Title: POS-374 PROXIMITY INTERACTION NETWORKS OF THE RHO-FAMILY OF SMALL GTPASES IN PODOCYTES.
Abstract:The Rho family of small GTPases plays a critical role in the regulation of podocyte cytoskeleton, and their alteration leads to foot-process effacement and the disruption of the filtration-barrier fun...The Rho family of small GTPases plays a critical role in the regulation of podocyte cytoskeleton, and their alteration leads to foot-process effacement and the disruption of the filtration-barrier function. However, the underlying regulatory mechanisms and the signaling networks of Rho GTPases in podocytes are still largely unknown. Therefore, we sought to investigate the interactome of the prototypical Rho GTPases (Rac1, CDC42 and RhoA) in human podocytes.Read More