Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3140897767', 'doi': 'https://doi.org/10.21203/rs.3.rs-71025/v1', 'title': 'HPF1 remodels PARP1 active site for ADP-ribosylation of histones on serine', 'display_name': 'HPF1 remodels PARP1 active site for ADP-ribosylation of histones on serine', 'publication_year': 2020, 'publication_date': '2020-09-18', 'ids': {'openalex': 'https://openalex.org/W3140897767', 'doi': 'https://doi.org/10.21203/rs.3.rs-71025/v1', 'mag': '3140897767'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.21203/rs.3.rs-71025/v1', 'pdf_url': 'https://www.researchsquare.com/article/rs-71025/v1.pdf', 'source': {'id': 'https://openalex.org/S4306402450', 'display_name': 'Research Square (Research Square)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210096694', 'host_organization_name': 'Research Square (United States)', 'host_organization_lineage': ['https://openalex.org/I4210096694'], 'host_organization_lineage_names': ['Research Square (United States)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.researchsquare.com/article/rs-71025/v1.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5006840181', 'display_name': 'Cai‐Hong Yun', 'orcid': 'https://orcid.org/0000-0002-5880-8307'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Cai-Hong Yun', 'raw_affiliation_strings': ['Peking University'], 'affiliations': [{'raw_affiliation_string': 'Peking University', 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039861577', 'display_name': 'Fa-Hui Sun', 'orcid': 'https://orcid.org/0000-0002-6375-6564'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Fa-Hui Sun', 'raw_affiliation_strings': ['Peking University'], 'affiliations': [{'raw_affiliation_string': 'Peking University', 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057131883', 'display_name': 'Peng Zhao', 'orcid': 'https://orcid.org/0000-0002-9296-5293'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Peng Zhao', 'raw_affiliation_strings': ['Peking University'], 'affiliations': [{'raw_affiliation_string': 'Peking University', 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100331346', 'display_name': 'Nan Zhang', 'orcid': 'https://orcid.org/0009-0001-6336-7534'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Nan Zhang', 'raw_affiliation_strings': ['Center for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University Lu-Lu Kong Peking University'], 'affiliations': [{'raw_affiliation_string': 'Center for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University Lu-Lu Kong Peking University', 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060851348', 'display_name': 'Lulu Kong', 'orcid': 'https://orcid.org/0009-0001-8454-1546'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lu-Lu Kong', 'raw_affiliation_strings': ['Peking University'], 'affiliations': [{'raw_affiliation_string': 'Peking University', 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5041836280', 'display_name': 'Catherine C. L. Wong', 'orcid': 'https://orcid.org/0000-0001-7270-980X'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Catherine Wong', 'raw_affiliation_strings': ['Center for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University'], 'affiliations': [{'raw_affiliation_string': 'Center for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University', 'institution_ids': ['https://openalex.org/I20231570']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 60}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11914', 'display_name': 'PARP inhibition in cancer therapy', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11914', 'display_name': 'PARP inhibition in cancer therapy', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T14117', 'display_name': 'Integrated Circuits and Semiconductor Failure Analysis', 'score': 0.9785, 'subfield': {'id': 'https://openalex.org/subfields/2208', 'display_name': 'Electrical and Electronic Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T12166', 'display_name': 'Ion-surface interactions and analysis', 'score': 0.9559, 'subfield': {'id': 'https://openalex.org/subfields/2206', 'display_name': 'Computational Mechanics'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/parp1', 'display_name': 'PARP1', 'score': 0.9456453}, {'id': 'https://openalex.org/keywords/adp-ribosylation', 'display_name': 'ADP-ribosylation', 'score': 0.75276124}], 'concepts': [{'id': 'https://openalex.org/C2778480876', 'wikidata': 'https://www.wikidata.org/wiki/Q21112674', 'display_name': 'PARP1', 'level': 5, 'score': 0.9456453}, {'id': 'https://openalex.org/C45510557', 'wikidata': 'https://www.wikidata.org/wiki/Q61420', 'display_name': 'ADP-ribosylation', 'level': 4, 'score': 0.75276124}, {'id': 'https://openalex.org/C2776414213', 'wikidata': 'https://www.wikidata.org/wiki/Q183290', 'display_name': 'Serine', 'level': 3, 'score': 0.56394863}, {'id': 'https://openalex.org/C64927066', 'wikidata': 'https://www.wikidata.org/wiki/Q36293', 'display_name': 'Histone', 'level': 3, 'score': 0.5206206}, {'id': 'https://openalex.org/C82381507', 'wikidata': 'https://www.wikidata.org/wiki/Q416878', 'display_name': 'Polymerase', 'level': 3, 'score': 0.5129318}, {'id': 'https://openalex.org/C16318435', 'wikidata': 'https://www.wikidata.org/wiki/Q149299', 'display_name': 'Mutagenesis', 'level': 4, 'score': 0.4859494}, {'id': 'https://openalex.org/C182979987', 'wikidata': 'https://www.wikidata.org/wiki/Q3907241', 'display_name': 'Poly ADP ribose polymerase', 'level': 4, 'score': 