Bisphenol A Induces Gene Expression Changes and Proliferative Effects through GPER in Breast Cancer Cells and Cancer-Associated Fibroblasts

Name: Work Video:
Duration: 3 min 30 s
Marco Pupo; Assunta Pisano; Rosamaria Lappano; Maria Francesca Santolla; Ernestina Marianna De Francesco; Sergio Abonante; Camillo Rosano; Marcello Maggiolini
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[60, 159], 'normal': [61], 'tumor': [63], 'cells.Objectives:': [64], 'We': [65, 90], 'studied': [66], 'transduction': [68, 134, 189], 'signaling': [69, 183], 'pathways': [70], 'which': [72, 192], 'influences': [74], 'cell': [75, 160], 'proliferation': [76], 'migration': [78, 154], 'human': [80], 'breast': [81, 97, 138, 176], 'cancer': [82, 98, 139, 177, 196], 'cells': [83, 99, 140, 178], 'cancer-associated': [85], 'fibroblasts': [86], '(CAFs).Methods': [87], 'results:': [89], 'used': [91, 114], 'as': [92], 'a': [93], 'model': [94], 'system': [95], 'SKBR3': [96, 137], 'CAFs': [101], 'lack': [103], 'ERs.': [106], 'Specific': [107], 'pharmacological': [108], 'inhibitors': [109], 'gene-silencing': [111], 'procedures': [112], 'were': [113], 'to': [115], 'show': [116], 'induces': [119], 'expression': [121], 'target': [125], 'genes': [126], 'c-FOS,': [127], 'EGR-1,': [128], 'CTGF': [130], 'GPER/EGFR/ERK': [133], 'pathway': [135], 'CAFs.': [142, 180], 'Moreover,': [143], 'we': [144], 'observed': [145], 'required': [149], 'for': [150], 'growth': [151], 'stimulated': [155], 'types.Conclusions:': [161], 'Results': [162], 'indicate': [163], 'biological': [170], 'action': [171], 'elicited': [172], 'Hence,': [181], 'GPER-mediated': [182], 'should': [184], 'be': [185], 'included': [186], 'among': [187], 'mechanisms': [190], 'may': [194], 'stimulate': [195], 'progression.': [197]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2095587552', 'counts_by_year': [{'year': 2024, 'cited_by_count': 13}, {'year': 2023, 'cited_by_count': 15}, {'year': 2022, 'cited_by_count': 19}, {'year': 2021, 'cited_by_count': 24}, {'year': 2020, 'cited_by_count': 21}, {'year': 2019, 'cited_by_count': 19}, {'year': 2018, 'cited_by_count': 19}, {'year': 2017, 'cited_by_count': 22}, {'year': 2016, 'cited_by_count': 27}, {'year': 2015, 'cited_by_count': 38}, {'year': 2014, 'cited_by_count': 20}, {'year': 2013, 'cited_by_count': 18}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-10T20:44:05.245022', 'created_date': '2016-06-24'}
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