Title: Evaluation of monoamine oxidase‐B (MAO‐B) inhibitory activity of different plant sources
Abstract: In humans, MAO‐B (EC 1.4.3.4) is located in neurons and glia where it is believed to contribute to age associated neurological disease and the generation of free radicals The purpose of the current study is to assess the ability of variety of plant sources in inhibiting MAO‐B aiming to identify natural products that can be used in the prevention or in retarding the progression of Parkinson's disease. In this study, enzyme activity of human MAO B‐ derived from insect cells infected with recombinant baculovirus was evaluated by monitoring production of peroxide upon the addition of the substrate benzylamine ± treatment (0.2–.83mg/ml final concentrations). Results obtained indicate that plant extracts having the greatest potency included: Humulus Lupulus, Gentian Root, Green Tea, Bakuchi Seed, Turmeric, Curcuma longa rhizome, Skull Cap, Amur Cork Tree, Spearmint, Wintergreen, Peppermint, Artemisia annual herb, Lady's Mantle, Psoralea corylifolia fruit, Glycyrrhiza uralensis Mai Dianthus superbus herb, Rosemary, Sage, Cilantro, Marjoram, Comfrey, Perilla frutescens leaf. Polygonum tinctorium levis, Isatis tinctoria and fruit extracts derived from orange, raspberry, strawberry and acai. The results of this study indicate that plant extracts examined which effectively inhibits MAO‐B may be promising for use in the management of patients with Parkinson's disease (Supported by a NIH grant RR 03020)
Publication Year: 2012
Publication Date: 2012-04-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 1
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