Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3142314375', 'doi': 'https://doi.org/10.1002/rcr2.742', 'title': 'Mepolizumab asthma treatment failure due to refractory airway eosinophilia, which responded to benralizumab', 'display_name': 'Mepolizumab asthma treatment failure due to refractory airway eosinophilia, which responded to benralizumab', 'publication_year': 2021, 'publication_date': '2021-04-01', 'ids': {'openalex': 'https://openalex.org/W3142314375', 'doi': 'https://doi.org/10.1002/rcr2.742', 'mag': '3142314375', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/33815803', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/8013786'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/rcr2.742', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764822511', 'display_name': 'Respirology Case Reports', 'issn_l': '2051-3380', 'issn': ['2051-3380'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8013786', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5039765793', 'display_name': 'Alistair Cook', 'orcid': 'https://orcid.org/0000-0003-3651-5041'}, 'institutions': [{'id': 'https://openalex.org/I2800479947', 'display_name': 'John Hunter Hospital', 'ror': 'https://ror.org/0187t0j49', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800479947', 'https://openalex.org/I4210154888']}, {'id': 'https://openalex.org/I4210087646', 'display_name': 'Hunter Medical Research Institute', 'ror': 'https://ror.org/0020x6414', 'country_code': 'AU', 'type': 'facility', 'lineage': ['https://openalex.org/I4210087646']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Alistair Cook', 'raw_affiliation_strings': ['Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton, NSW, Australia', 'Department of Respiratory Medicine, John Hunter Hospital, Newcastle, NSW, Australia'], 'affiliations': [{'raw_affiliation_string': 'Department of Respiratory Medicine, John Hunter Hospital, Newcastle, NSW, Australia', 'institution_ids': ['https://openalex.org/I2800479947']}, {'raw_affiliation_string': 'Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton, NSW, Australia', 'institution_ids': ['https://openalex.org/I4210087646']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014070406', 'display_name': 'John Harrington', 'orcid': 'https://orcid.org/0000-0003-1542-6250'}, 'institutions': [{'id': 'https://openalex.org/I2800479947', 'display_name': 'John Hunter Hospital', 'ror': 'https://ror.org/0187t0j49', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800479947', 'https://openalex.org/I4210154888']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'John Harrington', 'raw_affiliation_strings': ['Department of Respiratory Medicine, John Hunter Hospital, Newcastle, NSW, Australia'], 'affiliations': [{'raw_affiliation_string': 'Department of Respiratory Medicine, John Hunter Hospital, Newcastle, NSW, Australia', 'institution_ids': ['https://openalex.org/I2800479947']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078153354', 'display_name': 'Jodie L. Simpson', 'orcid': 'https://orcid.org/0000-0002-3626-680X'}, 'institutions': [{'id': 'https://openalex.org/I4210087646', 'display_name': 'Hunter Medical Research Institute', 'ror': 'https://ror.org/0020x6414', 'country_code': 'AU', 'type': 'facility', 'lineage': ['https://openalex.org/I4210087646']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Jodie L. Simpson', 'raw_affiliation_strings': ['Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton, NSW, Australia'], 'affiliations': [{'raw_affiliation_string': 'Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton, NSW, Australia', 'institution_ids': ['https://openalex.org/I4210087646']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5023800164', 'display_name': 'Peter Wark', 'orcid': 'https://orcid.org/0000-0001-5676-6126'}, 'institutions': [{'id': 'https://openalex.org/I4210087646', 'display_name': 'Hunter Medical Research Institute', 'ror': 'https://ror.org/0020x6414', 'country_code': 'AU', 'type': 'facility', 'lineage': ['https://openalex.org/I4210087646']}, {'id': 'https://openalex.org/I2800479947', 'display_name': 'John Hunter Hospital', 'ror': 