Publication Information

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561, 3449], 'Anfinsen': [1, 237, 527], 'demonstrated': [2, 134, 238, 370], 'that': [3, 135, 239, 371, 476, 532, 549, 1163, 1268, 3049, 3857, 4117, 4141], 'the': [4, 19, 26, 46, 72, 98, 108, 113, 119, 122, 136, 146, 167, 171, 178, 187, 199, 208, 220, 233, 240, 255, 262, 282, 308, 334, 344, 349, 355, 358, 372, 382, 403, 407, 414, 423, 435, 444, 456, 469, 474, 484, 514, 529, 533, 564, 584, 645, 661, 674, 681, 727, 782, 787, 797, 833, 868, 939, 946, 1015, 1028, 1031, 1041, 1048, 1059, 1099, 1103, 1164, 1167, 1183, 1188, 1191, 1287, 1614, 1635, 1639, 1725, 1734, 1988, 2009, 2015, 2125, 2244, 2365, 2400, 2492, 2559, 2621, 2879, 2996, 3012, 3022, 3030, 3033, 3046, 3051, 3082, 3092, 3112, 3115, 3118, 3122, 3130, 3134, 3146, 3162, 3166, 3176, 3182, 3194, 3199, 3232, 3270, 3297, 3315, 3339, 3343, 3359, 3388, 3446, 3555, 3567, 3574, 3584, 3587, 3590, 3600, 3735, 3783, 3790, 3840, 3863, 3873, 3894, 4028, 4039, 4045, 4048, 4051, 4058, 4067, 4075, 4113, 4131, 4137, 4150, 4158, 4161, 4165, 4181], 'information': [5, 241], 'encoded': [6, 242, 1637], 'in': [7, 16, 52, 71, 107, 232, 243, 252, 288, 307, 343, 468, 528, 580, 680, 734, 832, 867, 1030, 1058, 1102, 1153, 1157, 1219, 1518, 1616, 1932, 2096, 2496, 2786, 3273, 3290, 3311, 3313, 3384, 3392, 3581, 3605, 3632, 3759, 3763, 3782, 3862, 3872, 3893, 3979, 4069, 4092, 4144, 4173], 'a': [8, 53, 194, 244, 289, 430, 537, 570, 1025, 1271, 1290, 1691, 1822, 1835, 2617, 2626, 2934, 2983, 3327, 3404, 3578, 4036, 4105], "protein's": [9, 245], 'amino': [10, 60, 246, 296, 543, 729, 788], 'acid': [11, 61, 247, 297, 544, 730, 789], 'sequence': [12, 190, 248, 426, 545, 643, 1459, 2353, 2402, 3141, 3212, 3329, 4183], 'determines': [13, 249], 'its': [14, 59, 250, 295, 542, 2094, 2361, 2369, 2938], 'structure': [15, 21, 36, 77, 129, 138, 224, 251, 257, 272, 313, 365, 374, 460, 535, 1370, 1388, 1392, 1423, 1455, 1516, 1561, 1590, 1666, 1684, 1731, 1755, 1783, 1791, 1861, 1877, 1895, 1899, 1930, 1956, 1983, 2006, 2066, 2091, 2122, 2193, 2351, 2593, 3017, 3057, 3164, 3243, 3317, 3352, 3411, 3474, 3534, 3538, 3612, 3630, 3675, 3725, 3761, 3830, 3881, 3915, 3943, 3973, 4006, 4032, 4078, 4170], '1973,': [17, 253], 'solving': [18, 254, 4093], 'protein': [20, 35, 54, 104, 128, 137, 256, 271, 290, 340, 364, 373, 521, 538, 553, 565, 1026, 1035, 1044, 1171, 1176, 1201, 1266, 1304, 1331, 1369, 1387, 1484, 1515, 1560, 1589, 1665, 1754, 1790, 1824, 1876, 1894, 1929, 1955, 2038, 2062, 2090, 2121, 2141, 2172, 2326, 2371, 2401, 2424, 2447, 2472, 2592, 2723, 3016, 3037, 3052, 3056, 3098, 3120, 3211, 3316, 3351, 3410, 3473, 3501, 3533, 3611, 3629, 3674, 3724, 3829, 3880, 3914, 3942, 3972, 4005, 4031, 4077, 4094, 4169], 'prediction': [22, 37, 78, 130, 139, 225, 258, 273, 314, 366, 375, 461, 1482, 1517, 1562, 1591, 1685, 1732, 1784, 1833, 1862, 1931, 1957, 1984, 2007, 2092, 2445, 3018, 3058, 3244, 3318, 3353, 3412, 3631, 3676, 3726, 3762, 3831, 3882, 3916, 3944, 4007, 4079, 4171], 'problem': [23, 140, 259, 376, 3319, 3354, 4080], 'has': [24, 96, 204, 218, 260, 332, 440, 454, 568, 707, 1037, 3379, 3563, 3576, 3595, 4072], 'been': [25, 81, 97, 261, 317, 333, 724, 823, 1056, 2163, 3061, 3431, 3480, 3597], 'Holy': [27, 263], 'Grail': [28, 264], 'of': [29, 34, 49, 110, 121, 127, 148, 180, 189, 201, 222, 265, 270, 285, 346, 357, 363, 384, 416, 425, 437, 458, 536, 552, 572, 644, 676, 714, 785, 800, 830, 905, 948, 957, 1033, 1043, 1050, 1098, 1169, 1200, 1216, 1245, 1286, 1289, 1308, 1330, 1483, 1613, 1641, 1663, 1686, 1730, 1818, 2192, 2196, 2243, 2248, 2324, 2355, 2421, 2446, 2494, 2515, 2562, 2587, 2620, 2730, 2752, 2777, 2807, 2878, 2980, 2991, 2998, 3014, 3035, 3085, 3107, 3114, 3181, 3188, 3210, 3234, 3269, 3300, 3500, 3602, 3738, 3757, 3785, 3843, 3855, 3867, 3879, 3888, 3911, 3913, 3939, 3941, 3969, 3971, 4002, 4004, 4027, 4030, 4038, 4047, 4050, 4130, 4149, 4160, 4164], 'structural': [30, 266, 493, 1852, 2241, 2697, 3083, 3246], 'biology.': [31, 267], 'The': [32, 