Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4212982835', 'doi': 'https://doi.org/10.1002/jctb.7053', 'title': '<i>Bacillus subtilis</i> chassis in biomanufacturing 4.0', 'display_name': '<i>Bacillus subtilis</i> chassis in biomanufacturing 4.0', 'publication_year': 2022, 'publication_date': '2022-03-01', 'ids': {'openalex': 'https://openalex.org/W4212982835', 'doi': 'https://doi.org/10.1002/jctb.7053'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jctb.7053', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S112095004', 'display_name': 'Journal of Chemical Technology & Biotechnology', 'issn_l': '0268-2575', 'issn': ['0268-2575', '1097-4660'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.22541/au.163250934.42128224/v1', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5038539332', 'display_name': 'Wenbo Zhang', 'orcid': 'https://orcid.org/0000-0003-1661-3074'}, 'institutions': [{'id': 'https://openalex.org/I80626142', 'display_name': 'Xinxiang Medical University', 'ror': 'https://ror.org/038hzq450', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I80626142']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Wenbo Zhang', 'raw_affiliation_strings': ['Synthetic Biology Engineering Laboratory of Henan Province (SynBelHn), School of Life Sciences and Technology, Xinxiang Medical University, Xinxiang, China'], 'affiliations': [{'raw_affiliation_string': 'Synthetic Biology Engineering Laboratory of Henan Province (SynBelHn), School of Life Sciences and Technology, Xinxiang Medical University, Xinxiang, China', 'institution_ids': ['https://openalex.org/I80626142']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100932279', 'display_name': 'Xinshu Zhu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I80626142', 'display_name': 'Xinxiang Medical University', 'ror': 'https://ror.org/038hzq450', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I80626142']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xinshu Zhu', 'raw_affiliation_strings': ["College of Medical Technology, Jiangsu College of Nursing, Huai'an, China", 'Synthetic Biology Engineering Laboratory of Henan Province (SynBelHn), School of Life Sciences and Technology, Xinxiang Medical University, Xinxiang, China'], 'affiliations': [{'raw_affiliation_string': 'Synthetic Biology Engineering Laboratory of Henan Province (SynBelHn), School of Life Sciences and Technology, Xinxiang Medical University, Xinxiang, China', 'institution_ids': ['https://openalex.org/I80626142']}, {'raw_affiliation_string': "College of Medical Technology, Jiangsu College of Nursing, Huai'an, China", 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100322458', 'display_name': 'Yan Wang', 'orcid': 'https://orcid.org/0000-0001-5624-6745'}, 'institutions': [{'id': 'https://openalex.org/I80626142', 'display_name': 'Xinxiang Medical University', 'ror': 'https://ror.org/038hzq450', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I80626142']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yan Wang', 'raw_affiliation_strings': ['Synthetic Biology Engineering Laboratory of Henan Province (SynBelHn), School of Life Sciences and Technology, Xinxiang Medical University, Xinxiang, China'], 'affiliations': [{'raw_affiliation_string': 'Synthetic Biology Engineering Laboratory of Henan Province (SynBelHn), School of Life Sciences and Technology, Xinxiang Medical University, Xinxiang, China', 'institution_ids': ['https://openalex.org/I80626142']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5018581829', 'display_name': 'Li Tao', 'orcid': 'https://orcid.org/0000-0002-9343-7011'}, 'institutions': [{'id': 'https://openalex.org/I80626142', 'display_name': 'Xinxiang Medical University', 'ror': 'https://ror.org/038hzq450', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I80626142']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Tao Li', 