Publication Information

{'id': 'https://openalex.org/W1993646007', 'doi': 'https://doi.org/10.1158/0008-5472.sabcs11-p4-01-16', 'title': 'P4-01-16: The Influence of CYP2D6 Genetic Polymorphisms on Variability of Tamoxifen Metabolism in the Lebanese Breast Cancer Population.', 'display_name': 'P4-01-16: The Influence of CYP2D6 Genetic Polymorphisms on Variability of Tamoxifen Metabolism in the Lebanese Breast Cancer Population.', 'publication_year': 2011, 'publication_date': '2011-12-01', 'ids': {'openalex': 'https://openalex.org/W1993646007', 'doi': 'https://doi.org/10.1158/0008-5472.sabcs11-p4-01-16', 'mag': '1993646007'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.sabcs11-p4-01-16', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5074969801', 'display_name': 'Arafat Tfayli', 'orcid': 'https://orcid.org/0000-0002-0633-2538'}, 'institutions': [{'id': 'https://openalex.org/I98635879', 'display_name': 'American University of Beirut', 'ror': 'https://ror.org/04pznsd21', 'country_code': 'LB', 'type': 'education', 'lineage': ['https://openalex.org/I98635879']}], 'countries': ['LB'], 'is_corresponding': False, 'raw_author_name': 'A Tfayli', 'raw_affiliation_strings': ['1American University of Beirut, Beirut, Lebanon.'], 'affiliations': [{'raw_affiliation_string': '1American University of Beirut, Beirut, Lebanon.', 'institution_ids': ['https://openalex.org/I98635879']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066947022', 'display_name': 'Nathalie K. Zgheib', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98635879', 'display_name': 'American University of Beirut', 'ror': 'https://ror.org/04pznsd21', 'country_code': 'LB', 'type': 'education', 'lineage': ['https://openalex.org/I98635879']}], 'countries': ['LB'], 'is_corresponding': False, 'raw_author_name': 'N Zgheib', 'raw_affiliation_strings': ['1American University of Beirut, Beirut, Lebanon.'], 'affiliations': [{'raw_affiliation_string': '1American University of Beirut, Beirut, Lebanon.', 'institution_ids': ['https://openalex.org/I98635879']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001924359', 'display_name': 'J Holail', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98635879', 'display_name': 'American University of Beirut', 'ror': 'https://ror.org/04pznsd21', 'country_code': 'LB', 'type': 'education', 'lineage': ['https://openalex.org/I98635879']}], 'countries': ['LB'], 'is_corresponding': False, 'raw_author_name': 'J Holail', 'raw_affiliation_strings': ['1American University of Beirut, Beirut, Lebanon.'], 'affiliations': [{'raw_affiliation_string': '1American University of Beirut, Beirut, Lebanon.', 'institution_ids': ['https://openalex.org/I98635879']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001519074', 'display_name': 'Zuheir Habbal', 'orcid': 'https://orcid.org/0000-0003-3467-7848'}, 'institutions': [{'id': 'https://openalex.org/I98635879', 'display_name': 'American University of Beirut', 'ror': 'https://ror.org/04pznsd21', 'country_code': 'LB', 'type': 'education', 'lineage': ['https://openalex.org/I98635879']}], 'countries': ['LB'], 'is_corresponding': False, 'raw_author_name': 'M-Z Habbal', 'raw_affiliation_strings': ['1American University of Beirut, Beirut, Lebanon.'], 'affiliations': [{'raw_affiliation_string': '1American University of Beirut, Beirut, Lebanon.', 'institution_ids': ['https://openalex.org/I98635879']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067128861', 'display_name': 'Racha Halawi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98635879', 'display_name': 'American University of Beirut', 'ror': 'https://ror.org/04pznsd21', 'country_code': 'LB', 'type': 'education', 'lineage': ['https://openalex.org/I98635879']}], 'countries': ['LB'], 'is_corresponding': False, 'raw_author_name': 'R Halawi', 'raw_affiliation_strings': ['1American University of Beirut, Beirut, Lebanon.'], 'affiliations': [{'raw_affiliation_string': '1American University of Beirut, Beirut, Lebanon.', 'institution_ids': ['https://openalex.org/I98635879']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108762572', 'display_name': 'N. El-Saghir', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98635879', 'display_name': 'American University of Beirut', 'ror': 'https://ror.org/04pznsd21', 'country_code': 'LB', 'type': 'education', 'lineage': ['https://openalex.org/I98635879']}], 'countries': ['LB'], 'is_corresponding': False, 