Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3116590137', 'doi': 'https://doi.org/10.31557/apjcp.2020.21.12.3619', 'title': 'The Role of CYP2D6 Polymorphisms in Determining Response to Tamoxifen in Metastatic Breast Cancer Patients: Review and Egyptian Experience', 'display_name': 'The Role of CYP2D6 Polymorphisms in Determining Response to Tamoxifen in Metastatic Breast Cancer Patients: Review and Egyptian Experience', 'publication_year': 2020, 'publication_date': '2020-12-01', 'ids': {'openalex': 'https://openalex.org/W3116590137', 'doi': 'https://doi.org/10.31557/apjcp.2020.21.12.3619', 'mag': '3116590137', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/33369460', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/8046328'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.31557/apjcp.2020.21.12.3619', 'pdf_url': 'http://journal.waocp.org/article_89392_32015d14262748e0959c5f6d865972e6.pdf', 'source': {'id': 'https://openalex.org/S121579133', 'display_name': 'Asian Pacific Journal of Cancer Prevention', 'issn_l': '1513-7368', 'issn': ['1513-7368', '2476-762X'], 'is_oa': True, 'is_in_doaj': True, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319060', 'host_organization_name': 'West Asia Organization for Cancer Prevention', 'host_organization_lineage': ['https://openalex.org/P4310319060'], 'host_organization_lineage_names': ['West Asia Organization for Cancer Prevention'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://journal.waocp.org/article_89392_32015d14262748e0959c5f6d865972e6.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5023765521', 'display_name': 'Ibrahim Malash', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145487455', 'display_name': 'Cairo University', 'ror': 'https://ror.org/03q21mh05', 'country_code': 'EG', 'type': 'education', 'lineage': ['https://openalex.org/I145487455']}], 'countries': ['EG'], 'is_corresponding': False, 'raw_author_name': 'Ibrahim Malash', 'raw_affiliation_strings': ['Medical Oncology department, National Cancer Institute (NCI), Cairo University, Egypt.'], 'affiliations': [{'raw_affiliation_string': 'Medical Oncology department, National Cancer Institute (NCI), Cairo University, Egypt.', 'institution_ids': ['https://openalex.org/I145487455']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112830004', 'display_name': 'Osman Mansour', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145487455', 'display_name': 'Cairo University', 'ror': 'https://ror.org/03q21mh05', 'country_code': 'EG', 'type': 'education', 'lineage': ['https://openalex.org/I145487455']}], 'countries': ['EG'], 'is_corresponding': False, 'raw_author_name': 'Osman Mansour', 'raw_affiliation_strings': ['Medical Oncology department, National Cancer Institute (NCI), Cairo University, Egypt.'], 'affiliations': [{'raw_affiliation_string': 'Medical Oncology department, National Cancer Institute (NCI), Cairo University, Egypt.', 'institution_ids': ['https://openalex.org/I145487455']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079570684', 'display_name': 'Sabry Shaarawy', 'orcid': None}, 'institutions': [], 'countries': ['EG'], 'is_corresponding': False, 'raw_author_name': 'Sabry Shaarawy', 'raw_affiliation_strings': ['Medical Biochemistry and Molecular\nBiology, Egypt.'], 'affiliations': [{'raw_affiliation_string': 'Medical Biochemistry and Molecular\nBiology, Egypt.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033406657', 'display_name': 'Mona S. Abdellateif', 'orcid': 'https://orcid.org/0000-0002-5510-4435'}, 'institutions': [], 'countries': ['EG'], 'is_corresponding': False, 'raw_author_name': 'Mona Abdellateif', 'raw_affiliation_strings': ['Medical Biochemistry and Molecular\nBiology, Egypt.'], 'affiliations': [{'raw_affiliation_string': 'Medical Biochemistry and Molecular\nBiology, Egypt.