Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3131089254', 'doi': 'https://doi.org/10.1038/s41598-021-89006-9', 'title': 'The ratio of T790M to EGFR-activating mutation predicts response of osimertinib in 1st or 2nd generation EGFR-TKI-refractory NSCLC', 'display_name': 'The ratio of T790M to EGFR-activating mutation predicts response of osimertinib in 1st or 2nd generation EGFR-TKI-refractory NSCLC', 'publication_year': 2021, 'publication_date': '2021-05-05', 'ids': {'openalex': 'https://openalex.org/W3131089254', 'doi': 'https://doi.org/10.1038/s41598-021-89006-9', 'mag': '3131089254', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/33953280', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/8099906'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41598-021-89006-9', 'pdf_url': 'https://www.nature.com/articles/s41598-021-89006-9.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.nature.com/articles/s41598-021-89006-9.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5036738616', 'display_name': 'Motohiro Tamiya', 'orcid': 'https://orcid.org/0000-0001-6529-3092'}, 'institutions': [{'id': 'https://openalex.org/I4210101504', 'display_name': 'Osaka International Cancer Institute', 'ror': 'https://ror.org/010srfv22', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210101504']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Motohiro Tamiya', 'raw_affiliation_strings': ['Department of Thoracic Oncology, Osaka International Cancer Institute, Chuo-ku Otemae 3-1-69, Osaka City, Osaka, 541-8567, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Thoracic Oncology, Osaka International Cancer Institute, Chuo-ku Otemae 3-1-69, Osaka City, Osaka, 541-8567, Japan', 'institution_ids': ['https://openalex.org/I4210101504']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016465101', 'display_name': 'Akihiro Tamiya', 'orcid': 'https://orcid.org/0000-0003-3599-2583'}, 'institutions': [{'id': 'https://openalex.org/I4210160708', 'display_name': 'National Kinki Chuo Hospital for Chest Disease', 'ror': 'https://ror.org/05jp74k96', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137409', 'https://openalex.org/I4210160708']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Akihiro Tamiya', 'raw_affiliation_strings': ['Department of Internal Medicine, Kinki-Chuo Chest Medical Center, Kitaku Nagasone-cho 1180, Sakai City, Osaka, 591-8555, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Kinki-Chuo Chest Medical Center, Kitaku Nagasone-cho 1180, Sakai City, Osaka, 591-8555, Japan', 'institution_ids': ['https://openalex.org/I4210160708']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056165940', 'display_name': 'Norio Okamoto', 'orcid': 'https://orcid.org/0000-0001-7999-1836'}, 'institutions': [{'id': 'https://openalex.org/I3019022944', 'display_name': 'Osaka Prefectural Medical Center', 'ror': 'https://ror.org/00vcb6036', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3019022944']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Norio Okamoto', 'raw_affiliation_strings': ['Department of Thoracic Malignancy, Osaka Habikino Medical Center, Habikino 3-7-1, Habikino City, Osaka, 583-8588, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Thoracic Malignancy, Osaka Habikino Medical Center, Habikino 3-7-1, Habikino City, Osaka, 583-8588, Japan', 'institution_ids': ['https://openalex.org/I3019022944']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013472489', 'display_name': 'Yoshihiko Taniguchi', 'orcid': 'https://orcid.org/0000-0001-6387-3683'}, 'institutions': [{'id': 'https://openalex.org/I4210160708', 'display_name': 'National Kinki Chuo Hospital for Chest Disease', 'ror': 'https://ror.org/05jp74k96', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137409', 'https://openalex.org/I4210160708']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yoshihiko Taniguchi', 'raw_affiliation_strings': ['Department of Internal Medicine, Kinki-Chuo Chest Medical Center, Kitaku Nagasone-cho 1180, Sakai City, Osaka, 591-8555, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Kinki-Chuo Chest Medical Center, Kitaku Nagasone-cho 1180, Sakai City, Osaka, 591-8555, Japan', 'institution_ids': ['https://openalex.org/I4210160708']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032960175', 'display_name': 'Kazumi Nishino', 'orcid': 'https://orcid.org/0000-0003-2000-7472'}, 'institutions': [{'id': 'https://openalex.org/I4210101504', 'display_name': 'Osaka International Cancer Institute', 'ror': 'https://ror.org/010srfv22', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210101504']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazumi Nishino', 'raw_affiliation_strings': ['Department of Thoracic Oncology, Osaka International Cancer Institute, Chuo-ku Otemae 3-1-69, Osaka City, Osaka, 