Publication Information

{'id': 'https://openalex.org/W2161522518', 'doi': 'https://doi.org/10.1158/1541-7786.mcr-11-0616', 'title': 'Cdc42 and the Guanine Nucleotide Exchange Factors Ect2 and Trio Mediate Fn14-Induced Migration and Invasion of Glioblastoma Cells', 'display_name': 'Cdc42 and the Guanine Nucleotide Exchange Factors Ect2 and Trio Mediate Fn14-Induced Migration and Invasion of Glioblastoma Cells', 'publication_year': 2012, 'publication_date': '2012-05-10', 'ids': {'openalex': 'https://openalex.org/W2161522518', 'doi': 'https://doi.org/10.1158/1541-7786.mcr-11-0616', 'mag': '2161522518', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22571869', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3516844'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1541-7786.mcr-11-0616', 'pdf_url': 'https://mcr.aacrjournals.org/content/molcanres/10/7/958.full.pdf', 'source': {'id': 'https://openalex.org/S192067876', 'display_name': 'Molecular Cancer Research', 'issn_l': '1541-7786', 'issn': ['1541-7786', '1557-3125'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://mcr.aacrjournals.org/content/molcanres/10/7/958.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5051376334', 'display_name': 'Shannon P. Fortin Ensign', 'orcid': 'https://orcid.org/0000-0002-7433-528X'}, 'institutions': [{'id': 'https://openalex.org/I1327576362', 'display_name': 'Feinstein Institute for Medical Research', 'ror': 'https://ror.org/05dnene97', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1302444339', 'https://openalex.org/I1327576362']}, {'id': 'https://openalex.org/I1284308235', 'display_name': 'Translational Genomics Research Institute', 'ror': 'https://ror.org/02hfpnk21', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1284308235']}, {'id': 'https://openalex.org/I4210125099', 'display_name': 'Mayo Clinic in Arizona', 'ror': 'https://ror.org/03jp40720', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723', 'https://openalex.org/I4210125099']}, {'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}, {'id': 'https://openalex.org/I1317189400', 'display_name': 'Van Andel Institute', 'ror': 'https://ror.org/00wm07d60', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1317189400']}, {'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shannon P. Fortin', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix; 2Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona; 3Van Andel Research Institute, Grand Rapids, Michigan; 4University of Maryland School of Medicine, Baltimore, Maryland; 5Mayo Clinic, Scottsdale, Arizona; and 6Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York", 'Mayo Clinic, Scottsdale, Arizona', 'University of Maryland School of Medicine, Baltimore, Maryland', 'Van Andel Research Institute, Grand Rapids, Michigan'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix; 2Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona; 3Van Andel Research Institute, Grand Rapids, Michigan; 4University of Maryland School of Medicine, Baltimore, Maryland; 5Mayo Clinic, Scottsdale, Arizona; and 6Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York", 'institution_ids': ['https://openalex.org/I1327576362', 'https://openalex.org/I1284308235', 'https://openalex.org/I4210125099', 'https://openalex.org/I126744593', 'https://openalex.org/I1327576362', 'https://openalex.org/I1284308235', 'https://openalex.org/I4210125099', 'https://openalex.org/I126744593', 'https://openalex.org/I138006243', 'https://openalex.org/I138006243']}, {'raw_affiliation_string': 'Mayo Clinic, Scottsdale, Arizona', 'institution_ids': ['https://openalex.org/I4210125099']}, {'raw_affiliation_string': 'University of Maryland School of Medicine, Baltimore, Maryland', 'institution_ids': ['https://openalex.org/I126744593']}, {'raw_affiliation_string': 'Van Andel Research Institute, Grand Rapids, Michigan', 'institution_ids': ['https://openalex.org/I1317189400']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014754286', 'display_name': 'Matthew Ennis', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1327576362', 'display_name': 'Feinstein Institute for Medical Research', 'ror': 'https://ror.org/05dnene97', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1302444339', 'https://openalex.org/I1327576362']}, {'id': 'https://openalex.org/I1284308235', 'display_name': 'Translational Genomics Research Institute', 'ror': 'https://ror.org/02hfpnk21', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1284308235']}, {'id': 'https://openalex.org/I4210125099', 'display_name': 'Mayo Clinic in Arizona', 'ror': 'https://ror.org/03jp40720', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723', 'https://openalex.org/I4210125099']}, {'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}, {'id': 'https://openalex.org/I1317189400', 'display_name': 'Van Andel Institute', 'ror': 'https://ror.org/00wm07d60', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1317189400']}, {'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Matthew J. Ennis', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix; 2Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona; 3Van Andel Research Institute, Grand Rapids, Michigan; 4University of Maryland School of Medicine, Baltimore, Maryland; 