Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3202812053', 'doi': 'https://doi.org/10.32725/jab.2021.021', 'title': 'The NF-κB pathway is critically implicated in the oncogenic phenotype of human osteosarcoma cells', 'display_name': 'The NF-κB pathway is critically implicated in the oncogenic phenotype of human osteosarcoma cells', 'publication_year': 2021, 'publication_date': '2021-12-06', 'ids': {'openalex': 'https://openalex.org/W3202812053', 'doi': 'https://doi.org/10.32725/jab.2021.021', 'mag': '3202812053', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/34907738'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.32725/jab.2021.021', 'pdf_url': 'http://jab.zsf.jcu.cz/doi/10.32725/jab.2021.021.pdf', 'source': {'id': 'https://openalex.org/S49362916', 'display_name': 'Journal of Applied Biomedicine', 'issn_l': '1214-021X', 'issn': ['1214-021X', '1214-0287'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310314273', 'host_organization_name': 'University of South Bohemia in České Budějovice', 'host_organization_lineage': ['https://openalex.org/P4310314273'], 'host_organization_lineage_names': ['University of South Bohemia in České Budějovice'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://jab.zsf.jcu.cz/doi/10.32725/jab.2021.021.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5016152662', 'display_name': 'Bingyi Tan', 'orcid': 'https://orcid.org/0000-0003-4986-3272'}, 'institutions': [{'id': 'https://openalex.org/I4210163399', 'display_name': 'Shandong First Medical University', 'ror': 'https://ror.org/05jb9pq57', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210163399']}, {'id': 'https://openalex.org/I4210116517', 'display_name': 'Shandong Provincial Hospital', 'ror': 'https://ror.org/02ar2nf05', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210116517']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Bingyi Tan', 'raw_affiliation_strings': ['Department of Orthopaedics, Shangdong Provincial Hospital, No. 324, the Five Weft Seven Road, Jinan City, Shandong Province, 250021, P.R. China', 'Shandong First Medical University, Shandong Provincial Hospital, Department of Orthopaedics, Jinan City, China'], 'affiliations': [{'raw_affiliation_string': 'Shandong First Medical University, Shandong Provincial Hospital, Department of Orthopaedics, Jinan City, China', 'institution_ids': ['https://openalex.org/I4210163399', 'https://openalex.org/I4210116517']}, {'raw_affiliation_string': 'Department of Orthopaedics, Shangdong Provincial Hospital, No. 324, the Five Weft Seven Road, Jinan City, Shandong Province, 250021, P.R. China', 'institution_ids': ['https://openalex.org/I4210116517']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085841639', 'display_name': 'Zenong Yuan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210116517', 'display_name': 'Shandong Provincial Hospital', 'ror': 'https://ror.org/02ar2nf05', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210116517']}, {'id': 'https://openalex.org/I4210163399', 'display_name': 'Shandong First Medical University', 'ror': 'https://ror.org/05jb9pq57', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210163399']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zenong Yuan', 'raw_affiliation_strings': ['Department of Orthopaedics, Shangdong Provincial Hospital, No. 324, the Five Weft Seven Road, Jinan City, Shandong Province, 250021, P.R. China', 'Shandong First Medical University, Shandong Provincial Hospital, Department of Orthopaedics, Jinan City, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthopaedics, Shangdong Provincial Hospital, No. 324, the Five Weft Seven Road, Jinan City, Shandong Province, 250021, P.R. China', 'institution_ids': ['https://openalex.org/I4210116517']}, {'raw_affiliation_string': 'Shandong First Medical University, Shandong Provincial Hospital, Department of Orthopaedics, Jinan City, China', 'institution_ids': ['https://openalex.org/I4210116517', 'https://openalex.org/I4210163399']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100681540', 'display_name': 'Qingyu Zhang', 'orcid': 'https://orcid.org/0000-0002-0497-3630'}, 'institutions': [{'id': 'https://openalex.org/I4210163399', 'display_name': 'Shandong First Medical University', 'ror': 'https://ror.org/05jb9pq57', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210163399']}, {'id': 