Publication Information

{'id': 'https://openalex.org/W3158931776', 'doi': 'https://doi.org/10.3390/toxins13050327', 'title': 'Efflux at the Blood-Brain Barrier Reduces the Cerebral Exposure to Ochratoxin A, Ochratoxin α, Citrinin and Dihydrocitrinone', 'display_name': 'Efflux at the Blood-Brain Barrier Reduces the Cerebral Exposure to Ochratoxin A, Ochratoxin α, Citrinin and Dihydrocitrinone', 'publication_year': 2021, 'publication_date': '2021-04-30', 'ids': {'openalex': 'https://openalex.org/W3158931776', 'doi': 'https://doi.org/10.3390/toxins13050327', 'mag': '3158931776', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/33946578', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/8147254'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/toxins13050327', 'pdf_url': 'https://www.mdpi.com/2072-6651/13/5/327/pdf', 'source': {'id': 'https://openalex.org/S128990672', 'display_name': 'Toxins', 'issn_l': '2072-6651', 'issn': ['2072-6651'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/2072-6651/13/5/327/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5002804722', 'display_name': 'Matthias Behrens', 'orcid': 'https://orcid.org/0000-0001-5425-8144'}, 'institutions': [{'id': 'https://openalex.org/I22465464', 'display_name': 'University of Münster', 'ror': 'https://ror.org/00pd74e08', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I22465464']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Matthias Behrens', 'raw_affiliation_strings': ['Institute of Food Chemistry, Westfälische Wilhelms-Universität Münster, 48149 Münster, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Food Chemistry, Westfälische Wilhelms-Universität Münster, 48149 Münster, Germany', 'institution_ids': ['https://openalex.org/I22465464']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008467504', 'display_name': 'Sabine Hüwel', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I22465464', 'display_name': 'University of Münster', 'ror': 'https://ror.org/00pd74e08', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I22465464']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Sabine Hüwel', 'raw_affiliation_strings': ['Institute of Biochemistry, Westfälische Wilhelms-Universität Münster, 48149 Münster, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Biochemistry, Westfälische Wilhelms-Universität Münster, 48149 Münster, Germany', 'institution_ids': ['https://openalex.org/I22465464']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000919967', 'display_name': 'Hans‐Joachim Galla', 'orcid': 'https://orcid.org/0000-0003-1018-052X'}, 'institutions': [{'id': 'https://openalex.org/I22465464', 'display_name': 'University of Münster', 'ror': 'https://ror.org/00pd74e08', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I22465464']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Hans-Joachim Galla', 'raw_affiliation_strings': ['Institute of Biochemistry, Westfälische Wilhelms-Universität Münster, 48149 Münster, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Biochemistry, Westfälische Wilhelms-Universität Münster, 48149 Münster, Germany', 'institution_ids': ['https://openalex.org/I22465464']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5014265498', 'display_name': 'Hans‐Ulrich Humpf', 'orcid': 'https://orcid.org/0000-0003-3296-3058'}, 'institutions': [{'id': 'https://openalex.org/I22465464', 'display_name': 'University of Münster', 'ror': 'https://ror.org/00pd74e08', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I22465464']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Hans-Ulrich Humpf', 'raw_affiliation_strings': ['Institute of Food Chemistry, Westfälische Wilhelms-Universität Münster, 48149 Münster, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Food Chemistry, Westfälische Wilhelms-Universität Münster, 48149 Münster, Germany', 'institution_ids': ['https://openalex.org/I22465464']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5014265498'], 'corresponding_institution_ids': ['https://openalex.org/I22465464'], 'apc_list': {'value': 2400, 'currency': 'CHF', 'value_usd': 2598, 'provenance': 'doaj'}, 'apc_paid': {'value': 1287, 'currency': 'EUR', 'value_usd': 1388, 'provenance': 'openapc'}, 'fwci': 1.586, 'has_fulltext': False, 'cited_by_count': 12, 'citation_normalized_percentile': {'value': 0.74583, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '13', 'issue': '5', 'first_page': '327', 'last_page': '327'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10520', 'display_name': 'Mycotoxins in Agriculture and Food', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10520', 'display_name': 'Mycotoxins in Agriculture and Food', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10433', 