5Mayo Clinic, Scottsdale, Arizona; and 6Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York", 'Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona', 'Mayo Clinic, Scottsdale, Arizona', 'University of Maryland School of Medicine, Baltimore, Maryland', 'Van Andel Research Institute, Grand Rapids, Michigan'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix; 2Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona; 3Van Andel Research Institute, Grand Rapids, Michigan; 4University of Maryland School of Medicine, Baltimore, Maryland; 5Mayo Clinic, Scottsdale, Arizona; and 6Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York", 'institution_ids': ['https://openalex.org/I1327576362', 'https://openalex.org/I1284308235', 'https://openalex.org/I4210125099', 'https://openalex.org/I126744593', 'https://openalex.org/I138006243']}, {'raw_affiliation_string': 'Mayo Clinic, Scottsdale, Arizona', 'institution_ids': ['https://openalex.org/I4210125099']}, {'raw_affiliation_string': 'University of Maryland School of Medicine, Baltimore, Maryland', 'institution_ids': ['https://openalex.org/I126744593']}, {'raw_affiliation_string': 'Van Andel Research Institute, Grand Rapids, Michigan', 'institution_ids': ['https://openalex.org/I1317189400']}, {'raw_affiliation_string': 'Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona', 'institution_ids': ['https://openalex.org/I138006243']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113752391', 'display_name': 'Cassie Schumacher', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}, {'id': 'https://openalex.org/I1327576362', 'display_name': 'Feinstein Institute for Medical Research', 'ror': 'https://ror.org/05dnene97', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1302444339', 'https://openalex.org/I1327576362']}, {'id': 'https://openalex.org/I1284308235', 'display_name': 'Translational Genomics Research Institute', 'ror': 'https://ror.org/02hfpnk21', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1284308235']}, {'id': 'https://openalex.org/I4210125099', 'display_name': 'Mayo Clinic in Arizona', 'ror': 'https://ror.org/03jp40720', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723', 'https://openalex.org/I4210125099']}, {'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}, {'id': 'https://openalex.org/I1317189400', 'display_name': 'Van Andel Institute', 'ror': 'https://ror.org/00wm07d60', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1317189400']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Cassie A. Schumacher', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix; 2Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona; 3Van Andel Research Institute, Grand Rapids, Michigan; 4University of Maryland School of Medicine, Baltimore, Maryland; 5Mayo Clinic, Scottsdale, Arizona; and 6Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York", 'Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona', 'Mayo Clinic, Scottsdale, Arizona', 'University of Maryland School of Medicine, Baltimore, Maryland', 'Van Andel Research Institute, Grand Rapids, Michigan'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix; 2Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona; 3Van Andel Research Institute, Grand Rapids, Michigan; 4University of Maryland School of Medicine, Baltimore, Maryland; 5Mayo Clinic, Scottsdale, Arizona; and 6Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York", 'institution_ids': ['https://openalex.org/I138006243', 'https://openalex.org/I1327576362', 'https://openalex.org/I1284308235', 'https://openalex.org/I4210125099', 'https://openalex.org/I126744593']}, {'raw_affiliation_string': 'Mayo Clinic, Scottsdale, Arizona', 'institution_ids': ['https://openalex.org/I4210125099']}, {'raw_affiliation_string': 'University of Maryland School of Medicine, Baltimore, Maryland', 'institution_ids': ['https://openalex.org/I126744593']}, {'raw_affiliation_string': 'Van Andel Research Institute, Grand Rapids, Michigan', 'institution_ids': ['https://openalex.org/I1317189400']}, {'raw_affiliation_string': 'Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona', 'institution_ids': ['https://openalex.org/I138006243']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024322246', 'display_name': 'Cassandra R. Diegel', 'orcid': 'https://orcid.org/0000-0002-6526-9372'}, 'institutions': [{'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}, {'id': 'https://openalex.org/I1327576362', 'display_name': 'Feinstein Institute for Medical Research', 'ror': 'https://ror.org/05dnene97', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1302444339', 'https://openalex.org/I1327576362']}, {'id': 'https://openalex.org/I1284308235', 'display_name': 'Translational Genomics Research Institute', 'ror': 'https://ror.org/02hfpnk21', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1284308235']}, {'id': 'https://openalex.org/I4210125099', 'display_name': 'Mayo Clinic in Arizona', 'ror': 'https://ror.org/03jp40720', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723', 'https://openalex.org/I4210125099']}, {'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}, {'id': 'https://openalex.org/I1317189400', 'display_name': 'Van Andel Institute', 'ror': 