Title: The expression of nuclear transcription factor c-fos and c-jun in cerebral hypoxia-ischemia in newborn rats.
Abstract: Objective To investigate the relationship between the expression of c-fos as well as c-jun and cerebral hypoxia-ischemia in newborn rats. Methods 24 Wistar rats made the model of hypoxia-ischemia in experiment were divided into two groups,the experimental group was 18 rats and the control group was 6 rats. RT-PCR and blot hybridization were used in experiment. Results There were significant variation between the expression of c-fos and c-jun in different time (P0. 001) ,the groups of 72 hours and 96 hours were higher than the groups of 24 hours and in different areas (P0. 001. which the areas of CA3 of dental grays and basal ganglia were bigger than the areas of somatosenssr). Conclusion These results indicated that the increase in expression of c-fos and c-jun could be induced by cerebral hypoxia-ischemia, and the genes could be one of the genes induced neural cell damage.
Publication Year: 2000
Publication Date: 2000-01-01
Language: en
Type: article
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