Title: Introduction to ribosome factory, origin, and evolution of translation
Abstract: Ribosomes are microscopic particles made of ribonucleoproteins that are found in prokaryotic and eukaryotic cells, mitochondria, chloroplasts, and in bacteria. These nanomachines are indispensable for protein biosynthesis and hence are central to a cell's ability to grow and proliferate. The process of making ribosomes is called ribosome biogenesis, which is highly orchestrated, dynamic, energy consuming, and reasonably conserved among prokaryotes and eukaryotes. The efficient production of ribosomes involves the coordinated action of RNA polymerases in the transcription of ribosomal RNA (rRNA) and ribosomal protein (RP) genes, processing/modification of rRNAs, association of RPs with the rRNAs and their proper folding and finally their assembly as mature ribosomal subunits. Ribosomopathies include certain disorders in which genetic abnormalities lead to impaired ribosome biogenesis and function and exhibit specific clinical phenotypes. Many diseases whose etiology and pathology remained elusive are now considered to be ribosome-associated diseases. With ribosomal biogenesis being closely linked with cell proliferation and hence oncogenesis, several lines of chemical drugs that inhibit ribosome biogenesis could serve as potential therapeutic for cancer intervention.
Publication Year: 2021
Publication Date: 2021-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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Cited By Count: 1
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