Title: THE USE OF BONE MARROW SUSPENSION IN SUPERLETHAL IRRADIATION OF RATS
Abstract: Rats of the Wistar strain were irradiated with superlethal doses of gamma radiation (1200 to 1400 r). 24 hours later an isologous bone marrow suspension was introduced in the amount of 5 x 10/sup 7/, 5 x 10/sup 8/ and 1 x 10/sup 9/ cells per recipient. With increase of the irradiation level, the quantity of cells necessary for the maximal curative effect also rise. In the treatment of rats subjected to 1200 r, the best results were achieved with 5 x 10/ sup 8/ cells (survival-32.5%). In irradiation with a dose of 1400 r the highest curative effect was attained with 1 x 10/sup 9/ cells. The possible causes of effectiveness of greater quantities of bone marrow cells at these radiation levels are also discussed. (auth)
Publication Year: 1963
Publication Date: 1963-02-01
Language: en
Type: article
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