Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3126366955', 'doi': 'https://doi.org/10.1158/1078-0432.ccr-20-3363', 'title': 'Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for<i>GNAQ</i>-Driven Uveal Melanoma', 'display_name': 'Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for<i>GNAQ</i>-Driven Uveal Melanoma', 'publication_year': 2021, 'publication_date': '2021-02-10', 'ids': {'openalex': 'https://openalex.org/W3126366955', 'doi': 'https://doi.org/10.1158/1078-0432.ccr-20-3363', 'mag': '3126366955', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/34389658'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1078-0432.ccr-20-3363', 'pdf_url': 'https://aacrjournals.org/clincancerres/article-pdf/27/11/3190/3088187/3190.pdf', 'source': {'id': 'https://openalex.org/S183149254', 'display_name': 'Clinical Cancer Research', 'issn_l': '1078-0432', 'issn': ['1078-0432', '1557-3265'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://aacrjournals.org/clincancerres/article-pdf/27/11/3190/3088187/3190.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5033733278', 'display_name': 'Justine S. Paradis', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Justine S. Paradis', 'raw_affiliation_strings': ['1Moores Cancer Center, University of California San Diego, La Jolla, California.'], 'affiliations': [{'raw_affiliation_string': '1Moores Cancer Center, University of California San Diego, La Jolla, California.', 'institution_ids': ['https://openalex.org/I36258959']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016885261', 'display_name': 'Monica Acosta', 'orcid': 'https://orcid.org/0000-0003-4202-7765'}, 'institutions': [{'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Monica Acosta', 'raw_affiliation_strings': ['1Moores Cancer Center, University of California San Diego, La Jolla, California.'], 'affiliations': [{'raw_affiliation_string': '1Moores Cancer Center, University of California San Diego, La Jolla, California.', 'institution_ids': ['https://openalex.org/I36258959']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003822523', 'display_name': 'Robert Saddawi‐Konefka', 'orcid': 'https://orcid.org/0000-0002-9936-1695'}, 'institutions': [{'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert Saddawi-Konefka', 'raw_affiliation_strings': ['10Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, California.', '1Moores Cancer Center, University of California San Diego, La Jolla, California.'], 'affiliations': [{'raw_affiliation_string': '1Moores Cancer Center, University of California San Diego, La Jolla, California.', 'institution_ids': ['https://openalex.org/I36258959']}, {'raw_affiliation_string': '10Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, California.', 'institution_ids': ['https://openalex.org/I36258959']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103056679', 'display_name': 'Ayush Kishore', 'orcid': 'https://orcid.org/0009-0000-7367-3212'}, 'institutions': [{'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ayush Kishore', 'raw_affiliation_strings': ['1Moores Cancer Center, University of California San Diego, La Jolla, California.'], 'affiliations': [{'raw_affiliation_string': '1Moores Cancer Center, University of California San Diego, La Jolla, California.', 'institution_ids': ['https://openalex.org/I36258959']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051883082', 'display_name': 'Simone Lubrano', 'orcid': 'https://orcid.org/0000-0003-4779-5632'}, 'institutions': [{'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Simone Lubrano', 'raw_affiliation_strings': ['1Moores Cancer Center, University of California San Diego, La Jolla, California.'], 'affiliations': [{'raw_affiliation_string': '1Moores Cancer Center, University of California San Diego, La Jolla, California.', 'institution_ids': ['https://openalex.org/I36258959']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056565420', 'display_name': 'Frederico Gomes', 'orcid': 'https://orcid.org/0000-0003-4751-6111'}, 'institutions': [{'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Frederico Gomes', 'raw_affiliation_strings': ['1Moores Cancer Center, University