Title: Relationship between depression and non-motor symptoms in patients with Parkinson's disease
Abstract: Objective To investigate the relationship between depression and non-motor symptoms in patients with Parkinson's disease (PD).Methods 139 PD patients who were registered to Neurology Clinic of Beijing Tiantan Hospital between April 2008 and August 2009 were assessed with Hamilton depression scale (HMDS) and allocated into a depression group or a non-depression group based on outcomes.The two groups were studied and compared for data from general survey,Hoehn and Yahr stage (HY),unified Parkinson's disease rating scale (UPDRS),fatigue severity scale (FSS) and Mini-mental State Examination (MMSE).Logistic regression analysis was used to screen for risk factors associated with depression-complicated PD.Results Of 139 patients with PD,74 (53.2%) were identified as suffering from depression.Depression patients were more likely to experience sleep disturbance (50% vs 15.4%) and fatigue (68.9% vs 30.8%) than non-depression patients.The Hoehn and Yahr staging (2.1±0.8 vs 1.8±0.7) and UPDRS scores (UPDRS I,3.01±1.49 vs 1.32±1.00;UPDRSⅡ,11.89±5.89 vs 8.83±3.62;UPDRS Ⅲ,25.5±13.9 vs 17.5±9.6) were significantly higher in the depression group than in the non-depression group (all P0.05).There were no significant differences in gender,age at onset,course of disease,MMSE score and non-motor symptoms including constipation,seborrhagia,salivation,hyposmia and delusion between the two groups (P0.05).Logistic regression revealed that the most important predictor for depression were presence of sleep disturbance,fatigue,UPDRS part I and part III (P0.05).Conclusion Depression occurred frequently in patients with Parkinson's disease and correlated with non-motor symptoms such as sleep disturbance and fatigue.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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