'display_name': 'Carcinogens and Genotoxicity Assessment', 'score': 0.9913, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11872', 'display_name': 'Barrier Structure and Function Studies', 'score': 0.9874, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/citrinin', 'display_name': 'Citrinin', 'score': 0.9576192}, {'id': 'https://openalex.org/keywords/ochratoxin', 'display_name': 'Ochratoxins', 'score': 0.76351476}, {'id': 'https://openalex.org/keywords/efflux', 'display_name': 'Efflux', 'score': 0.5697636}, {'id': 'https://openalex.org/keywords/neurotoxicity', 'display_name': 'Neurotoxicity', 'score': 0.50734895}], 'concepts': [{'id': 'https://openalex.org/C2776008721', 'wikidata': 'https://www.wikidata.org/wiki/Q1885038', 'display_name': 'Ochratoxin A', 'level': 3, 'score': 0.9603489}, {'id': 'https://openalex.org/C2777064906', 'wikidata': 'https://www.wikidata.org/wiki/Q420354', 'display_name': 'Citrinin', 'level': 3, 'score': 0.9576192}, {'id': 'https://openalex.org/C2779459076', 'wikidata': 'https://www.wikidata.org/wiki/Q411901', 'display_name': 'Ochratoxin', 'level': 4, 'score': 0.76351476}, {'id': 'https://openalex.org/C2778402981', 'wikidata': 'https://www.wikidata.org/wiki/Q221694', 'display_name': 'Blood–brain barrier', 'level': 3, 'score': 0.70594144}, {'id': 'https://openalex.org/C84699730', 'wikidata': 'https://www.wikidata.org/wiki/Q422449', 'display_name': 'Mycotoxin', 'level': 2, 'score': 0.6669371}, {'id': 'https://openalex.org/C200082930', 'wikidata': 'https://www.wikidata.org/wiki/Q22327148', 'display_name': 'Efflux', 'level': 2, 'score': 0.5697636}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.55019486}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.5240415}, {'id': 'https://openalex.org/C2779491297', 'wikidata': 'https://www.wikidata.org/wiki/Q3338704', 'display_name': 'Neurotoxicity', 'level': 3, 'score': 0.50734895}, {'id': 'https://openalex.org/C2777367657', 'wikidata': 'https://www.wikidata.org/wiki/Q184651', 'display_name': 'Toxin', 'level': 2, 'score': 0.49719146}, {'id': 'https://openalex.org/C29730261', 'wikidata': 'https://www.wikidata.org/wiki/Q274160', 'display_name': 'Toxicity', 'level': 2, 'score': 0.4422448}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.3369636}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.30082503}, {'id': 'https://openalex.org/C31903555', 'wikidata': 'https://www.wikidata.org/wiki/Q1637030', 'display_name': 'Food science', 'level': 1, 'score': 0.2490297}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.20952526}, {'id': 'https://openalex.org/C529278444', 'wikidata': 'https://www.wikidata.org/wiki/Q47273', 'display_name': 'Central nervous system', 'level': 2, 'score': 0.14772272}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/toxins13050327', 'pdf_url': 'https://www.mdpi.com/2072-6651/13/5/327/pdf', 'source': {'id': 'https://openalex.org/S128990672', 'display_name': 'Toxins', 'issn_l': '2072-6651', 'issn': ['2072-6651'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/33f41e9938ce46e5a23ebafcc473e048', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://dx.doi.org/10.3390/toxins13050327', 'pdf_url': 'https://www.mdpi.com/2072-6651/13/5/327/pdf?version=1620286731', 'source': {'id': 'https://openalex.org/S4306400947', 'display_name': 'MDPI (MDPI AG)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210097602', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute (Switzerland)', 'host_organization_lineage': ['https://openalex.org/I4210097602'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute (Switzerland)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147254', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/toxins13050327', 'pdf_url': 'https://www.mdpi.com/2072-6651/13/5/327/pdf', 'source': {'id': 'https://openalex.org/S128990672', 'display_name': 'Toxins', 'issn_l': '2072-6651', 'issn': ['2072-6651'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 66, 'referenced_works': ['https://openalex.org/W147557705', 'https://openalex.org/W1579426814', 'https://openalex.org/W1968313531', 'https://openalex.org/W1971157934', 'https://openalex.org/W1973410835', 'https://openalex.org/W1973485004', 'https://openalex.org/W1973495421', 'https://openalex.org/W1973714454', 'https://openalex.org/W1975715586', 'https://openalex.org/W1976169273', 'https://openalex.org/W1978632356', 'https://openalex.org/W1982730947', 'https://openalex.org/W1984970076', 'https://openalex.org/W1985464285', 'https://openalex.org/W1986754635', 'https://openalex.org/W2003799525', 'https://openalex.org/W2005170411', 'https://openalex.org/W2005763057', 'https://openalex.org/W2006161539', 'https://openalex.org/W2007327291', 'https://openalex.org/W2011595626', 