Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2417440641', 'doi': 'https://doi.org/10.1038/ncomms11748', 'title': 'A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells', 'display_name': 'A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells', 'publication_year': 2016, 'publication_date': '2016-06-08', 'ids': {'openalex': 'https://openalex.org/W2417440641', 'doi': 'https://doi.org/10.1038/ncomms11748', 'mag': '2417440641', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27272143', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4899857'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/ncomms11748', 'pdf_url': 'https://www.nature.com/articles/ncomms11748.pdf', 'source': {'id': 'https://openalex.org/S64187185', 'display_name': 'Nature Communications', 'issn_l': '2041-1723', 'issn': ['2041-1723'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.nature.com/articles/ncomms11748.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5082602929', 'display_name': 'Ya Zhang', 'orcid': 'https://orcid.org/0000-0002-1746-3437'}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ya Zhang', 'raw_affiliation_strings': ['Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA'], 'affiliations': [{'raw_affiliation_string': 'Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210149717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040573243', 'display_name': 'Liang Huang', 'orcid': 'https://orcid.org/0000-0003-1663-7025'}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Liang Huang', 'raw_affiliation_strings': ['Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA'], 'affiliations': [{'raw_affiliation_string': 'Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210149717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019202221', 'display_name': 'Haiqing Fu', 'orcid': 'https://orcid.org/0000-0003-4764-1422'}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Haiqing Fu', 'raw_affiliation_strings': ['Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA'], 'affiliations': [{'raw_affiliation_string': 'Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210149717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022996455', 'display_name': 'Owen K. Smith', 'orcid': 'https://orcid.org/0000-0003-0880-2801'}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Owen K. Smith', 'raw_affiliation_strings': ['Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA'], 'affiliations': [{'raw_affiliation_string': 'Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210149717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112191057', 'display_name': 'Chii M. Lin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chii Mei Lin', 'raw_affiliation_strings': ['Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA'], 'affiliations': [{'raw_affiliation_string': 'Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210149717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077109718', 'display_name': 'Koichi Utani', 'orcid': 'https://orcid.org/0000-0002-8065-3161'}, 'institutions': [{'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}, {'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Koichi Utani', 'raw_affiliation_strings': ['Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA'], 'affiliations': [{'raw_affiliation_string': 'Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA', 'institution_ids': ['https://openalex.org/I4210149717', 'https://openalex.org/I4210140884', 'https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065552266', 'display_name': 'Mishal Rao', 'orcid': 'https://orcid.org/0000-0003-2044-682X'}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mishal Rao', 'raw_affiliation_strings': ['Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA'], 'affiliations': [{'raw_affiliation_string': 'Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210149717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069677416', 'display_name': 'William C. Reinhold', 'orcid': 'https://orcid.org/0000-0001-5513-9323'}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'William C. Reinhold', 'raw_affiliation_strings': ['Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA'], 'affiliations': [{'raw_affiliation_string': 'Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210149717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015342151', 'display_name': 'Christophe E. Redon', 'orcid': 'https://orcid.org/0000-0003-2799-2778'}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christophe E. Redon', 'raw_affiliation_strings': ['Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA'], 