Abstract: Cell-to-cell and cell-to-extracellular matrix (ECM) interactions in the functions of cell adhesion and signal transduction are important in global control of cell phenotypes and cell behavior and are crucial for maintenance of homeostasis and structural/functional stabilization of tissues and organs. Cell adhesion receptors are recognized as the molecular basis of cell adhesion. Cadherin and lntegrin are widely expressed adhesion receptors in most tissues. They are transmembrane glycoproteins which,through their cytoplasmic domain, bind to many proteins at the inner surface of cell membrane to form molecule-linkage complexes and then connect with the cytoskeleton. Through cell adhesion receptors a network functioning as cell adhesion and signal transduction is organized between tissue cells and cellECM. In this regard cell adhesion receptors play an important role in regulation of morphogenesis, cellcell recognition, cell migration, cell sorting and the determination of cell’s fate in development. They
Publication Year: 1999
Publication Date: 1999-01-01
Language: en
Type: article
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