of California San Diego, La Jolla, California.'], 'affiliations': [{'raw_affiliation_string': '1Moores Cancer Center, University of California San Diego, La Jolla, California.', 'institution_ids': ['https://openalex.org/I36258959']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026625543', 'display_name': 'Nadia Arang', 'orcid': 'https://orcid.org/0000-0002-8167-2188'}, 'institutions': [{'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nadia Arang', 'raw_affiliation_strings': ['1Moores Cancer Center, University of California San Diego, La Jolla, California.', '2Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, California.'], 'affiliations': [{'raw_affiliation_string': '2Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, California.', 'institution_ids': ['https://openalex.org/I36258959']}, {'raw_affiliation_string': '1Moores Cancer Center, University of California San Diego, La Jolla, California.', 'institution_ids': ['https://openalex.org/I36258959']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074055360', 'display_name': 'Manoela Tiago', 'orcid': 'https://orcid.org/0000-0003-0536-2580'}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Manoela Tiago', 'raw_affiliation_strings': ['3Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.'], 'affiliations': [{'raw_affiliation_string': '3Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.', 'institution_ids': ['https://openalex.org/I149251103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070873806', 'display_name': 'Sílvia Coma', 'orcid': 'https://orcid.org/0000-0001-8109-2813'}, 'institutions': [{'id': 'https://openalex.org/I4210154584', 'display_name': 'Verastem (United States)', 'ror': 'https://ror.org/0562yk913', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210154584']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Silvia Coma', 'raw_affiliation_strings': ['4Verastem Oncology, Needham, Massachusetts.'], 'affiliations': [{'raw_affiliation_string': '4Verastem Oncology, Needham, Massachusetts.', 'institution_ids': ['https://openalex.org/I4210154584']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062633858', 'display_name': 'Xingyu Wu', 'orcid': 'https://orcid.org/0000-0001-9289-7115'}, 'institutions': [{'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xingyu Wu', 'raw_affiliation_strings': ['1Moores Cancer Center, University of California San Diego, La Jolla, California.'], 'affiliations': [{'raw_affiliation_string': '1Moores Cancer Center, University of California San Diego, La Jolla, California.', 'institution_ids': ['https://openalex.org/I36258959']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026067532', 'display_name': 'Kyle Ford', 'orcid': 'https://orcid.org/0000-0002-9944-9216'}, 'institutions': [{'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kyle Ford', 'raw_affiliation_strings': ['5Department of Bioengineering, University of California San Diego, San Diego, California.'], 'affiliations': [{'raw_affiliation_string': '5Department of Bioengineering, University of California San Diego, San Diego, California.', 'institution_ids': ['https://openalex.org/I36258959']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002017233', 'display_name': 'Chi‐Ping Day', 'orcid': 'https://orcid.org/0000-0001-5200-2372'}, 'institutions': [{'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chi-Ping Day', 'raw_affiliation_strings': ['6Laboratory of Cancer Biology and Genetics, Center for Cancer Research, NCI, NIH, Maryland.'], 'affiliations': [{'raw_affiliation_string': '6Laboratory of Cancer Biology and Genetics, Center for Cancer Research, NCI, NIH, Maryland.', 'institution_ids': ['https://openalex.org/I4210149717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012702025', 'display_name': 'Glenn Merlino', 'orcid': 'https://orcid.org/0000-0001-8610-0616'}, 'institutions': [{'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Glenn Merlino', 'raw_affiliation_strings': ['6Laboratory of Cancer Biology and Genetics, Center for Cancer Research, NCI, NIH, Maryland.'], 'affiliations': [{'raw_affiliation_string': '6Laboratory of Cancer Biology and Genetics, Center for