'affiliations': [{'raw_affiliation_string': 'Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210149717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063865589', 'display_name': 'Michaël Ryan', 'orcid': 'https://orcid.org/0000-0003-4585-7174'}, 'institutions': [{'id': 'https://openalex.org/I4210122574', 'display_name': 'In Silico Biosciences (United States)', 'ror': 'https://ror.org/02xnk0c33', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210122574']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael Ryan', 'raw_affiliation_strings': ['In Silico Solutions, Fairfax, USA'], 'affiliations': [{'raw_affiliation_string': 'In Silico Solutions, Fairfax, USA', 'institution_ids': ['https://openalex.org/I4210122574']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072180225', 'display_name': 'RyangGuk Kim', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210122574', 'display_name': 'In Silico Biosciences (United States)', 'ror': 'https://ror.org/02xnk0c33', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210122574']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'RyangGuk Kim', 'raw_affiliation_strings': ['In Silico Solutions, Fairfax, USA'], 'affiliations': [{'raw_affiliation_string': 'In Silico Solutions, Fairfax, USA', 'institution_ids': ['https://openalex.org/I4210122574']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058035155', 'display_name': 'Yang You', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yang You', 'raw_affiliation_strings': ['Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA'], 'affiliations': [{'raw_affiliation_string': 'Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210149717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036311147', 'display_name': 'Harlington Hanna', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Harlington Hanna', 'raw_affiliation_strings': ['Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA'], 'affiliations': [{'raw_affiliation_string': 'Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210149717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013976252', 'display_name': 'Yves R. Boisclair', 'orcid': 'https://orcid.org/0000-0002-6621-498X'}, 'institutions': [{'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yves Boisclair', 'raw_affiliation_strings': ['Department of Animal Science, Cornell University, Ithaca, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Animal Science, Cornell University, Ithaca, USA', 'institution_ids': ['https://openalex.org/I205783295']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067928546', 'display_name': 'Qiaoming Long', 'orcid': 'https://orcid.org/0000-0001-8243-589X'}, 'institutions': [{'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Qiaoming Long', 'raw_affiliation_strings': ['Department of Animal Science, Cornell University, Ithaca, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Animal Science, Cornell University, Ithaca, USA', 'institution_ids': ['https://openalex.org/I205783295']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5045977241', 'display_name': 'Mirit I. Aladjem', 'orcid': 'https://orcid.org/0000-0002-1875-3110'}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Mirit I. Aladjem', 'raw_affiliation_strings': ['Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA'], 'affiliations': [{'raw_affiliation_string': 'Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210149717']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': ['https://openalex.org/A5045977241'], 'corresponding_institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210149717'], 'apc_list': {'value': 3920, 'currency': 'GBP', 'value_usd': 4808, 'provenance': 'doaj'}, 'apc_paid': {'value': 3920, 'currency': 'GBP', 'value_usd': 4808, 'provenance': 'doaj'}, 'fwci': 1.9, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 34, 'citation_normalized_percentile': {'value': 0.999984, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '7', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10492', 'display_name': 'Microtubule and mitosis dynamics', 'score': 0.9902, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/origin-recognition-complex', 'display_name': 'Origin recognition complex', 'score': 0.8310678}, {'id': 'https://openalex.org/keywords/pre-replication-complex', 'display_name': 'Pre-replication complex', 'score': 0.82896805}, {'id': 'https://openalex.org/keywords/replication-factor-c', 'display_name': 'Replication factor C', 'score': 0.7752855}, {'id': 'https://openalex.org/keywords/licensing-factor', 'display_name': 'Licensing factor', 'score': 0.73340225}, {'id': 'https://openalex.org/keywords/minichromosome-maintenance', 