268, 523, 766, 1079, 1419, 2057, 3105, 3350, 4147], 'goal': [33, 269], 'approaches': [38, 216, 274, 452, 1627, 3059, 3490], 'is': [39, 275, 539, 1161, 1178, 3109, 3126, 3402], 'to': [40, 44, 102, 276, 280, 338, 488, 502, 577, 709, 815, 825, 893, 1014, 1022, 1182, 1264, 1634, 1761, 2089, 2165, 2518, 2673, 2906, 3028, 3145, 3157, 3173, 3190, 3193, 3228, 3337, 3381, 3387, 3434, 3471, 3482, 3554, 3609, 4112, 4179], 'utilize': [41, 277], 'computational': [42, 278, 1626, 2325, 2759], 'modeling': [43, 86, 90, 114, 210, 279, 322, 326, 350, 446, 1667, 1792, 2123, 3067, 3071, 3223, 3272, 3288, 3489], 'determine': [45, 281], 'spatial': [47, 283, 1309], 'location': [48, 284], 'every': [50, 286, 1857], 'atom': [51, 287], 'molecule': [55, 291, 2667, 2936], 'starting': [56, 292], 'from': [57, 293, 491, 1334, 1565, 2399, 3091, 3161, 3342, 3445, 3504, 3679], 'only': [58, 294, 793], 'sequence.': [62, 298], 'Depending': [63, 299], 'on': [64, 229, 300, 465, 541, 1690, 2008, 2625, 2815, 3111, 3129, 3296, 3461, 3734, 3839], 'whether': [65, 301], 'homologous': [66, 302, 1688, 3395, 3440, 3860, 3870], 'structures': [67, 303, 517, 844, 890, 947, 1036, 1049, 1177, 1333, 1622, 3099, 3503, 3788], 'can': [68, 141, 304, 377, 3154, 3442, 4152], 'be': [69, 142, 158, 305, 378, 394, 838, 3321, 3356, 3382, 3443, 4153], 'found': [70, 306], 'Protein': [73, 309, 768, 977, 1060, 1080, 1139, 1422, 1454, 1762, 1982, 2005, 2277, 2350, 3242, 3303, 3741, 3846], 'Data': [74, 310, 1061, 1081], 'Bank': [75, 311, 1062], '(PDB),': [76, 312, 1091], 'methods': [79, 315, 943, 3075, 3096, 3429, 3451, 3912, 3940, 3970, 4003, 4115, 4167], 'have': [80, 133, 316, 369, 723, 822, 863, 1055, 1618, 2162, 3060, 3155, 3179, 3430, 3479], 'historically': [82, 318, 3565], 'categorized': [83, 319, 3063], 'as': [84, 184, 186, 320, 420, 422, 713, 803, 2360, 2982, 3064, 3483, 3570], 'template-based': [85, 321, 3066, 3271], '(TBM)': [87, 323, 3068], 'or': [88, 324, 2403, 3069, 3486], 'template-free': [89, 325, 3070], '(FM)': [91, 327, 3072], 'approaches.': [92, 328], 'Until': [93, 329], 'recently,': [94, 330], 'TBM': [95, 213, 331, 449, 3074, 3108, 3153, 3324, 3426, 3591], 'most': [99, 123, 335, 359, 940, 3023, 3874], 'reliable': [100, 111, 336, 347], 'approach': [101, 337, 2088, 2670, 3027], 'predicting': [103, 339], 'structures,': [105, 183, 341, 419, 3042], 'and': [106, 214, 217, 342, 450, 453, 504, 732, 836, 856, 887, 896, 925, 981, 989, 1019, 1155, 1173, 1343, 1371, 1394, 1424, 1768, 1793, 1821, 1831, 1878, 1901, 1985, 2065, 2093, 2194, 2352, 2364, 2373, 2423, 2594, 2647, 2699, 2725, 2733, 2758, 2829, 2839, 2908, 3039, 3080, 3121, 3136, 3231, 3245, 3390, 3467, 3476, 3513, 3540, 3592, 3865, 3890, 3976, 4042, 4124, 4134, 4155], 'absence': [109, 345], 'templates,': [112, 348, 3089, 3124, 3147], 'accuracy': [115, 351, 3106, 3224, 3569, 3723, 3828], 'sharply': [116, 352, 3225], 'declines.': [117, 353], 'Nevertheless,': [118, 354, 3377], 'results': [120, 356], 'recent': [124, 360, 3875, 4040], 'community-wide': [125, 361, 3876], 'assessment': [126, 362, 3289, 3897, 3910, 3938, 3968, 4001], 'experiment': [131, 367], '(CASP14)': [132, 368], 'largely': [143, 379, 3596, 4073], 'solved': [144, 380, 1034, 1175, 3041, 3322, 3357, 4074], 'through': [145, 207, 381, 443, 1728, 2471, 3599], 'use': [147, 383, 3454, 3601], 'end-to-end': [149, 385, 3607, 4070], 'deep': [150, 386, 1566, 2145, 2566, 3603, 3680, 3728, 3833, 4064], 'machine': [151, 387], 'learning': [152, 388, 1489, 4071], 'techniques,': [153, 389], 'where': [154, 390, 4066], 'correct': [155, 391], 'folds': [156, 392, 1633], 'could': [157, 393, 3320, 3355], 'built': [159, 395, 2814], 'for': [160, 193, 396, 429, 481, 944, 1094, 1224, 1367, 1724, 1785, 1834, 1874, 2061, 2616, 2836, 2876, 2902, 2995, 3148, 3165, 3302, 3407, 3437, 3583, 3740, 3768, 3845, 3852, 4168], 'nearly': [161, 397, 478], 'all': [162, 398, 2674], 'single-domain': [163, 399, 4076], 'proteins': [164, 400, 831, 855, 858, 882, 949, 1054, 1220, 1636, 1689, 2497, 3139, 3170, 3436, 3856, 