Cancer Research, NCI, NIH, Maryland.', 'institution_ids': ['https://openalex.org/I4210149717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102747646', 'display_name': 'Prashant Mali', 'orcid': 'https://orcid.org/0000-0002-3383-1287'}, 'institutions': [{'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Prashant Mali', 'raw_affiliation_strings': ['5Department of Bioengineering, University of California San Diego, San Diego, California.'], 'affiliations': [{'raw_affiliation_string': '5Department of Bioengineering, University of California San Diego, San Diego, California.', 'institution_ids': ['https://openalex.org/I36258959']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073675187', 'display_name': 'Jonathan A. Pachter', 'orcid': 'https://orcid.org/0000-0002-0263-474X'}, 'institutions': [{'id': 'https://openalex.org/I4210154584', 'display_name': 'Verastem (United States)', 'ror': 'https://ror.org/0562yk913', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210154584']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jonathan A. Pachter', 'raw_affiliation_strings': ['4Verastem Oncology, Needham, Massachusetts.'], 'affiliations': [{'raw_affiliation_string': '4Verastem Oncology, Needham, Massachusetts.', 'institution_ids': ['https://openalex.org/I4210154584']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053828591', 'display_name': 'Takami Sato', 'orcid': 'https://orcid.org/0000-0003-2221-0415'}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}, {'id': 'https://openalex.org/I4210106595', 'display_name': 'Sidney Kimmel Cancer Center', 'ror': 'https://ror.org/010h6g454', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210106595']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Takami Sato', 'raw_affiliation_strings': ['7Department of Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania.', '8Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.'], 'affiliations': [{'raw_affiliation_string': '7Department of Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania.', 'institution_ids': ['https://openalex.org/I149251103']}, {'raw_affiliation_string': '8Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.', 'institution_ids': ['https://openalex.org/I149251103', 'https://openalex.org/I4210106595']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062746446', 'display_name': 'Andrew E. Aplin', 'orcid': 'https://orcid.org/0000-0002-2734-3244'}, 'institutions': [{'id': 'https://openalex.org/I4210106595', 'display_name': 'Sidney Kimmel Cancer Center', 'ror': 'https://ror.org/010h6g454', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210106595']}, {'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Andrew E. Aplin', 'raw_affiliation_strings': ['3Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.', '8Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.'], 'affiliations': [{'raw_affiliation_string': '8Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.', 'institution_ids': ['https://openalex.org/I4210106595', 'https://openalex.org/I149251103']}, {'raw_affiliation_string': '3Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.', 'institution_ids': ['https://openalex.org/I149251103']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5038753309', 'display_name': 'J. Silvio Gutkind', 'orcid': 'https://orcid.org/0000-0002-5150-4482'}, 'institutions': [{'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'J. Silvio Gutkind', 'raw_affiliation_strings': ['1Moores Cancer Center, University of California San Diego, La Jolla, California.', '9Department of Pharmacology, University of California San Diego, La Jolla, California.'], 'affiliations': [{'raw_affiliation_string': '1Moores Cancer Center, University of California San Diego, La Jolla, California.', 'institution_ids': ['https://openalex.org/I36258959']}, {'raw_affiliation_string': '9Department of Pharmacology, University of California San Diego, La Jolla, California.', 'institution_ids': ['https://openalex.org/I36258959']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': ['https://openalex.org/A5038753309'], 'corresponding_institution_ids': ['https://openalex.org/I36258959'], 'apc_list': None, 