'display_name': 'Minichromosome maintenance', 'score': 0.628039}, {'id': 'https://openalex.org/keywords/replication-timing', 'display_name': 'Replication timing', 'score': 0.56920314}, {'id': 'https://openalex.org/keywords/ter-protein', 'display_name': 'Ter protein', 'score': 0.53016996}], 'concepts': [{'id': 'https://openalex.org/C151158763', 'wikidata': 'https://www.wikidata.org/wiki/Q1626856', 'display_name': 'Origin recognition complex', 'level': 5, 'score': 0.8310678}, {'id': 'https://openalex.org/C41141232', 'wikidata': 'https://www.wikidata.org/wiki/Q3685229', 'display_name': 'Pre-replication complex', 'level': 5, 'score': 0.82896805}, {'id': 'https://openalex.org/C188036394', 'wikidata': 'https://www.wikidata.org/wiki/Q14902224', 'display_name': 'Replication factor C', 'level': 5, 'score': 0.7752855}, {'id': 'https://openalex.org/C104690221', 'wikidata': 'https://www.wikidata.org/wiki/Q5165872', 'display_name': 'Control of chromosome duplication', 'level': 4, 'score': 0.7664953}, {'id': 'https://openalex.org/C54266558', 'wikidata': 'https://www.wikidata.org/wiki/Q6543075', 'display_name': 'Licensing factor', 'level': 5, 'score': 0.73340225}, {'id': 'https://openalex.org/C175193931', 'wikidata': 'https://www.wikidata.org/wiki/Q18047065', 'display_name': 'DNA replication factor CDT1', 'level': 5, 'score': 0.7038072}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.680301}, {'id': 'https://openalex.org/C73573662', 'wikidata': 'https://www.wikidata.org/wiki/Q130996', 'display_name': 'DNA replication', 'level': 3, 'score': 0.64301914}, {'id': 'https://openalex.org/C175248279', 'wikidata': 'https://www.wikidata.org/wiki/Q3858415', 'display_name': 'Minichromosome maintenance', 'level': 5, 'score': 0.628039}, {'id': 'https://openalex.org/C98086919', 'wikidata': 'https://www.wikidata.org/wiki/Q118019', 'display_name': 'Eukaryotic DNA replication', 'level': 4, 'score': 0.582645}, {'id': 'https://openalex.org/C58337764', 'wikidata': 'https://www.wikidata.org/wiki/Q976651', 'display_name': 'Origin of replication', 'level': 4, 'score': 0.5755186}, {'id': 'https://openalex.org/C2778512757', 'wikidata': 'https://www.wikidata.org/wiki/Q7314076', 'display_name': 'Replication timing', 'level': 4, 'score': 0.56920314}, {'id': 'https://openalex.org/C22840021', 'wikidata': 'https://www.wikidata.org/wiki/Q7701454', 'display_name': 'Ter protein', 'level': 5, 'score': 0.53016996}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.47731766}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3313986}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.29592413}], 'mesh': [{'descriptor_ui': 'D004261', 'descriptor_name': 'DNA Replication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008322', 'descriptor_name': 'Mammals', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018741', 'descriptor_name': 'Replication Origin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004622', 'descriptor_name': 'Embryo, Mammalian', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004622', 'descriptor_name': 'Embryo, Mammalian', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D056426', 'descriptor_name': 'Genetic Loci', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016678', 'descriptor_name': 'Genome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019901', 'descriptor_name': 'Locus Control Region', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008322', 'descriptor_name': 'Mammals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/ncomms11748', 'pdf_url': 'https://www.nature.com/articles/ncomms11748.pdf', 'source': {'id': 'https://openalex.org/S64187185', 'display_name': 'Nature Communications', 'issn_l': '2041-1723', 'issn': ['2041-1723'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/c6ff6c1a7efd4a8fa9a131eacd84cee4', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4899857', 'pdf_url': 'https://europepmc.org/articles/pmc4899857?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899857', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27272143', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/ncomms11748', 'pdf_url': 'https://www.nature.com/articles/ncomms11748.pdf', 'source': {'id': 'https://openalex.org/S64187185', 'display_name': 'Nature Communications', 'issn_l': '2041-1723', 'issn': ['2041-1723'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.48, 'id': 'https://metadata.un.org/sdg/15', 'display_name': 'Life on land'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 66, 'referenced_works': ['https://openalex.org/W1966691296', 'https://openalex.org/W1970315553', 'https://openalex.org/W1977305809', 