Title: Suppressing effect of extract from seeds of Magnolia zenii. on expression of NF-κB and IκBα
Abstract: Objective To study the suppressing effect molecular mechanism of extract from seeds of Magnolia zenii.(ESMZ) on NF-κB and IκBα.Methods Human hepatoma cancer cell HepG2 was treated with ESMZ.Western blot analysis was used to detect phospho-IκBα and NF-κB protein.Results ESMZ had significant suppressing effect on the phosphorylation and degradation of IκBα,and it could effectively suppress gene transcription mediated by NF-κB in HepG2 cell.Conclusion ESMZ can play a role of anti-inflammation and anti-carcinogenesis in human hepatoma cancer HepG cell line,by suppressing the phosphorylation and degradation of IκBα,blocking NF-κB activation and then restraining COX-2.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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