'https://openalex.org/I4210116517', 'display_name': 'Shandong Provincial Hospital', 'ror': 'https://ror.org/02ar2nf05', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210116517']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qingyu Zhang', 'raw_affiliation_strings': ['Department of Orthopaedics, Shangdong Provincial Hospital, No. 324, the Five Weft Seven Road, Jinan City, Shandong Province, 250021, P.R. China', 'Shandong First Medical University, Shandong Provincial Hospital, Department of Orthopaedics, Jinan City, China'], 'affiliations': [{'raw_affiliation_string': 'Shandong First Medical University, Shandong Provincial Hospital, Department of Orthopaedics, Jinan City, China', 'institution_ids': ['https://openalex.org/I4210163399', 'https://openalex.org/I4210116517']}, {'raw_affiliation_string': 'Department of Orthopaedics, Shangdong Provincial Hospital, No. 324, the Five Weft Seven Road, Jinan City, Shandong Province, 250021, P.R. China', 'institution_ids': ['https://openalex.org/I4210116517']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101464886', 'display_name': 'Xiqiang Xu', 'orcid': 'https://orcid.org/0000-0002-3360-2492'}, 'institutions': [{'id': 'https://openalex.org/I4210116517', 'display_name': 'Shandong Provincial Hospital', 'ror': 'https://ror.org/02ar2nf05', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210116517']}, {'id': 'https://openalex.org/I4210163399', 'display_name': 'Shandong First Medical University', 'ror': 'https://ror.org/05jb9pq57', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210163399']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xu Xiqiang', 'raw_affiliation_strings': ['Department of Orthopaedics, Shangdong Provincial Hospital, No. 324, the Five Weft Seven Road, Jinan City, Shandong Province, 250021, P.R. China', 'Shandong First Medical University, Shandong Provincial Hospital, Department of Orthopaedics, Jinan City, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthopaedics, Shangdong Provincial Hospital, No. 324, the Five Weft Seven Road, Jinan City, Shandong Province, 250021, P.R. China', 'institution_ids': ['https://openalex.org/I4210116517']}, {'raw_affiliation_string': 'Shandong First Medical University, Shandong Provincial Hospital, Department of Orthopaedics, Jinan City, China', 'institution_ids': ['https://openalex.org/I4210116517', 'https://openalex.org/I4210163399']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5084918710', 'display_name': 'Jun Dong', 'orcid': 'https://orcid.org/0000-0002-0026-6680'}, 'institutions': [{'id': 'https://openalex.org/I4210116517', 'display_name': 'Shandong Provincial Hospital', 'ror': 'https://ror.org/02ar2nf05', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210116517']}, {'id': 'https://openalex.org/I4210163399', 'display_name': 'Shandong First Medical University', 'ror': 'https://ror.org/05jb9pq57', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210163399']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jun Dong', 'raw_affiliation_strings': ['Department of Orthopaedics, Shangdong Provincial Hospital, No. 324, the Five Weft Seven Road, Jinan City, Shandong Province, 250021, P.R. China', 'Shandong First Medical University, Shandong Provincial Hospital, Department of Orthopaedics, Jinan City, China'], 'affiliations': [{'raw_affiliation_string': 'Shandong First Medical University, Shandong Provincial Hospital, Department of Orthopaedics, Jinan City, China', 'institution_ids': ['https://openalex.org/I4210116517', 'https://openalex.org/I4210163399']}, {'raw_affiliation_string': 'Department of Orthopaedics, Shangdong Provincial Hospital, No. 324, the Five Weft Seven Road, Jinan City, Shandong Province, 250021, P.R. China', 'institution_ids': ['https://openalex.org/I4210116517']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 300, 'currency': 'EUR', 'value_usd': 323, 'provenance': 'doaj'}, 'apc_paid': {'value': 300, 'currency': 'EUR', 'value_usd': 323, 'provenance': 'doaj'}, 'fwci': 0.904, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 8, 'citation_normalized_percentile': {'value': 0.649965, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 85, 'max': 87}, 'biblio': {'volume': '19', 'issue': '4', 'first_page': '190', 'last_page': '201'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11591', 