Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3215185969', 'doi': 'https://doi.org/10.1093/eurpub/ckab165.330', 'title': 'Cost-effectiveness of DNA testing for Lynch syndrome for colorectal cancer patients in Switzerland', 'display_name': 'Cost-effectiveness of DNA testing for Lynch syndrome for colorectal cancer patients in Switzerland', 'publication_year': 2021, 'publication_date': '2021-10-01', 'ids': {'openalex': 'https://openalex.org/W3215185969', 'doi': 'https://doi.org/10.1093/eurpub/ckab165.330', 'mag': '3215185969'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/eurpub/ckab165.330', 'pdf_url': 'https://academic.oup.com/eurpub/article-pdf/31/Supplement_3/ckab165.330/40782364/ckab165.330.pdf', 'source': {'id': 'https://openalex.org/S4210220588', 'display_name': 'European Journal of Public Health', 'issn_l': '1101-1262', 'issn': ['1101-1262', '1464-360X'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/eurpub/article-pdf/31/Supplement_3/ckab165.330/40782364/ckab165.330.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5045008732', 'display_name': 'Islam Salikhanov', 'orcid': 'https://orcid.org/0000-0002-0437-3125'}, 'institutions': [{'id': 'https://openalex.org/I1850255', 'display_name': 'University of Basel', 'ror': 'https://ror.org/02s6k3f65', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I1850255']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'I Salikhanov', 'raw_affiliation_strings': ['Medical Faculty, University of Basel, Basel, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Medical Faculty, University of Basel, Basel, Switzerland', 'institution_ids': ['https://openalex.org/I1850255']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026185185', 'display_name': 'Simon Wieser', 'orcid': 'https://orcid.org/0000-0003-1821-2944'}, 'institutions': [{'id': 'https://openalex.org/I858936495', 'display_name': 'ZHAW Zurich University of Applied Sciences', 'ror': 'https://ror.org/05pmsvm27', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I858936495']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'S Wieser', 'raw_affiliation_strings': ['School of Management and Law, ZHAW Zurich University of Applied Sciences, Zurich, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'School of Management and Law, ZHAW Zurich University of Applied Sciences, Zurich, Switzerland', 'institution_ids': ['https://openalex.org/I858936495']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5057700280', 'display_name': 'Maria C. Katapodi', 'orcid': 'https://orcid.org/0000-0003-3903-3750'}, 'institutions': [{'id': 'https://openalex.org/I1850255', 'display_name': 'University of Basel', 'ror': 'https://ror.org/02s6k3f65', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I1850255']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'M Katapodi', 'raw_affiliation_strings': ['Medical Faculty, University of Basel, Basel, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Medical Faculty, University of Basel, Basel, Switzerland', 'institution_ids': ['https://openalex.org/I1850255']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2553, 'currency': 'EUR', 'value_usd': 2753, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 57}, 'biblio': {'volume': '31', 'issue': 'Supplement_3', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11369', 'display_name': 'Genetic factors in colorectal cancer', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11369', 'display_name': 'Genetic factors in colorectal cancer', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10552', 'display_name': 'Colorectal Cancer Screening and Detection', 'score': 0.9562, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lynch-syndrome', 'display_name': 'Lynch Syndrome', 'score': 0.9475492}, {'id': 'https://openalex.org/keywords/microsatellite-instability', 'display_name': 'Microsatellite Instability', 'score': 0.7639954}, {'id': 'https://openalex.org/keywords/hereditary-cancer', 'display_name': 'Hereditary Cancer', 'score': 0.43885517}], 'concepts': [{'id': 'https://openalex.org/C2776559941', 'wikidata': 'https://www.wikidata.org/wiki/Q783644', 'display_name': 'Lynch syndrome', 'level': 5, 'score': 0.9475492}, {'id': 'https://openalex.org/C2780673598', 'wikidata': 'https://www.wikidata.org/wiki/Q285223', 'display_name': 'Genetic testing', 'level': 2, 'score': 0.83265233}, {'id': 'https://openalex.org/C2779767149', 'wikidata': 'https://www.wikidata.org/wiki/Q488212', 'display_name': 'Microsatellite instability', 'level': 5, 'score': 0.7639954}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.69688475}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.62365603}, {'id': 'https://openalex.org/C3019080777', 'wikidata': 'https://www.wikidata.org/wiki/Q1754768', 'display_name': 'Cost effectiveness', 'level': 2, 'score': 0.58647174}, {'id': 'https://openalex.org/C2909191862', 'wikidata': 'https://www.wikidata.org/wiki/Q1348398', 'display_name': 'Hereditary Cancer', 'level': 4, 'score': 0.43885517}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.4371124}, {'id': 'https://openalex.org/C512399662', 