HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones

Name: Work Video:
Duration: 3 min 30 s
Fa-Hui Sun; Peng Zhao; Nan Zhang; Lulu Kong; Catherine C. L. Wong; Cai‐Hong Yun
{'id': 'https://openalex.org/W3130199528', 'doi': 'https://doi.org/10.1038/s41467-021-21302-4', 'title': 'HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones', 'display_name': 'HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones', 'publication_year': 2021, 'publication_date': '2021-02-15', 'ids': {'openalex': 'https://openalex.org/W3130199528', 'doi': 'https://doi.org/10.1038/s41467-021-21302-4', 'mag': '3130199528', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/33589610', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7884425'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41467-021-21302-4', 'pdf_url': 'https://www.nature.com/articles/s41467-021-21302-4.pdf', 'source': {'id': 'https://openalex.org/S64187185', 'display_name': 'Nature Communications', 'issn_l': '2041-1723', 'issn': ['2041-1723'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.nature.com/articles/s41467-021-21302-4.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5039861577', 'display_name': 'Fa-Hui Sun', 'orcid': 'https://orcid.org/0000-0002-6375-6564'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Fa-Hui Sun', 'raw_affiliation_strings': ['Department of Biochemistry and Biophysics, Peking University Health Science Center, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Biophysics, Peking University Health Science Center, Beijing, China', 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057131883', 'display_name': 'Peng Zhao', 'orcid': 'https://orcid.org/0000-0002-9296-5293'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Peng Zhao', 'raw_affiliation_strings': ['Department of Biochemistry and Biophysics, Peking University Health Science Center, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Biophysics, Peking University Health Science Center, Beijing, China', 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100331346', 'display_name': 'Nan Zhang', 'orcid': 'https://orcid.org/0009-0001-6336-7534'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Nan Zhang', 'raw_affiliation_strings': ['School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China', 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060851348', 'display_name': 'Lulu Kong', 'orcid': 'https://orcid.org/0009-0001-8454-1546'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lu-Lu Kong', 'raw_affiliation_strings': ['Department of Integration of Chinese and Western Medicine, Peking University Health Science Center, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Integration of Chinese and Western Medicine, Peking University Health Science Center, Beijing, China', 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058744620', 'display_name': 'Catherine C. L. Wong', 'orcid': 'https://orcid.org/0000-0002-6855-2798'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Catherine C. L. Wong', 'raw_affiliation_strings': ['School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China', 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5006840181', 'display_name': 'Cai‐Hong Yun', 'orcid': 'https://orcid.org/0000-0002-5880-8307'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Cai-Hong Yun', 'raw_affiliation_strings': ['Department of Integration of Chinese and Western Medicine, Peking University Health Science Center, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Integration of Chinese and Western Medicine, Peking University Health Science Center, Beijing, China', 'institution_ids': ['https://openalex.org/I20231570']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3920, 'currency': 'GBP', 'value_usd': 4808, 'provenance': 'doaj'}, 'apc_paid': {'value': 3920, 'currency': 'GBP', 'value_usd': 4808, 'provenance': 'doaj'}, 'fwci': 6.442, 'has_fulltext': False, 'cited_by_count': 62, 'citation_normalized_percentile': {'value': 0.999964, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '12', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11914', 'display_name': 'PARP inhibition in cancer therapy', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11914', 'display_name': 'PARP inhibition in cancer therapy', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12477', 'display_name': 'Toxin Mechanisms and Immunotoxins', 'score': 0.9654, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 0.9632, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/adp-ribosylation', 'display_name': 'ADP-ribosylation', 'score': 0.75004244}, {'id': 'https://openalex.org/keywords/parp1', 'display_name': 'PARP1', 'score': 0.673452}], 'concepts': [{'id': 'https://openalex.org/C45510557', 'wikidata': 'https://www.wikidata.org/wiki/Q61420', 'display_name': 