3868], 'without': [165, 401, 3100], 'using': [166, 402, 1340, 1390, 1457, 1563, 1592, 1897, 1958, 1987, 2014, 2124, 2498, 2756, 2785, 2811, 2869, 3101, 3323, 3358, 3510, 3536, 3677, 3727, 3832], 'PDB': [168, 234, 404, 470, 3344, 3361, 3447, 3864], 'templates.': [169, 405, 3137], 'Critically,': [170, 406], 'model': [172, 408, 3435], 'quality': [173, 179, 409, 415, 3113, 3787], 'exhibited': [174, 410], 'little': [175, 411], 'correlation': [176, 412], 'with': [177, 413, 596, 859, 1336, 1733, 2565, 2671, 3140, 3171, 3506, 3559, 3869, 3885, 4024, 4176], 'available': [181, 417, 4177], 'template': [182, 230, 418, 466, 3103, 3236, 3456], 'well': [185, 421], 'number': [188, 424, 675, 1032, 1168, 3034], 'homologs': [191, 427], 'detected': [192, 428], 'given': [195, 431], 'target': [196, 432, 2939, 3119], 'protein.': [197, 433], 'Thus,': [198, 434, 3011], 'implementation': [200, 436], 'deep-learning': [202, 438], 'techniques': [203, 439], 'essentially': [205, 441, 806], 'broken': [206, 442], '50-year-old': [209, 445], 'border': [211, 447], 'between': [212, 448, 1166, 2368, 3032, 3117, 3133, 3589], 'FM': [215, 451, 3095, 3428, 3450, 3562, 3593], 'made': [219, 455, 511, 1186], 'success': [221, 457], 'high-resolution': [223, 459], 'significantly': [226, 462], 'less': [227, 463, 1095], 'dependent': [228, 464, 540, 3128], 'availability': [231, 467], 'library.': [235, 471, 3448], 'Proteins': [472], 'are': [473, 477, 510, 805, 817, 950, 1854, 4142], 'macromolecules': [475], 'ubiquitously': [479], 'responsible': [480], 'carrying': [482], 'out': [483], 'various': [485, 2167], 'functions': [486, 509, 799, 900, 3466], 'necessary': [487], 'sustain': [489], 'life,': [490], 'cell': [492, 499, 2779], 'support,': [494], 'immune': [495], 'protection,': [496], 'enzymatic': [497], 'catalysis,': [498], 'signal': [500], 'transduction': [501], 'transcription': [503], 'translation': [505], 'regulation.': [506], 'These': [507], 'diverse': [508], 'possible': [512], 'by': [513, 519, 526, 808, 1187, 1306, 1487, 1625, 1638, 1668, 1828, 1859, 2144, 2280, 2695, 2782, 3078, 3152, 3789, 4035, 4063, 4157], 'unique': [515, 2366], 'three-dimensional': [516, 810, 1273], 'adopted': [518], 'different': [520, 864], 'molecules.': [522], 'landmark': [524], 'study': [525, 2013], '1970s': [530], 'showed': [531], 'tertiary': [534, 843, 889, 1332, 1621, 3502, 3760], '(1Anfinsen': [546], 'C.B.': [547], 'Principles': [548, 980], 'govern': [550, 3050], 'folding': [551, 924, 1288, 2142, 2595], 'chains.Science.': [554], '1973;': [555], '181:': [556], '223-230Crossref': [557], 'PubMed': [558, 608, 651, 669, 702, 776, 873, 914, 933, 964, 1007, 1088, 1206, 1235, 1251, 1278, 1296, 1316, 1352, 1378, 1402, 1431, 1464, 1495, 1523, 1571, 1605, 1653, 1674, 1703, 1740, 1800, 1843, 1885, 1909, 1937, 1971, 1996, 2022, 2046, 2073, 2101, 2133, 2156, 2209, 2254, 2287, 2333, 2380, 2410, 2432, 2456, 2479, 2504, 2525, 2573, 2602, 2635, 2654, 2682, 2711, 2742, 2796, 2824, 2844, 2857, 2888, 2915, 2948, 3006, 3218, 3251, 3280, 3372, 3420, 3522, 3548, 3637, 3685, 3774, 3922, 3952, 3985, 4013, 4099], 'Google': [559, 609, 654, 672, 705, 779, 876, 917, 936, 965, 1010, 1089, 1147, 1207, 1236, 1254, 1279, 1297, 1319, 1355, 1379, 1405, 1434, 1467, 1498, 1526, 1574, 1608, 1656, 1677, 1706, 1743, 1803, 1846, 1886, 1912, 1940, 1974, 1999, 2025, 2049, 2076, 2104, 2136, 2159, 2212, 2257, 2288, 2336, 2383, 2413, 2435, 2459, 2482, 2507, 2528, 2576, 2605, 2638, 2657, 2685, 2714, 2745, 2768, 2799, 2827, 2845, 2860, 2891, 2918, 2951, 3009, 3221, 3254, 3283, 3375, 3423, 3525, 3551, 3640, 3688, 3777, 3925, 3955, 3988, 4016, 4102], 'Scholar).': [560, 780, 877, 937, 1011, 1148, 1847, 3010, 3307, 3376, 3424, 3552, 3778, 4017, 4103], 'then,': [562], 'understanding': [563], 'sequence–structure–function': [566], 'paradigm': [567], 'become': [569], 'cornerstone': [571], 'modern': [573], 'biomedical': [574, 2168], 'studies.': [575], 'Due': [576, 3553], 'significant': [578, 1016, 3235, 3859], 'efforts': [579], 'genome': [581, 1640, 2357], 