display_name': 'University of Calabria', 'ror': 'https://ror.org/02rc97e94', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45204951']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Vittoria Rago', 'raw_affiliation_strings': ['Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy', 'institution_ids': ['https://openalex.org/I45204951']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109151648', 'display_name': 'Jing Dong', 'orcid': 'https://orcid.org/0000-0002-4589-1471'}, 'institutions': [{'id': 'https://openalex.org/I86519309', 'display_name': 'The University of Texas at Austin', 'ror': 'https://ror.org/00hj54h04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86519309']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jing Dong', 'raw_affiliation_strings': ['Marine Science Institute, University of Texas at Austin, Port Aransas, TX 78373, USA'], 'affiliations': [{'raw_affiliation_string': 'Marine Science Institute, University of Texas at Austin, Port Aransas, TX 78373, USA', 'institution_ids': ['https://openalex.org/I86519309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029049466', 'display_name': 'Peter Thomas', 'orcid': 'https://orcid.org/0000-0001-6656-4907'}, 'institutions': [{'id': 'https://openalex.org/I86519309', 'display_name': 'The University of Texas at Austin', 'ror': 'https://ror.org/00hj54h04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86519309']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Peter Thomas', 'raw_affiliation_strings': ['Marine Science Institute, University of Texas at Austin, Port Aransas, TX 78373, USA'], 'affiliations': [{'raw_affiliation_string': 'Marine Science Institute, University of Texas at Austin, Port Aransas, TX 78373, USA', 'institution_ids': ['https://openalex.org/I86519309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022115028', 'display_name': 'Chieko Mineo', 'orcid': 'https://orcid.org/0000-0002-4978-6177'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chieko Mineo', 'raw_affiliation_strings': ['Center for Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA'], 'affiliations': [{'raw_affiliation_string': 'Center for Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA', 'institution_ids': ['https://openalex.org/I867280407']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049961945', 'display_name': 'Rosa Sirianni', 'orcid': 'https://orcid.org/0000-0002-8966-350X'}, 'institutions': [{'id': 'https://openalex.org/I45204951', 'display_name': 'University of Calabria', 'ror': 'https://ror.org/02rc97e94', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45204951']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'Rosa Sirianni', 'raw_affiliation_strings': ['Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy', 'institution_ids': ['https://openalex.org/I45204951']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5006986105', 'display_name': 'Philip W. Shaul', 'orcid': 'https://orcid.org/0000-0003-1157-4002'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Philip W. Shaul', 'raw_affiliation_strings': ['Center for Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA'], 'affiliations': [{'raw_affiliation_string': 'Center for Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA', 'institution_ids': ['https://openalex.org/I867280407']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5049961945', 'https://openalex.org/A5006986105'], 'corresponding_institution_ids': ['https://openalex.org/I45204951', 'https://openalex.org/I867280407'], 'apc_list': {'value': 2400, 'currency': 'CHF', 'value_usd': 2598, 'provenance': 'doaj'}, 'apc_paid': {'value': 2400, 'currency': 'CHF', 'value_usd': 2598, 'provenance': 'doaj'}, 'fwci': 3.198, 'has_fulltext': False, 'cited_by_count': 14, 'citation_normalized_percentile': {'value': 0.999942, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '14', 'issue': '6', 'first_page': '1521', 'last_page': '1521'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12465', 'display_name': 'Cancer, Lipids, and Metabolism', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11618', 'display_name': 'Cholesterol and Lipid Metabolism', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/gper', 'display_name': 'GPER', 'score': 0.9331778}, {'id': 