Abstract: 1. When mice are raised on a vitamin B6-deficient diet, there is a decrease in activity of the enzyme involved in the transamination reaction between γ-aminobutyric acid and α-ketoglutaric acid in the brain and the activity is restored by administration of vitamin B6.2. This enzyme is inhibited by carbonyl reagents and is restored by pyridoxal phosphate. There is no increase in activity, however, in normal animal brain when pyridoxal phosphate is added.3. The activity of the enzyme is lost by dialysis and restored by addition of pyridoxal phosphate.4. Pyridoxal phosphate is considered to be involved as a coenzyme of this enzyme.
Publication Year: 1959
Publication Date: 1959-01-01
Language: en
Type: article
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Cited By Count: 1
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