Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2398413522', 'doi': 'https://doi.org/10.1097/aci.0000000000000251', 'title': 'Interleukin-5 pathway inhibition in the treatment of eosinophilic respiratory disorders', 'display_name': 'Interleukin-5 pathway inhibition in the treatment of eosinophilic respiratory disorders', 'publication_year': 2016, 'publication_date': '2016-04-01', 'ids': {'openalex': 'https://openalex.org/W2398413522', 'doi': 'https://doi.org/10.1097/aci.0000000000000251', 'mag': '2398413522', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26859368', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4768650'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/aci.0000000000000251', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S13845130', 'display_name': 'Current Opinion in Allergy and Clinical Immunology', 'issn_l': '1473-6322', 'issn': ['1473-6322', '1528-4050'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc4768650?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5080048332', 'display_name': 'Gilda Varricchi', 'orcid': 'https://orcid.org/0000-0002-9285-4657'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Gilda Varricchi', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016801522', 'display_name': 'Diego Bagnasco', 'orcid': 'https://orcid.org/0000-0002-3661-5731'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Diego Bagnasco', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034826569', 'display_name': 'Francesco Borriello', 'orcid': 'https://orcid.org/0000-0001-9074-4828'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Francesco Borriello', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078033835', 'display_name': 'Enrico Heffler', 'orcid': 'https://orcid.org/0000-0002-0492-5663'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Enrico Heffler', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5030629710', 'display_name': 'Giorgio Walter Canonica', 'orcid': 'https://orcid.org/0000-0001-8467-2557'}, 'institutions': [{'id': 'https://openalex.org/I83816512', 'display_name': 'University of Genoa', 'ror': 'https://ror.org/0107c5v14', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I83816512']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'Giorgio W. Canonica', 'raw_affiliation_strings': ['to Giorgio W. Canonica, Respiratory Diseases and Allergy Clinic, University of Genoa, IRCCS AOU S. Martino Genoa, Genoa, Italy. E-mail: [email\xa0protected]'], 'affiliations': [{'raw_affiliation_string': 'to Giorgio W. Canonica, Respiratory Diseases and Allergy Clinic, University of Genoa, IRCCS AOU S. Martino Genoa, Genoa, Italy. E-mail: [email\xa0protected]', 'institution_ids': ['https://openalex.org/I83816512']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5030629710'], 'corresponding_institution_ids': ['https://openalex.org/I83816512'], 'apc_list': None, 'apc_paid': None, 'fwci': 3.978, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 157, 'citation_normalized_percentile': {'value': 0.999278, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '16', 'issue': '2', 'first_page': '186', 'last_page': '200'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10051', 'display_name': 'Asthma', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10051', 'display_name': 'Asthma', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12538', 'display_name': 'Diagnosis and Management of Eosinophilic Esophagitis', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12418', 'display_name': 'Diagnosis and Management of Chronic Cough', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/benralizumab', 'display_name': 'Benralizumab', 'score': 0.89035255}, {'id': 'https://openalex.org/keywords/eosinophils', 'display_name': 'Eosinophils', 'score': 0.548529}, {'id': 'https://openalex.org/keywords/eosinophilic-esophagitis', 'display_name': 'Eosinophilic Esophagitis', 'score': 0.515917}], 'concepts': [{'id': 'https://openalex.org/C2777832160', 'wikidata': 'https://www.wikidata.org/wiki/Q3306175', 'display_name': 'Mepolizumab', 