Publication Information

{'id': 'https://openalex.org/W3133812864', 'doi': 'https://doi.org/10.1117/12.2578660', 'title': 'Fluorescence lifetime imaging and spectroscopy for enhanced protoporphyrin IX guided brain tumor surgery', 'display_name': 'Fluorescence lifetime imaging and spectroscopy for enhanced protoporphyrin IX guided brain tumor surgery', 'publication_year': 2021, 'publication_date': '2021-03-04', 'ids': {'openalex': 'https://openalex.org/W3133812864', 'doi': 'https://doi.org/10.1117/12.2578660', 'mag': '3133812864'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1117/12.2578660', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'proceedings-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5061272217', 'display_name': 'David Reichert', 'orcid': 'https://orcid.org/0000-0002-9593-6447'}, 'institutions': [], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'David Reichert', 'raw_affiliation_strings': ['Medizinische Univ. Wien (Austria)'], 'affiliations': [{'raw_affiliation_string': 'Medizinische Univ. Wien (Austria)', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045542346', 'display_name': 'Mikael T. Erkkilä', 'orcid': 'https://orcid.org/0000-0002-5314-1486'}, 'institutions': [], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Mikael T. Erkkilä', 'raw_affiliation_strings': ['Medizinische Univ. Wien (Austria)'], 'affiliations': [{'raw_affiliation_string': 'Medizinische Univ. Wien (Austria)', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064983617', 'display_name': 'Georg Widhalm', 'orcid': 'https://orcid.org/0000-0001-6014-0273'}, 'institutions': [], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Georg Widhalm', 'raw_affiliation_strings': ['Medizinische Univ. Wien (Austria)'], 'affiliations': [{'raw_affiliation_string': 'Medizinische Univ. Wien (Austria)', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037366722', 'display_name': 'Barbara Kiesel', 'orcid': 'https://orcid.org/0000-0003-0939-9831'}, 'institutions': [], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Barbara Kiesel', 'raw_affiliation_strings': ['Medizinische Univ. Wien (Austria)'], 'affiliations': [{'raw_affiliation_string': 'Medizinische Univ. Wien (Austria)', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049990174', 'display_name': 'Lisa I. Wadiura', 'orcid': None}, 'institutions': [], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Lisa Wadiura', 'raw_affiliation_strings': ['Medizinische Univ. Wien (Austria)'], 'affiliations': [{'raw_affiliation_string': 'Medizinische Univ. Wien (Austria)', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062099952', 'display_name': 'Petra A. Mercea', 'orcid': None}, 'institutions': [], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Petra Mercea', 'raw_affiliation_strings': ['Medizinische Univ. Wien (Austria)'], 'affiliations': [{'raw_affiliation_string': 'Medizinische Univ. Wien (Austria)', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078506141', 'display_name': 'Marco Andreana', 'orcid': 'https://orcid.org/0000-0002-8212-0545'}, 'institutions': [], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Marco Andreana', 'raw_affiliation_strings': ['Medizinische Univ. Wien (Austria)'], 'affiliations': [{'raw_affiliation_string': 'Medizinische Univ. Wien (Austria)', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040312905', 'display_name': 'Angelika Unterhuber', 'orcid': 'https://orcid.org/0000-0002-1251-3001'}, 'institutions': [], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Angelika Unterhuber', 'raw_affiliation_strings': ['Medizinische Univ. Wien (Austria)'], 'affiliations': [{'raw_affiliation_string': 'Medizinische Univ. Wien (Austria)', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005370492', 'display_name': 'Marco Wilzbach', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1302207122', 'display_name': 'Carl Zeiss (Germany)', 'ror': 'https://ror.org/02mp31p96', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I1302207122']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Marco Wilzbach', 