'https://openalex.org/W1977586435', 'https://openalex.org/W1980356512', 'https://openalex.org/W1988418140', 'https://openalex.org/W1989654707', 'https://openalex.org/W2001199959', 'https://openalex.org/W2001831501', 'https://openalex.org/W2004768852', 'https://openalex.org/W2005029480', 'https://openalex.org/W2006193637', 'https://openalex.org/W2006388798', 'https://openalex.org/W2008411282', 'https://openalex.org/W2009631794', 'https://openalex.org/W2018843280', 'https://openalex.org/W2023528999', 'https://openalex.org/W2024055173', 'https://openalex.org/W2027243820', 'https://openalex.org/W2030665161', 'https://openalex.org/W2031000298', 'https://openalex.org/W2033338722', 'https://openalex.org/W2034253224', 'https://openalex.org/W2036111506', 'https://openalex.org/W2038740785', 'https://openalex.org/W2044053548', 'https://openalex.org/W2048036743', 'https://openalex.org/W2049103142', 'https://openalex.org/W2050987515', 'https://openalex.org/W2055524182', 'https://openalex.org/W2056298514', 'https://openalex.org/W2057007071', 'https://openalex.org/W2057321580', 'https://openalex.org/W2057896961', 'https://openalex.org/W2063061401', 'https://openalex.org/W2063442590', 'https://openalex.org/W2068784898', 'https://openalex.org/W2071919914', 'https://openalex.org/W2081464942', 'https://openalex.org/W2095907362', 'https://openalex.org/W2099117602', 'https://openalex.org/W2099929096', 'https://openalex.org/W2100032426', 'https://openalex.org/W2101412414', 'https://openalex.org/W2101477651', 'https://openalex.org/W2104190830', 'https://openalex.org/W2110670854', 'https://openalex.org/W2112429774', 'https://openalex.org/W2116966280', 'https://openalex.org/W2123660387', 'https://openalex.org/W2132353168', 'https://openalex.org/W2139705441', 'https://openalex.org/W2141609688', 'https://openalex.org/W2143999026', 'https://openalex.org/W2146090455', 'https://openalex.org/W2150017499', 'https://openalex.org/W2152070513', 'https://openalex.org/W2153963453', 'https://openalex.org/W2159539440', 'https://openalex.org/W2159790702', 'https://openalex.org/W2165937665', 'https://openalex.org/W2166828381', 'https://openalex.org/W2168050478', 'https://openalex.org/W2171439401', 'https://openalex.org/W2411606084', 'https://openalex.org/W4238483534'], 'related_works': ['https://openalex.org/W3139440102', 'https://openalex.org/W3136565871', 'https://openalex.org/W3134744679', 'https://openalex.org/W3099246975', 'https://openalex.org/W2991021748', 'https://openalex.org/W2417440641', 'https://openalex.org/W2165204343', 'https://openalex.org/W2098324291', 'https://openalex.org/W2082627754', 'https://openalex.org/W1970614468'], 'abstract_inverted_index': {'Abstract': [0], 'Mammalian': [1], 'chromosome': [2], 'replication': [3, 22, 58, 67, 70, 92, 106, 124, 132], 'starts': [4], 'from': [5, 68], 'distinct': [6, 128], 'sites;': [7], 'however,': [8], 'the': [9, 73, 76, 91, 96], 'principles': [10], 'governing': [11], 'initiation': [12, 64, 125], 'site': [13], 'selection': [14], 'are': [15, 115], 'unclear': [16], 'because': [17], 'proteins': [18], 'essential': [19], 'for': [20, 63], 'DNA': [21, 27, 66], 'do': [23], 'not': [24], 'exhibit': [25, 56, 104], 'sequence-specific': [26], 'binding.': [28], 'Here': [29], 'we': [30], 'identify': [31], 'a': [32, 39, 51, 118, 127], 'replication-initiation': [33, 42, 111], 'determinant': [34], '(RepID)': [35], 'protein': [36], 'that': [37, 121], 'binds': [38], 'subset': [40], 'of': [41, 47, 65, 130], 'sites.': [43], 'A': [44], 'large': [45], 'fraction': [46], 'RepID-binding': [48], 'sites': [49], 'share': [50], 'common': [52], 'G-rich': [53], 'motif': [54], 'and': [55, 95, 109], 'elevated': [57], 'initiation.': [59], 'RepID': [60, 84, 122], 'is': [61, 85], 'required': [62], 'RepID-bound': [69], 'origins,': [71], 'including': [72], 'origin': [74, 93], 'at': [75, 126], 'human': [77, 131], 'beta-globin': [78], '(HBB)': [79], 'locus.': [80], 'At': [81], 'HBB': [82], ',': [83], 'involved': [86], 'in': [87], 'an': [88], 'interaction': [89], 'between': [90], '(Rep-P)': [94], 'locus': [97], 'control': [98], 'region.': [99], 'RepID-depleted': [100], 'murine': [101], 'embryonic': [102], 'fibroblasts': [103], 'abnormal': [105], 'fork': [107], 'progression': [108], 'fewer': [110], 'events.': [112], 'These': [113], 'observations': [114], 'consistent': [116], 'with': [117], 'model,': [119], 'suggesting': [120], 'facilitates': [123], 'group': [129], 'origins.': [133]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2417440641', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 3}], 'updated_date': '2025-01-09T15:50:37.743310', 'created_date': '2016-06-24'}