'https://ror.org/00wm07d60', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1317189400']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Cassandra R. Zylstra-Diegel', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix; 2Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona; 3Van Andel Research Institute, Grand Rapids, Michigan; 4University of Maryland School of Medicine, Baltimore, Maryland; 5Mayo Clinic, Scottsdale, Arizona; and 6Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York", 'Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona', 'Mayo Clinic, Scottsdale, Arizona', 'University of Maryland School of Medicine, Baltimore, Maryland', 'Van Andel Research Institute, Grand Rapids, Michigan'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix; 2Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona; 3Van Andel Research Institute, Grand Rapids, Michigan; 4University of Maryland School of Medicine, Baltimore, Maryland; 5Mayo Clinic, Scottsdale, Arizona; and 6Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York", 'institution_ids': ['https://openalex.org/I138006243', 'https://openalex.org/I1327576362', 'https://openalex.org/I1284308235', 'https://openalex.org/I4210125099', 'https://openalex.org/I126744593']}, {'raw_affiliation_string': 'Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona', 'institution_ids': ['https://openalex.org/I138006243']}, {'raw_affiliation_string': 'Mayo Clinic, Scottsdale, Arizona', 'institution_ids': ['https://openalex.org/I4210125099']}, {'raw_affiliation_string': 'University of Maryland School of Medicine, Baltimore, Maryland', 'institution_ids': ['https://openalex.org/I126744593']}, {'raw_affiliation_string': 'Van Andel Research Institute, Grand Rapids, Michigan', 'institution_ids': ['https://openalex.org/I1317189400']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035423584', 'display_name': 'Bart O. Williams', 'orcid': 'https://orcid.org/0000-0002-5261-5301'}, 'institutions': [{'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}, {'id': 'https://openalex.org/I1327576362', 'display_name': 'Feinstein Institute for Medical Research', 'ror': 'https://ror.org/05dnene97', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1302444339', 'https://openalex.org/I1327576362']}, {'id': 'https://openalex.org/I1284308235', 'display_name': 'Translational Genomics Research Institute', 'ror': 'https://ror.org/02hfpnk21', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1284308235']}, {'id': 'https://openalex.org/I4210125099', 'display_name': 'Mayo Clinic in Arizona', 'ror': 'https://ror.org/03jp40720', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723', 'https://openalex.org/I4210125099']}, {'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}, {'id': 'https://openalex.org/I1317189400', 'display_name': 'Van Andel Institute', 'ror': 'https://ror.org/00wm07d60', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1317189400']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bart O. Williams', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix; 2Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona; 3Van Andel Research Institute, Grand Rapids, Michigan; 4University of Maryland School of Medicine, Baltimore, Maryland; 5Mayo Clinic, Scottsdale, Arizona; and 6Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York", 'Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona', 'Mayo Clinic, Scottsdale, Arizona', 'University of Maryland School of Medicine, Baltimore, Maryland', 'Van Andel Research Institute, Grand Rapids, Michigan'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix; 2Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona; 3Van Andel Research Institute, Grand Rapids, Michigan; 4University of Maryland School of Medicine, Baltimore, Maryland; 5Mayo Clinic, Scottsdale, Arizona; and 6Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York", 'institution_ids': ['https://openalex.org/I138006243', 'https://openalex.org/I1327576362', 'https://openalex.org/I1284308235', 'https://openalex.org/I4210125099', 'https://openalex.org/I126744593']}, {'raw_affiliation_string': 'Mayo Clinic, Scottsdale, Arizona', 'institution_ids': ['https://openalex.org/I4210125099']}, {'raw_affiliation_string': 'University of Maryland School of Medicine, Baltimore, Maryland', 'institution_ids': ['https://openalex.org/I126744593']}, {'raw_affiliation_string': 'Van Andel Research Institute, Grand Rapids, Michigan', 'institution_ids': ['https://openalex.org/I1317189400']}, {'raw_affiliation_string': 'Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona', 'institution_ids': ['https://openalex.org/I138006243']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082609665', 'display_name': 'Julianna T.D. Ross', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1284308235', 'display_name': 'Translational Genomics Research Institute', 'ror': 'https://ror.org/02hfpnk21', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1284308235']}, {'id': 'https://openalex.org/I4210125099', 'display_name': 'Mayo Clinic in Arizona', 'ror': 'https://ror.org/03jp40720', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723', 'https://openalex.org/I4210125099']}, {'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}, {'id': 