Publication Information

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'Internal': [186, 1171], '5323': [194, 1179], 'Harry': [195, 1180], 'Hines': [196, 1181], 'Boulevard,': [197, 1182], 'Dallas,': [198, 248, 1157, 1183], '75390.': [200, 1185], 'Email': [201, 251, 1160, 1186], 'E-mail': [202, 252], 'Address:': [203, 253], '[email': [204, 254, 1161], 'protected]': [205, 255], 'https://orcid.org/0000-0003-4878-891X': [206], 'LevineBenjamin': [226], 'Levine,': [231, 1140], '7232': [245, 1154], 'Greenville': [246, 1155], 'Avenue,': [247, 1156], '75231;': [250, 1159], 'https://orcid.org/0000-0001-9064-7251': [256], 'Originally': [273, 1612], 'published29': [274], 'Mar': [275], '2021https://doi.org/10.1161/CIRCULATIONAHA.120.050418Circulation.': [276], '2021;143:1533–1535Other': [277], 'version(s)': [278], 'this': [280, 289, 430, 461, 628], 'articleYou': [281], 'are': [282, 329, 333, 630, 780, 1026], 'viewing': [283], 'the': [284, 341, 345, 390, 434, 449, 472, 520, 591, 612, 625, 633, 690, 828, 864, 947, 997, 1004, 1009, 1013, 1020, 1045, 1096, 1100, 1110, 1426, 1471, 1575], 'most': [285], 'recent': [286], 'version': [287], 'article.': [290], 'Previous': [291, 1322], 'versions:': [292], 'March': [293], '29,': [294, 1614], '2021:': [295], 'Ahead': [296], 'Print': [298], 'Benoît': [299, 745, 765, 814], 'Lecomte': [300, 746, 766], '(B.L.)': [301], 'swam': [302, 470, 475, 496], '2821': [303], 'kilometers': [304], 'over': [305, 373, 827], '159': [306, 477], 'days,': [307], 'Scott': [309, 748, 769, 790, 821], 'Kelly': [310, 749, 770, 791], '(S.K.)': [311], 'spent': [312, 534], '340': [313, 535], 'days': [314, 478, 490, 536], 'in': [315, 325, 397, 402, 409, 416, 423, 460, 514, 519, 537, 644, 680, 734, 789, 851, 910, 912, 964, 1023, 1064, 1071, 1212, 1341, 1381, 1418, 1474, 1526, 1586], 'space.': [316], 'What': [317], 'do': [318], 'extreme-duration': [319, 322, 438, 1087], 'swimming': [320, 439, 505, 899, 942, 1050], 'spaceflight': [323, 421, 441], 'have': [324, 528, 848, 902], 'common,': [326], 'how': [328], 'they': [330], 'different?': [331], 'Both': [332, 674, 1006], 'associated': [334, 929, 1206], 'with': [335, 484, 590, 714, 930, 1028, 1207], 'removal': [336], 'gravitational': [338, 394, 1056], 'loading': [339], 'musculoskeletal': [342], 'system': [343], 'absence': [346], 'weight-bearing': [348], 'activities.': [349], 'Water': [350], 'immersion': [351, 1066, 1211], 'supine': [353, 523], 'bed': [354, 839, 1032, 1242], 'rest,': [355], 'ground-based': [356], 'models': [357], 'spaceflight,': [359, 389, 715], 'initially': [360], 'increase': [361], 'central': [362], 'blood': [363, 410, 991, 1278], 'volume': [364, 411, 709, 992, 1279], 'as': [365, 844], 'a': [366, 393, 398, 406, 413, 511, 529, 552, 685, 895, 906, 953, 958], 'result': [367, 909], 'reversed': [369], 'hydrostatic': [370, 885, 1057], 'gradients': [371, 1058], 'but': [372], 'time': [374, 861], 'lead': [375], 'diuresis': [377], 'partially': [378], 'through': [379, 689, 1059], 'atrial': [380], 'natriuretic': [381, 1202], 'peptide': [382], 'stimulation': [383], 'antidiuretic': [385], 'hormone': [386], 'inhibition.1,2': [387], 'loss': [391, 710, 1054, 1072], 'gradient': [395], 'results': [396, 422], 'similar': [399, 642, 763, 961], 'short-term': [400], 'rise': [401], 'preload,': [403], 'followed': [404], 'by': [405, 569, 573, 598, 611, 650, 662, 971, 1286], 'compensatory': [407], 'decrease': [408], 'long-term': [414], 'reduction': [415], 'preload.2': [417], 'Without': [418], 'countermeasures,': [419], 'extended': [420], 