'raw_author_name': 'N El-Saghir', 'raw_affiliation_strings': ['1American University of Beirut, Beirut, Lebanon.'], 'affiliations': [{'raw_affiliation_string': '1American University of Beirut, Beirut, Lebanon.', 'institution_ids': ['https://openalex.org/I98635879']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5066754681', 'display_name': 'Z. Salem', 'orcid': 'https://orcid.org/0000-0002-0126-3043'}, 'institutions': [{'id': 'https://openalex.org/I98635879', 'display_name': 'American University of Beirut', 'ror': 'https://ror.org/04pznsd21', 'country_code': 'LB', 'type': 'education', 'lineage': ['https://openalex.org/I98635879']}], 'countries': ['LB'], 'is_corresponding': False, 'raw_author_name': 'Z Salem', 'raw_affiliation_strings': ['1American University of Beirut, Beirut, Lebanon.'], 'affiliations': [{'raw_affiliation_string': '1American University of Beirut, Beirut, Lebanon.', 'institution_ids': ['https://openalex.org/I98635879']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.4484, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 65, 'max': 72}, 'biblio': {'volume': '71', 'issue': '24_Supplement', 'first_page': 'P4', 'last_page': '16'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9813, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9813, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2777176818', 'wikidata': 'https://www.wikidata.org/wiki/Q412178', 'display_name': 'Tamoxifen', 'level': 4, 'score': 0.97303367}, {'id': 'https://openalex.org/C33664856', 'wikidata': 'https://www.wikidata.org/wiki/Q3271142', 'display_name': 'CYP2D6', 'level': 4, 'score': 0.86444914}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.81591284}, {'id': 'https://openalex.org/C55775858', 'wikidata': 'https://www.wikidata.org/wiki/Q1152227', 'display_name': 'Pharmacogenetics', 'level': 4, 'score': 0.5158752}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.49576482}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.48934883}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.46772897}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.4593698}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.44157872}, {'id': 'https://openalex.org/C180754005', 'wikidata': 'https://www.wikidata.org/wiki/Q80726', 'display_name': 'Allele', 'level': 3, 'score': 0.4376085}, {'id': 'https://openalex.org/C2777944059', 'wikidata': 'https://www.wikidata.org/wiki/Q903917', 'display_name': 'Selective estrogen receptor modulator', 'level': 5, 'score': 0.43518174}, {'id': 'https://openalex.org/C31467283', 'wikidata': 'https://www.wikidata.org/wiki/Q912147', 'display_name': 'Genotyping', 'level': 4, 'score': 0.4325795}, {'id': 'https://openalex.org/C37463918', 'wikidata': 'https://www.wikidata.org/wiki/Q387981', 'display_name': 'Allele frequency', 'level': 4, 'score': 0.4291801}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4031159}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.39945447}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.34358153}, {'id': 'https://openalex.org/C135763542', 'wikidata': 'https://www.wikidata.org/wiki/Q106016', 'display_name': 'Genotype', 'level': 3, 'score': 0.31841168}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.18098864}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.14781004}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.13165492}, {'id': 'https://openalex.org/C526171541', 'wikidata': 'https://www.wikidata.org/wiki/Q407693', 'display_name': 'Cytochrome P450', 'level': 3, 'score': 0.07895473}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.sabcs11-p4-01-16', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.84}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4220676153', 'https://openalex.org/W2964083386', 'https://openalex.org/W2784747145', 'https://openalex.org/W2403618362', 'https://openalex.org/W2092460775', 'https://openalex.org/W1993646007', 'https://openalex.org/W1969825491', 'https://openalex.org/W1967079243', 'https://openalex.org/W1603230448', 'https://openalex.org/W1514995717'], 'abstract_inverted_index': {'Abstract': [0], 'Introduction': [1], 'The': [2, 176], 'selective': [3], 'estrogen': [4], 'receptor': [5], 'modulator': [6], 'tamoxifen': [7, 55, 114, 129, 155, 169, 226, 234, 311], 'is': [8, 283, 319], 'commonly': [9], 'used': [10], 'for': [11, 77, 115, 148, 354], 'the': [12, 25, 67, 78, 123, 132, 212, 224, 232, 260, 284, 288, 