'level': 4, 'score': 0.9410428}, {'id': 'https://openalex.org/C2779185760', 'wikidata': 'https://www.wikidata.org/wiki/Q3638304', 'display_name': 'Benralizumab', 'level': 5, 'score': 0.89035255}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8660208}, {'id': 'https://openalex.org/C181901479', 'wikidata': 'https://www.wikidata.org/wiki/Q14877650', 'display_name': 'Interleukin 5', 'level': 4, 'score': 0.67817}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.6703851}, {'id': 'https://openalex.org/C2779758542', 'wikidata': 'https://www.wikidata.org/wiki/Q2106364', 'display_name': 'Eosinophilic', 'level': 2, 'score': 0.6243653}, {'id': 'https://openalex.org/C2777129736', 'wikidata': 'https://www.wikidata.org/wiki/Q505142', 'display_name': 'Eosinophilia', 'level': 2, 'score': 0.56863874}, {'id': 'https://openalex.org/C2776042228', 'wikidata': 'https://www.wikidata.org/wiki/Q35869', 'display_name': 'Asthma', 'level': 2, 'score': 0.55196977}, {'id': 'https://openalex.org/C2777037409', 'wikidata': 'https://www.wikidata.org/wiki/Q107238', 'display_name': 'Eosinophil', 'level': 3, 'score': 0.5433922}, {'id': 'https://openalex.org/C2776780178', 'wikidata': 'https://www.wikidata.org/wiki/Q199804', 'display_name': 'COPD', 'level': 2, 'score': 0.41938508}, {'id': 'https://openalex.org/C74172505', 'wikidata': 'https://www.wikidata.org/wiki/Q194908', 'display_name': 'Interleukin', 'level': 3, 'score': 0.39865837}, {'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.24369165}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.21839675}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.19193482}], 'mesh': [{'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': True}, {'descriptor_ui': 'D004804', 'descriptor_name': 'Eosinophils', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D014890', 'descriptor_name': 'Granulomatosis with Polyangiitis', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': True}, {'descriptor_ui': 'D015848', 'descriptor_name': 'Interleukin-5', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D029424', 'descriptor_name': 'Pulmonary Disease, Chronic Obstructive', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': True}, {'descriptor_ui': 'D053649', 'descriptor_name': 'Receptors, Interleukin-5', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D002986', 'descriptor_name': 'Clinical Trials as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004804', 'descriptor_name': 'Eosinophils', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004804', 'descriptor_name': 'Eosinophils', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D014890', 'descriptor_name': 'Granulomatosis with Polyangiitis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014890', 'descriptor_name': 'Granulomatosis with Polyangiitis', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015848', 'descriptor_name': 'Interleukin-5', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029424', 'descriptor_name': 'Pulmonary Disease, Chronic Obstructive', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029424', 'descriptor_name': 'Pulmonary Disease, Chronic Obstructive', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D053649', 'descriptor_name': 'Receptors, Interleukin-5', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/aci.0000000000000251', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S13845130', 'display_name': 'Current Opinion in Allergy and Clinical Immunology', 'issn_l': '1473-6322', 'issn': ['1473-6322', '1528-4050'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4768650', 'pdf_url': 'https://europepmc.org/articles/pmc4768650?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768650', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26859368', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4768650', 'pdf_url': 'https://europepmc.org/articles/pmc4768650?