'https://ror.org/0187t0j49', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800479947', 'https://openalex.org/I4210154888']}], 'countries': ['AU'], 'is_corresponding': True, 'raw_author_name': 'Peter Wark', 'raw_affiliation_strings': ['Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton, NSW, Australia', 'Department of Respiratory Medicine, John Hunter Hospital, Newcastle, NSW, Australia'], 'affiliations': [{'raw_affiliation_string': 'Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton, NSW, Australia', 'institution_ids': ['https://openalex.org/I4210087646']}, {'raw_affiliation_string': 'Department of Respiratory Medicine, John Hunter Hospital, Newcastle, NSW, Australia', 'institution_ids': ['https://openalex.org/I2800479947']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5023800164'], 'corresponding_institution_ids': ['https://openalex.org/I4210087646', 'https://openalex.org/I2800479947'], 'apc_list': {'value': 800, 'currency': 'USD', 'value_usd': 800, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.657, 'has_fulltext': False, 'cited_by_count': 4, 'citation_normalized_percentile': {'value': 0.776289, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 77, 'max': 80}, 'biblio': {'volume': '9', 'issue': '5', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10051', 'display_name': 'Asthma', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10051', 'display_name': 'Asthma', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12538', 'display_name': 'Diagnosis and Management of Eosinophilic Esophagitis', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12418', 'display_name': 'Diagnosis and Management of Chronic Cough', 'score': 0.9945, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/benralizumab', 'display_name': 'Benralizumab', 'score': 0.9852972}, {'id': 'https://openalex.org/keywords/refractory', 'display_name': 'Refractory (planetary science)', 'score': 0.54681116}, {'id': 'https://openalex.org/keywords/treatment', 'display_name': 'Treatment', 'score': 0.492215}, {'id': 'https://openalex.org/keywords/airway-hyperresponsiveness', 'display_name': 'Airway hyperresponsiveness', 'score': 0.42495304}], 'concepts': [{'id': 'https://openalex.org/C2777832160', 'wikidata': 'https://www.wikidata.org/wiki/Q3306175', 'display_name': 'Mepolizumab', 'level': 4, 'score': 0.9956448}, {'id': 'https://openalex.org/C2779185760', 'wikidata': 'https://www.wikidata.org/wiki/Q3638304', 'display_name': 'Benralizumab', 'level': 5, 'score': 0.9852972}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.829424}, {'id': 'https://openalex.org/C2777129736', 'wikidata': 'https://www.wikidata.org/wiki/Q505142', 'display_name': 'Eosinophilia', 'level': 2, 'score': 0.8222219}, {'id': 'https://openalex.org/C181901479', 'wikidata': 'https://www.wikidata.org/wiki/Q14877650', 'display_name': 'Interleukin 5', 'level': 4, 'score': 0.6037429}, {'id': 'https://openalex.org/C2776042228', 'wikidata': 'https://www.wikidata.org/wiki/Q35869', 'display_name': 'Asthma', 'level': 2, 'score': 0.5951893}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.55868256}, {'id': 'https://openalex.org/C142424586', 'wikidata': 'https://www.wikidata.org/wiki/Q7307572', 'display_name': 'Refractory (planetary science)', 'level': 2, 'score': 0.54681116}, {'id': 'https://openalex.org/C2777037409', 'wikidata': 'https://www.wikidata.org/wiki/Q107238', 'display_name': 'Eosinophil', 'level': 3, 'score': 0.51728916}, {'id': 'https://openalex.org/C105922876', 'wikidata': 'https://www.wikidata.org/wiki/Q1423981', 'display_name': 'Airway', 'level': 2, 'score': 0.4663716}, {'id': 'https://openalex.org/C163864487', 'wikidata': 'https://www.wikidata.org/wiki/Q6901461', 'display_name': 'Monoclonal', 'level': 4, 'score': 0.44481346}, {'id': 'https://openalex.org/C3019828301', 'wikidata': 'https://www.wikidata.org/wiki/Q3801533', 'display_name': 'Airway hyperresponsiveness', 'level': 3, 'score': 0.42495304}, {'id': 'https://openalex.org/C542903549', 'wikidata': 'https://www.wikidata.org/wiki/Q422248', 'display_name': 'Monoclonal antibody', 'level': 3, 'score': 0.3773775}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.20596856}, {'id': 