293, 305, 330, 339, 355], 'treatment': [13], 'and': [14, 35, 69, 120, 152, 182, 187, 199, 229, 246, 265, 278, 304, 326, 346], 'prevention': [15], 'of': [16, 71, 80, 107, 113, 125, 150, 154, 168, 179, 191, 255, 295, 307, 357], 'breast': [17, 118, 142, 301], 'cancer.': [18], 'Tamoxifen': [19, 205], 'needs': [20], 'to': [21, 30, 37, 57, 121, 352], 'be': [22], 'converted': [23], 'by': [24], 'highly': [26], 'polymorphic': [27], 'enzyme,': [28], 'CYP2D6,': [29], 'its': [31, 39], 'active': [32], 'metabolites': [33, 156], '(4-hydroxytamoxifen': [34], 'endoxifen)': [36], 'exert': [38], 'anti-estrogenic': [40], 'effect.': [41], 'Several': [42], 'clinical': [43], 'trials': [44], 'have': [45, 51, 63, 314], 'shown': [46, 315], 'that': [47, 291, 316], 'CYP2D6': [48, 72, 159, 197, 296, 317], 'poor': [49], 'metabolizers': [50], 'decreased': [52], 'benefit': [53], 'from': [54], 'compared': [56], 'extensive': [58], 'metabolizers.': [59], 'Large': [60], 'ethnic': [61], 'variations': [62], 'been': [64], 'noticed': [65], 'in': [66, 104, 131, 241, 274, 287, 298, 335, 360], 'frequency': [68, 79], 'effect': [70, 124, 306], 'polymorphisms.': [73], 'Objectives': [74], 'To': [75], 'assess': [76, 122, 353], 'CYP2D6*3,': [81, 180], '*4,': [82, 181], '*5': [83, 87], '(nonfunctional': [84], 'alleles': [85], 'with': [86, 322], 'being': [88, 171, 350], 'a': [89, 105, 217, 251, 299], 'gene': [90], 'deletion),': [91], '*41': [92, 183], '(reduced': [93], 'functional': [94], 'allele)': [95], 'as': [96, 98], 'well': [97], 'CYP2D6*x': [99], 'N': [100], '(allele': [101], 'copy': [102], 'number)': [103], 'sample': [106], 'Lebanese': [108, 141, 300], 'participants': [109], 'receiving': [110], 'maintenance': [111], 'doses': [112], 'early': [116], 'stage': [117], 'cancer,': [119], 'these': [126, 308, 358], 'polymorphisms': [127, 309, 359], 'on': [128, 310], 'metabolism': [130], 'same': [133], 'subjects.': [134], 'Methods': [135], '111': [136], '(median': [137], 'age=': [138], '48.7±': [139], '8.6years)': [140], 'cancer': [143, 302], 'women': [144], 'were': [145, 170, 184, 267], 'recruited.': [146], 'Blood': [147], 'isolation': [149], 'DNA': [151], 'measurement': [153], 'was': [157, 161, 219, 250], 'collected.': [158], 'genotyping': [160], 'performed': [162, 351], 'using': [163, 173], 'real-time': [164], 'PCR.': [165], 'Plasma': [166], 'levels': [167], 'measured': [172], 'HPLC.': [174], 'Results': [175], 'allele': [177], 'frequencies': [178, 294], '0.9,': [185], '15.9': [186], '12.1': [188], 'respectively.': [189], '18.9%': [190], 'patients': [192], 'had': [193, 201, 223, 231, 329, 338], 'more': [194], 'than': [195], '2': [196], 'copies': [198], '9%': [200], 'only': [202], '1': [203], 'copy.': [204], 'plasma': [206, 227, 235, 239, 257, 272, 333, 342], 'concentration': [207], "didn't": [208], 'significantly': [209, 320], 'vary': [210], 'among': [211, 259], '4': [213], 'phenotypic': [214, 261], 'groups,': [215], 'although': [216], 'trend': [218], 'observed': [220], 'whereby': [221], 'PMs': [222, 264, 325], 'highest': [225, 331], 'concentrations': [228, 236, 240, 258, 273], 'UMs': [230, 337], 'lowest': [233, 340], '(Tamoxifen': [237], 'median': [238, 271], 'μg/L:': [242, 275], 'PM=290,': [243], 'IM=210,': [244], 'EM=190': [245], 'UM=170).': [247], 'Furthermore,': [248], 'there': [249], 'statistically': [252], 'significant': [253], 'variation': [254], 'Z-tamoxifen': [256, 270, 323, 332, 341], 'groups': [262], 'when': [263], 'IMs': [266], 'grouped': [268], 'together:': [269], 'PM+IM=130,': [276], 'EM=90': [277], 'UM=62': [279], '(P=0.03).': [280], 'Conclusion': [281], 'This': [282], 'first': [285], 'study': [286], 'Middle': [289], 'East': [290], 'evaluates': [292], 'polymorhisms': [297], 'population': [303], 'metabolism.': [312], 'We': [313], 'phenotype': [318], 'correlated': [321], 'levels.': [324], 'IM': [327], 'group': [328], 'concentrations;': [334], 'contrast': [336], 'concentrations.': [343], 'Further': [344], 'recruitment': [345], 'follow': [347], 'up': [348], 'are': [349], 'role': [356], 'disease': [361], 'outcome.': [362], 'Citation': [363], 'Information:': [364], 'Cancer': [365], 'Res': [366], '2011;71(24': [367], 'Suppl):Abstract': [368], 'nr': [369], 'P4-01-16.': [370]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1993646007', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}], 'updated_date': '2025-01-12T21:26:58.060598', 'created_date': '2016-06-24'}