'apc_paid': None, 'fwci': 10.589, 'has_fulltext': False, 'cited_by_count': 46, 'citation_normalized_percentile': {'value': 0.999881, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '27', 'issue': '11', 'first_page': '3190', 'last_page': '3200'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11328', 'display_name': 'Ocular Cancer Research and Treatment', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2731', 'display_name': 'Ophthalmology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11328', 'display_name': 'Ocular Cancer Research and Treatment', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2731', 'display_name': 'Ophthalmology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12065', 'display_name': 'Role of Hippo Signaling Pathway in Mechanotransduction', 'score': 0.9963, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10691', 'display_name': 'Molecular Mechanisms of Retinal Degeneration and Regeneration', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/gnaq', 'display_name': 'GNAQ', 'score': 0.90100604}, {'id': 'https://openalex.org/keywords/uveal-melanoma', 'display_name': 'Uveal Melanoma', 'score': 0.642959}, {'id': 'https://openalex.org/keywords/cancer', 'display_name': 'Cancer', 'score': 0.504148}, {'id': 'https://openalex.org/keywords/intraocular-chemotherapy', 'display_name': 'Intraocular Chemotherapy', 'score': 0.500144}, {'id': 'https://openalex.org/keywords/targeted-therapy', 'display_name': 'Targeted therapy', 'score': 0.4496966}], 'concepts': [{'id': 'https://openalex.org/C2779176653', 'wikidata': 'https://www.wikidata.org/wiki/Q18026236', 'display_name': 'GNAQ', 'level': 4, 'score': 0.90100604}, {'id': 'https://openalex.org/C2777658100', 'wikidata': 'https://www.wikidata.org/wiki/Q180614', 'display_name': 'Melanoma', 'level': 2, 'score': 0.8231738}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.71781343}, {'id': 'https://openalex.org/C57074206', 'wikidata': 'https://www.wikidata.org/wiki/Q14197552', 'display_name': 'MAPK/ERK pathway', 'level': 3, 'score': 0.62205315}, {'id': 'https://openalex.org/C2781249067', 'wikidata': 'https://www.wikidata.org/wiki/Q17142288', 'display_name': 'MEK inhibitor', 'level': 4, 'score': 0.5639571}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.4773086}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.4615455}, {'id': 'https://openalex.org/C2781230642', 'wikidata': 'https://www.wikidata.org/wiki/Q492646', 'display_name': 'Targeted therapy', 'level': 3, 'score': 0.4496966}, {'id': 'https://openalex.org/C21790070', 'wikidata': 'https://www.wikidata.org/wiki/Q18030215', 'display_name': 'Neuroblastoma RAS viral oncogene homolog', 'level': 5, 'score': 0.42133325}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.39249304}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.352333}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.17323247}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.17058247}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.119767785}, {'id': 'https://openalex.org/C2781187634', 'wikidata': 'https://www.wikidata.org/wiki/Q20969980', 'display_name': 'KRAS', 'level': 4, 'score': 0.10060844}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.095118314}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.08318293}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D051417', 'descriptor_name': 'Focal Adhesion Kinase 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D043802', 'descriptor_name': 'GTP-Binding Protein alpha Subunits, Gq-G11', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D005820', 'descriptor_name': 'Genetic Testing', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D020935', 'descriptor_name': 'MAP Kinase Signaling System', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D014604', 'descriptor_name': 'Uveal Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003131', 'descriptor_name': 'Combined Modality Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000073659', 'descriptor_name': 'Gain of Function Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016688', 'descriptor_name': 'Mice, Inbred NOD', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016513', 