Health-Related Quality of Life of Patients with Recurrent or Metastatic Cutaneous Squamous Cell Carcinoma Treated with Pembrolizumab in KEYNOTE-629

Name: Work Video:
Duration: 3 min 30 s
Brett Hughes; René González Mendoza; Nicole Basset‐Séguin; Olga Vornicova; Jacob Schachter; Abhishek Joshi; Nicolás Meyer; Florent Grange; Josep M. Piulats; Jessica R. Bauman; Diana Chirovsky; Pingye Zhang; Burak Gümüşçü; Ramona F. Swaby; Jean‐Jacques Grob
{'id': 'https://openalex.org/W3201549363', 'doi': 'https://doi.org/10.1007/s13555-021-00598-6', 'title': 'Health-Related Quality of Life of Patients with Recurrent or Metastatic Cutaneous Squamous Cell Carcinoma Treated with Pembrolizumab in KEYNOTE-629', 'display_name': 'Health-Related Quality of Life of Patients with Recurrent or Metastatic Cutaneous Squamous Cell Carcinoma Treated with Pembrolizumab in KEYNOTE-629', 'publication_year': 2021, 'publication_date': '2021-09-23', 'ids': {'openalex': 'https://openalex.org/W3201549363', 'doi': 'https://doi.org/10.1007/s13555-021-00598-6', 'mag': '3201549363', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/34558040', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/8484388'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s13555-021-00598-6', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007/s13555-021-00598-6.pdf', 'source': {'id': 'https://openalex.org/S4210222097', 'display_name': 'Dermatology and Therapy', 'issn_l': '2190-9172', 'issn': ['2190-9172', '2193-8210'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320330', 'host_organization_name': 'Adis, Springer Healthcare', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320330'], 'host_organization_lineage_names': ['Springer Nature', 'Adis, Springer Healthcare'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://link.springer.com/content/pdf/10.1007/s13555-021-00598-6.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5051086683', 'display_name': 'Brett Hughes', 'orcid': 'https://orcid.org/0000-0002-1811-0537'}, 'institutions': [{'id': 'https://openalex.org/I2799393793', 'display_name': "Royal Brisbane and Women's Hospital", 'ror': 'https://ror.org/05p52kj31', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1302211766', 'https://openalex.org/I2799393793', 'https://openalex.org/I2801244131']}], 'countries': ['AU'], 'is_corresponding': True, 'raw_author_name': 'Brett G. M. Hughes', 'raw_affiliation_strings': ["Royal Brisbane and Women's Hospital, Herston, QLD, Australia"], 'affiliations': [{'raw_affiliation_string': "Royal Brisbane and Women's Hospital, Herston, QLD, Australia", 'institution_ids': ['https://openalex.org/I2799393793']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026073899', 'display_name': 'René González Mendoza', 'orcid': None}, 'institutions': [], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Rene Gonzalez Mendoza', 'raw_affiliation_strings': ['Centro Estatal de Cancerológia de Chihuahua, Chihuahua, Mexico'], 'affiliations': [{'raw_affiliation_string': 'Centro Estatal de Cancerológia de Chihuahua, Chihuahua, Mexico', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059444495', 'display_name': 'Nicole Basset‐Séguin', 'orcid': 'https://orcid.org/0000-0002-9136-1244'}, 'institutions': [{'id': 'https://openalex.org/I4210144610', 'display_name': 'Hôpital Saint-Louis', 'ror': 'https://ror.org/049am9t04', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159', 'https://openalex.org/I4210144610']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Nicole Basset-Seguin', 'raw_affiliation_strings': ['Hôpital Saint-Louis, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Hôpital Saint-Louis, Paris, France', 'institution_ids': ['https://openalex.org/I4210144610']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088349668', 