'cardiac': [424, 435, 854, 959, 1074, 1084, 1339, 1378, 1414], 'atrophy': [425, 1085, 1240], 'orthostatic': [427, 857], 'intolerance.': [428], 'In': [429], 'study,': [431], 'we': [432], 'compare': [433], 'effects': [436, 450, 948, 1046, 1459], 'determine': [443], 'whether': [444], 'low-intensity,': [445, 940], 'long-duration': [446, 941], 'exercise': [447, 547, 900, 1078, 1417], 'counteracts': [448], 'repeated': [452, 950], 'weightlessness.Both': [453], 'individuals': [454, 823, 1036], 'gave': [455, 618], 'permission': [456], 'identify': [458], 'them': [459], 'report.': [462], 'B.L.,': [463], 'an': [464, 677, 707, 786], 'elite': [465], 'endurance': [466], 'swimmer': [467], 'who': [468], 'previously': [469], 'across': [471, 750], 'Atlantic': [473], 'Ocean,': [474], '(June': [479], '5,': [480], '2018–November': [481], '11,': [482], '2018),': [483], 'breaks': [485], '7': [487], '32': [489], 'because': [491], 'unfavorable': [493], 'weather.': [494], 'He': [495, 525], 'average': [497, 696, 703], '5.8': [499], 'hours': [500, 510, 923], '(range,': [501], '1.1–9': [502], 'hours)': [503], 'per': [504], 'day': [506], 'slept': [508], '8': [509], 'night,': [512], 'resulting': [513], '9': [515, 1532], '17': [517], 'h/d': [518], 'prone': [521, 1062], 'or': [522, 557, 1061], 'position.': [524], 'did': [526, 730], 'not': [527, 731, 888], 'set': [530], 'hydration': [531, 869], 'regimen.': [532], 'S.K.': [533, 1134], 'space': [538], '(March': [539], '27,': [540], '2015–March': [541], '1,': [542], '2016)': [543], 'was': [545, 596, 609, 712, 762, 943, 969], 'prescribed': [546], '6': [548], 'd/wk': [549], 'that': [550, 623, 711, 894, 939, 963], 'included': [551], 'combination': [553], 'cycling,': [555], 'treadmill,': [556], 'resistive': [558], 'exercise.': [559, 837], 'Two-dimensional': [560], 'Doppler': [562], 'echocardiograms': [563], '(Vivid': [564], 'Q,': [565, 1509], 'GE)': [566], 'were': [567, 588, 870], 'performed': [568], 'sonographers': [570], 'before': [571], 'remote': [574], 'guidance': [575], 'during': [576, 1086, 1209, 1416], 'their': [577, 738, 751, 831, 1038, 1126, 1136], 'respective': [578, 752], 'campaigns.': [579, 753], 'Left': [580], 'ventricular': [581, 759], '(LV)': [582, 760], 'mass': [583, 639, 648, 660, 761, 826, 914, 989], 'LV': [585, 681, 722, 782, 825, 913, 932, 1024], 'ejection': [586, 723], 'fraction': [587, 724, 795], 'measured': [589], 'Teichholz': [592, 998, 1014], 'method.': [593], 'Diastolic': [594], 'function': [595, 729], 'assessed': [597], 'mitral': [599], 'inflow': [600], 'velocity': [601], 'early': [603], 'diastolic': [604, 682, 728, 783, 798], 'recoil': [605, 799], 'velocity.': [606], 'The': [607, 621, 754, 1106, 1123, 1543], 'study': [608, 629, 968, 1091], 'approved': [610], 'institutional': [613], 'review': [614], 'board,': [615], 'subjects': [617, 675, 1007], 'informed': [619], 'consent.': [620], 'data': [622, 743], 'support': [624], 'findings': [626], 'available': [631], 'from': [632], 'corresponding': [634], 'author': [635], 'on': [636, 996, 1425, 1470], 'reasonable': [637], 'request.LV': [638], 'declined': [640], 'at': [641, 925, 1099], 'rates': [643], 'both': [645], 'individuals.': [646], "B.L.'s": [647, 859, 981], 'dropped': [649, 661], '0.72': [651], 'g/wk': [652, 664], '(95%': [653, 665], 'CI,': [654, 666], '−0.14': [655], '1.58)': [657], "S.K.'s": [659, 1017], '0.74': [663], '0.13–1.34)': [667], 'when': [668], 'linear': [669], 'regression': [670, 775], 'is': [671, 928, 937, 1092, 1422], 'applied': [672], '(Figure).': [673], 