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043878687', 'display_name': 'Anan Omar', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145487455', 'display_name': 'Cairo University', 'ror': 'https://ror.org/03q21mh05', 'country_code': 'EG', 'type': 'education', 'lineage': ['https://openalex.org/I145487455']}], 'countries': ['EG'], 'is_corresponding': False, 'raw_author_name': 'Anan Omar', 'raw_affiliation_strings': ['Molecular Virology and Immunology Unit, Cancer Biology Department, NCI, Cairo University, Egypt.'], 'affiliations': [{'raw_affiliation_string': 'Molecular Virology and Immunology Unit, Cancer Biology Department, NCI, Cairo University, Egypt.', 'institution_ids': ['https://openalex.org/I145487455']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053271744', 'display_name': 'Rabab Gaafer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145487455', 'display_name': 'Cairo University', 'ror': 'https://ror.org/03q21mh05', 'country_code': 'EG', 'type': 'education', 'lineage': ['https://openalex.org/I145487455']}], 'countries': ['EG'], 'is_corresponding': False, 'raw_author_name': 'Rabab Gaafer', 'raw_affiliation_strings': ['Medical Oncology department, National Cancer Institute (NCI), Cairo University, Egypt.'], 'affiliations': [{'raw_affiliation_string': 'Medical Oncology department, National Cancer Institute (NCI), Cairo University, Egypt.', 'institution_ids': ['https://openalex.org/I145487455']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017609278', 'display_name': 'Abdel-Rhaman Zekri', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145487455', 'display_name': 'Cairo University', 'ror': 'https://ror.org/03q21mh05', 'country_code': 'EG', 'type': 'education', 'lineage': ['https://openalex.org/I145487455']}], 'countries': ['EG'], 'is_corresponding': False, 'raw_author_name': 'Abdel-Rhaman Zekri', 'raw_affiliation_strings': ['Molecular Virology and Immunology Unit, Cancer Biology Department, NCI, Cairo University, Egypt.'], 'affiliations': [{'raw_affiliation_string': 'Molecular Virology and Immunology Unit, Cancer Biology Department, NCI, Cairo University, Egypt.', 'institution_ids': ['https://openalex.org/I145487455']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101888358', 'display_name': 'Ola S. Ahmed', 'orcid': 'https://orcid.org/0000-0001-6201-0907'}, 'institutions': [{'id': 'https://openalex.org/I145487455', 'display_name': 'Cairo University', 'ror': 'https://ror.org/03q21mh05', 'country_code': 'EG', 'type': 'education', 'lineage': ['https://openalex.org/I145487455']}], 'countries': ['EG'], 'is_corresponding': False, 'raw_author_name': 'Ola Ahmed', 'raw_affiliation_strings': ['Molecular Virology and Immunology Unit, Cancer Biology Department, NCI, Cairo University, Egypt.'], 'affiliations': [{'raw_affiliation_string': 'Molecular Virology and Immunology Unit, Cancer Biology Department, NCI, Cairo University, Egypt.', 'institution_ids': ['https://openalex.org/I145487455']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5016320447', 'display_name': 'Abeer A. Bahnassy', 'orcid': 'https://orcid.org/0000-0001-5454-6576'}, 'institutions': [{'id': 'https://openalex.org/I145487455', 'display_name': 'Cairo University', 'ror': 'https://ror.org/03q21mh05', 'country_code': 'EG', 'type': 'education', 'lineage': ['https://openalex.org/I145487455']}], 'countries': ['EG'], 'is_corresponding': False, 'raw_author_name': 'Abeer Bahnassy', 'raw_affiliation_strings': ['Tissue\nCulture and Cytogenetics Unit, Department of Pathology, National Cancer Institute, Cairo University, Egypt.'], 'affiliations': [{'raw_affiliation_string': 'Tissue\nCulture and Cytogenetics Unit, Department of Pathology, National Cancer Institute, Cairo