'raw_affiliation_strings': ['Carl Zeiss Meditec AG (Germany)'], 'affiliations': [{'raw_affiliation_string': 'Carl Zeiss Meditec AG (Germany)', 'institution_ids': ['https://openalex.org/I1302207122']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113861459', 'display_name': 'Christoph Hauger', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1302207122', 'display_name': 'Carl Zeiss (Germany)', 'ror': 'https://ror.org/02mp31p96', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I1302207122']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Christoph Hauger', 'raw_affiliation_strings': ['Carl Zeiss Meditec AG (Germany)'], 'affiliations': [{'raw_affiliation_string': 'Carl Zeiss Meditec AG (Germany)', 'institution_ids': ['https://openalex.org/I1302207122']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037124866', 'display_name': 'Wolfgang Drexler', 'orcid': 'https://orcid.org/0000-0002-3557-6398'}, 'institutions': [], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Wolfgang Drexler', 'raw_affiliation_strings': ['Medizinische Univ. Wien (Austria)'], 'affiliations': [{'raw_affiliation_string': 'Medizinische Univ. Wien (Austria)', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056039044', 'display_name': 'Rainer A. Leitgeb', 'orcid': 'https://orcid.org/0000-0002-0131-4111'}, 'institutions': [], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Rainer Leitgeb', 'raw_affiliation_strings': ['Medizinische Univ. Wien (Austria)'], 'affiliations': [{'raw_affiliation_string': 'Medizinische Univ. Wien (Austria)', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000495748', 'display_name': 'Thomas Rötzer', 'orcid': None}, 'institutions': [], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Thomas Rötzer', 'raw_affiliation_strings': ['Medizinische Univ. Wien (Austria)'], 'affiliations': [{'raw_affiliation_string': 'Medizinische Univ. Wien (Austria)', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5113739640', 'display_name': 'Adelheid Wöhrer', 'orcid': None}, 'institutions': [], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Adelheid Wöhrer', 'raw_affiliation_strings': ['Medizinische Univ. Wien (Austria)'], 'affiliations': [{'raw_affiliation_string': 'Medizinische Univ. Wien (Austria)', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 57}, 'biblio': {'volume': None, 'issue': None, 'first_page': '1', 'last_page': '1'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10957', 'display_name': 'Photodynamic Therapy Research Studies', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10957', 'display_name': 'Photodynamic Therapy Research Studies', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10782', 'display_name': 'Nanoplatforms for cancer theranostics', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T12015', 'display_name': 'Photoacoustic and Ultrasonic Imaging', 'score': 0.9926, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/protoporphyrin-ix', 'display_name': 'Protoporphyrin IX', 'score': 0.97657543}, {'id': 'https://openalex.org/keywords/autofluorescence', 'display_name': 'Autofluorescence', 'score': 0.93111753}, {'id': 'https://openalex.org/keywords/fluorescence-lifetime-imaging-microscopy', 'display_name': 'Fluorescence-lifetime imaging microscopy', 'score': 0.65138173}, {'id': 'https://openalex.org/keywords/ex-vivo', 'display_name': 'Ex vivo', 'score': 0.64970493}], 'concepts': [{'id': 'https://openalex.org/C2779671804', 'wikidata': 'https://www.wikidata.org/wiki/Q619815', 'display_name': 'Protoporphyrin IX', 'level': 3, 'score': 0.97657543}, {'id': 'https://openalex.org/C179687394', 'wikidata': 'https://www.wikidata.org/wiki/Q4826281', 'display_name': 'Autofluorescence', 'level': 3, 'score': 0.93111753}, {'id': 'https://openalex.org/C91881484', 'wikidata': 'https://www.wikidata.org/wiki/Q191807', 'display_name': 'Fluorescence', 'level': 2, 'score': 0.73753405}, {'id': 'https://openalex.org/C2778227246', 'wikidata': 'https://www.wikidata.org/wiki/Q1365309', 'display_name': 'Glioma', 'level': 2, 'score': 0.6797503}, {'id': 'https://openalex.org/C57477423', 