Publication Information

{'id': 'https://openalex.org/W2058542300', 'doi': 'https://doi.org/10.2174/092986612803217015', 'title': 'Principles, Challenges and Advances in ab initio Protein Structure Prediction', 'display_name': 'Principles, Challenges and Advances in ab initio Protein Structure Prediction', 'publication_year': 2012, 'publication_date': '2012-09-01', 'ids': {'openalex': 'https://openalex.org/W2058542300', 'doi': 'https://doi.org/10.2174/092986612803217015', 'mag': '2058542300', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22587787'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/092986612803217015', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3577691', 'display_name': 'Protein and Peptide Letters', 'issn_l': '0929-8665', 'issn': ['0929-8665', '1875-5305'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5058052530', 'display_name': 'J. Arunachalam', 'orcid': 'https://orcid.org/0000-0002-1281-6336'}, 'institutions': [{'id': 'https://openalex.org/I932239252', 'display_name': 'SASTRA University', 'ror': 'https://ror.org/032jk8892', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I932239252']}], 'countries': ['IN'], 'is_corresponding': True, 'raw_author_name': 'Arunachalam Jothi', 'raw_affiliation_strings': ['Department of Bioinformatics, SCBT, SASTRA University, Thanjavur, India.'], 'affiliations': [{'raw_affiliation_string': 'Department of Bioinformatics, SCBT, SASTRA University, Thanjavur, India.', 'institution_ids': ['https://openalex.org/I932239252']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5058052530'], 'corresponding_institution_ids': ['https://openalex.org/I932239252'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.637, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 24, 'citation_normalized_percentile': {'value': 0.893545, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '19', 'issue': '11', 'first_page': '1194', 'last_page': '1204'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10044', 'display_name': 'Protein Structure and Dynamics', 'score': 0.9951, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10044', 'display_name': 'Protein Structure and Dynamics', 'score': 0.9951, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11162', 'display_name': 'Enzyme Structure and Function', 'score': 0.9829, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T13937', 'display_name': 'Genetics, Bioinformatics, and Biomedical Research', 'score': 0.9096, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/casp', 'display_name': 'CASP', 'score': 0.83914876}, {'id': 'https://openalex.org/keywords/sequence', 'display_name': 'Sequence (biology)', 'score': 0.41216642}], 'concepts': [{'id': 'https://openalex.org/C18051474', 'wikidata': 'https://www.wikidata.org/wiki/Q899656', 'display_name': 'Protein structure prediction', 'level': 3, 'score': 0.8481599}, {'id': 'https://openalex.org/C66153294', 'wikidata': 'https://www.wikidata.org/wiki/Q899291', 'display_name': 'CASP', 'level': 4, 'score': 0.83914876}, {'id': 'https://openalex.org/C2781442258', 'wikidata': 'https://www.wikidata.org/wiki/Q46310', 'display_name': 'Ab initio', 'level': 2, 'score': 0.808188}, {'id': 'https://openalex.org/C47701112', 'wikidata': 'https://www.wikidata.org/wiki/Q735188', 'display_name': 'Protein structure', 'level': 2, 'score': 0.6006752}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.45556286}, {'id': 'https://openalex.org/C2778112365', 'wikidata': 'https://www.wikidata.org/wiki/Q3511065', 'display_name': 'Sequence (biology)', 'level': 2, 'score': 0.41216642}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.40975028}, {'id': 'https://openalex.org/C147597530', 'wikidata': 'https://www.wikidata.org/wiki/Q369472', 'display_name': 'Computational chemistry', 'level': 1, 'score': 0.37685895}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.27572182}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.20050704}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.066652596}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D019295', 'descriptor_name': 'Computational Biology', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000465', 