'https://openalex.org/keywords/skbr3', 'display_name': 'SKBR3', 'score': 0.74584734}, {'id': 'https://openalex.org/keywords/oxysterol', 'display_name': 'Oxysterol', 'score': 0.4548583}], 'concepts': [{'id': 'https://openalex.org/C166471694', 'wikidata': 'https://www.wikidata.org/wiki/Q18268232', 'display_name': 'GPER', 'level': 5, 'score': 0.9331778}, {'id': 'https://openalex.org/C84606932', 'wikidata': 'https://www.wikidata.org/wiki/Q416496', 'display_name': 'Estrogen receptor', 'level': 4, 'score': 0.7893122}, {'id': 'https://openalex.org/C191560914', 'wikidata': 'https://www.wikidata.org/wiki/Q7390592', 'display_name': 'SKBR3', 'level': 5, 'score': 0.74584734}, {'id': 'https://openalex.org/C119056186', 'wikidata': 'https://www.wikidata.org/wiki/Q1431332', 'display_name': 'Gene silencing', 'level': 3, 'score': 0.54632926}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5224965}, {'id': 'https://openalex.org/C2778111914', 'wikidata': 'https://www.wikidata.org/wiki/Q7116159', 'display_name': 'Oxysterol', 'level': 3, 'score': 0.4548583}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.4516111}, {'id': 'https://openalex.org/C2777164284', 'wikidata': 'https://www.wikidata.org/wiki/Q277954', 'display_name': 'Estrogen', 'level': 2, 'score': 0.4449901}, {'id': 'https://openalex.org/C2778163477', 'wikidata': 'https://www.wikidata.org/wiki/Q43656', 'display_name': 'Cholesterol', 'level': 2, 'score': 0.42525953}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.42140603}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.41737467}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.41494957}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.36450118}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.3067146}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2780069}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.26063585}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.24091095}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.19821781}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.09773609}, {'id': 'https://openalex.org/C2994423619', 'wikidata': 'https://www.wikidata.org/wiki/Q9103', 'display_name': 'Human breast', 'level': 4, 'score': 0.039669365}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/cancers14061521', 'pdf_url': 'https://www.mdpi.com/2072-6694/14/6/1521/pdf?version=1648017047', 'source': {'id': 'https://openalex.org/S168415115', 'display_name': 'Cancers', 'issn_l': '2072-6694', 'issn': ['2072-6694'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946696', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/35326671', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/cancers14061521', 'pdf_url': 'https://www.mdpi.com/2072-6694/14/6/1521/pdf?version=1648017047', 'source': {'id': 'https://openalex.org/S168415115', 'display_name': 'Cancers', 'issn_l': '2072-6694', 'issn': ['2072-6694'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.84, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320324143', 'funder_display_name': 'Fondazione Italiana per la Ricerca sul Cancro', 'award_id': 'IG15230'}], 'datasets': [], 'versions': [], 'referenced_works_count': 62, 'referenced_works': ['https://openalex.org/W1523672843', 'https://openalex.org/W1897724420', 'https://openalex.org/W1964506243', 'https://openalex.org/W1979624565', 'https://openalex.org/W1981073876', 'https://openalex.org/W1996168740', 'https://openalex.org/W1998740208', 'https://openalex.org/W2009453863', 'https://openalex.org/W2022650450', 'https://openalex.org/W2031540681', 'https://openalex.org/W2035864186', 'https://openalex.org/W2036192035', 'https://openalex.org/W2036427463', 'https://openalex.org/W2037790468', 'https://openalex.org/W2039817035', 'https://openalex.org/W2044702943', 'https://openalex.org/W2045586109', 'https://openalex.org/W2053131885', 'https://openalex.org/W2060222731', 'https://openalex.org/W2070432942', 'https://openalex.org/W2075443461', 'https://openalex.org/W2080303509', 'https://openalex.org/W2088436733', 'https://openalex.org/W2091624467', 'https://openalex.org/W2094646101', 'https://openalex.org/W2097255042', 'https://openalex.org/W2105052532', 'https://openalex.org/W2107220744', 'https://openalex.org/W2108300301', 