'display_name': 'Olga Vornicova', 'orcid': 'https://orcid.org/0000-0001-6979-2120'}, 'institutions': [{'id': 'https://openalex.org/I2801301638', 'display_name': 'Rambam Health Care Campus', 'ror': 'https://ror.org/01fm87m50', 'country_code': 'IL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801301638']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Olga Vornicova', 'raw_affiliation_strings': ['Rambam Health Care Campus, Haifa, Israel'], 'affiliations': [{'raw_affiliation_string': 'Rambam Health Care Campus, Haifa, Israel', 'institution_ids': ['https://openalex.org/I2801301638']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026967523', 'display_name': 'Jacob Schachter', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2799810450', 'display_name': 'Sheba Medical Center', 'ror': 'https://ror.org/020rzx487', 'country_code': 'IL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799810450']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Jacob Schachter', 'raw_affiliation_strings': ['The Chaim Sheba Medical Center at Tel HaShomer, Ramat Gan, Israel'], 'affiliations': [{'raw_affiliation_string': 'The Chaim Sheba Medical Center at Tel HaShomer, Ramat Gan, Israel', 'institution_ids': ['https://openalex.org/I2799810450']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077439144', 'display_name': 'Abhishek Joshi', 'orcid': 'https://orcid.org/0000-0002-7786-0039'}, 'institutions': [{'id': 'https://openalex.org/I2800639112', 'display_name': 'Townsville Hospital', 'ror': 'https://ror.org/021zqhw10', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1302211766', 'https://openalex.org/I2800639112', 'https://openalex.org/I2801244131']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Abhishek Joshi', 'raw_affiliation_strings': ['Townsville University Hospital, Townsville, QLD, Australia'], 'affiliations': [{'raw_affiliation_string': 'Townsville University Hospital, Townsville, QLD, Australia', 'institution_ids': ['https://openalex.org/I2800639112']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067794998', 'display_name': 'Nicolás Meyer', 'orcid': 'https://orcid.org/0000-0003-4519-8666'}, 'institutions': [{'id': 'https://openalex.org/I4210098740', 'display_name': 'Institut universitaire du cancer de Toulouse Oncopole', 'ror': 'https://ror.org/014hxhm89', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210098740']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Nicolas Meyer', 'raw_affiliation_strings': ['Institut Universitaire du Cancer de Toulouse–Oncopole, Toulouse, France'], 'affiliations': [{'raw_affiliation_string': 'Institut Universitaire du Cancer de Toulouse–Oncopole, Toulouse, France', 'institution_ids': ['https://openalex.org/I4210098740']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059800915', 'display_name': 'Florent Grange', 'orcid': 'https://orcid.org/0000-0003-3387-0283'}, 'institutions': [{'id': 'https://openalex.org/I4210126712', 'display_name': 'Hôpital Robert-Debré', 'ror': 'https://ror.org/02dcqy320', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159', 'https://openalex.org/I4210126712']}, {'id': 'https://openalex.org/I96226040', 'display_name': 'Université de Reims Champagne-Ardenne', 'ror': 'https://ror.org/03hypw319', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I96226040']}, {'id': 'https://openalex.org/I4210105796', 'display_name': 'Centre Hospitalier Universitaire de Reims', 'ror': 'https://ror.org/01jbb3w63', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105796']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Florent Grange', 'raw_affiliation_strings': ['Centre Hospitalier Universitaire de Reims–Hoˆpital\nRobert Debre, Reims, France'], 'affiliations': [{'raw_affiliation_string': 'Centre Hospitalier Universitaire de