'sequencing': [582, 595], 'over': [583, 710, 1190, 4136], 'last': [585, 1192, 4138], '4': [586], 'decades': [587, 1194], '(2Sanger': [588], 'F.': [589, 2750], 'Nicklen': [590], 'S.': [591, 603, 747, 848, 976, 1111, 1230, 1437, 1470, 1551, 1555, 1585, 1600, 1648, 1698, 1746, 1951, 1966, 2111, 2151, 2204, 2317, 2553, 2748, 2771, 2775, 2894, 2978, 3367, 3665, 3669], 'Coulson': [592], 'A.R.': [593], 'DNA': [594], 'chain-terminating': [597], 'inhibitors.Proc.': [598], 'Natl.': [599, 1226, 1596, 1644, 1694, 1962, 2147, 2200, 3363], 'Acad.': [600, 1227, 1597, 1645, 1695, 1963, 2148, 2201, 3364], 'Sci.': [601, 1228, 1598, 1646, 1696, 1964, 2149, 2202, 3365], 'U.': [602, 1229, 1599, 1647, 1697, 1965, 2150, 2203, 3366], 'A.': [604, 737, 846, 850, 852, 1107, 1115, 1135, 1198, 1231, 1284, 1300, 1358, 1360, 1412, 1543, 1547, 1601, 1649, 1661, 1699, 1748, 1750, 1758, 1865, 1867, 1967, 2054, 2152, 2205, 2237, 2239, 2276, 2301, 2309, 2466, 2512, 2547, 2610, 2688, 2863, 3241, 3257, 3267, 3368, 3657, 3661, 3694, 3706, 3708, 3714, 3718, 3799, 3811, 3813, 3819, 3823, 3900, 3932, 3936, 3962, 3966, 3995, 3999], '1977;': [605, 1248], '74:': [606], '5463-5467Crossref': [607], 'Scholar,': [610, 655, 918, 1208, 1237, 1255, 1280, 1298, 1320, 1356, 1380, 1406, 1435, 1468, 1499, 1527, 1575, 1657, 1678, 1707, 1744, 1776, 1804, 1887, 1913, 1941, 1975, 2000, 2026, 2050, 2077, 2105, 2137, 2213, 2258, 2289, 2337, 2414, 2436, 2460, 2483, 2508, 2529, 2577, 2639, 2658, 2686, 2715, 2746, 2769, 2800, 2846, 2861, 2892, 2919, 2952, 3255, 3284, 3526, 3641, 3689, 3746, 3926, 3956, 3989], '3Venter': [611], 'J.C.': [612], 'Adams': [613], 'M.D.': [614], 'Myers': [615], 'E.W.': [616, 685, 2345], 'Li': [617, 1473, 1502, 1916, 2220, 2538, 2554, 3616], 'P.W.': [618], 'Mural': [619], 'R.J.': [620], 'Sutton': [621], 'G.G.': [622], 'Smith': [623], 'H.O.': [624], 'Yandell': [625], 'M.': [626, 687, 755, 1196, 1243, 1711, 1810, 2107, 2270, 2966, 3698, 3753, 3803, 3904], 'Evans': [627, 1530, 3644], 'C.A.': [628], 'Holt': [629], 'R.A.': [630], 'Gocayne': [631], 'J.D.': [632], 'Amanatides': [633], 'P.': [634, 1557, 2184, 2291, 2390, 3671], 'Ballew': [635], 'R.M.': [636], 'Huson': [637], 'D.H.': [638], 'Wortman': [639], 'J.R.': [640], 'et': [641, 1136, 1558, 2320, 3672, 3721, 3826], 'al.The': [642, 1137], 'human': [646, 834, 1017, 2563, 2589, 2676, 2808], 'genome.Science.': [647], '2001;': [648, 3248], '291:': [649], '1304-1351Crossref': [650], 'Scopus': [652, 670, 703, 777, 874, 915, 934, 1008, 1252, 1317, 1353, 1403, 1432, 1465, 1496, 1524, 1572, 1606, 1654, 1675, 1704, 1741, 1801, 1844, 1910, 1938, 1972, 1997, 2023, 2047, 2074, 2102, 2134, 2157, 2210, 2255, 2334, 2381, 2411, 2433, 2457, 2480, 2505, 2526, 2574, 2603, 2636, 2655, 2683, 2712, 2743, 2797, 2825, 2858, 2889, 2916, 2949, 3007, 3219, 3252, 3281, 3373, 3421, 3523, 3549, 3638, 3686, 3775, 3923, 3953, 3986, 4014, 4100], '(10183)': [653], '4Metzker': [656], 'M.L.': [657, 2319], 'Sequencing': [658], 'technologies': [659], '-': [660, 1221, 3946], 'next': [662], 'generation.Nat.': [663], 'Rev.': [664], 'Genet.': [665, 2569], '2010;': [666, 1375, 1882, 2098], '11:': [667, 2652, 2794], '31-46Crossref': [668], '(4726)': [671], 'Scholar),': [673, 966, 988, 1609, 2160, 2384, 2606, 2828, 3222, 3851], 'known': [677, 1170, 1272, 3036], 'nucleotide': [678, 718], 'sequences': [679, 731, 790, 1101, 1172, 1267, 1339, 3038, 3509], 'GenBank': [682], 'database': [683, 1105, 2586], '(5Sayers': [684], 'Cavanaugh': [686], 'Clark': [688, 2292], 'K.': [689, 1119, 1553, 2225, 2303, 2307, 2972, 3261, 3667, 3700, 3805, 3906, 3930, 3960, 3993], 'Ostell': [690], 'J.': [691, 970, 1066, 1282, 1408, 1416, 1533, 1535, 1577, 1682, 1943, 2030, 2052, 2081, 2083, 2113, 2119, 2139, 2229, 2266, 2274, 2545, 2549, 2551, 2579, 2662, 2719, 2721, 2848, 2896, 2910, 2974, 2976, 3263, 3349, 3398, 3647, 3649, 3908, 3928, 3958, 3991], 'Pruitt': [692], 'K.D.': [693], 'Karsch-Mizrachi': [694], 'I.': [695, 1579, 1945, 2217], 'GenBank.Nucleic': [696], 'Acids': [697, 771, 1083, 1142, 