'https://openalex.org/W2015541518', 'https://openalex.org/W2016505105', 'https://openalex.org/W2020484676', 'https://openalex.org/W2024709028', 'https://openalex.org/W2025501309', 'https://openalex.org/W2028943470', 'https://openalex.org/W2031169064', 'https://openalex.org/W2034576932', 'https://openalex.org/W2034930349', 'https://openalex.org/W2037984580', 'https://openalex.org/W2044759309', 'https://openalex.org/W2050555390', 'https://openalex.org/W2056678236', 'https://openalex.org/W2059718647', 'https://openalex.org/W2067846830', 'https://openalex.org/W2068337543', 'https://openalex.org/W2079242039', 'https://openalex.org/W2083589308', 'https://openalex.org/W2091272720', 'https://openalex.org/W2093634741', 'https://openalex.org/W2093854522', 'https://openalex.org/W2094136471', 'https://openalex.org/W2095064844', 'https://openalex.org/W2098924785', 'https://openalex.org/W2103003264', 'https://openalex.org/W2103307767', 'https://openalex.org/W2104939594', 'https://openalex.org/W2109239846', 'https://openalex.org/W2109824567', 'https://openalex.org/W2113415151', 'https://openalex.org/W2127955110', 'https://openalex.org/W2143860657', 'https://openalex.org/W2145975509', 'https://openalex.org/W2149567003', 'https://openalex.org/W2159821105', 'https://openalex.org/W2167011079', 'https://openalex.org/W2169092074', 'https://openalex.org/W2173023263', 'https://openalex.org/W2182751001', 'https://openalex.org/W2253779935', 'https://openalex.org/W2482018841', 'https://openalex.org/W2808785825', 'https://openalex.org/W2947256805', 'https://openalex.org/W2952294913', 'https://openalex.org/W69018839'], 'related_works': ['https://openalex.org/W4236651465', 'https://openalex.org/W3212402077', 'https://openalex.org/W3158931776', 'https://openalex.org/W2246143721', 'https://openalex.org/W2157375478', 'https://openalex.org/W2073275769', 'https://openalex.org/W2034100173', 'https://openalex.org/W1982831609', 'https://openalex.org/W165403482', 'https://openalex.org/W1521632858'], 'abstract_inverted_index': {'Recent': [0], 'studies': [1], 'have': [2], 'implied': [3], 'that': [4], 'environmental': [5], 'toxins,': [6], 'such': [7], 'as': [8, 19], 'mycotoxins,': [9], 'are': [10], 'risk': [11], 'factors': [12], 'for': [13], 'neurodegenerative': [14], 'diseases.': [15], 'To': [16], 'act': [17], 'directly': [18], 'neurotoxins,': [20], 'mycotoxins': [21, 96], 'need': [22], 'to': [23, 75, 133, 138, 144, 158, 182], 'penetrate': [24], 'or': [25, 78], 'affect': [26], 'the': [27, 30, 35, 51, 54, 95, 98, 142, 145, 163], 'integrity': [28], 'of': [29, 48, 57, 81, 94, 114, 168], 'blood-brain': [31, 164], 'barrier,': [32, 165], 'which': [33], 'protects': [34], 'mammalian': [36], 'brain': [37, 69, 103, 146], 'from': [38, 153], 'potentially': [39], 'harmful': [40], 'substances.': [41], 'As': [42], 'common': [43, 191], 'food': [44], 'and': [45, 61, 87, 91, 119, 126, 174, 178], 'feed': [46], 'contaminants': [47], 'fungal': [49], 'origin,': [50], 'interest': [52], 'in': [53, 187], 'potential': [55], 'neurotoxicity': [56, 179], 'ochratoxin': [58, 82, 84, 123, 169, 171], 'A,': [59, 83, 170], 'citrinin': [60, 86, 125, 173], 'their': [62, 154, 159, 188], 'metabolites': [63], 'has': [64], 'recently': [65], 'increased.': [66], 'Primary': [67], 'porcine': [68, 102], 'capillary': [70, 104], 'endothelial': [71, 105], 'cells': [72], 'were': [73, 108], 'used': [74], 'investigate': [76], 'cytotoxic': [77, 118], 'barrier-weakening': [79, 120], 'effects': [80, 131], 'α,': [85, 124, 172], 'dihydrocitrinone.': [88], 'The': [89], 'transfer': [90, 143, 161], 'transport': [92], 'properties': [93], 'across': [97, 162], 'barrier': [99], 'formed': [100], 'by': [101], 'cell': [106], 'monolayers': [107], 'analysed': [109], 'using': [110], 'HPLC-MS/MS.': [111], 'High': [112], 'levels': [113], 'Ochratoxin': [115], 'A': [116], 'caused': [117], 'effects,': [121], 'whereas': [122], 'dihydrocitrinone': [127, 175], 'showed': [128], 'no': [129], 'adverse': [130], 'up': [132], '10': [134], 'µM.': [135], 'Likely': [136], 'due': [137], 'efflux': [139], 'transporter': [140], 'proteins,': [141], 'compartment': [147], 'was': [148], 'much': [149], 'slower': [150], 'than': [151], 'expected': [152], 'high': [155], 'lipophilicity.': [156], 'Due': [157], 'slow': [160], 'cerebral': [166], 'exposure': [167], 'is': [176, 180], 'low': [177], 'likely': [181], 'play': [183], 'a': [184], 'subordinate': [185], 'role': [186], 'toxicity': [189], 'at': [190], 'physiological': [192], 'concentrations.': [193]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3158931776', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 3}], 'updated_date': '2024-12-10T09:44:52.325331', 'created_date': '2021-05-10'}