'https://openalex.org/I1317189400', 'display_name': 'Van Andel Institute', 'ror': 'https://ror.org/00wm07d60', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1317189400']}, {'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}, {'id': 'https://openalex.org/I1327576362', 'display_name': 'Feinstein Institute for Medical Research', 'ror': 'https://ror.org/05dnene97', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1302444339', 'https://openalex.org/I1327576362']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Julianna T.D. Ross', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix; 2Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona; 3Van Andel Research Institute, Grand Rapids, Michigan; 4University of Maryland School of Medicine, Baltimore, Maryland; 5Mayo Clinic, Scottsdale, Arizona; and 6Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York", 'Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona', 'Mayo Clinic, Scottsdale, Arizona', 'University of Maryland School of Medicine, Baltimore, Maryland', 'Van Andel Research Institute, Grand Rapids, Michigan'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix; 2Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona; 3Van Andel Research Institute, Grand Rapids, Michigan; 4University of Maryland School of Medicine, Baltimore, Maryland; 5Mayo Clinic, Scottsdale, Arizona; and 6Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York", 'institution_ids': ['https://openalex.org/I1284308235', 'https://openalex.org/I4210125099', 'https://openalex.org/I126744593', 'https://openalex.org/I138006243', 'https://openalex.org/I1327576362']}, {'raw_affiliation_string': 'Mayo Clinic, Scottsdale, Arizona', 'institution_ids': ['https://openalex.org/I4210125099']}, {'raw_affiliation_string': 'University of Maryland School of Medicine, Baltimore, Maryland', 'institution_ids': ['https://openalex.org/I126744593']}, {'raw_affiliation_string': 'Van Andel Research Institute, Grand Rapids, Michigan', 'institution_ids': ['https://openalex.org/I1317189400']}, {'raw_affiliation_string': 'Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona', 'institution_ids': ['https://openalex.org/I138006243']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032029297', 'display_name': 'Jeffrey A. Winkles', 'orcid': 'https://orcid.org/0000-0002-3305-1424'}, 'institutions': [{'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}, {'id': 'https://openalex.org/I1327576362', 'display_name': 'Feinstein Institute for Medical Research', 'ror': 'https://ror.org/05dnene97', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1302444339', 'https://openalex.org/I1327576362']}, {'id': 'https://openalex.org/I1284308235', 'display_name': 'Translational Genomics Research Institute', 'ror': 'https://ror.org/02hfpnk21', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1284308235']}, {'id': 'https://openalex.org/I4210125099', 'display_name': 'Mayo Clinic in Arizona', 'ror': 'https://ror.org/03jp40720', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723', 'https://openalex.org/I4210125099']}, {'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}, {'id': 'https://openalex.org/I1317189400', 'display_name': 'Van Andel Institute', 'ror': 'https://ror.org/00wm07d60', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1317189400']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jeffrey A. Winkles', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix; 2Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona; 3Van Andel Research Institute, Grand Rapids, Michigan; 4University of Maryland School of Medicine, Baltimore, Maryland; 5Mayo Clinic, Scottsdale, Arizona; and 6Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York", 'Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona', 'Mayo Clinic, Scottsdale, Arizona', 'University of Maryland School of Medicine, Baltimore, Maryland', 'Van Andel Research Institute, Grand Rapids, Michigan'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix; 2Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona; 3Van Andel Research Institute, Grand Rapids, Michigan; 4University of Maryland School of Medicine, Baltimore, Maryland; 5Mayo Clinic, Scottsdale, Arizona; and 6Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York", 'institution_ids': ['https://openalex.org/I138006243', 'https://openalex.org/I1327576362', 'https://openalex.org/I1284308235', 'https://openalex.org/I4210125099', 'https://openalex.org/I126744593']}, {'raw_affiliation_string': 'Mayo Clinic, Scottsdale, Arizona', 'institution_ids': ['https://openalex.org/I4210125099']}, {'raw_affiliation_string': 'University of Maryland School of Medicine, Baltimore, Maryland', 'institution_ids': ['https://openalex.org/I126744593']}, {'raw_affiliation_string': 'Van Andel Research Institute, Grand Rapids, Michigan', 'institution_ids': ['https://openalex.org/I1317189400']}, {'raw_affiliation_string': 'Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona', 'institution_ids': ['https://openalex.org/I138006243']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103252276', 'display_name': 'Joseph C. Loftus', 'orcid': 'https://orcid.org/0000-0001-9350-7182'}, 'institutions': [{'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}, {'id': 