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'by': [59], 'expanded': [60], 'substrate': [61, 167], 'specificity': [62, 168, 176, 188], 'and': [63, 70, 74, 119, 192, 194], 'reactions': [66, 118], 'with': [67, 121, 197], 'L-amino': [68, 190], 'acids': [69, 191], '(R)-(+)-1-phenylethylamine': [71, 178], 'using': [72], 'α-ketoglutarate': [73, 193], 'pyruvate': [75], 'amino': [77], 'acceptors.': [78], 'We': [79, 172], 'performed': [80], 'site-directed': [81], 'mutagenesis': [82], 'to': [83, 102, 107, 147], 'create': [84], 'a': [85, 103, 132], 'panel': [86], 'enzyme': [89, 101], 'variants,': [90], 'which': [91, 139], 'differ': [92], 'active': [95, 137, 162], 'site': [96, 163], 'residues': [97, 164], 'parent': [100], 'putative': [104], 'specific': [106], '(R)-primary': [108], 'amines.': [109], 'The': [110], 'variants': [111, 130], 'were': [112], 'examined': [113], 'overall': [116], 'transamination': [117], 'half-reaction': [120], '(R)-(+)-1-phenylethylamine.': [122], 'A': [123], 'structural': [124], 'analysis': [125], 'most': [128], 'prominent': [129], 'revealed': [131], 'spatial': [133], 'reorganization': [134], 'sites,': [138], 'caused': [140], 'changes': [141], 'activity.': [143], 'Although': [144], 'was': [150], 'not': [151], 'implemented,': [152], 'succeeded': [154], 'role': [158], 'particular': [161], 'expanding': [166], 'enzyme.': [171], 'showed': [173], 'that': [174], 'T.': [182], 'terrenum': [183], 'arises': [184], 'without': [185], 'sacrificing': [186], 'consensus': [196], 'it.': [198]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3184552242', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}], 'updated_date': '2024-09-13T16:00:56.665580', 'created_date': '2021-08-02'}