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.8, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 119, 'referenced_works': ['https://openalex.org/W1165233182', 'https://openalex.org/W1480061809', 'https://openalex.org/W1488555984', 'https://openalex.org/W1517597786', 'https://openalex.org/W1557717457', 'https://openalex.org/W1579241601', 'https://openalex.org/W1581074935', 'https://openalex.org/W1590286073', 'https://openalex.org/W1723117224', 'https://openalex.org/W1760281680', 'https://openalex.org/W1786797005', 'https://openalex.org/W1802054883', 'https://openalex.org/W1846706131', 'https://openalex.org/W1916962812', 'https://openalex.org/W1935628316', 'https://openalex.org/W1935891692', 'https://openalex.org/W1965786377', 'https://openalex.org/W1972175300', 'https://openalex.org/W1972474621', 'https://openalex.org/W1974058875', 'https://openalex.org/W1979129445', 'https://openalex.org/W1979832741', 'https://openalex.org/W1988239900', 'https://openalex.org/W1988758075', 'https://openalex.org/W1992648705', 'https://openalex.org/W1993261989', 'https://openalex.org/W1997048122', 'https://openalex.org/W1999068577', 'https://openalex.org/W2001028378', 'https://openalex.org/W2002474633', 'https://openalex.org/W2002980147', 'https://openalex.org/W2003325833', 'https://openalex.org/W2005694123', 'https://openalex.org/W2006153464', 'https://openalex.org/W2008791411', 'https://openalex.org/W2008930833', 'https://openalex.org/W2013105339', 'https://openalex.org/W2015385334', 'https://openalex.org/W2016952830', 'https://openalex.org/W2017336448', 'https://openalex.org/W2021852404', 'https://openalex.org/W2022723713', 'https://openalex.org/W2022737640', 'https://openalex.org/W2027746633', 'https://openalex.org/W2033380992', 'https://openalex.org/W2033946555', 'https://openalex.org/W2037801848', 'https://openalex.org/W2038462158', 'https://openalex.org/W2039710848', 'https://openalex.org/W2044682405', 'https://openalex.org/W2048988599', 'https://openalex.org/W2050684618', 'https://openalex.org/W2051620815', 'https://openalex.org/W2055172715', 'https://openalex.org/W2055203083', 'https://openalex.org/W2056266780', 'https://openalex.org/W2062456152', 'https://openalex.org/W2062918919', 'https://openalex.org/W2065797637', 'https://openalex.org/W2067575094', 'https://openalex.org/W2070672259', 'https://openalex.org/W2071380169', 'https://openalex.org/W2073959308', 'https://openalex.org/W2074163656', 'https://openalex.org/W2075699130', 'https://openalex.org/W2076101846', 'https://openalex.org/W2077034527', 'https://openalex.org/W2079176701', 'https://openalex.org/W2088102919', 'https://openalex.org/W2088294506', 'https://openalex.org/W2095754126', 'https://openalex.org/W2097446240', 'https://openalex.org/W2101500685', 'https://openalex.org/W2101965993', 'https://openalex.org/W2103742780', 'https://openalex.org/W2104268211', 'https://openalex.org/W2104905930', 'https://openalex.org/W2106334460', 'https://openalex.org/W2106779701', 'https://openalex.org/W2107953278', 'https://openalex.org/W2109029867', 'https://openalex.org/W2111241532', 'https://openalex.org/W2112580075', 'https://openalex.org/W2115232380', 'https://openalex.org/W2120018683', 'https://openalex.org/W2121195755', 'https://openalex.org/W2122556001', 'https://openalex.org/W2125616834', 'https://openalex.org/W2126460438', 'https://openalex.org/W2127951128', 'https://openalex.org/W2130633620', 'https://openalex.org/W2131836314', 'https://openalex.org/W2133406974', 'https://openalex.org/W2138355864', 'https://openalex.org/W2142587628', 'https://openalex.org/W2149810044', 'https://openalex.org/W2151353276', 'https://openalex.org/W2151579950', 'https://openalex.org/W2155852085', 'https://openalex.org/W2160134481', 'https://openalex.org/W2160619682', 'https://openalex.org/W2161422861', 'https://openalex.org/W2161725198', 'https://openalex.org/W2162294621', 'https://openalex.org/W2162759126', 'https://openalex.org/W2164979744', 'https://openalex.org/W2167829087', 'https://openalex.org/W2170148763', 'https://openalex.org/W2171524064', 'https://openalex.org/W2171875475', 'https://openalex.org/W2195424142', 'https://openalex.org/W2288102166', 'https://openalex.org/W2294059599', 'https://openalex.org/W2319319604', 