'display_name': 'NF-?B Signaling in Inflammation and Cancer', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11591', 'display_name': 'NF-?B Signaling in Inflammation and Cancer', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10952', 'display_name': 'mTOR Signaling in Growth and Disease', 'score': 0.9944, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11503', 'display_name': 'Role of STAT3 in Cancer Inflammation and Immunity', 'score': 0.9925, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nf-?b', 'display_name': 'NF-?B', 'score': 0.538748}, {'id': 'https://openalex.org/keywords/ly294002', 'display_name': 'LY294002', 'score': 0.51581496}, {'id': 'https://openalex.org/keywords/cancer', 'display_name': 'Cancer', 'score': 0.51512}, {'id': 'https://openalex.org/keywords/iκbα', 'display_name': 'IκBα', 'score': 0.50027347}], 'concepts': [{'id': 'https://openalex.org/C2777609662', 'wikidata': 'https://www.wikidata.org/wiki/Q416356', 'display_name': 'PTEN', 'level': 4, 'score': 0.8057089}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.76498866}, {'id': 'https://openalex.org/C2777730290', 'wikidata': 'https://www.wikidata.org/wiki/Q411114', 'display_name': 'NF-κB', 'level': 3, 'score': 0.7099073}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.7084464}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.6912094}, {'id': 'https://openalex.org/C2777760704', 'wikidata': 'https://www.wikidata.org/wiki/Q549534', 'display_name': 'Osteosarcoma', 'level': 2, 'score': 0.65497184}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.5736392}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.55062485}, {'id': 'https://openalex.org/C2776912716', 'wikidata': 'https://www.wikidata.org/wiki/Q4042503', 'display_name': 'LY294002', 'level': 4, 'score': 0.51581496}, {'id': 'https://openalex.org/C2779730028', 'wikidata': 'https://www.wikidata.org/wiki/Q15325101', 'display_name': 'IκBα', 'level': 4, 'score': 0.50027347}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.4980917}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.37845573}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.35081965}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.33734295}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.31401134}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.20162436}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.10301158}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.05888298}], 'mesh': [{'descriptor_ui': 'D001859', 'descriptor_name': 'Bone Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D012516', 'descriptor_name': 'Osteosarcoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D001859', 'descriptor_name': 'Bone Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D063646', 'descriptor_name': 'Carcinogenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D063646', 'descriptor_name': 'Carcinogenesis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012516', 'descriptor_name': 'Osteosarcoma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012516', 'descriptor_name': 'Osteosarcoma', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.32725/jab.2021.021', 'pdf_url': 'http://jab.zsf.jcu.cz/doi/10.32725/jab.2021.021.pdf', 'source': {'id': 'https://openalex.org/S49362916', 'display_name': 'Journal of Applied Biomedicine', 'issn_l': '1214-021X', 'issn': ['1214-021X', '1214-0287'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310314273', 'host_organization_name': 'University of South Bohemia in České Budějovice', 'host_organization_lineage': ['https://openalex.org/P4310314273'], 'host_organization_lineage_names': ['University of South Bohemia in České Budějovice'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/34907738', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.32725/jab.2021.021', 'pdf_url': 'http://jab.zsf.jcu.cz/doi/10.32725/jab.2021.021.pdf', 'source': {'id': 'https://openalex.org/S49362916', 'display_name': 'Journal of Applied Biomedicine', 'issn_l': '1214-021X', 'issn': ['1214-021X', '1214-0287'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310314273', 'host_organization_name': 'University of South Bohemia in České Budějovice', 'host_organization_lineage': ['https://openalex.org/P4310314273'], 'host_organization_lineage_names': ['University of South Bohemia in České