'ADP-ribosylation', 'level': 4, 'score': 0.75004244}, {'id': 'https://openalex.org/C2778480876', 'wikidata': 'https://www.wikidata.org/wiki/Q21112674', 'display_name': 'PARP1', 'level': 5, 'score': 0.673452}, {'id': 'https://openalex.org/C64927066', 'wikidata': 'https://www.wikidata.org/wiki/Q36293', 'display_name': 'Histone', 'level': 3, 'score': 0.6534021}, {'id': 'https://openalex.org/C2776414213', 'wikidata': 'https://www.wikidata.org/wiki/Q183290', 'display_name': 'Serine', 'level': 3, 'score': 0.6173806}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.34983268}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.33631873}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.3255415}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.29888892}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.26720962}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.23759007}, {'id': 'https://openalex.org/C182979987', 'wikidata': 'https://www.wikidata.org/wiki/Q3907241', 'display_name': 'Poly ADP ribose polymerase', 'level': 4, 'score': 0.22578934}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.14035302}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.118423074}, {'id': 'https://openalex.org/C82381507', 'wikidata': 'https://www.wikidata.org/wiki/Q416878', 'display_name': 'Polymerase', 'level': 3, 'score': 0.08721852}, {'id': 'https://openalex.org/C75520062', 'wikidata': 'https://www.wikidata.org/wiki/Q15321392', 'display_name': 'NAD+ kinase', 'level': 3, 'score': 0.08000255}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.0670861}], 'mesh': [{'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D006657', 'descriptor_name': 'Histones', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000071137', 'descriptor_name': 'Poly (ADP-Ribose) Polymerase-1', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D012694', 'descriptor_name': 'Serine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000074744', 'descriptor_name': 'ADP-Ribosylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003001', 'descriptor_name': 'Cloning, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018360', 'descriptor_name': 'Crystallography, X-Ray', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005822', 'descriptor_name': 'Genetic Vectors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005822', 'descriptor_name': 'Genetic Vectors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D005822', 'descriptor_name': 'Genetic Vectors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005973', 'descriptor_name': 'Glutamine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005973', 'descriptor_name': 'Glutamine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006657', 'descriptor_name': 'Histones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006657', 'descriptor_name': 'Histones', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006657', 'descriptor_name': 'Histones', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000071137', 'descriptor_name': 'Poly (ADP-Ribose) Polymerase-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071137', 'descriptor_name': 'Poly (ADP-Ribose) Polymerase-1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000071137', 'descriptor_name': 'Poly (ADP-Ribose) Polymerase-1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072756', 'descriptor_name': 'Protein Conformation, alpha-Helical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072757', 'descriptor_name': 'Protein Conformation, beta-Strand', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054730', 'descriptor_name': 'Protein Interaction Domains and Motifs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020033', 'descriptor_name': 'Protein Isoforms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020033', 'descriptor_name': 'Protein Isoforms', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D020033', 'descriptor_name': 'Protein Isoforms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020033', 'descriptor_name': 'Protein Isoforms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016415', 'descriptor_name': 'Sequence Alignment', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017386', 'descriptor_name': 'Sequence Homology, Amino Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012694', 'descriptor_name': 'Serine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055672', 'descriptor_name': 'Static Electricity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41467-021-21302-4', 'pdf_url': 'https://www.nature.com/articles/s41467-021-21302-4.pdf', 'source': {'id': 'https://openalex.org/S64187185', 'display_name': 'Nature Communications', 'issn_l': '2041-1723', 'issn': ['2041-1723'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/5521b4d0d2ee4c4d8454f7128bbf8047', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884425', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.21203/rs.3.rs-71025/v1', 