'https://openalex.org/I1327576362', 'display_name': 'Feinstein Institute for Medical Research', 'ror': 'https://ror.org/05dnene97', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1302444339', 'https://openalex.org/I1327576362']}, {'id': 'https://openalex.org/I4210125099', 'display_name': 'Mayo Clinic in Arizona', 'ror': 'https://ror.org/03jp40720', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723', 'https://openalex.org/I4210125099']}, {'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}, {'id': 'https://openalex.org/I1317189400', 'display_name': 'Van Andel Institute', 'ror': 'https://ror.org/00wm07d60', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1317189400']}, {'id': 'https://openalex.org/I1284308235', 'display_name': 'Translational Genomics Research Institute', 'ror': 'https://ror.org/02hfpnk21', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1284308235']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joseph C. Loftus', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix; 2Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona; 3Van Andel Research Institute, Grand Rapids, Michigan; 4University of Maryland School of Medicine, Baltimore, Maryland; 5Mayo Clinic, Scottsdale, Arizona; and 6Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York", 'Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona', 'Mayo Clinic, Scottsdale, Arizona', 'University of Maryland School of Medicine, Baltimore, Maryland', 'Van Andel Research Institute, Grand Rapids, Michigan'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix; 2Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona; 3Van Andel Research Institute, Grand Rapids, Michigan; 4University of Maryland School of Medicine, Baltimore, Maryland; 5Mayo Clinic, Scottsdale, Arizona; and 6Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York", 'institution_ids': ['https://openalex.org/I138006243', 'https://openalex.org/I1327576362', 'https://openalex.org/I4210125099', 'https://openalex.org/I1284308235', 'https://openalex.org/I126744593']}, {'raw_affiliation_string': 'Mayo Clinic, Scottsdale, Arizona', 'institution_ids': ['https://openalex.org/I4210125099']}, {'raw_affiliation_string': 'University of Maryland School of Medicine, Baltimore, Maryland', 'institution_ids': ['https://openalex.org/I126744593']}, {'raw_affiliation_string': 'Van Andel Research Institute, Grand Rapids, Michigan', 'institution_ids': ['https://openalex.org/I1317189400']}, {'raw_affiliation_string': 'Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona', 'institution_ids': ['https://openalex.org/I138006243']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070462994', 'display_name': 'Marc Symons', 'orcid': 'https://orcid.org/0000-0003-1432-5888'}, 'institutions': [{'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}, {'id': 'https://openalex.org/I1327576362', 'display_name': 'Feinstein Institute for Medical Research', 'ror': 'https://ror.org/05dnene97', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1302444339', 'https://openalex.org/I1327576362']}, {'id': 'https://openalex.org/I1284308235', 'display_name': 'Translational Genomics Research Institute', 'ror': 'https://ror.org/02hfpnk21', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1284308235']}, {'id': 'https://openalex.org/I4210125099', 'display_name': 'Mayo Clinic in Arizona', 'ror': 'https://ror.org/03jp40720', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723', 'https://openalex.org/I4210125099']}, {'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}, {'id': 'https://openalex.org/I1317189400', 'display_name': 'Van Andel Institute', 'ror': 'https://ror.org/00wm07d60', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1317189400']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Marc H. Symons', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix; 2Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona; 3Van Andel Research Institute, Grand Rapids, Michigan; 4University of Maryland School of Medicine, Baltimore, Maryland; 5Mayo Clinic, Scottsdale, Arizona; and 6Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York", 'Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona', 'Mayo Clinic, Scottsdale, Arizona', 'University of Maryland School of Medicine, Baltimore, Maryland', 'Van Andel Research Institute, Grand Rapids, Michigan'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix; 2Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona; 3Van Andel Research Institute, Grand Rapids, Michigan; 4University of Maryland School of Medicine, Baltimore, Maryland; 5Mayo Clinic, Scottsdale, Arizona; and 6Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York", 'institution_ids': ['https://openalex.org/I138006243', 'https://openalex.org/I1327576362', 'https://openalex.org/I1284308235', 'https://openalex.org/I4210125099', 'https://openalex.org/I126744593']}, {'raw_affiliation_string': 'Mayo Clinic, Scottsdale, Arizona', 'institution_ids': ['https://openalex.org/I4210125099']}, {'raw_affiliation_string': 'University of Maryland School of Medicine, Baltimore, Maryland', 'institution_ids': ['https://openalex.org/I126744593']}, {'raw_affiliation_string': 'Van Andel Research