541-8567, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Thoracic Oncology, Osaka International Cancer Institute, Chuo-ku Otemae 3-1-69, Osaka City, Osaka, 541-8567, Japan', 'institution_ids': ['https://openalex.org/I4210101504']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066357817', 'display_name': 'Shinji Atagi', 'orcid': 'https://orcid.org/0000-0003-1876-7069'}, 'institutions': [{'id': 'https://openalex.org/I4210160708', 'display_name': 'National Kinki Chuo Hospital for Chest Disease', 'ror': 'https://ror.org/05jp74k96', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137409', 'https://openalex.org/I4210160708']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shinji Atagi', 'raw_affiliation_strings': ['Department of Clinical Research Center, Kinki-Chuo Chest Medical Center, Kitaku Nagasone-cho 1180, Sakai City, Osaka, 591-8555, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Research Center, Kinki-Chuo Chest Medical Center, Kitaku Nagasone-cho 1180, Sakai City, Osaka, 591-8555, Japan', 'institution_ids': ['https://openalex.org/I4210160708']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052287605', 'display_name': 'Tomonori Hirashima', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3019022944', 'display_name': 'Osaka Prefectural Medical Center', 'ror': 'https://ror.org/00vcb6036', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3019022944']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tomonori Hirashima', 'raw_affiliation_strings': ['Department of Thoracic Malignancy, Osaka Habikino Medical Center, Habikino 3-7-1, Habikino City, Osaka, 583-8588, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Thoracic Malignancy, Osaka Habikino Medical Center, Habikino 3-7-1, Habikino City, Osaka, 583-8588, Japan', 'institution_ids': ['https://openalex.org/I3019022944']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047714811', 'display_name': 'Fumio Imamura', 'orcid': 'https://orcid.org/0009-0009-5961-2101'}, 'institutions': [{'id': 'https://openalex.org/I4210101504', 'display_name': 'Osaka International Cancer Institute', 'ror': 'https://ror.org/010srfv22', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210101504']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Fumio Imamura', 'raw_affiliation_strings': ['Department of Thoracic Oncology, Osaka International Cancer Institute, Chuo-ku Otemae 3-1-69, Osaka City, Osaka, 541-8567, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Thoracic Oncology, Osaka International Cancer Institute, Chuo-ku Otemae 3-1-69, Osaka City, Osaka, 541-8567, Japan', 'institution_ids': ['https://openalex.org/I4210101504']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101797898', 'display_name': 'Toru Kumagai', 'orcid': 'https://orcid.org/0000-0002-1232-0015'}, 'institutions': [{'id': 'https://openalex.org/I4210101504', 'display_name': 'Osaka International Cancer Institute', 'ror': 'https://ror.org/010srfv22', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210101504']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toru Kumagai', 'raw_affiliation_strings': ['Department of Thoracic Oncology, Osaka International Cancer Institute, Chuo-ku Otemae 3-1-69, Osaka City, Osaka, 541-8567, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Thoracic Oncology, Osaka International Cancer Institute, Chuo-ku Otemae 3-1-69, Osaka City, Osaka, 541-8567, Japan', 'institution_ids': ['https://openalex.org/I4210101504']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101794774', 'display_name': 'Hidekazu Suzuki', 'orcid': 'https://orcid.org/0000-0002-1556-1199'}, 'institutions': [{'id': 'https://openalex.org/I3019022944', 'display_name': 'Osaka Prefectural Medical Center', 'ror': 'https://ror.org/00vcb6036', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3019022944']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hidekazu Suzuki', 'raw_affiliation_strings': ['Department of Thoracic Malignancy, Osaka Habikino Medical Center, Habikino 3-7-1, Habikino City, Osaka, 583-8588, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Thoracic Malignancy, Osaka Habikino Medical Center, Habikino 3-7-1, Habikino City, Osaka, 583-8588, Japan', 'institution_ids': ['https://openalex.org/I3019022944']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5036738616'], 'corresponding_institution_ids': ['https://openalex.org/I4210101504'], 'apc_list': {'value': 1890, 'currency': 'EUR', 'value_usd': 2190, 'provenance': 'doaj'}, 'apc_paid': {'value': 1890, 'currency': 'EUR', 'value_usd': 2190, 'provenance': 'doaj'}, 'fwci': 0.561, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.680437, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 73, 'max': 77}, 'biblio': {'volume': '11', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10417', 'display_name': 'Advancements in Lung