'raw_affiliation_strings': ['Synthetic Biology Engineering Laboratory of Henan Province (SynBelHn), School of Life Sciences and Technology, Xinxiang Medical University, Xinxiang, China'], 'affiliations': [{'raw_affiliation_string': 'Synthetic Biology Engineering Laboratory of Henan Province (SynBelHn), School of Life Sciences and Technology, Xinxiang Medical University, Xinxiang, China', 'institution_ids': ['https://openalex.org/I80626142']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5038539332'], 'corresponding_institution_ids': ['https://openalex.org/I80626142'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.622, 'has_fulltext': False, 'cited_by_count': 4, 'citation_normalized_percentile': {'value': 0.615055, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 81, 'max': 84}, 'biblio': {'volume': '97', 'issue': '10', 'first_page': '2665', 'last_page': '2674'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10878', 'display_name': 'Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated proteins', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10878', 'display_name': 'Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated proteins', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10932', 'display_name': 'Metabolic Engineering and Synthetic Biology', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10120', 'display_name': 'Bacterial Physiology and Genetics', 'score': 0.995, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/biomanufacturing', 'display_name': 'Biomanufacturing', 'score': 0.98015404}, {'id': 'https://openalex.org/keywords/chassis', 'display_name': 'Chassis', 'score': 0.97256017}, {'id': 'https://openalex.org/keywords/industrial-biotechnology', 'display_name': 'Industrial biotechnology', 'score': 0.7180155}, {'id': 'https://openalex.org/keywords/metabolic-engineering', 'display_name': 'Metabolic engineering', 'score': 0.61443627}, {'id': 'https://openalex.org/keywords/synthetic-biology', 'display_name': 'Synthetic Biology', 'score': 0.482028}], 'concepts': [{'id': 'https://openalex.org/C2775893736', 'wikidata': 'https://www.wikidata.org/wiki/Q25324110', 'display_name': 'Biomanufacturing', 'level': 2, 'score': 0.98015404}, {'id': 'https://openalex.org/C512993513', 'wikidata': 'https://www.wikidata.org/wiki/Q1068107', 'display_name': 'Chassis', 'level': 2, 'score': 0.97256017}, {'id': 'https://openalex.org/C191908910', 'wikidata': 'https://www.wikidata.org/wiki/Q862838', 'display_name': 'Synthetic biology', 'level': 2, 'score': 0.8763268}, {'id': 'https://openalex.org/C2991947430', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Industrial biotechnology', 'level': 2, 'score': 0.7180155}, {'id': 'https://openalex.org/C2777272437', 'wikidata': 'https://www.wikidata.org/wiki/Q131238', 'display_name': 'Bacillus subtilis', 'level': 3, 'score': 0.7133125}, {'id': 'https://openalex.org/C6350086', 'wikidata': 'https://www.wikidata.org/wiki/Q6822347', 'display_name': 'Metabolic engineering', 'level': 3, 'score': 0.61443627}, {'id': 'https://openalex.org/C183696295', 'wikidata': 'https://www.wikidata.org/wiki/Q2487696', 'display_name': 'Biochemical engineering', 'level': 1, 'score': 0.4765114}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.39021757}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.37671697}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.31469294}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.27400807}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.26550984}, {'id': 'https://openalex.org/C78519656', 'wikidata': 'https://www.wikidata.org/wiki/Q101333', 'display_name': 'Mechanical engineering', 'level': 1, 'score': 0.09759244}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jctb.7053', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S112095004', 'display_name': 'Journal of Chemical Technology & Biotechnology', 'issn_l': '0268-2575', 