0.48538864}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.48001662}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4279259}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.40320423}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.39158612}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.38525158}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.37306535}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.37217602}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.19532368}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.15572545}, {'id': 'https://openalex.org/C75520062', 'wikidata': 'https://www.wikidata.org/wiki/Q15321392', 'display_name': 'NAD+ kinase', 'level': 3, 'score': 0.09323284}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.091584295}], 'mesh': [], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.21203/rs.3.rs-71025/v1', 'pdf_url': 'https://www.researchsquare.com/article/rs-71025/v1.pdf', 'source': {'id': 'https://openalex.org/S4306402450', 'display_name': 'Research Square (Research Square)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210096694', 'host_organization_name': 'Research Square (United States)', 'host_organization_lineage': ['https://openalex.org/I4210096694'], 'host_organization_lineage_names': ['Research Square (United States)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41467-021-21302-4', 'pdf_url': 'https://www.nature.com/articles/s41467-021-21302-4.pdf', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.21203/rs.3.rs-71025/v1', 'pdf_url': 'https://www.researchsquare.com/article/rs-71025/v1.pdf', 'source': {'id': 'https://openalex.org/S4306402450', 'display_name': 'Research Square (Research Square)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210096694', 'host_organization_name': 'Research Square (United States)', 'host_organization_lineage': ['https://openalex.org/I4210096694'], 'host_organization_lineage_names': ['Research Square (United States)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'score': 0.66, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 21, 'referenced_works': ['https://openalex.org/W1973268287', 'https://openalex.org/W1974916823', 'https://openalex.org/W1989006164', 'https://openalex.org/W1991742606', 'https://openalex.org/W2073660843', 'https://openalex.org/W2083946902', 'https://openalex.org/W2088689845', 'https://openalex.org/W2095798342', 'https://openalex.org/W2123745604', 'https://openalex.org/W2172631200', 'https://openalex.org/W2177419974', 'https://openalex.org/W2334440167', 'https://openalex.org/W2530540719', 'https://openalex.org/W2587003776', 'https://openalex.org/W2588135595', 'https://openalex.org/W2732346161', 'https://openalex.org/W2788939638', 'https://openalex.org/W2807452056', 'https://openalex.org/W2910350699', 'https://openalex.org/W2914939061', 'https://openalex.org/W3004782200'], 'related_works': ['https://openalex.org/W4367056786', 'https://openalex.org/W4362522364', 'https://openalex.org/W3212892569', 'https://openalex.org/W3212265315', 'https://openalex.org/W3192395138', 'https://openalex.org/W3134530449', 'https://openalex.org/W3125049294', 'https://openalex.org/W3004782200', 'https://openalex.org/W2981812204', 'https://openalex.org/W2788939638'], 'abstract_inverted_index': {'Abstract': [0], 'Upon': [1], 'binding': [2, 132], 'to': [3, 15, 78, 110, 125], 'DNA': [4, 17, 27], 'breaks,': [5], 'poly(ADP-ribose)': [6], 'polymerase': [7], '1': [8], '(PARP1)': [9], 'ADP-ribosylates': [10], 'itself': [11], 'and': [12, 49, 51, 57, 64, 98, 129, 142], 'other': [13], 'factors': [14], 'initiate': [16], 'repair.': [18], 'Serine': [19], 'is': [20], 'the': [21, 37, 69, 74, 84, 93, 120, 135, 143], 'major': [22], 'residue': [23], 'for': [24, 87, 115], 'ADP-ribosylation': [25], 'upon': [26], 'damage,': [28], 'which': [29], 'strictly': [30], 'depends': [31], 'on': [32], 'HPF1.': [33], 'Here': [34], 'we': [35, 81], 'report': [36], 'crystal': [38], 'structures': [39, 63], 'of': [40, 123, 138], 'human': [41, 52], 'HPF1/PARP1-CAT': [42], 'ΔHD': [43], 'complex': [44], 'at': [45, 54], '1.98': [46], 'Å': [47, 56, 59], 'resolution': [48], 'mouse': [50], 'HPF1': [53, 124], '1.71': [55], '1.57': [58], 'resolution,': [60], 'respectively.': [61], 'These': [62, 140], 'mutagenesis': [65], 'data': [66, 105, 146], 'confirm': [67], 'that': [68, 107], 'structural': [70, 145], 'insights': [71], 'obtained': [72], 'in': [73], 'HPF1/PARP2': [75], 'study': [76], 'apply': [77], 'PARP1.': [79, 152], 'Moreover,': [80], 'quantitatively': [82], 'characterize': [83], 'key': [85], 'residues': [86], 'HPF1/PARP1': [88, 96, 131], 'binding.': [89], 'This': [90], 'information': [91], 'clarifies': [92], 'confusion': [94], 'regarding': [95], 'assembly': [97], 'can': [99], 'direct': [100], 'following': [101], 'functional': [102], 'studies.': [103], 'Our': [104], 'show': [106], 'through': [108, 133], 'salt-bridging': [109], 'Glu284/Asp286,': [111], 'Arg239': [112], 'positions': [113], 'Glu284': [114], 'catalyzing': [116], 'serine': [117], 'ADP-ribosylation,': [118], 'maintains': [119], 'local': [121], 'conformation': [122], 'limit': [126], 'PARP1': [127], 'automodification': [128], 'facilitates': [130], 'neutralizing': [134], 'negative': [136], 'charge': [137], 'Glu284.': [139], 'findings': [141], 'high-resolution': [144], 'may': [147], 'facilitate': [148], 'drug': [149], 'discovery': [150], 'targeting': [151]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3140897767', 'counts_by_year': [], 'updated_date': '2024-12-26T14:44:02.533442', 'created_date': '2021-04-13'}