Cancer Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10417', 'display_name': 'Advancements in Lung Cancer Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11845', 'display_name': 'DNA Topoisomerases: Structure, Function, and Inhibition', 'score': 0.9861, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11067', 'display_name': 'Advancements in Colorectal Cancer Research', 'score': 0.9842, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/osimertinib', 'display_name': 'Osimertinib', 'score': 0.97801393}, {'id': 'https://openalex.org/keywords/t790m', 'display_name': 'T790M', 'score': 0.95299846}, {'id': 'https://openalex.org/keywords/afatinib', 'display_name': 'Afatinib', 'score': 0.9523967}, {'id': 'https://openalex.org/keywords/egfr-mutations', 'display_name': 'EGFR Mutations', 'score': 0.536751}, {'id': 'https://openalex.org/keywords/refractory', 'display_name': 'Refractory (planetary science)', 'score': 0.5290455}, {'id': 'https://openalex.org/keywords/resistance-mutation', 'display_name': 'Resistance mutation', 'score': 0.41794553}], 'concepts': [{'id': 'https://openalex.org/C2777626846', 'wikidata': 'https://www.wikidata.org/wiki/Q21506464', 'display_name': 'Osimertinib', 'level': 5, 'score': 0.97801393}, {'id': 'https://openalex.org/C2777930144', 'wikidata': 'https://www.wikidata.org/wiki/Q25100112', 'display_name': 'T790M', 'level': 5, 'score': 0.95299846}, {'id': 'https://openalex.org/C2780586478', 'wikidata': 'https://www.wikidata.org/wiki/Q4688818', 'display_name': 'Afatinib', 'level': 5, 'score': 0.9523967}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6902727}, {'id': 'https://openalex.org/C2776256026', 'wikidata': 'https://www.wikidata.org/wiki/Q47912', 'display_name': 'Lung cancer', 'level': 2, 'score': 0.6009838}, {'id': 'https://openalex.org/C142424586', 'wikidata': 'https://www.wikidata.org/wiki/Q7307572', 'display_name': 'Refractory (planetary science)', 'level': 2, 'score': 0.5290455}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5039174}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.4672582}, {'id': 'https://openalex.org/C2779438470', 'wikidata': 'https://www.wikidata.org/wiki/Q424401', 'display_name': 'Epidermal growth factor receptor', 'level': 3, 'score': 0.42297637}, {'id': 'https://openalex.org/C182707283', 'wikidata': 'https://www.wikidata.org/wiki/Q7315622', 'display_name': 'Resistance mutation', 'level': 5, 'score': 0.41794553}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.38644323}, {'id': 'https://openalex.org/C2778087573', 'wikidata': 'https://www.wikidata.org/wiki/Q418369', 'display_name': 'Erlotinib', 'level': 4, 'score': 0.32345587}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.269193}, {'id': 'https://openalex.org/C2780580887', 'wikidata': 'https://www.wikidata.org/wiki/Q417824', 'display_name': 'Gefitinib', 'level': 4, 'score': 0.2625286}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.1695686}, {'id': 'https://openalex.org/C49105822', 'wikidata': 'https://www.wikidata.org/wiki/Q176996', 'display_name': 'Polymerase chain reaction', 'level': 3, 'score': 0.099659175}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0917331}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0870038}, {'id': 'https://openalex.org/C156719811', 'wikidata': 'https://www.wikidata.org/wiki/Q28774', 'display_name': 'Reverse transcriptase', 'level': 4, 'score': 0.05959928}, {'id': 'https://openalex.org/C87355193', 'wikidata': 'https://www.wikidata.org/wiki/Q411', 'display_name': 'Astrobiology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000178', 'descriptor_name': 'Acrylamides', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000814', 'descriptor_name': 'Aniline Compounds', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D004815', 'descriptor_name': 'Epidermal Growth Factor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000178', 'descriptor_name': 'Acrylamides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000814', 'descriptor_name': 'Aniline Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004815', 'descriptor_name': 'Epidermal Growth Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41598-021-89006-9', 'pdf_url': 'https://www.nature.com/articles/s41598-021-89006-9.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/971c6d6d531f455c899f4cb3858135b3', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099906', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.21203/rs.3.rs-154532/v1', 'pdf_url': 'https://www.researchsquare.com/article/rs-154532/latest.pdf', 'source': {'id': 'https://openalex.org/S4306402450', 'display_name': 'Research Square (Research Square)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210096694', 'host_organization_name': 'Research Square (United States)', 'host_organization_lineage': ['https://openalex.org/I4210096694'], 'host_organization_lineage_names': ['Research Square (United States)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/33953280', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41598-021-89006-9', 'pdf_url': 'https://www.nature.com/articles/s41598-021-89006-9.