University, Egypt.', 'institution_ids': ['https://openalex.org/I145487455']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 200, 'currency': 'USD', 'value_usd': 200, 'provenance': 'doaj'}, 'apc_paid': {'value': 200, 'currency': 'USD', 'value_usd': 200, 'provenance': 'doaj'}, 'fwci': 0.715, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 6, 'citation_normalized_percentile': {'value': 0.60541, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 81, 'max': 82}, 'biblio': {'volume': '21', 'issue': '12', 'first_page': '3619', 'last_page': '3625'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10375', 'display_name': 'Pharmacogenetics and Drug Metabolism', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11752', 'display_name': 'Cancer Treatment and Pharmacology', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2777176818', 'wikidata': 'https://www.wikidata.org/wiki/Q412178', 'display_name': 'Tamoxifen', 'level': 4, 'score': 0.8687235}, {'id': 'https://openalex.org/C33664856', 'wikidata': 'https://www.wikidata.org/wiki/Q3271142', 'display_name': 'CYP2D6', 'level': 4, 'score': 0.74812376}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.72231567}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6784349}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.6721686}, {'id': 'https://openalex.org/C2775930923', 'wikidata': 'https://www.wikidata.org/wiki/Q12859063', 'display_name': 'Metastatic breast cancer', 'level': 4, 'score': 0.58683157}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5542952}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.41044772}, {'id': 'https://openalex.org/C29456083', 'wikidata': 'https://www.wikidata.org/wiki/Q1221899', 'display_name': 'Gynecology', 'level': 1, 'score': 0.35623276}, {'id': 'https://openalex.org/C526171541', 'wikidata': 'https://www.wikidata.org/wiki/Q407693', 'display_name': 'Cytochrome P450', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.31557/apjcp.2020.21.12.3619', 'pdf_url': 'http://journal.waocp.org/article_89392_32015d14262748e0959c5f6d865972e6.pdf', 'source': {'id': 'https://openalex.org/S121579133', 'display_name': 'Asian Pacific Journal of Cancer Prevention', 'issn_l': '1513-7368', 'issn': ['1513-7368', '2476-762X'], 'is_oa': True, 'is_in_doaj': True, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319060', 'host_organization_name': 'West Asia Organization for Cancer Prevention', 'host_organization_lineage': ['https://openalex.org/P4310319060'], 'host_organization_lineage_names': ['West Asia Organization for Cancer Prevention'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046328', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.31557/apjcp.2020.21.12.3619', 'pdf_url': 'http://journal.waocp.org/article_89392_32015d14262748e0959c5f6d865972e6.pdf', 'source': {'id': 'https://openalex.org/S121579133', 'display_name': 'Asian Pacific Journal of Cancer Prevention', 'issn_l': '1513-7368', 'issn': ['1513-7368', '2476-762X'], 'is_oa': True, 'is_in_doaj': True, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319060', 'host_organization_name': 'West Asia Organization for Cancer Prevention', 'host_organization_lineage': ['https://openalex.org/P4310319060'], 'host_organization_lineage_names': ['West Asia Organization for Cancer Prevention'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.54, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 32, 'referenced_works': ['https://openalex.org/W1998891209', 'https://openalex.org/W2008825099', 'https://openalex.org/W2013145602', 'https://openalex.org/W2013956549', 'https://openalex.org/W2031547755', 'https://openalex.org/W2044308633', 'https://openalex.org/W2063345843', 'https://openalex.org/W2077172989', 'https://openalex.org/W2089595068', 