Institute, Grand Rapids, Michigan', 'institution_ids': ['https://openalex.org/I1317189400']}, {'raw_affiliation_string': 'Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona', 'institution_ids': ['https://openalex.org/I138006243']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5016790638', 'display_name': 'Nhan L. Tran', 'orcid': 'https://orcid.org/0000-0003-0908-9964'}, 'institutions': [{'id': 'https://openalex.org/I4210125099', 'display_name': 'Mayo Clinic in Arizona', 'ror': 'https://ror.org/03jp40720', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723', 'https://openalex.org/I4210125099']}, {'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}, {'id': 'https://openalex.org/I1317189400', 'display_name': 'Van Andel Institute', 'ror': 'https://ror.org/00wm07d60', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1317189400']}, {'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}, {'id': 'https://openalex.org/I1327576362', 'display_name': 'Feinstein Institute for Medical Research', 'ror': 'https://ror.org/05dnene97', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1302444339', 'https://openalex.org/I1327576362']}, {'id': 'https://openalex.org/I1284308235', 'display_name': 'Translational Genomics Research Institute', 'ror': 'https://ror.org/02hfpnk21', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1284308235']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Nhan L. Tran', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix; 2Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona; 3Van Andel Research Institute, Grand Rapids, Michigan; 4University of Maryland School of Medicine, Baltimore, Maryland; 5Mayo Clinic, Scottsdale, Arizona; and 6Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York", 'Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona', 'Mayo Clinic, Scottsdale, Arizona', 'University of Maryland School of Medicine, Baltimore, Maryland', 'Van Andel Research Institute, Grand Rapids, Michigan'], 'affiliations': [{'raw_affiliation_string': 'Mayo Clinic, Scottsdale, Arizona', 'institution_ids': ['https://openalex.org/I4210125099']}, {'raw_affiliation_string': 'University of Maryland School of Medicine, Baltimore, Maryland', 'institution_ids': ['https://openalex.org/I126744593']}, {'raw_affiliation_string': 'Van Andel Research Institute, Grand Rapids, Michigan', 'institution_ids': ['https://openalex.org/I1317189400']}, {'raw_affiliation_string': "Authors' Affiliations:\u20081Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix; 2Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona; 3Van Andel Research Institute, Grand Rapids, Michigan; 4University of Maryland School of Medicine, Baltimore, Maryland; 5Mayo Clinic, Scottsdale, Arizona; and 6Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York", 'institution_ids': ['https://openalex.org/I138006243', 'https://openalex.org/I1327576362', 'https://openalex.org/I1284308235', 'https://openalex.org/I4210125099', 'https://openalex.org/I126744593']}, {'raw_affiliation_string': 'Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona', 'institution_ids': ['https://openalex.org/I138006243']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 6, 'corresponding_author_ids': ['https://openalex.org/A5070462994', 'https://openalex.org/A5016790638'], 'corresponding_institution_ids': ['https://openalex.org/I138006243', 'https://openalex.org/I1327576362', 'https://openalex.org/I1284308235', 'https://openalex.org/I4210125099', 'https://openalex.org/I126744593', 'https://openalex.org/I1317189400', 'https://openalex.org/I4210125099', 'https://openalex.org/I126744593', 'https://openalex.org/I1317189400', 'https://openalex.org/I138006243', 'https://openalex.org/I1327576362', 'https://openalex.org/I1284308235'], 'apc_list': None, 'apc_paid': None, 'fwci': 4.034, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 85, 'citation_normalized_percentile': {'value': 0.906107, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '10', 'issue': '7', 'first_page': '958', 'last_page': '968'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11591', 'display_name': 'NF-κB Signaling Pathways', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11591', 'display_name': 'NF-κB Signaling Pathways', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12620', 'display_name': 'Signaling Pathways in Disease', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10169', 'display_name': 'Protein Kinase Regulation and GTPase Signaling', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cdc42', 'display_name': 'CDC42', 'score': 0.9486814}, {'id': 'https://openalex.org/keywords/small-gtpase', 'display_name': 'Small GTPase', 'score': 0.50740045}, {'id': 'https://openalex.org/keywords/rac-gtp-binding-proteins', 'display_name': 'Rac GTP-Binding Proteins', 'score': 0.4117224}], 'concepts': [{'id': 'https://openalex.org/C2780040266', 'wikidata': 'https://www.wikidata.org/wiki/Q15311701', 'display_name': 'CDC42', 'level': 3, 'score': 0.9486814}, {'id': 'https://openalex.org/C2779717556', 'wikidata': 'https://www.wikidata.org/wiki/Q15325735', 'display_name': 'RAC1', 'level': 3, 'score': 0.8849077}, {'id': 'https://openalex.org/C126619667', 'wikidata': 'https://www.wikidata.org/wiki/Q901088', 