Reims–Hoˆpital\nRobert Debre, Reims, France', 'institution_ids': ['https://openalex.org/I4210126712', 'https://openalex.org/I96226040', 'https://openalex.org/I4210105796']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019869973', 'display_name': 'Josep M. Piulats', 'orcid': 'https://orcid.org/0000-0002-3606-1724'}, 'institutions': [{'id': 'https://openalex.org/I4210143012', 'display_name': 'Duran i Reynals Hospital', 'ror': 'https://ror.org/03qwghy04', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210143012']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Josep M. Piulats', 'raw_affiliation_strings': ['Hospital Duran i Reinals ICO de Hospitalet, Barcelona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Hospital Duran i Reinals ICO de Hospitalet, Barcelona, Spain', 'institution_ids': ['https://openalex.org/I4210143012']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017176613', 'display_name': 'Jessica R. Bauman', 'orcid': 'https://orcid.org/0000-0001-8691-0387'}, 'institutions': [{'id': 'https://openalex.org/I1289437631', 'display_name': 'Fox Chase Cancer Center', 'ror': 'https://ror.org/0567t7073', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1289437631', 'https://openalex.org/I4210122924']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jessica R. Bauman', 'raw_affiliation_strings': ['Fox Chase Cancer Center, Philadelphia, PA, USA'], 'affiliations': [{'raw_affiliation_string': 'Fox Chase Cancer Center, Philadelphia, PA, USA', 'institution_ids': ['https://openalex.org/I1289437631']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077022459', 'display_name': 'Diana Chirovsky', 'orcid': 'https://orcid.org/0000-0003-1641-1990'}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Diana Chirovsky', 'raw_affiliation_strings': ['Merck & Co., Inc, Kenilworth, NJ, USA'], 'affiliations': [{'raw_affiliation_string': 'Merck & Co., Inc, Kenilworth, NJ, USA', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011293836', 'display_name': 'Pingye Zhang', 'orcid': 'https://orcid.org/0000-0001-5061-1131'}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Pingye Zhang', 'raw_affiliation_strings': ['Merck & Co., Inc, Kenilworth, NJ, USA'], 'affiliations': [{'raw_affiliation_string': 'Merck & Co., Inc, Kenilworth, NJ, USA', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059172426', 'display_name': 'Burak Gümüşçü', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Burak Gumuscu', 'raw_affiliation_strings': ['Merck & Co., Inc, Kenilworth, NJ, USA'], 'affiliations': [{'raw_affiliation_string': 'Merck & Co., Inc, Kenilworth, NJ, USA', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033216433', 'display_name': 'Ramona F. Swaby', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ramona F. Swaby', 'raw_affiliation_strings': ['Merck & Co., Inc, Kenilworth, NJ, USA'], 'affiliations': [{'raw_affiliation_string': 'Merck & Co., Inc, Kenilworth, NJ, USA', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5061072132', 'display_name': 'Jean‐Jacques Grob', 'orcid': 'https://orcid.org/0000-0002-0667-153X'}, 'institutions': [{'id': 'https://openalex.org/I21491767', 'display_name': 'Aix-Marseille Université', 'ror': 'https://ror.org/035xkbk20', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I21491767']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Jean-Jacques Grob', 'raw_affiliation_strings': ['Aix-Marseille University, Marseille, France'], 'affiliations': [{'raw_affiliation_string': 'Aix-Marseille University, Marseille, France', 'institution_ids': ['https://openalex.org/I21491767']}]}], 'institution_assertions': [], 'countries_distinct_count': 6, 'institutions_distinct_count': 13, 'corresponding_author_ids': ['https://openalex.org/A5051086683'], 