1991, 2041, 2068, 2405, 2474], 'Res.': [698, 772, 1084, 1143, 1839, 1992, 2042, 2069, 2376, 2406, 2475, 2521], '2019;': [699, 871, 1520, 1934, 2153, 3003, 3634, 3771, 3919], '47:': [700, 2633], 'D94-D99Crossref': [701], '(179)': [704], 'Scholar)': [706, 1090], 'grown': [708], '2600': [711], 'million': [712, 722, 1053], '2021.': [715], 'Of': [716], 'these': [717, 804, 3560, 4121], 'sequences,': [719], 'approximately': [720, 1051, 3853], '200': [721], 'translated': [725], 'into': [726, 796, 1270], 'corresponding': [728], 'deposited': [733, 1057], 'UniProt': [735, 1104], '(6Bairoch': [736], 'Apweiler': [738], 'R.': [739, 753, 1259, 1410, 1507, 1531, 1659, 1719, 1921, 2180, 2392, 3286, 3621, 3645, 3704, 3809], 'Wu': [740], 'C.H.': [741], 'Barker': [742], 'W.C.': [743], 'Boeckmann': [744, 1124], 'B.': [745, 1125, 2235, 2898, 3207, 3259, 3416, 3720, 3825], 'Ferro': [746], 'Gasteiger': [748], 'E.': [749, 1129, 1326, 2388, 2462, 2510, 2962, 3496, 4082], 'Huang': [750, 1325, 1442, 2342, 3495], 'H.Z.': [751], 'Lopez': [752], 'Magrane': [754], 'Martin': [756], 'M.J.': [757, 2004], 'Natale': [758], 'D.A.': [759], "O'Donovan": [760], 'C.': [761, 1324, 1505, 1541, 1806, 1919, 2272, 2305, 2339, 2581, 2956, 2958, 3494, 3619, 3655, 3710, 3815], 'Redaschi': [762], 'N.': [763, 1441, 2032, 2176, 2416, 2543], 'Yeh': [764], 'L.S.L.': [765], 'Universal': [767, 1138], 'Resource': [769, 1140], '(UniProt).Nucleic': [770, 1141], '2005;': [773, 2070, 2407, 2885, 3369], '33:': [774, 2071, 2408], 'D154-D159Crossref': [775], '(1346)': [778], 'Despite': [781, 3308], 'impressive': [783], 'accumulation': [784, 1042], 'data,': [786], 'themselves': [791], 'provide': [792], 'limited': [794, 4156], 'insight': [795], 'biological': [798, 899], 'each': [801], 'protein,': [802], 'determined': [807], 'their': [809, 894, 898, 1620], 'structures.': [811, 3104], 'An': [812, 2036], 'interesting': [813], 'exception': [814], 'this': [816, 3309, 3378, 4019, 4145, 4174], 'intrinsically': [818, 860, 880, 906], 'disordered': [819, 854, 861, 881, 907], 'proteins,': [820, 3087], 'which': [821, 1092, 2161, 3125, 3438], 'estimated': [824], 'make': [826], 'up': [827, 3156], 'roughly': [828], '30%': [829], 'proteome,': [835], 'may': [837, 883, 4119], 'functional': [839, 865], 'despite': [840], 'lacking': [841], 'well-defined': [842], '(7Deiana': [845], 'Forcelloni': [847], 'Porrello': [849], 'Giansanti': [851], 'Intrinsically': [853], 'structured': [857], 'regions': [862, 3184], 'roles': [866], 'cell.PLoS': [869], 'One.': [870], '14e0217889Crossref': [872], '(31)': [875, 1802], 'However,': [878, 1012, 3197, 3572], 'even': [879, 3325], 'undergo': [884], 'disordered-to-ordered': [885], 'transitions': [886], 'adopt': [888], 'upon': [891, 2397, 2450], 'binding': [892, 2693, 2726, 2940], 'partners': [895], 'performing': [897, 3792], '(8Uversky': [901], 'V.N.': [902], 'Unusual': [903], 'biophysics': [904], 'proteins.Biochim.': [908], 'Biophys.': [909], 'Acta.': [910], '2013;': [911, 1797, 2330], '1834:': [912], '932-951Crossref': [913], '(349)': [916], '9Wright': [919], 'P.E.': [920, 1078], 'Dyson': [921], 'H.J.': [922], 'Linking': [923], 'binding.Curr.': [926], 'Opin.': [927, 2426, 2761], 'Struct.': [928, 2427], 'Biol.': [929, 1312, 1348, 1492, 1737, 2283, 2428, 2598, 2738, 2820, 3518], '2009;': [930, 2019, 2251, 2284, 2429, 2739], '19:': [931, 2378, 2430], '31-38Crossref': [932], '(757)': [935], 'Among': [938], 'accurate': [941], 'experimental': [942, 2757, 3786], 'determining': [945], 'X-ray': [951, 955], 'crystallography': [952, 956], '(10Glusker': [953], 'J.P.': [954], 'proteins.Methods': [958], 'Biochem.': [959], 'Anal.': [960], '1994;': [961], '37:': [962], '1-72Crossref': [963], 'NMR': [967, 978], 'spectroscopy': [968], '(11Cavanaugh': [969], 'Fairbrother': [971], 'W.J.': [972], 'Palmer': [973], 'A.G.': [974], 'N': [975], 'Spectroscopy:': [979], 'Practice.': [982], 'Academic': [983], 'Press,': [984], 'New': [985, 1772], 'York,': [986, 1773], 'NY1996Google': [987], 'cryo-electron': [990], 