Budějovice'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.62}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 43, 'referenced_works': ['https://openalex.org/W1548282166', 'https://openalex.org/W1826976540', 'https://openalex.org/W1964479298', 'https://openalex.org/W1965627667', 'https://openalex.org/W1975842098', 'https://openalex.org/W1998812648', 'https://openalex.org/W2006582907', 'https://openalex.org/W2013329576', 'https://openalex.org/W2017288695', 'https://openalex.org/W2019077971', 'https://openalex.org/W2033466149', 'https://openalex.org/W2057271298', 'https://openalex.org/W2063879050', 'https://openalex.org/W2099257830', 'https://openalex.org/W2100592123', 'https://openalex.org/W2106454275', 'https://openalex.org/W2120950553', 'https://openalex.org/W2122044177', 'https://openalex.org/W2124343538', 'https://openalex.org/W2125163614', 'https://openalex.org/W2132052921', 'https://openalex.org/W2136095930', 'https://openalex.org/W2145028653', 'https://openalex.org/W2145933752', 'https://openalex.org/W2152710824', 'https://openalex.org/W2157647588', 'https://openalex.org/W2169499277', 'https://openalex.org/W2350153786', 'https://openalex.org/W2553578746', 'https://openalex.org/W2578815944', 'https://openalex.org/W2754569077', 'https://openalex.org/W2774786449', 'https://openalex.org/W2802952282', 'https://openalex.org/W2884378719', 'https://openalex.org/W2938145015', 'https://openalex.org/W2946125881', 'https://openalex.org/W2946524196', 'https://openalex.org/W2955486707', 'https://openalex.org/W2970487896', 'https://openalex.org/W3000667365', 'https://openalex.org/W3005015580', 'https://openalex.org/W3018060759', 'https://openalex.org/W3033672408'], 'related_works': ['https://openalex.org/W4313377149', 'https://openalex.org/W4238464314', 'https://openalex.org/W3118133458', 'https://openalex.org/W2799349558', 'https://openalex.org/W2508800546', 'https://openalex.org/W2377917104', 'https://openalex.org/W2371214321', 'https://openalex.org/W2091162155', 'https://openalex.org/W2091075555', 'https://openalex.org/W2069649695'], 'abstract_inverted_index': {'NF-κB': [0, 24, 38, 49, 71, 86, 119, 142, 153], 'is': [1, 72], 'activated': [2], 'in': [3, 12, 25, 43, 63, 75, 114], 'a': [4, 40, 103, 155], 'variety': [5], 'of': [6, 23, 29, 37, 48, 78, 92, 97, 102, 148, 152, 161], 'human': [7, 45], 'cancers.': [8], 'However,': [9], 'its': [10, 95], 'role': [11], 'osteosarcoma': [13], '(OS)': [14], 'remains': [15], 'unknown.': [16], 'Here,': [17], 'we': [18], 'have': [19], 'elucidated': [20], 'the': [21, 26, 44, 76, 90, 100, 115, 129, 144, 159], 'implication': [22], 'oncogenic': [27], 'phenotype': [28], 'OS': [30, 67], 'tumor': [31, 112], 'cells.': [32], 'We': [33], 'reported': [34], 'that': [35, 70, 141], 'activation': [36], 'was': [39], 'common': [41], 'event': [42], 'OS.': [46, 79, 149, 162], 'Inhibition': [47], 'using': [50], 'inhibitor': [51], 'Bay': [52, 81, 109, 126], '11-7085': [53, 82, 110, 127], 'repressed': [54], 'proliferation,': [55], 'survival,': [56], 'migration,': [57], 'and': [58, 65, 120, 128, 146], 'invasion': [59], 'but': [60, 87], 'increased': [61], 'apoptosis': [62], '143B': [64], 'MG63': [66], 'cells,': [68], 'indicating': [69], 'critically': [73], 'implicated': [74], 'oncogenesis': [77], 'Notably,': [80], 'not': [83], 'only': [84], 'inactivated': [85], 'also': [88], 'reduced': [89], 'phosphorylation': [91], 'AKT': [93], 'via': [94], 'induction': [96], 'PTEN,': [98], 'suggesting': [99], 'existence': [101], 'novel': [104], 'NF-κB/PTEN/PI3K/AKT': [105], 'axis.': [106], 'In': [107], 'vivo,': [108], 'suppressed': [111], 'growth': [113, 145], 'bone': [116], 'by': [117], 'targeting': [118], 'AKT.': [121], 'Interestingly,': [122], 'combined': [123], 'treatment': [124, 160], 'with': [125], 'PI3K': [130], 'inhibitor,': [131], 'LY294002,': [132], 'triggered': [133], 'an': [134], 'augmented': [135], 'antitumor': [136], 'effect.': [137], 'Our': [138], 'results': [139], 'demonstrate': [140], 'potentiates': [143], 'aggressiveness': [147], 'Pharmacological': [150], 'inhibition': [151], 'represents': [154], 'promising': [156], 'therapy': [157], 'for': [158]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3202812053', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}], 'updated_date': '2024-09-12T07:29:44.403311', 'created_date': '2021-10-11'}