'corresponding_institution_ids': ['https://openalex.org/I2799393793'], 'apc_list': {'value': 4700, 'currency': 'GBP', 'value_usd': 6850, 'provenance': 'doaj'}, 'apc_paid': {'value': 4700, 'currency': 'GBP', 'value_usd': 6850, 'provenance': 'doaj'}, 'fwci': 1.732, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 11, 'citation_normalized_percentile': {'value': 0.791689, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 88, 'max': 89}, 'biblio': {'volume': '11', 'issue': '5', 'first_page': '1777', 'last_page': '1790'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11306', 'display_name': 'Nonmelanoma Skin Cancer Studies', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11306', 'display_name': 'Nonmelanoma Skin Cancer Studies', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy and Biomarkers', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11827', 'display_name': 'Polyomavirus and related diseases', 'score': 0.9959, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.87548685}, {'id': 'https://openalex.org/C2779951463', 'wikidata': 'https://www.wikidata.org/wiki/Q7268788', 'display_name': 'Quality of life (healthcare)', 'level': 2, 'score': 0.77543545}, {'id': 'https://openalex.org/C2780057760', 'wikidata': 'https://www.wikidata.org/wiki/Q13896859', 'display_name': 'Pembrolizumab', 'level': 4, 'score': 0.73357284}, {'id': 'https://openalex.org/C44249647', 'wikidata': 'https://www.wikidata.org/wiki/Q208498', 'display_name': 'Confidence interval', 'level': 2, 'score': 0.6264244}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.43361396}, {'id': 'https://openalex.org/C1862650', 'wikidata': 'https://www.wikidata.org/wiki/Q186005', 'display_name': 'Physical therapy', 'level': 1, 'score': 0.39935315}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3886339}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.38039094}, {'id': 'https://openalex.org/C159110408', 'wikidata': 'https://www.wikidata.org/wiki/Q121176', 'display_name': 'Nursing', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C2777701055', 'wikidata': 'https://www.wikidata.org/wiki/Q1427096', 'display_name': 'Immunotherapy', 'level': 3, 'score': 0.0}], 'mesh': [], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s13555-021-00598-6', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007/s13555-021-00598-6.pdf', 'source': {'id': 'https://openalex.org/S4210222097', 'display_name': 'Dermatology and Therapy', 'issn_l': '2190-9172', 'issn': ['2190-9172', '2193-8210'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320330', 'host_organization_name': 'Adis, Springer Healthcare', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320330'], 'host_organization_lineage_names': ['Springer Nature', 'Adis, Springer Healthcare'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484388', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/34558040', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s13555-021-00598-6', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007/s13555-021-00598-6.pdf', 'source': {'id': 'https://openalex.org/S4210222097', 'display_name': 'Dermatology and Therapy', 'issn_l': '2190-9172', 'issn': ['2190-9172', '2193-8210'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320330', 'host_organization_name': 'Adis, Springer Healthcare', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320330'], 'host_organization_lineage_names': ['Springer Nature', 'Adis, Springer Healthcare'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Responsible consumption and production', 'score': 0.58, 'id': 'https://metadata.un.org/sdg/12'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 28, 'referenced_works': ['https://openalex.org/W1548784211', 'https://openalex.org/W1947168884', 'https://openalex.org/W1990166011', 'https://openalex.org/W2040600853', 