'microscopy': [991], '(12Cheng': [992], 'Y.': [993, 1362, 1384, 1418, 1503, 1511, 1680, 1752, 1780, 1816, 1869, 1891, 1917, 1925, 2215, 2260, 2349, 2442, 2539, 2583, 2690, 2804, 2921, 3347, 3530, 3617, 3625], 'Single-particle': [994], 'cryo-EM': [995], 'at': [996, 3326], 'crystallographic': [997], 'resolution.Cell.': [998], '2015;': [999, 1428, 2476], '161:': [1000], '450-457Abstract': [1001], 'Full': [1002, 1004, 2706, 2708], 'Text': [1003, 1005, 2707, 2709], 'PDF': [1006, 2710], '(310)': [1009], 'due': [1013, 3227, 3386], 'effort': [1018, 1185], 'expenses': [1020], 'required': [1021], 'experimentally': [1023, 1174, 3040], 'solve': [1024], 'structure,': [1027], 'growth': [1029], 'lagged': [1038], 'far': [1039], 'behind': [1040], 'sequences.': [1045], 'So': [1046], 'far,': [1047], '0.18': [1052], '(13Berman': [1063], 'H.M.': [1064], 'Westbrook': [1065], 'Feng': [1067], 'Z.': [1068, 1474, 1583, 1949, 2079, 2115, 2221], 'Gilliland': [1069], 'G.': [1070, 2188, 2311, 2612, 2641], 'Bhat': [1071], 'T.N.': [1072, 1717], 'Weissig': [1073], 'H.': [1074, 1439, 1449, 1549, 1581, 1947, 2109, 2117, 2533, 2660, 3663], 'Shindyalov': [1075], 'I.N.': [1076], 'Bourne': [1077], 'Bank.Nucleic': [1082], '2000;': [1085, 2854], '28:': [1086], '235-242Crossref': [1087], 'accounts': [1093], 'than': [1096], '0.1%': [1097], 'total': [1100], '(14Bairoch': [1106], 'Bougueleret': [1108], 'L.': [1109, 1127, 1133, 1537, 1709, 2223, 2438, 2531, 2968, 3651], 'Altairac': [1110], 'Amendolia': [1112], 'V.': [1113], 'Auchincloss': [1114], 'Puy': [1116], 'G.A.': [1117, 1445], 'Axelsen': [1118], 'Baratin': [1120], 'D.': [1121, 1261, 1328, 1382, 1414, 1453, 1587, 1629, 1631, 1715, 1721, 1778, 1889, 1953, 1979, 1981, 2219, 2262, 2268, 3239, 3498, 3528], 'Blatter': [1122], 'M.C.': [1123, 2034], 'Bollondi': [1126], 'Boutet': [1128], 'Quintaje': [1130], 'S.B.': [1131], 'Breuza': [1132], 'Bridge': [1134], '2008;': [1144], '36:': [1145], 'D190-D195PubMed': [1146], 'This': [1149, 3779], 'percentage': [1150], 'was': [1151], '0.7%': [1152], '2010': [1154], '2%': [1156], '2004;': [1158, 1700, 1993, 2632], 'therefore,': [1159], 'it': [1160], 'apparent': [1162], 'gap': [1165, 3588], 'continually': [1179], 'widening.': [1180], 'Thanks': [1181], 'tremendous': [1184], 'community': [1189], 'few': [1193], '(15Levitt': [1195], 'Warshel': [1197], 'Computer-simulation': [1199], 'folding.Nature.': [1202], '1975;': [1203], '253:': [1204, 1276], '694-698Crossref': [1205], '16Lewis': [1209], 'P.N.': [1210], 'Momany': [1211], 'F.A.': [1212], 'Scheraga': [1213], 'H.A.': [1214], 'Folding': [1215], 'polypeptide': [1217], 'chains': [1218], 'proposed': [1222], 'mechanism': [1223], 'folding.Proc.': [1225], '1971;': [1232], '68:': [1233], '2293-2297Crossref': [1234], '17Mccammon': [1238], 'J.A.': [1239, 2541], 'Gelin': [1240], 'B.R.': [1241], 'Karplus': [1242], 'Dynamics': [1244], 'folded': [1246], 'proteins.Nature.': [1247], '267:': [1249], '585-590Crossref': [1250], '(1296)': [1253], '18Bowie': [1256], 'J.U.': [1257], 'Luthy': [1258], 'Eisenberg': [1260, 1630], 'A': [1262, 1364, 1871, 2011, 2085, 2585, 2664, 2851, 3754], 'method': [1263], 'identify': [1265, 3338], 'fold': [1269, 1794], 'structure.Science.': [1274], '1991;': [1275], '164-170Crossref': [1277], '19Skolnick': [1281], 'Kolinski': [1283], 'Simulations': [1285], 'globular': [1291], 'protein.Science.': [1292], '1990;': [1293], '250:': [1294], '1121-1125Crossref': [1295], '20Sali': [1299], 'Blundell': [1301, 2488], 'T.L.': [1302, 2489], 'Comparative': [1303], 'modelling': [1305], 'satisfaction': [1307], 'restraints.J.': [1310], 'Mol.': [1311, 1347, 2597, 2737, 2819, 3517], '1993;': [1313], '234:': [1314], '779-815Crossref': [1315], '(10062)': [1318], '21Simons': [1321], 'K.T.': [1322, 3492], 'Kooperberg': [1323, 3493], 'Baker': [1327, 1452, 1586, 1720, 1952, 1980, 3497], 'Assembly': [1329, 3499], 'fragments': [1335, 1393, 1900, 3505, 3539], 'similar': [1337, 3507], 'local': [1338, 2700, 2731, 3508], 'simulated': [1341, 3511], 'annealing': [1342, 