'had': [676], 'initial': [678, 708, 787, 977, 1021], 'drop': [679], 'diameter': [683, 784], 'lower': [686, 1273, 1464], 'steady': [687], 'state': [688], 'campaign': [691], '(B.L.,': [692], '5': [693], 'cm': [694, 701], '4.7': [697], 'cm;': [698], 'S.K.,': [699], '5.3': [700], '4.6': [704], 'cm),': [705], 'suggesting': [706], 'greater': [713], 'although': [716], 'biological': [717], 'variability': [718], 'cannot': [719], 'be': [720, 1080], 'excluded.': [721], 'markers': [726], 'consistently': [732], 'change': [733], 'either': [735], 'individual': [736], 'throughout': [737], 'campaign.Download': [739], 'figureDownload': [740], 'PowerPointFigure.': [741], 'Individual': [742], 'overall': [755], 'trend': [756], 'left': [758, 817], 'between': [764, 976], '(▴)': [767], '(○)': [771], '(Top,': [772, 792], 'left).': [773], 'Linear': [774], 'equation': [776], 'best-fit': [778], 'line': [779], 'shown.': [781], 'shows': [785], 'decline': [788, 1022], 'right).': [793], 'Ejection': [794], '(Bottom,': [796, 806], 'left),': [797], "(e',": [800], 'Bottom,': [801], 'middle),': [802], 'E/A': [804], 'ratio': [805], 'right)': [807], 'show': [808], 'no': [809], 'consistent': [810, 1027], 'trend.': [811], 'BL': [812], 'indicates': [813], 'Lecomte;': [815], 'LV,': [816], 'ventricular;': [818], 'SL,': [820], 'Kelly.Both': [822], 'lost': [824], 'duration': [829, 897, 1049], 'campaigns': [832], 'despite': [833], 'substantial': [834], 'amounts': [835], 'Full-time': [838], 'rest': [840, 1033, 1243], 'studies,': [841], 'which': [842], 'serve': [843], 'analogs': [845], 'weightlessness,': [847], 'shown': [849], 'reductions': [850], 'plasma': [852, 877, 890], 'volume,': [853], 'mass,': [855, 1002, 1025], 'tolerance.2': [858], 'awake': [860], 'out': [862], 'water': [865, 1065, 1210], 'ad': [867], 'libitum': [868], 'likely': [871], 'insufficient': [872, 944, 1081], 'completely': [874], 'preserve': [875, 889], 'his': [876, 984], 'volume.': [878, 916], 'Daily': [879], 'lower-body': [880], 'negative': [881, 1275, 1468], 'pressure': [882, 1276, 1469], '(partially': [883], 'reinstating': [884], 'gradients)': [886], 'does': [887], 'volume.3': [891], 'We': [892], 'anticipated': [893], 'long': [896], 'would': [901], 'been': [903], 'enough': [904], 'stimulus': [907], 'increases': [911], 'Swim': [917], 'training': [918], '1': [920], '3': [922], 'daily': [924], 'high': [926], 'intensity': [927], 'increased': [931], 'size': [933], 'mass.4': [935], 'It': [936], 'surprising': [938], 'overcome': [946], 'exposure': [951], 'weightlessness': [954, 1060], 'analog,': [955], 'leading': [956], 'adaptation': [960], 'prolonged': [965], 'spaceflight.': [966, 1052], 'This': [967], 'limited': [970, 1003], 'real-world': [972], 'issues,': [973], 'including': [974, 1019], 'delays': [975], 'scans,': [978], 'interruptions': [979], 'swim': [982, 1312], '(for': [983], 'safety),': [985], 'lack': [986], 'body': [988, 1274, 1465], 'measures,': [993], 'reliance': [995], 'method': [999], 'estimate': [1001], 'study.': [1005], 'meet': [1008], 'geometric': [1010], 'assumptions': [1011], 'method,': [1015, 1427], 'results,': [1018], 'prior': [1029], 'studies': [1030], 'spaceflight.2These': [1035], 'extraordinary': [1039], 'feats': [1040], 'provide': [1041], 'unique': [1042], 'insight': [1043], 'into': [1044], 'extreme': [1048], 'Extended': [1053], 'positioning': [1063], 'without': [1067], 'proper': [1068], 'countermeasures': [1069], 'resulted': [1070], 'mass.': [1075], 'Consistent,': [1076], 'low-intensity': [1077], 'may': [1079], 