Human ORC/MCM density is low in active genes and correlates with replication time but does not delimit initiation zones

Name: Work Video:
Duration: 3 min 30 s
Nina Kirstein; Alexander Buschle; Xia Wu; Stefan Krebs; Helmut Blum; Elisabeth Kremmer; Ina Vorberg; Wolfgang Hammerschmidt; Laurent Lacroix; Olivier Hyrien; Benjamin Audit; Aloys Schepers
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'been': [11], 'licensed': [12], 'in': [13, 74, 77, 87, 134, 156], 'the': [14, 24, 48, 54, 116], 'preceding': [15], 'G1': [16], 'phase.': [17], 'Here,': [18], 'we': [19], 'compare': [20], 'ChIP-seq': [21], 'profiles': [22, 40], 'of': [23, 118, 141], 'licensing': [25], 'factors': [26], 'Orc2,': [27], 'Orc3,': [28], 'Mcm3,': [29], 'and': [30, 37, 45, 53, 61, 71, 100, 138, 152], 'Mcm7': [31], 'with': [32, 108], 'gene': [33, 69, 139], 'expression,': [34], 'timing,': [36], 'fork': [38, 144], 'directionality': [39], 'obtained': [41], 'by': [42], 'RNA-seq,': [43], 'Repli-seq,': [44], 'OK-seq.': [46], 'Both,': [47], 'origin': [49, 130], 'recognition': [50], 'complex': [51, 57], '(ORC)': [52], 'minichromosome': [55], 'maintenance': [56], '(MCM)': [58], 'are': [59], 'significantly': [60], 'homogeneously': [62], 'depleted': [63], 'transcribed': [65], 'genes,': [66], 'enriched': [67, 133], 'at': [68], 'promoters,': [70], 'more': [72], 'abundant': [73], 'early-': [75], 'than': [76], 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[151], 'where': [153], 'human': [157], 'cells.': [158]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3134744679', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 14}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 8}], 'updated_date': '2025-01-10T08:52:15.174243', 'created_date': '2021-03-15'}
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