'https://openalex.org/W2050344966', 'https://openalex.org/W2065870141', 'https://openalex.org/W2080192722', 'https://openalex.org/W2098428600', 'https://openalex.org/W2167571044', 'https://openalex.org/W2339890238', 'https://openalex.org/W2466943428', 'https://openalex.org/W2537643370', 'https://openalex.org/W2560322684', 'https://openalex.org/W2602907503', 'https://openalex.org/W2761252392', 'https://openalex.org/W2805968856', 'https://openalex.org/W2811088815', 'https://openalex.org/W2892903770', 'https://openalex.org/W2903493423', 'https://openalex.org/W2945409099', 'https://openalex.org/W2947026438', 'https://openalex.org/W2986633517', 'https://openalex.org/W2998989384', 'https://openalex.org/W3007541271', 'https://openalex.org/W3030495851', 'https://openalex.org/W3043252982', 'https://openalex.org/W3134887329', 'https://openalex.org/W3211488171'], 'related_works': ['https://openalex.org/W4200023723', 'https://openalex.org/W3041652591', 'https://openalex.org/W3037068108', 'https://openalex.org/W2945780494', 'https://openalex.org/W2891524425', 'https://openalex.org/W2585407512', 'https://openalex.org/W2521234799', 'https://openalex.org/W2517747645', 'https://openalex.org/W2062691140', 'https://openalex.org/W2059423835'], 'abstract_inverted_index': {'Pembrolizumab': [0], 'provided': [1], 'durable': [2], 'responses': [3], 'and': [4, 88, 106, 115, 126, 150, 180, 194, 216, 282, 295, 327, 333, 391, 403, 414, 454], 'acceptable': [5], 'safety': [6], 'in': [7, 17, 83, 122, 206, 217, 285, 302, 497], 'recurrent': [8], 'or': [9, 59, 253, 341], 'metastatic': [10], '(R/M)': [11], 'cutaneous': [12], 'squamous': [13, 259], 'cell': [14, 260], 'carcinoma': [15, 261], '(cSCC)': [16, 262], 'the': [18, 46, 140, 240, 264, 289, 293, 320, 325, 343, 386, 422, 493], 'KEYNOTE-629': [19, 381, 396], 'study.': [20], 'In': [21], 'this': [22], 'elderly,': [23], 'fragile': [24], 'population': [25], 'with': [26, 52, 135, 237, 349, 368, 463, 499], 'disfiguring': [27], 'tumours,': [28], 'preservation': [29, 252], 'of': [30, 33, 50, 90, 93, 109, 208, 222, 243, 269, 288, 355, 376, 424, 426, 441, 468, 488, 495], 'health-related': [31], 'quality': [32, 354, 375, 423, 467, 487], 'life': [34, 425, 469], '(HRQoL)': [35], 'is': [36, 263, 274, 298, 307, 358], 'critical.': [37], 'Here,': [38, 416], 'we': [39, 417, 432], 'present': [40], 'pre-specified': [41], 'exploratory': [42], 'HRQoL': [43, 73, 251], 'analyses': [44], 'from': [45, 78, 117, 165], 'first': [47], 'interim': [48], 'analysis': [49], 'KEYNOTE-629.Patients': [51], 'R/M': [53, 238], 'cSCC': [54, 273, 297, 306, 350, 369, 390], 'not': [55], 'amenable': [56], 'to': [57, 80, 167, 178, 189, 280, 361, 365, 435, 478, 483], 'surgery': [58], 'radiation': [60], 'therapy': [61], 'received': [62], 'pembrolizumab': [63, 244, 388, 411, 420, 464, 479, 496], '200': [64], 'mg': [65], 'every': [66], '3': [67], 'weeks': [68], 'for': [69, 86, 147, 152, 170, 210, 213], '≤': [70], '24': [71], 'months.': [72], 'end': [74], 'points': [75], 'included': [76, 144, 397], 'change': [77, 116, 342], 'baseline': [79, 118, 166], 'week': [81, 120, 159, 168, 200], '12': [82, 169], 'European': [84, 107], 'Organisation': [85], 'Research': [87], 'Treatment': [89], 'Cancer': [91], 'Quality': [92, 108], 'Life': [94, 110], 'Questionnaire': [95], 'Core': [96], '30': [97], '(EORTC': [98], 'QLQ-C30)': [99], 'global': [100], 'health': [101, 448], 'status': [102], '(GHS)/QoL,': [103], 'functioning,': [104, 192, 215, 231, 451], 'symptom': [105], '5-Dimension': [111], '5-Level': [112], '(EQ-5D-5L)': [113], 'scores': [114, 162, 196, 203], 'through': [119], '48': [121], 'EORTC': [123, 148], 'QLQ-C30': [124, 149], 'GHS/QoL': [125, 171], 'physical': [127, 181, 214, 230, 345, 450], 'functioning': [128, 182], 'scores.': [129], 