'https://openalex.org/W2122015809', 'https://openalex.org/W2131994307', 'https://openalex.org/W2132619562', 'https://openalex.org/W2148187428', 'https://openalex.org/W2148678536', 'https://openalex.org/W2152105216', 'https://openalex.org/W2162012682', 'https://openalex.org/W2162866906', 'https://openalex.org/W2164019843', 'https://openalex.org/W2259802687', 'https://openalex.org/W2267899699', 'https://openalex.org/W2285362178', 'https://openalex.org/W2401101711', 'https://openalex.org/W2486752612', 'https://openalex.org/W2553847567', 'https://openalex.org/W2559807396', 'https://openalex.org/W2586277811', 'https://openalex.org/W2609031243', 'https://openalex.org/W2728999631', 'https://openalex.org/W2739995106', 'https://openalex.org/W2756539505', 'https://openalex.org/W2763053047', 'https://openalex.org/W2782007985', 'https://openalex.org/W2884732684', 'https://openalex.org/W2904363145', 'https://openalex.org/W2913304445', 'https://openalex.org/W2969263349', 'https://openalex.org/W2987571897', 'https://openalex.org/W2987649810', 'https://openalex.org/W2999854125', 'https://openalex.org/W3015058708', 'https://openalex.org/W3035590367', 'https://openalex.org/W4231953333'], 'related_works': ['https://openalex.org/W4389025690', 'https://openalex.org/W4288730575', 'https://openalex.org/W4220654221', 'https://openalex.org/W3013731915', 'https://openalex.org/W2752012830', 'https://openalex.org/W2615306316', 'https://openalex.org/W2095587552', 'https://openalex.org/W2054737225', 'https://openalex.org/W1995318696', 'https://openalex.org/W1992642689'], 'abstract_inverted_index': {'Cholesterol': [0, 16], 'affects': [1], 'the': [2, 24, 59, 65, 119, 176], 'proliferation': [3, 52, 76], 'of': [4, 11, 26, 61, 67, 118, 125, 178], 'breast': [5], 'cancer': [6], '(BC)': [7], 'and': [8, 70, 114, 130, 133, 173, 175], 'in': [9, 34, 58], 'particular': [10], 'estrogen': [12], 'receptor-negative': [13], '(ER-)': [14], 'BC.': [15, 28], 'is': [17, 55, 104, 180], 'converted': [18], 'to': [19, 93], '27-hydroxycholesterol': [20], '(27HC),': [21], 'which': [22, 54, 150], 'promotes': [23, 147, 169], 'growth': [25, 172], 'ER+': [27], 'Potentially,': [29], '27HC': [30, 73, 97, 103, 146, 168], 'can': [31], 'be': [32, 94], 'involved': [33], 'cholesterol-dependent': [35], 'ER-': [36, 141, 170], 'BC': [37, 142, 171], 'proliferation.': [38], 'Stable': [39], 'MDA-MB-231': [40, 69], 'silenced': [41, 158], 'clones': [42], 'for': [43, 108, 182], 'CYP7B1': [44], '(27HC': [45], 'metabolizing': [46], 'enzyme)': [47], 'show': [48, 111], 'an': [49], 'increased': [50, 74], 'basal': [51, 132], 'rate,': [53], 'not': [56, 152], 'observed': [57], 'presence': [60], 'lipoprotein-deprived': [62], 'serum.': [63], 'Furthermore,': [64], 'treatment': [66], 'SKBR3,': [68], 'MDA-MB-468': [71], 'with': [72, 145, 154], 'cell': [75], 'that': [77, 102, 112, 164], 'was': [78], 'prevented': [79], 'by': [80], 'G15,': [81], 'a': [82, 95, 105], 'selective': [83], 'G': [84], 'Protein-Coupled': [85], 'Estrogen': [86], 'Receptor': [87], '(GPER)': [88], 'inhibitor,': [89], 'suggested': [90], 'this': [91], 'receptor': [92], 'potential': [96], 'target.': [98], 'Binding': [99], 'experiments': [100], 'demonstrate': [101, 163], 'new': [106], 'ligand': [107], 'GPER.': [109], 'We': [110], 'ERK1/2': [113], 'NFκB': [115, 128], 'are': [116], 'part': [117], '27HC/GPER': [120], 'pathway.': [121], 'The': [122], 'stable': [123], 'silencing': [124], 'GPER': [126, 157, 179], 'prevents': [127], 'activation': [129], 'reduces': [131], '27HC-dependent': [134], 'tumor': [135], 'growth.': [136], 'Additionally,': [137], 'conditioned': [138], 'medium': [139], 'from': [140, 156], 'cells': [143], 'treated': [144], 'tube': [148], 'formation,': [149], 'does': [151], 'occur': [153], 'CM': [155], 'cells.': [159], 'Collectively,': [160], 'these': [161], 'data': [162], 'cholesterol': [165], 'conversion': [166], 'into': [167], 'progression,': [174], 'expression': [177], 'required': [181], 'its': [183], 'effects.': [184]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4220654221', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 2}], 'updated_date': '2024-12-24T05:06:39.404259', 'created_date': '2022-04-03'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