3512], 'Bayesian': [1344, 3514], 'scoring': [1345, 3515], 'functions.J.': [1346, 3516], '1997;': [1349, 1650, 1670, 3519], '268:': [1350, 3520], '209-225Crossref': [1351, 3521], '(1066)': [1354, 3524], '22Roy': [1357], 'Kucukural': [1359, 1866], 'Zhang': [1361, 1383, 1417, 1475, 1504, 1510, 1751, 1779, 1815, 1868, 1890, 1918, 1924, 2348, 2441, 2580, 2582, 2689, 2803, 3529, 3618, 3624], 'I-TASSER:': [1363, 1870], 'unified': [1365, 1872], 'platform': [1366, 1873], 'automated': [1368, 1875, 2037], 'function': [1372, 1425, 1830, 1879, 2173, 2195, 2278, 2327, 2724], 'prediction.Nat.': [1373, 1426, 1880, 2328], 'Protoc.': [1374, 1881, 2018, 2129], '5:': [1376, 1883], '725-738Crossref': [1377, 1884], '23Xu': [1381, 1888, 3527], 'Ab': [1385, 1781, 1892, 3531], 'initio': [1386, 1893, 3485, 3532], 'assembly': [1389, 1896, 3535], 'continuous': [1391, 1898, 3537], 'optimized': [1395, 1902, 3541], 'knowledge-based': [1396, 1903, 3464, 3542], 'force': [1397, 1904, 3543], 'field.Proteins.': [1398, 1905, 3544], '2012;': [1399, 1906, 2130, 2679, 2703, 3545], '80:': [1400, 1907, 3546], '1715-1735Crossref': [1401, 1908, 3547], '(28)': [1404, 1911, 3550], '24Yang': [1407], 'Yan': [1409], 'Roy': [1411, 1749], 'Xu': [1413, 1477, 2118, 2550, 2969], 'Poisson': [1415], 'I-TASSER': [1420], 'suite:': [1421], 'Methods.': [1427, 2329], '12:': [1429, 3216], '7-8Crossref': [1430], '(3137)': [1433], '25Ovchinnikov': [1436], 'Park': [1438, 1580, 1946], 'Varghese': [1440], 'P.S.': [1443], 'Pavlopoulos': [1444], 'Kim': [1446, 2922], 'D.E.': [1447, 1977, 2485, 2931], 'Kamisetty': [1448], 'Kyrpides': [1450], 'N.C.': [1451], 'determination': [1456], 'metagenome': [1458], 'data.Science.': [1460], '2017;': [1461, 1493, 3417], '355:': [1462], '294-298Crossref': [1463], '(278)': [1466], '26Wang': [1469], 'Sun': [1471], 'S.Q.': [1472], 'R.Y.': [1476], 'J.B.': [1478], 'Accurate': [1479], 'de': [1480, 3487], 'novo': [1481, 3488], 'contact': [1485], 'map': [1486], 'ultra-deep': [1488], 'model.PLoS': [1490], 'Comput.': [1491], '13e1005324Crossref': [1494], '(400)': [1497], '27Zheng': [1500, 1914], 'W.': [1501, 1808, 1915, 2341, 2960, 3615], 'Pearce': [1506, 1920, 3620], 'Mortuza': [1508, 1922, 3622], 'S.M.': [1509, 1923, 3623], 'Deep-learning': [1512, 1926, 3626], 'contact-map': [1513, 1927, 3627], 'guided': [1514, 1928, 3628], 'CASP13.Proteins.': [1519, 1933, 3633], '87:': [1521, 1935, 3635, 3772, 3920], '1149-1164Crossref': [1522, 1936, 3636], '(21)': [1525, 1939, 3639], '28Senior': [1528, 3642], 'A.W.': [1529, 3643], 'Jumper': [1532, 3646, 3691, 3796], 'Kirkpatrick': [1534, 3648], 'Sifre': [1536, 3650], 'Green': [1538, 3652, 3695, 3800], 'T.': [1539, 2028, 2299, 2464, 2865, 2970, 3265, 3653, 3696, 3801, 3902, 3934, 3964, 3997], 'Qin': [1540, 2957, 3654], 'Žídek': [1542, 3656, 3705, 3810], 'Nelson': [1544, 3658], 'A.W.R.': [1545, 3659], 'Bridgland': [1546, 3660, 3707, 3812], 'Penedones': [1548, 3662], 'Petersen': [1550, 3664], 'Simonyan': [1552, 3666], 'Crossan': [1554, 3668], 'Kohli': [1556, 3670], 'al.Improved': [1559, 3673], 'potentials': [1564, 3678], 'learning.Nature.': [1567, 3681], '2020;': [1568, 1602, 1968, 2377, 2793, 2821, 3682, 4096], '577:': [1569, 3683], '706-710Crossref': [1570, 3684], '(701)': [1573, 3687], '29Yang': [1576, 1942], 'Anishchenko': [1578, 1944], 'Peng': [1582, 1948, 2112], 'Ovchinnikov': [1584, 1950], 'Improved': [1588, 1954], 'predicted': [1593, 1959], 'interresidue': [1594, 1960], 'orientations.Proc.': [1595, 1961], '117:': [1603, 1969], '1496-1503Crossref': [1604, 1970], '(308)': [1607, 1973], 'an': [1610, 3186, 3886, 4025, 4128], 'increasing': [1611], 'portion': [1612], 'genes': [1615, 1820], 'organisms': [1617], 'had': [1619], 'reliably': [1623], 'modeled': [1624], '(30Fischer': [1628], 'Assigning': [1632], 'Mycoplasma': [1642], 'genitalium.Proc.': [1643], '94:': [1651], '11929-11934Crossref': [1652], '(0)': [1655, 1676, 1705, 2211, 2637, 2656, 2684, 2713, 3776, 4015, 4101], '31Sanchez': [1658], 'Sali': [1660, 3240], 'Evaluation': [1662, 