'issn': ['0268-2575', '1097-4660'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.22541/au.163250934.42128224/v1', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402105', 'display_name': 'Authorea (Authorea)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.22541/au.163250934.42128224/v1', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402105', 'display_name': 'Authorea (Authorea)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'display_name': 'Industry, innovation and infrastructure', 'score': 0.7, 'id': 'https://metadata.un.org/sdg/9'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 137, 'referenced_works': ['https://openalex.org/W1587481053', 'https://openalex.org/W1730500298', 'https://openalex.org/W1965349726', 'https://openalex.org/W1969089930', 'https://openalex.org/W1970001809', 'https://openalex.org/W1977097697', 'https://openalex.org/W1978668215', 'https://openalex.org/W1998369603', 'https://openalex.org/W2005548066', 'https://openalex.org/W2011117077', 'https://openalex.org/W2011406414', 'https://openalex.org/W2011893021', 'https://openalex.org/W2015793616', 'https://openalex.org/W2020370706', 'https://openalex.org/W2024412400', 'https://openalex.org/W2024664836', 'https://openalex.org/W2032414816', 'https://openalex.org/W2033550474', 'https://openalex.org/W2033565485', 'https://openalex.org/W2033910658', 'https://openalex.org/W2049388301', 'https://openalex.org/W2052195823', 'https://openalex.org/W2052655393', 'https://openalex.org/W2057771611', 'https://openalex.org/W2060701550', 'https://openalex.org/W2073265639', 'https://openalex.org/W2079536459', 'https://openalex.org/W2085403960', 'https://openalex.org/W2085675571', 'https://openalex.org/W2087241614', 'https://openalex.org/W2089022150', 'https://openalex.org/W2097002638', 'https://openalex.org/W2102025599', 'https://openalex.org/W2104597175', 'https://openalex.org/W2115941371', 'https://openalex.org/W2119002042', 'https://openalex.org/W2120353169', 'https://openalex.org/W2121695681', 'https://openalex.org/W2124703740', 'https://openalex.org/W2138835511', 'https://openalex.org/W2149378314', 'https://openalex.org/W2150389885', 'https://openalex.org/W2152025465', 'https://openalex.org/W2164997719', 'https://openalex.org/W2167299815', 'https://openalex.org/W2192151272', 'https://openalex.org/W2227339975', 'https://openalex.org/W2265495650', 'https://openalex.org/W2295306814', 'https://openalex.org/W2295369589', 'https://openalex.org/W2304674135', 'https://openalex.org/W2343741934', 'https://openalex.org/W2382100040', 'https://openalex.org/W2403639486', 'https://openalex.org/W2406620869', 'https://openalex.org/W2407174002', 'https://openalex.org/W2433199239', 'https://openalex.org/W2462203997', 'https://openalex.org/W2469570449', 'https://openalex.org/W2477942967', 'https://openalex.org/W2483849704', 'https://openalex.org/W2504319800', 'https://openalex.org/W2515138080', 'https://openalex.org/W2518339325', 'https://openalex.org/W2519903392', 'https://openalex.org/W2524455237', 'https://openalex.org/W2524589437', 'https://openalex.org/W2525182831', 'https://openalex.org/W2528152669', 'https://openalex.org/W2528808089', 'https://openalex.org/W2530327021', 'https://openalex.org/W2531156685', 'https://openalex.org/W2551974565', 'https://openalex.org/W2555362571', 'https://openalex.org/W2556443379', 'https://openalex.org/W2560220907', 'https://openalex.org/W2566894387', 'https://openalex.org/W2577609822', 'https://openalex.org/W2580048230', 'https://openalex.org/W2588939280', 'https://openalex.org/W2590923316', 'https://openalex.org/W2592150400', 'https://openalex.org/W2599872458', 'https://openalex.org/W2605733173', 'https://openalex.org/W2616983714', 'https://openalex.org/W2731144179', 'https://openalex.org/W2792054180', 'https://openalex.org/W2801885456', 'https://openalex.org/W2802851075', 'https://openalex.org/W2804799006', 