'descriptor_name': 'Mice, SCID', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058990', 'descriptor_name': 'Molecular Targeted Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 11, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1078-0432.ccr-20-3363', 'pdf_url': 'https://aacrjournals.org/clincancerres/article-pdf/27/11/3190/3088187/3190.pdf', 'source': {'id': 'https://openalex.org/S183149254', 'display_name': 'Clinical Cancer Research', 'issn_l': '1078-0432', 'issn': ['1078-0432', '1557-3265'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895627', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1078-0432.22478109', 'pdf_url': None, 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1078-0432.22478112', 'pdf_url': None, 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1078-0432.22478115', 'pdf_url': None, 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1078-0432.22478118', 'pdf_url': None, 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1078-0432.22478109.v1', 'pdf_url': None, 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1078-0432.22478112.v1', 'pdf_url': None, 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1078-0432.22478118.v1', 'pdf_url': None, 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1078-0432.22478115.v1', 'pdf_url': None, 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/33568347', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1078-0432.ccr-20-3363', 'pdf_url': 'https://aacrjournals.org/clincancerres/article-pdf/27/11/3190/3088187/3190.pdf', 'source': {'id': 'https://openalex.org/S183149254', 'display_name': 'Clinical Cancer Research', 'issn_l': '1078-0432', 'issn': ['1078-0432', '1557-3265'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.82}], 'grants': [{'funder': 'https://openalex.org/F4320306076', 'funder_display_name': 'National Science Foundation', 'award_id': 'DGE-1650112'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'R33CA225291'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'R01CA196278'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'U54CA209891'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'R01CA182635'}], 'datasets': [], 'versions': [], 'referenced_works_count': 50, 'referenced_works': ['https://openalex.org/W1516077090', 'https://openalex.org/W1969052506', 'https://openalex.org/W1972760976', 'https://openalex.org/W1988097700', 'https://openalex.org/W1997335773', 'https://openalex.org/W2025605951', 'https://openalex.org/W2035922600', 'https://openalex.org/W2038434969', 'https://openalex.org/W2039939270', 'https://openalex.org/W2053520756', 'https://openalex.org/W2064297593', 'https://openalex.org/W2072569544', 'https://openalex.org/W2077517114', 'https://openalex.org/W2077730236', 'https://openalex.org/W2096439168', 'https://openalex.org/W2099540110', 'https://openalex.org/W2103557568', 'https://openalex.org/W2103562758', 'https://openalex.org/W2107060734', 'https://openalex.org/W2109014958', 'https://openalex.org/W2129420347', 'https://openalex.org/W2144026118', 'https://openalex.org/W2171564107', 'https://openalex.org/W2172162633', 'https://openalex.org/W2341757648', 'https://openalex.org/W2401574182', 'https://openalex.org/W2516337088', 'https://openalex.org/W2590325114', 'https://openalex.org/W2613209365', 'https://openalex.org/W2615656179', 'https://openalex.org/W2762938139', 'https://openalex.org/W2770300757', 'https://openalex.org/W2793005533', 'https://openalex.org/W2809699427', 'https://openalex.org/W2904226822', 'https://openalex.org/W2911710737', 'https://openalex.org/W2915459742', 'https://openalex.org/W2915951698', 'https://openalex.org/W2922555277', 'https://openalex.org/W2937925411', 'https://openalex.org/W2948545594', 'https://openalex.org/W2949451543', 'https://openalex.org/W2952481429', 'https://openalex.org/W2953090895', 'https://openalex.org/W2955441129', 'https://openalex.org/W3005387289', 'https://openalex.org/W3011990562', 'https://openalex.org/W3015906309', 'https://openalex.org/W3083120491', 'https://openalex.org/W4211078348'], 'related_works': ['https://openalex.org/W4282927540', 'https://openalex.org/W3046077529', 