'prevent': [1083], 'swimming,': [1088], 'though': [1089], 'further': [1090], 'needed.AcknowledgmentsThe': [1093], 'authors': [1094, 1124], 'acknowledge': [1095], 'many': [1097], 'people': [1098], 'National': [1101], 'Aeronautics': [1102], 'Space': [1104], 'Administration,': [1105], 'Longest': [1107], 'Swim,': [1108], 'Medicine': [1116], 'supporting': [1118], 'these': [1119], 'unprecedented': [1120], 'human': [1121, 1549], 'achievements.': [1122], 'express': [1125], 'utmost': [1127], 'gratitude': [1128], 'admiration': [1130], 'B.L.': [1132], 'accomplishments.Disclosures': [1137], 'None.Footnoteshttps://www.ahajournals.org/journal/circBenjamin': [1138], 'protected]orgVlad': [1162], 'vlad.[email': [1187], 'protected]eduReferences1.': [1188], 'Anderson': [1189, 1455], 'JV,': [1190], 'Millar': [1191], 'ND,': [1192], "O'Hare": [1193], 'JP,': [1194, 1263], 'Mackenzie': [1195], 'JC,': [1196, 1228], 'Corrall': [1197], 'RJ,': [1198], 'Bloom': [1199], 'SR.': [1200], 'Atrial': [1201], 'peptide:': [1203], 'physiological': [1204, 1550], 'release': [1205], 'natriuresis': [1208], 'man.Clin': [1213], 'Sci': [1214, 1314], '(Lond).': [1215], '1986;': [1216], '71:319–322.': [1217], 'doi:': [1218, 1251, 1319], '10.1042/cs0710319CrossrefMedlineGoogle': [1219], 'Scholar2.': [1220], 'Perhonen': [1221], 'MA,': [1222], 'Franco': [1223], 'F,': [1224, 1297], 'Lane': [1225], 'LD,': [1226], 'Buckey': [1227, 1452], 'Blomqvist': [1229], 'CG,': [1230], 'Zerwekh': [1231], 'JE,': [1232, 1261], 'Peshock': [1233], 'RM,': [1234], 'Weatherall': [1235], 'PT,': [1236], 'BD.': [1238, 1271], 'Cardiac': [1239, 1523], 'after': [1241], 'spaceflight.J': [1245], 'Appl': [1246], 'Physiol': [1247], '(1985).': [1248], '2001;': [1249], '91:645–653.': [1250], '10.1152/jappl.2001.91.2.645CrossrefMedlineGoogle': [1252], 'Scholar3.': [1253], 'KA,': [1255], 'Hearon': [1256], 'CM,': [1257], 'Babu': [1258], 'G,': [1259, 1356, 1481, 1505], 'Marshall': [1260], 'Leidner': [1264], 'J,': [1265, 1301, 1360, 1487], 'Gillespie': [1266], 'M,': [1267, 1354, 1362, 1364, 1368, 1370, 1443, 1451], 'Peters': [1268], 'K,': [1269], 'Nightly': [1272], 'redistributes': [1277], 'prevents': [1281], 'maladaptive': [1282], 'vascular': [1283], 'remodeling': [1284], 'induced': [1285], 'microgravity.Circulation.': [1287], '2020;': [1288], '142:A14436.': [1289], 'Abstract.LinkGoogle': [1290], 'Scholar4.': [1291], 'Wasfy': [1292], 'MM,': [1293], 'Weiner': [1294], 'RB,': [1295], 'Wang': [1296], 'Berkstresser': [1298], 'B,': [1299], 'Deluca': [1300], 'Hutter': [1302], 'AM,': [1303], 'Picard': [1304], 'MH,': [1305], 'Baggish': [1306], 'AL.': [1307], 'Myocardial': [1308], 'adaptations': [1309], 'competitive': [1311], 'training.Med': [1313], 'Sports': [1315], 'Exerc.': [1316], '2019;': [1317], '51:1987–1994.': [1318], '10.1249/MSS.0000000000002022CrossrefMedlineGoogle': [1320], 'Scholar': [1321], 'Back': [1323], 'top': [1325], 'Next': [1326], 'FiguresReferencesRelatedDetailsCited': [1327], 'By': [1328], 'T,': [1330], 'Juarros': [1331], 'M': [1332], 'Leinwand': [1334], 'L': [1335, 1405], '(2023)': [1336], 'Regression': [1337], 'hypertrophy': [1340], 'health': [1342], 'disease:': [1344], 'mechanisms': [1345], 'therapeutic': [1347], 'potential,': [1348], 'Nature': [1349], 'Reviews': [1350], 'Cardiology,': [1351], '10.1038/s41569-022-00806-6': [1352], 'Fischer': [1353], 'Moralez': [1355], 'S,': [1358, 1366], 'Cramer': [1361], 'Huang': [1363], 'Romero': [1365], 'Hieda': [1367], 'Shibasaki': [1369], 'Ogoh': [1371], 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