'display_name': 'Guanine nucleotide exchange factor', 'level': 3, 'score': 0.74333143}, {'id': 'https://openalex.org/C137738243', 'wikidata': 'https://www.wikidata.org/wiki/Q189092', 'display_name': 'Cell migration', 'level': 3, 'score': 0.58220947}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.5122759}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5078121}, {'id': 'https://openalex.org/C2780298669', 'wikidata': 'https://www.wikidata.org/wiki/Q415071', 'display_name': 'Small GTPase', 'level': 3, 'score': 0.50740045}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.48937315}, {'id': 'https://openalex.org/C207332259', 'wikidata': 'https://www.wikidata.org/wiki/Q769143', 'display_name': 'GTPase', 'level': 2, 'score': 0.4680616}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.41340733}, {'id': 'https://openalex.org/C2909331102', 'wikidata': 'https://www.wikidata.org/wiki/Q7278834', 'display_name': 'Rac GTP-Binding Proteins', 'level': 4, 'score': 0.4117224}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.35700253}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.24050137}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.07007539}], 'mesh': [{'descriptor_ui': 'D005909', 'descriptor_name': 'Glioblastoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D018124', 'descriptor_name': 'Receptors, Tumor Necrosis Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D020764', 'descriptor_name': 'cdc42 GTP-Binding Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001254', 'descriptor_name': 'Astrocytoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001254', 'descriptor_name': 'Astrocytoma', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001254', 'descriptor_name': 'Astrocytoma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000074049', 'descriptor_name': 'Cytokine TWEAK', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005909', 'descriptor_name': 'Glioblastoma', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005909', 'descriptor_name': 'Glioblastoma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020662', 'descriptor_name': 'Guanine Nucleotide Exchange Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020662', 'descriptor_name': 'Guanine Nucleotide Exchange Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009361', 'descriptor_name': 'Neoplasm Invasiveness', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009361', 'descriptor_name': 'Neoplasm Invasiveness', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009479', 'descriptor_name': 'Neuropeptides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009479', 'descriptor_name': 'Neuropeptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010750', 'descriptor_name': 'Phosphoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010750', 'descriptor_name': 'Phosphoproteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein-Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein-Serine-Threonine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018124', 'descriptor_name': 'Receptors, Tumor Necrosis Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018124', 'descriptor_name': 'Receptors, Tumor Necrosis Factor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000074050', 'descriptor_name': 'TWEAK Receptor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048069', 'descriptor_name': 'Tumor Necrosis Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048069', 'descriptor_name': 'Tumor Necrosis Factors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D020764', 'descriptor_name': 'cdc42 GTP-Binding Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020764', 'descriptor_name': 'cdc42 GTP-Binding Protein', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020744', 'descriptor_name': 'rac GTP-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020744', 'descriptor_name': 'rac GTP-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020830', 'descriptor_name': 'rac1 GTP-Binding Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1541-7786.mcr-11-0616', 'pdf_url': 'https://mcr.aacrjournals.org/content/molcanres/10/7/958.full.pdf', 'source': {'id': 'https://openalex.org/S192067876', 'display_name': 'Molecular Cancer Research', 'issn_l': '1541-7786', 'issn': ['1541-7786', '1557-3125'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3516844', 'pdf_url': 'https://europepmc.org/articles/pmc3516844?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516844', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22571869', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1541-7786.mcr-11-0616', 'pdf_url': 'https://mcr.aacrjournals.org/content/molcanres/10/7/958.full.pdf', 'source': {'id': 'https://openalex.org/S192067876', 'display_name': 'Molecular Cancer Research', 'issn_l': '1541-7786', 'issn': ['1541-7786', '1557-3125'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.47}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 50, 'referenced_works': ['https://openalex.org/W1522344314', 'https://openalex.org/W1545165945', 'https://openalex.org/W1568345151', 'https://openalex.org/W1606615500', 'https://openalex.org/W1736595122', 'https://openalex.org/W1904875888', 'https://openalex.org/W1978956991', 'https://openalex.org/W1983159021', 