'https://openalex.org/W2098867544', 'https://openalex.org/W2104775804', 'https://openalex.org/W2113861056', 'https://openalex.org/W2131662866', 'https://openalex.org/W2141349182', 'https://openalex.org/W2141647078', 'https://openalex.org/W2147099166', 'https://openalex.org/W2157867661', 'https://openalex.org/W2167785958', 'https://openalex.org/W2314827670', 'https://openalex.org/W2400221045', 'https://openalex.org/W2594792238', 'https://openalex.org/W2736577360', 'https://openalex.org/W2737379530', 'https://openalex.org/W2768884428', 'https://openalex.org/W2784747145', 'https://openalex.org/W2785817081', 'https://openalex.org/W2898252910', 'https://openalex.org/W2905335582', 'https://openalex.org/W2965660916', 'https://openalex.org/W2975923334', 'https://openalex.org/W3145244725', 'https://openalex.org/W4317213885'], 'related_works': ['https://openalex.org/W2322209746', 'https://openalex.org/W2138151507', 'https://openalex.org/W2113225995', 'https://openalex.org/W2092209681', 'https://openalex.org/W2073973349', 'https://openalex.org/W2013479777', 'https://openalex.org/W1994401414', 'https://openalex.org/W1993646007', 'https://openalex.org/W1980756636', 'https://openalex.org/W1514995717'], 'abstract_inverted_index': {'Background:': [0], 'Metastatic': [1], 'breast': [2], 'cancer': [3], '(MBC)': [4, 65], 'represents': [5], 'a': [6], 'major': [7], 'health': [8], 'problem': [9], 'in': [10, 47, 95, 118, 133, 154, 181], 'Egypt': [11], 'and': [12, 15, 28, 41, 50, 87, 105, 127, 157, 173], 'worldwide.': [13], 'Prognostic': [14], 'predictive': [16, 42], 'factors': [17], 'for': [18, 25, 71], 'patients': [19, 68, 159, 183], 'with': [20, 143, 176], 'MBC': [21, 182], 'are': [22], 'highly': [23], 'required': [24], 'better': [26], 'management': [27], 'improved': [29], 'survival.': [30], 'The': [31, 111], 'aim': [32], 'of': [33, 44, 55, 81, 100], 'this': [34], 'study': [35], 'was': [36, 69], 'to': [37, 77, 85, 170], 'assess': [38], 'the': [39, 82, 119, 125, 134], 'prognostic': [40], 'value(s)': [43], 'CYP2D6': [45, 72, 91, 112, 139, 164], 'polymorphisms': [46, 92, 165], 'Tamoxifen': [48, 171], 'responders': [49, 109, 135], 'non-responders.': [51], 'Methods:': [52], 'A': [53], 'cohort': [54], '157': [56], 'hormone': [57], 'receptor': [58], 'positive,': [59], 'locally': [60], 'recurrent': [61], 'inoperable': [62], 'and/or': [63], 'metastatic': [64], 'Egyptian': [66], 'female': [67], 'assessed': [70], 'polymorphisms.': [73], 'Data': [74], 'were': [75, 93, 103, 108, 115, 130], 'correlated': [76], 'relevant': [78], 'clinic-pathological': [79], 'features': [80], 'patients,': [83], 'response': [84, 169], 'tamoxifen,': [86], 'survival': [88, 152, 179], 'rates.': [89], 'Results:': [90], 'detected': [94], '44/157': [96], 'cases': [97], '(28%),': [98], '30': [99], 'them': [101], '(68.2%)': [102], 'refractory': [104, 120, 156], '14': [106], '(31.8%)': [107], '(P=0.027).': [110], '*3,*4': [113], 'variants': [114, 129], 'significantly': [116, 142, 167], 'prevalent': [117], 'group': [121], '26/30': [122], '(86.6%),': [123], 'while': [124], '*10/*10': [126], '*10/*3': [128], 'more': [131], 'common': [132], '12/14': [136], '(85.71%,': [137], 'P=0.027).': [138], 'polymorphism': [140], 'associated': [141], 'Her-2': [144], 'amplification': [145], '(P=0.001)': [146], 'as': [147, 149], 'well': [148], 'reduced': [150], 'overall': [151, 178], 'rates': [153, 180], 'both': [155], 'responder': [158], '(p': [160], '<': [161], '0.001).': [162], 'Conclusion:': [163], 'can': [166], 'predict': [168], 'treatment,': [172], 'also': [174], 'associates': [175], 'poor': [177]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3116590137', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 1}], 'updated_date': '2025-01-22T08:02:55.089591', 'created_date': '2021-01-05'}