Title: Correlation of COX-2 Expression with the Clinicopathological Features of Colorectal Cancer
Abstract: Objective: To investigate the expression of cyclooxygenase-2(COX-2) and its correlation with the clinicopathological features of colorectal cancer. Methods: From August 2017 to June 2019, 60 patients with colorectal cancer who underwent surgery in our hospital were enrolled. The specimens of the lesions and adjacent tissues were collected from all patients. The expression of mRNA and protein of COX-2 were detected by PCR and immunohistochemistry, the clinicopathological features of the patients were investigated and were given correlation analysis. Results: The positive rates of COX-2 mRNA and protein expression in lesion tissues were 63.3% and 55.0%, respectively, which were significantly higher than those in adjacent tissues(20.0% and 16.7%)(P<0.05). With the increased of pathological stage, degree of differentiation and lymph node metastasis of colorectal cancer, the positive rates of COX-2 mRNA and protein expression in lesion tissues were increased significantly(P<0.05). Spearman rank correlation analysis showed that the positive rate of COX-2 mRNA and protein expression in the lesion tissues were correlated with clinical stage, histological differentiation and lymph node metastasis(P<0.05). Multivariate analysis of Cox model showed that clinical stage, histological differentiation and lymph node metastasis were the main factors affectedCOX-2 protein expression(P<0.05). Conclusion: The mRNA and protein of COX-2 in colorectal cancer are highly expressed, which aresignificantly correlated with clinical stage, histological differentiation and lymph node metastasis.
Publication Year: 2020
Publication Date: 2020-01-01
Language: en
Type: article
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