'https://openalex.org/W1990580084', 'https://openalex.org/W1996107157', 'https://openalex.org/W1997773537', 'https://openalex.org/W1998329681', 'https://openalex.org/W1999064468', 'https://openalex.org/W2000732072', 'https://openalex.org/W2005061638', 'https://openalex.org/W2005216911', 'https://openalex.org/W2017859547', 'https://openalex.org/W2020410964', 'https://openalex.org/W2021681212', 'https://openalex.org/W2027810531', 'https://openalex.org/W2033555492', 'https://openalex.org/W2036105610', 'https://openalex.org/W2039233803', 'https://openalex.org/W2041795984', 'https://openalex.org/W2053353977', 'https://openalex.org/W2053404479', 'https://openalex.org/W2060818768', 'https://openalex.org/W2061335575', 'https://openalex.org/W2063575573', 'https://openalex.org/W2067575756', 'https://openalex.org/W2069421644', 'https://openalex.org/W2071018921', 'https://openalex.org/W2076496694', 'https://openalex.org/W2078621313', 'https://openalex.org/W2083309890', 'https://openalex.org/W2084715356', 'https://openalex.org/W2100807457', 'https://openalex.org/W2101099943', 'https://openalex.org/W2107312134', 'https://openalex.org/W2111785219', 'https://openalex.org/W2116463110', 'https://openalex.org/W2116636871', 'https://openalex.org/W2140858258', 'https://openalex.org/W2146473598', 'https://openalex.org/W2150842506', 'https://openalex.org/W2158681922', 'https://openalex.org/W2159340323', 'https://openalex.org/W2159976463', 'https://openalex.org/W2165799545', 'https://openalex.org/W2170210185'], 'related_works': ['https://openalex.org/W2322472561', 'https://openalex.org/W2295841818', 'https://openalex.org/W2142685635', 'https://openalex.org/W2128797396', 'https://openalex.org/W2128738231', 'https://openalex.org/W2112668385', 'https://openalex.org/W2111785219', 'https://openalex.org/W2080620205', 'https://openalex.org/W2070765312', 'https://openalex.org/W2025896887'], 'abstract_inverted_index': {'Abstract': [0], 'Malignant': [1], 'glioblastomas': [2], 'are': [3], 'characterized': [4], 'by': [5, 92], 'their': [6], 'ability': [7], 'to': [8, 28], 'infiltrate': [9], 'into': [10], 'normal': [11], 'brain.': [12], 'We': [13], 'previously': [14], 'reported': [15], 'that': [16, 46, 95, 202], 'binding': [17], 'of': [18, 25, 55, 64, 68, 117, 123, 158, 191, 222], 'the': [19, 184, 187, 192, 203, 223], 'multifunctional': [20], 'cytokine': [21], 'TNF-like': [22], 'weak': [23], 'inducer': [24], 'apoptosis': [26], '(TWEAK)': [27], 'its': [29], 'receptor': [30], 'fibroblast': [31], 'growth': [32], 'factor–inducible': [33], '14': [34], '(Fn14)': [35], 'induces': [36, 180], 'glioblastoma': [37, 197], 'cell': [38, 79, 138, 209], 'invasion': [39, 212], 'via': [40], 'Rac1': [41, 74, 85, 99, 130, 148], 'activation.': [42, 100, 154], 'Here,': [43], 'we': [44, 102], 'show': [45], 'Cdc42': [47, 69, 90, 96, 118, 128, 153], 'plays': [48], 'an': [49, 61, 168], 'essential': [50], 'role': [51], 'in': [52, 114, 162, 165, 176, 188, 196], 'Fn14-mediated': [53], 'activation': [54, 63, 75, 91, 116, 149], 'Rac1.': [56], 'TWEAK-treated': [57], 'glioma': [58, 78, 137, 208, 234], 'cells': [59], 'display': [60], 'increased': [62], 'Cdc42,': [65], 'and': [66, 76, 81, 111, 119, 129, 140, 211, 219], 'depletion': [67, 86, 145], 'using': [70, 167], 'siRNA': [71], 'abolishes': [72], 'TWEAK-induced': [73, 115, 127, 147, 152], 'abrogates': [77, 125], 'migration': [80, 139, 182, 210], 'invasion.': [82, 141, 198], 'In': [83, 142], 'contrast,': [84, 143], 'does': [87], 'not': [88, 151], 'affect': [89], 'Fn14,': [93], 'showing': [94], 'mediates': [97], 'TWEAK-stimulated': [98], 'Furthermore,': [101], 'identified': [103], 'two': [104, 214], 'guanine': [105], 'nucleotide': [106], 'exchange': [107], 'factors': [108], '(GEF),': [109], 'Ect2': [110, 124, 161], 'Trio,': [112], 'involved': [113], 'Rac1,': [120], 'respectively.': [121], 'Depletion': [122], 'both': [126], 'activation,': [131], 'as': [132, 134], 'well': [133], 'subsequent': [135], 'TWEAK-Fn14–directed': [136], 'Trio': [144], 'inhibits': [146], 'but': [150], 'Finally,': [155], 'inappropriate': [156], 'expression': [157], 'Fn14': [159], 'or': [160], 'mouse': [163], 'astrocytes': [164], 'vivo': [166], 'RCAS': [169], 'vector': [170], 'system': [171], 'for': [172, 233], 'glial-specific': [173], 'gene': [174], 'transfer': [175], 'G-tva': [177], 'transgenic': [178], 'mice': [179], 'astrocyte': [181], 'within': [183], 'brain,': [185], 'corroborating': [186], 'vitro': [189], 'importance': [190], 'TWEAK-Fn14': [193, 204], 'signaling': [194, 205, 216, 227], 'cascade': [195], 'Our': [199], 'results': [200], 'suggest': [201], 'axis': [206], 'stimulates': [207], 'through': [213], 'GEF-GTPase': [215], 'units,': [217], 'Ect2-Cdc42': [218], 'Trio-Rac1.': [220], 'Components': [221], 'Fn14-Rho': [224], 'GEF-Rho': [225], 'GTPase': [226], 'pathway': [228], 'present': [229], 'innovative': [230], 'drug': [231], 'targets': [232], 'therapy.': [235], 'Mol': [236], 'Cancer': [237], 'Res;': [238], '10(7);': [239], '958–68.': [240], '©2012': [241], 'AACR.': [242]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2161522518', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 11}, {'year': 2013, 'cited_by_count': 13}], 'updated_date': '2024-12-10T02:35:38.170550', 'created_date': '2016-06-24'}