[18F]PR04.MZ PET/CT Imaging for Evaluation of Nigrostriatal Neuron Integrity in Patients With Parkinson Disease

Name: Work Video:
Duration: 3 min 30 s
Carlos Juri; Vasko Kramer; Patrick J. Riss; Cristian Soza‐Ried; Arlette Haeger; Rossana Pruzzo; Frank Rösch; Horacio Amaral; Pedro Chaná‐Cuevas
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'Here': [55], 'we': [56], 'describe': [57], 'our': [58], 'initial': [59, 207], 'experience': [60], 'PET/CT': [65, 102, 266], 'in': [66, 157, 171, 201, 205, 252, 279, 282], 'larger': [68], 'cohort': [69], 'healthy': [71, 85], 'controls': [72], 'patients': [75, 90, 97, 255], 'as': [76], 'proof-of-concept': [78], 'study': [79], 'this': [81], 'tracer.': [82], 'Methods': [83], 'Eighteen': [84], 'subjects,': [86], '19': [87], 'early': [88], '(Hoehn-Yahr': [91, 98], 'I–II),': [92], '13': [94], 'moderate-advanced': [95], 'III–IV)': [99], 'underwent': [100], 'static': [101], 'scans': [103], '60': [104], 'to': [105, 214], '90': [106], 'minutes': [107], 'after': [108], 'injection': [109], '5.16': [111], '±': [112, 116, 184, 187, 191], '1.03': [113], 'mCi': [114], '(191': [115], '38': [117], 'MBq)': [118], 'F]PR04.MZ.': [121], 'Specific': [122], 'binding': [123, 170], 'ratios': [124], '(SBRs)': [125], 'were': [126, 182], 'calculated': [127], 'caudate': [129], 'nucleus,': [130], 'anterior': [131, 229], 'putamen,': [132, 134, 159], 'posterior': [133, 226, 240], 'substantia': [135, 162, 232], 'nigra': [136, 163, 233], '(SNpc),': [137], 'compared': [138], 'different': [140], 'groups': [141], 'correlated': [143, 258], 'clinical': [145], 'ratings.': [146], 'Results': [147], 'showed': [151], 'very': [152, 167], 'high': [153], 'specific': [155], 'uptake': [156], 'caudate,': [160, 237], 'pars': [164, 234], 'compacta': [165, 235], 'low': [168], 'nonspecific': [169], 'other': [172], 'brain': [173], 'regions,': [174], 'SBR': [176, 197], 'values': [177, 198], 'control': [180], 'group': [181], '22.3': [183], '4.1,': [185], '19.1': [186], '3.5,': [188], '5.4': [190], '1.2,': [192], 'respectively.': [193], 'A': [194], 'reduction': [195, 224], 'was': [199, 225, 250], 'observed': [200, 221], 'all': [202, 253], 'regions': [203], 'both': [206], 'moderate': [209], 'PD,': [210], 'ranging': [211], 'from': [212], '35%': [213], '89%': [215], '(': [216], 'P': [217], '&lt;': [218], '0.001).': [219], 'The': [220], 'pattern': [222], 'putamen': [227, 230, 241], '&gt;': [228, 231, 236], 'contralateral': [239], 'being': [242], 'most': [244], 'affected': [245], 'region.': [246], 'Rostrocaudal': [247], 'depletion': [248], 'gradient': [249], 'evident': [251], 'progression': [257], 'motor': [260], 'manifestations.': [261], 'Conclusions': [262], 'highly': [269], 'sensitive': [270], 'modality': [272], 'detection': [275], 'dopaminergic': [277], 'deficit': [278], 'pathways': [281], 'PD.': [283]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3112274140', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 1}], 'updated_date': '2024-12-11T01:13:50.552284', 'created_date': '2020-12-21'}
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