3268], 'comparative': [1664], 'MODELLER-3.Proteins.': [1669], 'Suppl.': [1671], '1:': [1672, 3278], '50-58Crossref': [1673], '32Zhang': [1679], 'Skolnick': [1681, 2661, 3348], 'Automated': [1683], 'weakly': [1687], 'genomic': [1692], 'scale.Proc.': [1693], '101:': [1701], '7594-7599Crossref': [1702], '33Malmstrom': [1708], 'Riffle': [1710], 'Strauss': [1712], 'C.E.': [1713], 'Chivian': [1714, 1978], 'Davis': [1716], 'Bonneau': [1718], 'Superfamily': [1722], 'assignments': [1723], 'yeast': [1726], 'proteome': [1727], 'integration': [1729], 'gene': [1735], 'ontology.PLoS': [1736], '2007;': [1738, 2912], '5e76Crossref': [1739], '(40)': [1742], '34Mukherjee': [1745], 'Szilagyi': [1747], 'Genome-wide': [1753], 'prediction.in:': [1756], 'Kolniski': [1757], 'Multiscale': [1759], 'Approaches': [1760], 'Modeling:': [1763], 'Structure': [1764, 3304, 3742, 3847], 'Prediction,': [1765], 'Dynamics,': [1766], 'Thermodynamics': [1767], 'Macromolecular': [1769], 'Assemblies.': [1770], 'Springer-London,': [1771], 'NY2010:': [1774], '810-842Google': [1775], '35Xu': [1777], 'Initio': [1782], 'Escherichia': [1786], 'coli:': [1787], 'Towards': [1788], 'genome-wide': [1789], 'assignment.Sci.': [1795], 'Rep.': [1796], '3:': [1798], '1895Crossref': [1799], '36Zhang': [1805], 'Zheng': [1807, 2340], 'Cheng': [1809, 2082], 'Omenn': [1811], 'G.S.': [1812], 'Freddolino': [1813, 2183], 'P.L.': [1814], 'Functions': [1817], 'essential': [1819], 'scale-free': [1823], 'interaction': [1825, 1832, 2754], 'network': [1826, 2247], 'revealed': [1827], 'structure-based': [1829, 2171, 2788], 'minimal': [1836], 'genome.J.': [1837], 'Proteome': [1838, 2375], '2021;': [1840, 2599], '20:': [1841, 2704], '1178-1189Crossref': [1842], '(1)': [1845, 2604, 2826], 'In': [1848, 2899, 4018, 4053], 'addition,': [1849], 'numerous': [1850], 'high-quality': [1851], 'models': [1853, 3077, 3150, 3177, 3475, 3613], 'being': [1855], 'created': [1856], 'day': [1858], 'online': [1860], 'systems': [1863], '(22Roy': [1864], '37Kim': [1976], 'analysis': [1986, 2386], 'Robetta': [1989], 'server.Nucleic': [1990, 2040], '32:': [1994, 2454], 'W526-W531Crossref': [1995], '(1116)': [1998], '38Kelley': [2001], 'L.A.': [2002, 3748], 'Sternberg': [2003], 'web:': [2010], 'case': [2012], 'Phyre': [2016], 'server.Nat.': [2017, 2128], '4:': [2020, 2523], '363-371Crossref': [2021], '(3472)': [2024], '39Schwede': [2027], 'Kopp': [2029], 'Guex': [2031], 'Peitsch': [2033], 'SWISS-MODEL:': [2035], 'homology-modeling': [2039], '2003;': [2043], '31:': [2044], '3381-3385Crossref': [2045], '(4288)': [2048], '40Soding': [2051], 'Biegert': [2053], 'Lupas': [2055], 'A.N.': [2056], 'HHpred': [2058], 'interactive': [2059], 'server': [2060], 'homology': [2063, 2628, 2871], 'detection': [2064], 'prediction.Nucleic': [2067], 'W244-248Crossref': [2072], '(2432)': [2075], '41Wang': [2078], 'Eickholt': [2080], 'MULTICOM:': [2084], 'multi-level': [2086], 'combination': [2087], 'assessments': [2095], 'CASP8.Bioinformatics.': [2097], '26:': [2099], '882-888Crossref': [2100], '(72)': [2103], '42Källberg': [2106], 'Wang': [2108, 2110, 2114, 2955, 2965, 2977], 'Lu': [2116], 'Template-based': [2120, 3287], 'RaptorX': [2126], 'web': [2127], '7:': [2131], '1511-1522Crossref': [2132], '(1010)': [2135], '43Xu': [2138], 'Distance-based': [2140], 'powered': [2143], 'learning.Proc.': [2146], '116:': [2154], '16856-16865Crossref': [2155], '(125)': [2158], 'used': [2164, 3433], 'assist': [2166], 'studies,': [2169], 'including': [2170], 'annotation': [2174, 2279], '(44Vaidehi': [2175], 'Floriano': [2177], 'W.B.': [2178], 'Trabanino': [2179], 'Hall': [2181], 'S.E.': [2182], 'Choi': [2185], 'E.J.': [2186], 'Zamanakos': [2187], 'Goddard': [2189], 'W.A.': [2190], 'Prediction': [2191], 'G': [2197], 'protein-coupled': [2198], 'receptors.Proc.': [2199], '2002;': [2206], '99:': [2207], '12622-12627Crossref': [2208], '45Zhang': [2214], 'Thiele': [2216], 'Weekes': [2218], 'Jaroszewski': [2222], 'Ginalski': 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