'descriptor_name': 'Algorithms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019295', 'descriptor_name': 'Computational Biology', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056004', 'descriptor_name': 'Molecular Dynamics Simulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009010', 'descriptor_name': 'Monte Carlo Method', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017510', 'descriptor_name': 'Protein Folding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013816', 'descriptor_name': 'Thermodynamics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/092986612803217015', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3577691', 'display_name': 'Protein and Peptide Letters', 'issn_l': '0929-8665', 'issn': ['0929-8665', '1875-5305'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22587787', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.85, 'display_name': 'Affordable and clean energy', 'id': 'https://metadata.un.org/sdg/7'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4280569813', 'https://openalex.org/W4248328359', 'https://openalex.org/W4210958064', 'https://openalex.org/W2946599741', 'https://openalex.org/W2943955904', 'https://openalex.org/W2782554660', 'https://openalex.org/W2154436290', 'https://openalex.org/W2058542300', 'https://openalex.org/W2054063760', 'https://openalex.org/W1998728673'], 'abstract_inverted_index': {'The': [0, 85], 'gap': [1], 'between': [2], 'known': [3, 113], 'protein': [4, 34, 57, 78, 90, 101, 129, 160, 184, 190], 'sequences': [5, 50], 'and': [6, 11, 120, 145, 178], 'structures': [7], 'is': [8, 26], 'increasing': [9], 'rapidly': [10], 'experimental': [12, 74], 'methods': [13, 31, 39, 86, 116, 141, 163], 'alone': [14], 'will': [15], 'not': [16, 67], 'be': [17, 41, 83], 'able': [18], 'to': [19, 28, 32, 95, 122], 'fill': [20], 'in': [21, 154], 'this': [22], 'gap.': [23], 'Therefore': [24], 'it': [25], 'necessary': [27], 'use': [29, 110, 117], 'computational': [30], 'predict': [33, 96], 'structures.': [35, 58, 114], 'Template': [36], 'based': [37], 'modeling': [38], 'could': [40], 'used': [42], 'for': [43], 'sequences,': [44], 'which': [45, 65], 'have': [46], 'detectable': [47, 70], 'relationship': [48, 72], 'with': [49, 73], 'of': [51, 63, 99, 111, 127, 134, 157, 181], 'one': [52], 'or': [53], 'more': [54], 'experimentally': [55], 'determined': [56], 'For': [59], 'predicting': [60], 'the': [61, 97, 103, 124, 131, 155, 165, 172, 175], 'structure': [62, 79, 91, 98, 126, 161, 185, 191], 'proteins,': [64], 'does': [66], 'share': [68], 'a': [69, 100, 128, 135], 'sequence': [71, 104], 'structures,': [75], 'ab': [76, 88, 158, 182, 188], 'initio': [77, 89, 183, 189], 'prediction': [80, 92, 162], 'techniques': [81], 'must': [82], 'used.': [84], 'under': [87], 'category': [93], 'aim': [94], 'from': [102], 'information': [105], 'alone,': [106], 'without': [107], 'any': [108], 'explicit': [109], 'previously': [112], 'These': [115], 'thermodynamic': [118], 'principles': [119], 'try': [121], 'identify': [123], 'native': [125], 'as': [130], 'global': [132, 198], 'minimum': [133, 199], 'potential': [136, 205], 'energy': [137, 196, 206], 'landscape.': [138], 'However,': [139], 'such': [140], 'are': [142, 146], 'computationally': [143], 'complex': [144], 'extraordinarily': [147], 'challenging.': [148], 'There': [149], 'has': [150], 'been': [151], 'significant': [152], 'progress': [153], 'development': [156], 'inito': [159], 'over': [164], 'past': [166], 'few': [167], 'years.': [168], 'This': [169], 'review': [170], 'describes': [171], 'basic': [173], 'principles,': [174], 'complexity,': [176], 'challenges': [177], 'recent': [179], 'progresses': [180], 'prediction.': [186], 'Keywords:': [187], 'prediction,': [192], 'CASP;': [193], 'conformational': [194], 'search,': [195], 'functions,': [197], 'structure,': [200], 'local': [201], 'minimum,': [202], 'optimization': [203], 'methods,': [204], 'surface.': [207]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2058542300', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-17T11:47:08.480874', 'created_date': '2016-06-24'}