'wikidata': 'https://www.wikidata.org/wiki/Q1434196', 'display_name': 'Fluorescence-lifetime imaging microscopy', 'level': 3, 'score': 0.65138173}, {'id': 'https://openalex.org/C26291073', 'wikidata': 'https://www.wikidata.org/wiki/Q310484', 'display_name': 'Ex vivo', 'level': 3, 'score': 0.64970493}, {'id': 'https://openalex.org/C169274487', 'wikidata': 'https://www.wikidata.org/wiki/Q840211', 'display_name': 'Fluorescence microscope', 'level': 3, 'score': 0.5439766}, {'id': 'https://openalex.org/C147080431', 'wikidata': 'https://www.wikidata.org/wiki/Q1074953', 'display_name': 'Microscopy', 'level': 2, 'score': 0.5184897}, {'id': 'https://openalex.org/C158711907', 'wikidata': 'https://www.wikidata.org/wiki/Q1768467', 'display_name': 'Fluorescence spectroscopy', 'level': 3, 'score': 0.4626364}, {'id': 'https://openalex.org/C46141821', 'wikidata': 'https://www.wikidata.org/wiki/Q209402', 'display_name': 'Nuclear magnetic resonance', 'level': 1, 'score': 0.43335563}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.43331254}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.38560465}, {'id': 'https://openalex.org/C192562407', 'wikidata': 'https://www.wikidata.org/wiki/Q228736', 'display_name': 'Materials science', 'level': 0, 'score': 0.3851994}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.38057324}, {'id': 'https://openalex.org/C136229726', 'wikidata': 'https://www.wikidata.org/wiki/Q327092', 'display_name': 'Biomedical engineering', 'level': 1, 'score': 0.3685058}, {'id': 'https://openalex.org/C120665830', 'wikidata': 'https://www.wikidata.org/wiki/Q14620', 'display_name': 'Optics', 'level': 1, 'score': 0.29784042}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.22485527}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.1259414}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.12376985}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.11180037}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1117/12.2578660', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.46}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W943367353', 'https://openalex.org/W2533665438', 'https://openalex.org/W2159982756', 'https://openalex.org/W2146944199', 'https://openalex.org/W2078437878', 'https://openalex.org/W2037276225', 'https://openalex.org/W2009432835', 'https://openalex.org/W1966978880', 'https://openalex.org/W1833947617', 'https://openalex.org/W1672167011'], 'abstract_inverted_index': {'Protoporphyrin': [0], 'IX': [1], '(PpIX)': [2], 'fluorescence-guided': [3], 'surgery': [4], 'has': [5], 'established': [6], 'as': [7], 'a': [8, 56, 59], 'standard': [9], 'for': [10], 'resecting': [11], 'malign': [12], 'glioma.': [13], 'However,': [14], 'low-grade': [15], 'glioma': [16, 65], 'or': [17], 'sparsely': [18], 'infiltrated': [19], 'brain': [20], 'often': [21], 'emit': [22], 'weak': [23, 69], 'PpIX': [24, 45, 70, 94], 'fluorescence': [25, 51, 71], 'and': [26], 'are': [27], 'hard': [28], 'to': [29], 'distinguish': [30], 'from': [31, 75], 'non-pathological': [32], 'tissue.': [33, 97], 'Furthermore,': [34], 'spectrally': [35], 'overlapping': [36], 'autofluorescence': [37, 77], 'inherently': [38], 'limits': [39], 'the': [40, 76, 85, 96], 'sensitivity': [41], 'of': [42, 93], 'fluorescence-intensity': [43], 'based': [44], 'detection.': [46], 'We': [47], 'therefore': [48], 'integrated': [49], 'frequency-domain': [50], 'lifetime': [52], 'imaging': [53], 'together': [54], 'with': [55], 'spectrometer': [57], 'in': [58, 84, 95], 'surgical': [60], 'microscope.': [61], 'When': [62], 'analyzing': [63], 'human': [64], 'samples': [66], 'ex': [67], 'vivo,': [68], 'could': [72], 'be': [73], 'differentiated': [74], 'background': [78], 'through': [79], 'increased': [80], 'lifetimes.': [81], 'Characteristic': [82], 'peaks': [83], 'spectral': [86], 'measurements': [87], '(635,': [88], '705nm)': [89], 'confirmed': [90], 'low': [91], 'concentrations': [92]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3133812864', 'counts_by_year': [], 'updated_date': '2024-12-06T05:48:16.758546', 'created_date': '2021-03-15'}