'Improvement': [130], '(≥': [131], '10-point': [132], 'increase': [133], 'post-baseline': [134], 'confirmation)': [136], 'was': [137, 155, 394, 412], 'assessed': [138], 'using': [139], 'exact': [141], 'binomial': [142], 'method.Analyses': [143], '99': [145], 'patients': [146, 209, 236, 367, 398, 434, 459, 473, 498], '100': [151], 'EQ-5D-5L.': [153], 'Compliance': [154], '>': [156], '80%': [157], 'at': [158, 199], '12.': [160, 201], 'Mean': [161], 'were': [163, 204, 400, 461, 480], 'stable': [164, 198, 466], '(4.95': [172], 'points;': [173, 184], '95%': [174, 185], 'confidence': [175, 186], 'interval,': [176, 187], '-1.00': [177], '10.90)': [179], '(-3.38': [183], '-8.80': [188], '2.04).': [190], 'EORTC-QLQ-C30': [191], 'symptom,': [193], 'EQ-5D-5L': [195], 'remained': [197], 'Post-baseline': [202], 'improved': [205, 486], '29.3%': [207], 'GHS/QoL,': [211], '17.2%': [212], 'a': [218, 247], 'numerically': [219], 'higher': [220], 'proportion': [221], 'responders': [223], 'versus': [224, 228, 233], 'non-responders': [225], '(GHS/QoL,': [226], '55.6%': [227], '16.1%;': [229], '36.1%': [232], '7.1%).In': [234], 'elderly': [235], 'cSCC,': [239], 'clinical': [241], 'efficacy': [242], 'translates': [245], 'into': [246], 'benefit': [248], 'validated': [249], 'by': [250, 277, 314], 'improvement': [254], 'during': [255, 470], 'treatment.ClinicalTrials.gov': [256], 'identifier:': [257], 'NCT03284424.Cutaneous': [258], 'second': [265], 'most': [266, 299], 'common': [267], 'type': [268], 'non-melanoma': [270], 'skin': [271], 'cancer.': [272], 'usually': [275], 'caused': [276], 'cumulative': [278], 'exposure': [279], 'sunlight': [281], 'often': [283, 300, 351], 'occurs': [284], 'exposed': [286], 'parts': [287], 'body': [290, 326], 'such': [291, 444], 'as': [292, 445], 'head': [294], 'neck.': [296], 'seen': [301], 'older': [303, 402], 'people.': [304], 'If': [305], 'detected': [308], 'early,': [309], 'it': [310, 393], 'can': [311, 322, 336], 'be': [312, 337], 'removed': [313], 'surgery;': [315], 'however,': [316], 'if': [317], 'left': [318], 'untreated,': [319], 'cancer': [321, 475], 'spread': [323], 'throughout': [324], 'cause': [328, 339], 'death.': [329], 'The': [330, 378, 407], 'disease': [331], 'itself': [332], 'its': [334], 'treatment': [335], 'painful,': [338], 'scarring,': [340], 'patient’s': [344], 'appearance.': [346], 'Hence,': [347], 'people': [348], 'have': [352, 484], 'poor': [353], 'life.': [356, 377, 489], 'It': [357], 'therefore': [359], 'important': [360, 439], 'develop': [362], 'new': [363], 'drugs': [364], 'help': [366], 'live': [370], 'longer': [371], 'without': [372], 'worsening': [373], 'their': [374, 442, 446], 'phase': [379], '2': [380], 'study': [382], 'investigated': [383, 418], 'how': [384, 419], 'well': [385, 477], 'drug': [387], 'treated': [389, 462], 'whether': [392], 'safe.': [395, 415], 'who': [399, 460], 'mostly': [401], 'had': [404, 465], 'advanced': [405, 500], 'cSCC.': [406, 501], 'results': [408, 491], 'showed': [409], 'that': [410, 458], 'effective': [413], 'affected': [421], 'these': [427], 'patients.': [428], 'To': [429], 'do': [430], 'this,': [431], 'asked': [433], 'answer': [436], 'questionnaires': [437], 'on': [438], 'aspects': [440], 'experience,': [443], 'general': [447], 'status,': [449], 'emotional': [452], 'wellbeing,': [453], 'symptoms.': [455], 'We': [456], 'found': [457], 'treatment.': [471], 'Furthermore,': [472], 'whose': [474], 'responded': [476], 'more': [481], 'likely': [482], 'an': [485], 'These': [490], 'support': [492], 'use': [494]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3201549363', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 5}], 'updated_date': '2025-01-12T11:50:18.368377', 'created_date': '2021-09-27'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