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.79, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 36, 'referenced_works': ['https://openalex.org/W1967304777', 'https://openalex.org/W2022670843', 'https://openalex.org/W2065293650', 'https://openalex.org/W2088540000', 'https://openalex.org/W2096198395', 'https://openalex.org/W2108371618', 'https://openalex.org/W2111662961', 'https://openalex.org/W2129360604', 'https://openalex.org/W2132157071', 'https://openalex.org/W2138089710', 'https://openalex.org/W2138851777', 'https://openalex.org/W2139804581', 'https://openalex.org/W2159013299', 'https://openalex.org/W2160982674', 'https://openalex.org/W2171139285', 'https://openalex.org/W2339311613', 'https://openalex.org/W2373606074', 'https://openalex.org/W2416111151', 'https://openalex.org/W2560717039', 'https://openalex.org/W2760639821', 'https://openalex.org/W2770828094', 'https://openalex.org/W2781928898', 'https://openalex.org/W2810156769', 'https://openalex.org/W2885289995', 'https://openalex.org/W2896248377', 'https://openalex.org/W2899679902', 'https://openalex.org/W2903043657', 'https://openalex.org/W2953884587', 'https://openalex.org/W2976334328', 'https://openalex.org/W2996577950', 'https://openalex.org/W2999801017', 'https://openalex.org/W3046313638', 'https://openalex.org/W3082658746', 'https://openalex.org/W3094892024', 'https://openalex.org/W3105369138', 'https://openalex.org/W3109841362'], 'related_works': ['https://openalex.org/W4362609540', 'https://openalex.org/W4252148494', 'https://openalex.org/W3131089254', 'https://openalex.org/W3002825748', 'https://openalex.org/W2981762400', 'https://openalex.org/W2903782160', 'https://openalex.org/W2903701123', 'https://openalex.org/W2901732362', 'https://openalex.org/W2887887720', 'https://openalex.org/W2767471949'], 'abstract_inverted_index': {'The': [0, 124, 143, 152], 'most': [1], 'frequent': [2], 'mechanism': [3], 'of': [4, 79], 'resistance': [5, 89], 'after': [6, 62], '1st/2nd-generation': [7], '(G)': [8], 'epidermal': [9], 'growth': [10], 'factor': [11], 'receptor': [12], '(EGFR)-tyrosine': [13], 'kinase': [14], 'inhibitors': [15], '(TKIs)': [16], 'is': [17], 'secondary': [18], 'point': [19], 'mutation': [20, 58, 83, 105], 'Thr790Met': [21], '(T790M)': [22], 'in': [23, 86, 127, 147, 154, 164, 175, 199], 'EGFR.': [24], 'Afatinib': [25], 'followed': [26, 45], 'by': [27, 46], 'osimertinib': [28, 47, 61, 159, 190], '(Afa': [29], 'group)': [30], 'may': [31], 'provide': [32], 'better': [33], 'outcomes': [34], 'for': [35], 'T790M-positive': [36], 'non-small': [37], 'cell': [38], 'lung': [39], 'cancer': [40], '(NSCLC)': [41], 'than': [42, 107, 163], '1st-G': [43, 108, 136, 178], 'EGFR-TKI': [44, 66, 88], '(1st-G': [48], 'group).': [49], 'We': [50, 75], 'studied': [51], '111': [52], 'consecutive': [53], 'NSCLC': [54], 'patients': [55, 112], 'with': [56, 60, 113, 156, 189], 'T790M': [57, 80, 104, 145, 185], 'treated': [59], 'progression': [63], 'following': [64], '1st/2nd-G': [65, 197, 200], 'between': [67, 195], 'March': [68, 72], '28,': [69], '2016': [70], 'and': [71, 135, 172, 177, 192], '31,': [73], '2018.': [74], 'analyzed': [76, 118], 'the': [77, 103, 165, 196], 'ratio': [78, 146, 153, 186], 'to': [81, 158], 'EGFR-activating': [82], '(T790M': [84], 'ratio)': [85], 'post': [87], 're-biopsy': [90, 115], 'tissue': [91], 'using': [92], 'droplet': [93], 'digital': [94], 'polymerase': [95], 'chain': [96], 'reaction.': [97], 'And': [98], 'investigated': [99], 'whether': [100], 'afatinib': [101], 'purified': [102], 'more': [106], 'EGFR-TKI.': [109], 'Among': [110], '60': [111], 'preserved': [114], 'tissue,': [116], 'we': [117], '38': [119], 'having': [120], 'adequate': [121], 'DNA': [122], 'content.': [123], 'response': [125, 157, 191], 'rate': [126], 'Afa': [128, 176], 'group': [129, 137, 179], 'was': [130, 138, 150, 160, 173, 193], '81.8%': [131], '(n': [132, 140], '=': [133, 141, 170, 183], '11)': [134], '85.2%': [139], '27).': [142], 'mean': [144], 'total': [148], 'population': [149], '0.3643.': [151], 'those': [155], 'significantly': [161, 187], 'higher': [162], 'non-responders': [166], '(0.395,': [167], '0.202;': [168], 'p': [169, 182], '0.0231)': [171], 'similar': [174, 194], '(0.371,': [180], '0.362;': [181], '0.9693).': [184], 'correlated': [188], 'EGFR-TKIs': [198], 'EGFR-TKI-refractory': [201], 'tumors.': [202]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3131089254', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}], 'updated_date': '2024-09-13T15:42:45.247688', 'created_date': '2021-03-01'}