'https://openalex.org/W2806888215', 'https://openalex.org/W2809386196', 'https://openalex.org/W2810757918', 'https://openalex.org/W2884273232', 'https://openalex.org/W2886516874', 'https://openalex.org/W2887934197', 'https://openalex.org/W2888105641', 'https://openalex.org/W2889969897', 'https://openalex.org/W2892145897', 'https://openalex.org/W2893537303', 'https://openalex.org/W2901474145', 'https://openalex.org/W2902944401', 'https://openalex.org/W2904314998', 'https://openalex.org/W2904503583', 'https://openalex.org/W2907630779', 'https://openalex.org/W2921115230', 'https://openalex.org/W2941279440', 'https://openalex.org/W2946280749', 'https://openalex.org/W2946567891', 'https://openalex.org/W2950236183', 'https://openalex.org/W2954536068', 'https://openalex.org/W2961022631', 'https://openalex.org/W2976284515', 'https://openalex.org/W2995057300', 'https://openalex.org/W2999150714', 'https://openalex.org/W3004796331', 'https://openalex.org/W3005999948', 'https://openalex.org/W3008762545', 'https://openalex.org/W3010060858', 'https://openalex.org/W3025909004', 'https://openalex.org/W3033416712', 'https://openalex.org/W3035463609', 'https://openalex.org/W3035897124', 'https://openalex.org/W3036815713', 'https://openalex.org/W3037274379', 'https://openalex.org/W3045734105', 'https://openalex.org/W3046076378', 'https://openalex.org/W3080484125', 'https://openalex.org/W3083888592', 'https://openalex.org/W3084518985', 'https://openalex.org/W3087535495', 'https://openalex.org/W3088828832', 'https://openalex.org/W3090013033', 'https://openalex.org/W3091847020', 'https://openalex.org/W3093715889', 'https://openalex.org/W3095428376', 'https://openalex.org/W3105011923'], 'related_works': ['https://openalex.org/W4223457571', 'https://openalex.org/W4212990602', 'https://openalex.org/W4212982835', 'https://openalex.org/W3185130928', 'https://openalex.org/W2999104882', 'https://openalex.org/W2998379617', 'https://openalex.org/W2970949995', 'https://openalex.org/W2806888215', 'https://openalex.org/W2792366154', 'https://openalex.org/W2136174202'], 'abstract_inverted_index': {'Abstract': [0], 'Synthetic': [1], 'biology,': [2], 'an': [3], 'emerging': [4], 'research': [5], 'field,': [6], 'can': [7], 'promote': [8], 'biomanufacturing': [9], '4.0': [10], 'by': [11], 'offering': [12], 'various': [13], 'efficient': [14], 'chassis.': [15], 'Engineering': [16], 'Bacillus': [17], 'subtilis': [18, 92, 102], ',': [19], 'a': [20, 32, 57, 73], 'prominent': [21], 'workhorse': [22], 'in': [23, 44, 54, 100], 'industrial': [24], 'biotechnology,': [25], 'through': [26], 'synthetic': [27, 58, 68], 'biology': [28, 59], 'approaches': [29], 'may': [30], 'be': [31, 72], 'disruptive': [33], 'innovation.': [34], 'Diverse': [35], 'chassis': [36, 55, 85, 98], 'forms': [37], 'are': [38], 'envisaged': [39], 'to': [40], 'deal': [41], 'with': [42], 'challenges': [43, 96], 'metabolic': [45, 47], 'complexity,': [46], 'burden,': [48], 'and': [49, 67, 88, 95], 'systems': [50], 'robustness.': [51], 'Thus,': [52], 'advancements': [53], 'engineering,': [56], 'strategy': [60], 'for': [61, 90, 97], 'genome‐reduced': [62], 'cell': [63], 'factories,': [64], 'cell‐free': [65], 'systems,': [66], 'microbial': [69, 77], 'consortia': [70], 'would': [71], 'driving': [74], 'force': [75], 'facilitating': [76], 'production.': [78], 'In': [79], 'this': [80], 'review': [81], 'article,': [82], 'we': [83], 'summarized': [84], 'engineering': [86, 99], 'categories': [87], 'applications': [89], 'B.': [91, 101], '.': [93], 'Prospects': [94], 'were': [103], 'also': [104], 'discussed.': [105], '©': [106], '2022': [107], 'Society': [108], 'of': [109], 'Chemical': [110], 'Industry': [111], '(SCI).': [112]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4212982835', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}], 'updated_date': '2024-09-13T17:32:08.571721', 'created_date': '2022-02-24'}