'https://openalex.org/W242058159', 'https://openalex.org/W296951886', 'https://openalex.org/W3023846844', 'https://openalex.org/W3139670185', 'https://openalex.org/W946260445'], 'related_works': ['https://openalex.org/W4322491797', 'https://openalex.org/W4225912389', 'https://openalex.org/W3142314375', 'https://openalex.org/W3120641611', 'https://openalex.org/W3009099684', 'https://openalex.org/W2799775149', 'https://openalex.org/W2795629650', 'https://openalex.org/W2398413522', 'https://openalex.org/W2339552918', 'https://openalex.org/W1935691507'], 'abstract_inverted_index': {'Purpose': [0], 'of': [1, 18, 23, 30, 70, 86, 144, 148, 203], 'review': [2, 196], 'Human': [3], 'eosinophils': [4, 26, 204], 'were': [5], 'first': [6], 'identified': [7], 'and': [8, 43, 49, 57, 73, 77, 88, 104, 106, 122, 139, 146, 184, 205, 221], 'named': [9], 'by': [10], 'Paul': [11], 'Ehrlich': [12], 'in': [13, 116, 137, 152, 169, 189, 200], '1879': [14], 'on': [15, 93], 'the': [16, 19, 36, 40, 83, 91, 142, 182, 201, 208], 'basis': [17], "cell's": [20], 'granular': [21], 'uptake': [22], 'eosin.': [24], 'Although': [25], 'represent': [27], 'approximately': [28], '1%': [29], 'peripheral': [31], 'blood': [32, 41, 138], 'leukocytes,': [33], 'they': [34], 'have': [35, 111], 'propensity': [37], 'to': [38, 55, 101, 214, 227], 'leave': [39], 'stream': [42], 'migrate': [44], 'into': [45], 'inflamed': [46], 'tissues.': [47], 'Eosinophils': [48, 63, 81], 'their': [50, 94], 'mediators': [51], 'are': [52, 64, 82, 114], 'critical': [53], 'effectors': [54], 'asthma': [56], 'eosinophilic': [58, 119, 157, 192, 230], 'granulomatosis': [59], 'with': [60, 66, 118, 133, 155, 171, 191, 217, 229], 'polyangiitis': [61], '(EGPA).': [62], 'equipped': [65], 'a': [67, 134, 166], 'large': [68], 'number': [69, 143], 'cell-surface': [71], 'receptors': [72], 'produce': [74], 'specific': [75], 'cytokines': [76], 'chemokines.': [78], 'Recent': [79], 'findings': [80], 'major': [84], 'source': [85], 'interleukin-5': [87, 102, 209], 'highly': [89], 'express': [90], 'interleukin-5Rα': [92, 109], 'surface.': [95], 'Clinical': [96], 'trials': [97], 'evaluating': [98], 'monoclonal': [99], 'antibodies': [100], '(mepolizumab': [103], 'reslizumab)': [105], 'its': [107], 'receptor': [108], '(benralizumab)': [110], 'been': [112], 'or': [113], 'underway': [115], 'patients': [117, 154, 170, 190, 216, 228], 'asthma,': [120, 219], 'EGPA': [121], 'chronic': [123], 'obstructive': [124], 'pulmonary': [125], 'disease': [126], '(COPD).': [127], 'Overall,': [128], 'targeting': [129, 207], 'interleukin-5/interleukin-5Rα': [130], 'is': [131], 'associated': [132], 'marked': [135], 'decrease': [136], 'sputum': [140], 'eosinophilia,': [141], 'exacerbations': [145, 183], 'improvement': [147], 'some': [149, 215], 'clinical': [150], 'parameters': [151], 'adult': [153], 'severe': [156, 218], 'asthma.': [158], 'Pilot': [159], 'studies': [160], 'suggest': [161], 'that': [162, 177], 'mepolizumab': [163], 'might': [164, 211], 'be': [165], 'glucocorticoid-sparing': [167], 'treatment': [168], 'EGPA.': [172], 'A': [173], 'preliminary': [174], 'study': [175], 'found': [176], 'benralizumab': [178], 'did': [179, 185], 'not': [180], 'reduce': [181], 'modify': [186], 'lung': [187], 'function': [188], 'COPD.': [193, 222], 'Summary': [194], 'The': [195], 'examines': [197], 'recent': [198], 'advances': [199], 'biology': [202], 'how': [206], 'pathway': [210], 'offer': [212, 225], 'benefit': [213], 'EGPA,': [220], 'Interleukin-5/interleukin-5Rα-targeted': [223], 'treatments': [224], 'promises': [226], 'respiratory': [231], 'disorders.': [232]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2398413522', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 14}, {'year': 2022, 'cited_by_count': 13}, {'year': 2021, 'cited_by_count': 22}, {'year': 2020, 'cited_by_count': 22}, {'year': 2019, 'cited_by_count': 21}, {'year': 2018, 'cited_by_count': 25}, {'year': 2017, 'cited_by_count': 23}, {'year': 2016, 'cited_by_count': 14}], 'updated_date': '2024-09-13T12:25:20.097734', 'created_date': '2016-06-24'}