'https://openalex.org/W2783013315', 'https://openalex.org/W2557541291', 'https://openalex.org/W2345165199', 'https://openalex.org/W2162147276', 'https://openalex.org/W2040693125', 'https://openalex.org/W2032240223', 'https://openalex.org/W1936181472', 'https://openalex.org/W1770613257'], 'abstract_inverted_index': {'Abstract': [0], 'Purpose:': [1], 'Uveal': [2, 51], 'melanoma': [3, 18, 22, 52, 157, 203, 215, 231], 'is': [4, 36, 53], 'the': [5, 25, 32, 68, 78, 87, 170, 225, 233], 'most': [6, 44], 'common': [7], 'eye': [8], 'cancer': [9, 121], 'in': [10, 24, 58, 155, 160, 163, 201, 213, 221], 'adults.': [11], 'Approximately': [12], '50%': [13], 'of': [14, 31, 81, 89, 192, 229, 235], 'patients': [15, 46], 'with': [16, 182, 232], 'uveal': [17, 21, 156, 202, 214, 230], 'develop': [19], 'metastatic': [20], '(mUM)': [23], 'liver,': [26], 'even': [27], 'after': [28, 179], 'successful': [29], 'treatment': [30, 124], 'primary': [33], 'lesions.': [34], 'mUM': [35, 45, 159, 219, 256], 'refractory': [37], 'to': [38, 120, 135, 210], 'current': [39], 'chemo-': [40], 'and': [41, 43, 83, 123, 158, 162, 172, 194, 205, 217, 244], 'immune-therapies,': [42], 'die': [47], 'within': [48], 'a': [49, 73, 91, 104, 130, 186, 249], 'year.': [50], 'characterized': [54], 'by': [55, 152, 261], 'gain-of-function': [56], 'mutations': [57], 'GNAQ/GNA11,': [59], 'encoding': [60], 'Gαq': [61], 'proteins.': [62], 'We': [63, 128], 'have': [64], 'recently': [65], 'shown': [66], 'that': [67, 141, 242], 'Gαq–oncogenic': [69], 'signaling': [70, 106, 174], 'circuitry': [71], 'involves': [72], 'noncanonical': [74], 'pathway': [75], 'distinct': [76], 'from': [77, 109], 'classical': [79], 'activation': [80, 88, 184], 'PLCβ': [82], 'MEK–ERK.': [84], 'GNAQ': [85], 'promotes': [86], 'YAP1,': [90], 'key': [92], 'oncogenic': [93], 'driver,': [94], 'through': [95], 'focal': [96], 'adhesion': [97], 'kinase': [98], '(FAK),': [99], 'thereby': [100], 'identifying': [101], 'FAK': [102, 180, 195, 243], 'as': [103], 'druggable': [105], 'hub': [107], 'downstream': [108], 'GNAQ.': [110], 'However,': [111], 'targeted': [112], 'therapies': [113], 'often': [114], 'activate': [115], 'compensatory': [116], 'resistance': [117, 148, 188], 'mechanisms': [118, 149], 'leading': [119, 209], 'relapse': [122], 'failure.': [125], 'Experimental': [126], 'Design:': [127], 'performed': [129], 'kinome-wide': [131], 'CRISPR-Cas9': [132], 'sgRNA': [133], 'screen': [134], 'identify': [136], 'synthetic': [137], 'lethal': [138], 'gene': [139], 'interactions': [140], 'can': [142], 'be': [143], 'exploited': [144], 'therapeutically.': [145], 'Candidate': [146], 'adaptive': [147], 'were': [150, 176], 'investigated': [151], 'cotargeting': [153, 246], 'strategies': [154], 'vitro': [161], 'vivo': [164], 'experimental': [165], 'systems.': [166], 'Results:': [167], 'sgRNAs': [168], 'targeting': [169], 'PKC': [171], 'MEK–ERK': [173, 245], 'pathways': [175], 'significantly': [177], 'depleted': [178], 'inhibition,': [181], 'ERK': [183], 'representing': [185], 'predominant': [187], 'mechanism.': [189], 'Pharmacologic': [190], 'inhibition': [191], 'MEK': [193], 'showed': [196], 'remarkable': [197], 'synergistic': [198], 'growth-inhibitory': [199], 'effects': [200], 'cells': [204], 'exerted': [206], 'cytotoxic': [207], 'effects,': [208], 'tumor': [211], 'collapse': [212], 'xenograft': [216], 'liver': [218], 'models': [220], 'vivo.': [222], 'Conclusions:': [223], 'Coupling': [224], 'unique': [226], 'genetic': [227, 237], 'landscape': [228], 'power': [234], 'unbiased': [236], 'screens,': [238], 'our': [239], 'studies': [240], 'reveal': [241], 'may': [247], 'provide': [248], 'new': [250], 'network-based': [251], 'precision': [252], 'therapeutic': [253], 'strategy': [254], 'for': [255], 'treatment.': [257], 'See': [258], 'related': [259], 'commentary': [260], 'Harbour,': [262], 'p.': [263], '2967': [264]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3126366955', 'counts_by_year': [{'year': 2024, 'cited_by_count': 11}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 13}, {'year': 2021, 'cited_by_count': 10}], 'updated_date': '2024-09-14T02:12:28.342463', 'created_date': '2021-02-15'}