Title: Deamination of 5‐Hydroxytryptamine by Both Forms of Monoamine Oxidase in the Rat Brain
Abstract: Abstract: K m and V max values of monoamine oxidase (MAO) A and B towards 5‐hydroxytryptamine were determined for rat brain homogenates after the in vitro inhibition of one of the two forms by the selective inhibitors clorgyline and l ‐deprenyl. K m values of 178 and 1170μ m , and V max values of 0.73 and 0.09 nmol·mg protein −1 ·min −1 towards 5‐hydroxytryptamine were found for MAO‐A and ‐B, respectively. The K 1 for 5‐hydroxytryptamine as a competitive inhibitor of β‐phenethylamine oxidation by MAO‐B was found to be 1400 μm. The significance of these findings is discussed.
Publication Year: 1982
Publication Date: 1982-03-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 127
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