'pdf_url': 'https://www.researchsquare.com/article/rs-71025/v1.pdf', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/33589610', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41467-021-21302-4', 'pdf_url': 'https://www.nature.com/articles/s41467-021-21302-4.pdf', 'source': {'id': 'https://openalex.org/S64187185', 'display_name': 'Nature Communications', 'issn_l': '2041-1723', 'issn': ['2041-1723'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.66}], 'grants': [{'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '31270769'}], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1973268287', 'https://openalex.org/W1974916823', 'https://openalex.org/W1982891627', 'https://openalex.org/W1989006164', 'https://openalex.org/W1991742606', 'https://openalex.org/W2009007206', 'https://openalex.org/W2022350916', 'https://openalex.org/W2058058143', 'https://openalex.org/W2073660843', 'https://openalex.org/W2083946902', 'https://openalex.org/W2088689845', 'https://openalex.org/W2095798342', 'https://openalex.org/W2103503400', 'https://openalex.org/W2109306755', 'https://openalex.org/W2114622716', 'https://openalex.org/W2123745604', 'https://openalex.org/W2124026197', 'https://openalex.org/W2171972386', 'https://openalex.org/W2172631200', 'https://openalex.org/W2177419974', 'https://openalex.org/W2180229411', 'https://openalex.org/W2334440167', 'https://openalex.org/W2412963709', 'https://openalex.org/W2530540719', 'https://openalex.org/W2587003776', 'https://openalex.org/W2588135595', 'https://openalex.org/W2604136844', 'https://openalex.org/W2686389580', 'https://openalex.org/W2732346161', 'https://openalex.org/W2766471599', 'https://openalex.org/W2788939638', 'https://openalex.org/W2789041139', 'https://openalex.org/W2807452056', 'https://openalex.org/W2901569771', 'https://openalex.org/W2910350699', 'https://openalex.org/W2914939061', 'https://openalex.org/W3004782200', 'https://openalex.org/W4210539972'], 'related_works': ['https://openalex.org/W4399565798', 'https://openalex.org/W3192395138', 'https://openalex.org/W3173764271', 'https://openalex.org/W3140897767', 'https://openalex.org/W3134530449', 'https://openalex.org/W3130199528', 'https://openalex.org/W3111748707', 'https://openalex.org/W2766575289', 'https://openalex.org/W2530540719', 'https://openalex.org/W1521732896'], 'abstract_inverted_index': {'Upon': [0], 'binding': [1, 123], 'to': [2, 14, 82, 101, 106, 116], 'DNA': [3, 16, 26], 'breaks,': [4], 'poly(ADP-ribose)': [5], 'polymerase': [6], '1': [7], '(PARP1)': [8], 'ADP-ribosylates': [9], 'itself': [10], 'and': [11, 48, 50, 56, 63, 120], 'other': [12], 'factors': [13], 'initiate': [15], 'repair.': [17], 'Serine': [18], 'is': [19], 'the': [20, 36, 68, 88, 111, 126, 135], 'major': [21], 'residue': [22], 'for': [23, 92], 'ADP-ribosylation': [24], 'upon': [25], 'damage,': [27], 'which': [28], 'strictly': [29], 'depends': [30], 'on': [31], 'HPF1.': [32], 'Here,': [33], 'we': [34, 85], 'report': [35], 'crystal': [37], 'structures': [38, 62], 'of': [39, 114, 129], 'human': [40, 51], 'HPF1/PARP1-CAT': [41], 'ΔHD': [42], 'complex': [43], 'at': [44, 53], '1.98': [45], 'Å': [46, 55, 58], 'resolution,': [47, 59], 'mouse': [49], 'HPF1': [52, 115], '1.71': [54], '1.57': [57], 'respectively.': [60], 'Our': [61, 95], 'mutagenesis': [64], 'data': [65, 96], 'confirm': [66], 'that': [67, 98], 'structural': [69, 137], 'insights': [70], 'obtained': [71], 'in': [72], 'a': [73], 'recent': [74], 'HPF1/PARP2': [75], 'study': [76], 'by': [77, 124], 'Suskiewicz': [78], 'et': [79], 'al.': [80], 'apply': [81], 'PARP1.': [83, 144], 'Moreover,': [84], 'quantitatively': [86], 'characterize': [87], 'key': [89], 'residues': [90], 'necessary': [91], 'HPF1/PARP1': [93, 122], 'binding.': [94], 'show': [97], 'through': [99], 'salt-bridging': [100], 'Glu284/Asp286,': [102], 'Arg239': [103], 'positions': [104], 'Glu284': [105], 'catalyze': [107], 'serine': [108], 'ADP-ribosylation,': [109], 'maintains': [110], 'local': [112], 'conformation': [113], 'limit': [117], 'PARP1': [118], 'automodification,': [119], 'facilitates': [121], 'neutralizing': [125], 'negative': [127], 'charge': [128], 'Glu284.': [130], 'These': [131], 'findings,': [132], 'along': [133], 'with': [134], 'high-resolution': [136], 'data,': [138], 'may': [139], 'facilitate': [140], 'drug': [141], 'discovery': [142], 'targeting': [143]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3130199528', 'counts_by_year': [{'year': 2024, 'cited_by_count': 17}, {'year': 2023, 'cited_by_count': 19}, {'year': 2022, 'cited_by_count': 11}, {'year': 2021, 'cited_by_count': 15}], 'updated_date': '2024-12-13T04:36:11.521591', 'created_date': '2021-03-01'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