'wikidata': 'https://www.wikidata.org/wiki/Q3505712', 'display_name': 'Family medicine', 'level': 1, 'score': 0.43274522}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.37271768}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.36027712}, {'id': 'https://openalex.org/C60748783', 'wikidata': 'https://www.wikidata.org/wiki/Q2984243', 'display_name': 'DNA mismatch repair', 'level': 4, 'score': 0.26924455}, {'id': 'https://openalex.org/C61320498', 'wikidata': 'https://www.wikidata.org/wiki/Q265193', 'display_name': 'Microsatellite', 'level': 4, 'score': 0.21207532}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.15614974}, {'id': 'https://openalex.org/C180754005', 'wikidata': 'https://www.wikidata.org/wiki/Q80726', 'display_name': 'Allele', 'level': 3, 'score': 0.1215879}, {'id': 'https://openalex.org/C112930515', 'wikidata': 'https://www.wikidata.org/wiki/Q4389547', 'display_name': 'Risk analysis (engineering)', 'level': 1, 'score': 0.11896533}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.08433601}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/eurpub/ckab165.330', 'pdf_url': 'https://academic.oup.com/eurpub/article-pdf/31/Supplement_3/ckab165.330/40782364/ckab165.330.pdf', 'source': {'id': 'https://openalex.org/S4210220588', 'display_name': 'European Journal of Public Health', 'issn_l': '1101-1262', 'issn': ['1101-1262', '1464-360X'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/eurpub/ckab165.330', 'pdf_url': 'https://academic.oup.com/eurpub/article-pdf/31/Supplement_3/ckab165.330/40782364/ckab165.330.pdf', 'source': {'id': 'https://openalex.org/S4210220588', 'display_name': 'European Journal of Public Health', 'issn_l': '1101-1262', 'issn': ['1101-1262', '1464-360X'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3202142565', 'https://openalex.org/W3089414716', 'https://openalex.org/W3080281526', 'https://openalex.org/W2979905376', 'https://openalex.org/W2944573181', 'https://openalex.org/W2099852142', 'https://openalex.org/W2038159883', 'https://openalex.org/W2019689469', 'https://openalex.org/W1986822098', 'https://openalex.org/W1966893636'], 'abstract_inverted_index': {'Abstract': [0], 'Purpose': [1], 'To': [2], 'estimate': [3], 'the': [4, 78, 128, 134, 141, 160, 186, 189, 233, 236], 'cost-effectiveness': [5, 74, 108, 126], 'of': [6, 77, 92, 127, 133, 140, 150, 188, 235], 'genetic': [7, 46, 83, 143, 174, 195, 221], 'testing': [8, 21, 47, 84, 91, 144, 196], 'for': [9, 22, 44, 48, 66, 85, 197, 200], 'Lynch': [10, 49, 86, 198], 'syndrome': [11, 50, 87, 199], 'among': [12], 'newly': [13], 'diagnosed': [14], 'patients': [15, 67, 151, 184, 202, 231], 'with': [16, 68, 88, 159, 203], 'colorectal': [17, 69, 204], 'cancer': [18], 'and': [19, 32, 152, 157, 176, 182, 223, 229], 'targeted': [20], 'their': [23, 93], 'relatives': [24, 94, 153], 'in': [25, 104, 131, 208], 'Switzerland.': [26], 'Methods': [27], 'We': [28], 'integrated': [29], 'decision': [30], 'tree': [31], 'Markov': [33], 'model': [34], 'to': [35, 52, 154, 180, 227], 'calculate': [36], 'incremental': [37, 73], 'costs': [38], 'per': [39, 98, 113], 'quality': [40], 'adjusted': [41], 'life-year': [42], 'saved': [43], 'universal': [45, 82, 142], 'relative': [51], 'using': [53, 81], 'preliminary': [54], 'tumor': [55], 'tests': [56], '(immunohistochemistry': [57], 'or': [58], 'microsatellite': [59], 'instability)': [60], 'followed': [61], 'by': [62], 'DNA': [63], 'sequencing': [64], 'test': [65], 'cancer.': [70], 'Results': [71], 'The': [72, 116, 137], 'ratio': [75], '(ICER)': [76], 'proposed': [79, 129], 'strategy': [80], 'systematic': [89], 'CASCADE': [90], 'is': [95, 102, 110, 119, 145, 178, 206, 225], 'CHF': [96, 111], '65,058': [97], 'QALY': [99, 114], 'saved,': [100], 'which': [101], 'cost-effective': [103, 207], 'Swiss': [105, 209], 'settings': [106], 'where': [107], 'threshold': [109], '100,000': [112], 'saved.': [115, 122], 'gained': [117], 'utility': [118], '361,358': [120], 'QALYs': [121], 'Sensitivity': [123], 'analysis': [124], 'demonstrated': [125], 'strategies': [130], 'most': [132], 'scenarios.': [135], 'Conclusions': [136], 'overall': [138], 'effectiveness': [139], 'greatly': [146], 'dependent': [147], 'on': [148], 'willingness': [149], 'be': [155], 'tested': [156], 'compliance': [158], 'increased': [161], 'surveillance.': [162], 'Therefore,': [163], 'close': [164], 'cooperation': [165, 212], 'across': [166, 213], 'different': [167], 'stakeholders': [168, 215], 'such': [169, 216], 'as': [170, 217], 'family': [171, 218], 'doctors,': [172, 219], 'oncologists,': [173, 220], 'clinicians,': [175, 222], 'laboratories': [177, 224], 'crucial': [179, 226], 'encourage': [181, 228], 'educate': [183, 230], 'about': [185, 232], 'importance': [187, 234], 'LS': [190, 237], 'screening.': [191], 'Key': [192], 'messages': [193], 'Universal': [194], 'all': [201, 214], 'caner': [205], 'settings.': [210], 'Close': [211], 'testing.': [238]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3215185969', 'counts_by_year': [], 'updated_date': '2024-12-12T04:24:41.035884', 'created_date': '2021-12-06'}