'https://openalex.org/C74172505', 'wikidata': 'https://www.wikidata.org/wiki/Q194908', 'display_name': 'Interleukin', 'level': 3, 'score': 0.15013477}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.10743794}, {'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.05915633}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C87355193', 'wikidata': 'https://www.wikidata.org/wiki/Q411', 'display_name': 'Astrobiology', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/rcr2.742', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764822511', 'display_name': 'Respirology Case Reports', 'issn_l': '2051-3380', 'issn': ['2051-3380'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/a1af90eb141f4ca0afc4f1b17a08691b', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8013786', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/33815803', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8013786', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.83, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1926391481', 'https://openalex.org/W1965786377', 'https://openalex.org/W1978768608', 'https://openalex.org/W1989626763', 'https://openalex.org/W1992648705', 'https://openalex.org/W1993997407', 'https://openalex.org/W2039710848', 'https://openalex.org/W2052195634', 'https://openalex.org/W2062918919', 'https://openalex.org/W2065797637', 'https://openalex.org/W2075699130', 'https://openalex.org/W2095754126', 'https://openalex.org/W2120018683', 'https://openalex.org/W2127303736', 'https://openalex.org/W2131076474', 'https://openalex.org/W2138355864', 'https://openalex.org/W2142587628', 'https://openalex.org/W2144082759', 'https://openalex.org/W2154263136', 'https://openalex.org/W2154766995', 'https://openalex.org/W2211024346', 'https://openalex.org/W2399333254', 'https://openalex.org/W2511267861', 'https://openalex.org/W2615817830', 'https://openalex.org/W2751711353', 'https://openalex.org/W2755765772', 'https://openalex.org/W2757963532', 'https://openalex.org/W2786548885', 'https://openalex.org/W2802349168', 'https://openalex.org/W2982894420', 'https://openalex.org/W3014621925', 'https://openalex.org/W3027043096', 'https://openalex.org/W3142314375'], 'related_works': ['https://openalex.org/W4322491797', 'https://openalex.org/W3155706359', 'https://openalex.org/W3142314375', 'https://openalex.org/W3120641611', 'https://openalex.org/W3009099684', 'https://openalex.org/W2799775149', 'https://openalex.org/W2795629650', 'https://openalex.org/W2398413522', 'https://openalex.org/W2339552918', 'https://openalex.org/W1935691507'], 'abstract_inverted_index': {'Abstract': [0], 'Monoclonal': [1], 'antibodies': [2], 'directed': [3], 'against': [4], 'interleukin': [5], '(IL)‐5,': [6], 'such': [7], 'as': [8, 38], 'mepolizumab': [9, 36, 56], 'and': [10, 15, 74, 92], 'benralizumab,': [11], 'are': [12], 'an': [13], 'effective': [14], 'established': [16], 'treatment': [17, 67], 'for': [18], 'severe': [19], 'eosinophilic': [20, 28], 'asthma.': [21], 'Here,': [22], 'we': [23], 'present': [24], 'a': [25, 31], 'patient': [26], 'with': [27, 30, 69], 'asthma': [29], 'partial': [32, 64], 'clinical': [33], 'response': [34], 'to': [35, 48, 59, 76], 'initially,': [37], 'measured': [39], 'by': [40], 'these': [41], 'biomarkers,': [42], 'who': [43], 'when': [44], 'investigated': [45], 'was': [46, 71], 'found': [47], 'have': [49], 'refractory': [50], 'airway': [51, 79], 'eosinophilia.': [52, 80], 'Escalation': [53], 'of': [54, 78, 96, 98], 'the': [55, 83, 90, 93, 99], 'dose': [57], 'led': [58, 75], 'further': [60], 'but': [61], 'still': [62], 'only': [63], 'response.': [65], 'A': [66], 'trial': [68], 'benralizumab': [70], 'more': [72], 'successful': [73], 'suppression': [77], 'We': [81], 'review': [82], 'literature,': [84], 'focusing': [85], 'on': [86], 'eosinophil': [87], 'biology': [88], 'at': [89], 'tissues': [91], 'different': [94], 'mechanisms': [95], 'action': [97], 'two': [100], 'agents.': [101]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3142314375', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}], 'updated_date': '2024-09-14T23:32:52.593585', 'created_date': '2021-04-13'}