Abstract 1273: Discovery of a potent, selective, and orally bioavailable SOS1 inhibitor, RMC-023, an <i>in vivo</i> tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction

Name: Work Video:
Duration: 3 min 30 s
Andreas Buckl; Elsa Quintana; Grace J. Lee; Nataliya Tovbis Shifrin; Mengqi Zhong; Lindsay S. Garrenton; David Montgomery; Carlos Stahlhut; Frances Zhao; Dan Whalen; Severin K. Thompson; Arlyn Tambo-ong; Micah J. Gliedt; John E. Knox; James J. Cregg; Naing Aay; Jong Bum Choi; Bao N. Nguyen; Atti Tripathi; Ruiping Zhao; Mae Saldajeno-Concar; Abby Marquez; Daphne Hsieh; Laura McDowell; Elena S. Koltun; Alun Bermingham; David Wildes; Mallika Singh; Zhengping Wang; Richard A. Hansen; Jan A. Smith; Adrian L. Gill
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