Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3112221891', 'doi': 'https://doi.org/10.1002/alz.037364', 'title': 'PS1 FAD mutants inactivate ephrinB1 and BDNF‐dependent neuroprotection against excitotoxicity by affecting neuroprotective complexes of NMDA receptor', 'display_name': 'PS1 FAD mutants inactivate ephrinB1 and BDNF‐dependent neuroprotection against excitotoxicity by affecting neuroprotective complexes of NMDA receptor', 'publication_year': 2020, 'publication_date': '2020-12-01', 'ids': {'openalex': 'https://openalex.org/W3112221891', 'doi': 'https://doi.org/10.1002/alz.037364', 'mag': '3112221891'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/alz.037364', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.037364', 'source': {'id': 'https://openalex.org/S108427512', 'display_name': 'Alzheimer s & Dementia', 'issn_l': '1552-5260', 'issn': ['1552-5260', '1552-5279'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.037364', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5030098316', 'display_name': 'Md Al Rahim', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98704320', 'display_name': 'Icahn School of Medicine at Mount Sinai', 'ror': 'https://ror.org/04a9tmd77', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1320796813', 'https://openalex.org/I98704320']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Md A. Rahim', 'raw_affiliation_strings': ['Icahn School of Medicine at Mount Sinai, New York, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Icahn School of Medicine at Mount Sinai, New York, NY, USA', 'institution_ids': ['https://openalex.org/I98704320']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5030098316'], 'corresponding_institution_ids': ['https://openalex.org/I98704320'], 'apc_list': {'value': 4000, 'currency': 'USD', 'value_usd': 4000, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 61}, 'biblio': {'volume': '16', 'issue': 'S2', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12061', 'display_name': 'Axon Guidance and Neuronal Signaling', 'score': 0.994, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12061', 'display_name': 'Axon Guidance and Neuronal Signaling', 'score': 0.994, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13551', 'display_name': 'Biochemical effects in animals', 'score': 0.9772, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13505', 'display_name': 'Apelin-related biomedical research', 'score': 0.9709, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/excitotoxicity', 'display_name': 'Excitotoxicity', 'score': 0.924719}], 'concepts': [{'id': 'https://openalex.org/C25498285', 'wikidata': 'https://www.wikidata.org/wiki/Q1981368', 'display_name': 'Neuroprotection', 'level': 2, 'score': 0.97138333}, {'id': 'https://openalex.org/C2781012912', 'wikidata': 'https://www.wikidata.org/wiki/Q901117', 'display_name': 'Excitotoxicity', 'level': 4, 'score': 0.924719}, {'id': 'https://openalex.org/C2776925932', 'wikidata': 'https://www.wikidata.org/wiki/Q1755122', 'display_name': 'Neurodegeneration', 'level': 3, 'score': 0.68066573}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.62954265}, {'id': 'https://openalex.org/C67018056', 'wikidata': 'https://www.wikidata.org/wiki/Q414896', 'display_name': 'NMDA receptor', 'level': 3, 'score': 0.6275993}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4848846}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.45374542}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.4132468}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.33155796}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.25063005}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.20066446}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.17299098}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.104833394}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.048315436}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/alz.037364', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.037364', 'source': {'id': 'https://openalex.org/S108427512', 'display_name': 'Alzheimer s & Dementia', 'issn_l': '1552-5260', 'issn': ['1552-5260', '1552-5279'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/alz.037364', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.037364', 'source': {'id': 'https://openalex.org/S108427512', 'display_name': 'Alzheimer s & Dementia', 'issn_l': '1552-5260', 'issn': ['1552-5260', '1552-5279'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Zero hunger', 'score': 0.59, 'id': 'https://metadata.un.org/sdg/2'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W90782486', 'https://openalex.org/W3146544726', 'https://openalex.org/W2401562497', 'https://openalex.org/W2218862885', 'https://openalex.org/W2102870106', 'https://openalex.org/W2084167126', 'https://openalex.org/W2079144484', 'https://openalex.org/W2022062858', 'https://openalex.org/W2014967627', 'https://openalex.org/W184092676'], 'abstract_inverted_index': {'Abstract': [0], 'Background': [1], 'Excitotoxicity': [2], 'is': [3], 'thought': [4], 'to': [5, 75, 112, 143, 172, 256], 'play': [6], 'a': [7, 300, 309], 'key': [8], 'role': [9, 78], 'in': [10, 150, 200, 232, 242, 285], 'brain': [11], 'neurodegeneration': [12], 'and': [13, 27, 51, 105, 127, 129, 164, 168, 189, 211, 245, 307, 334], 'stroke.': [14], 'Here,': [15], 'we': [16], 'show': [17], 'that': [18, 227, 246], 'neuroprotection': [19, 319], 'against': [20, 305, 320], 'excitotoxicity': [21, 306], 'by': [22, 272, 311], 'trophic': [23], 'factors': [24], 'ephrinB1': [25], '(efnB1)': [26], 'BDNF': [28], '(called': [29], 'here': [30], 'Factors)': [31], 'involves': [32], 'de': [33, 193], 'novo': [34, 194], 'formation': [35, 160, 174], 'of': [36, 43, 79, 116, 147, 156, 161, 175, 187, 192, 220, 248, 261, 279, 288, 331], '“survival': [37], 'complexes”': [38], 'which': [39, 312], 'are': [40, 253, 270], 'Factor‐stimulated': [41, 181, 195], 'complexes': [42, 124, 163, 177, 197, 230, 281], 'NMDA': [44], 'receptor': [45, 49], '(NMDAR)': [46], 'with': [47, 125], 'Factor': [48], '(FR)': [50], 'PS1.': [52], 'Method': [53], 'Primary': [54], 'cortical': [55], 'neuronal': [56], 'cultures': [57], 'from': [58, 62, 239], 'wild': [59], 'type': [60], 'or': [61, 66], 'PS1': [63, 80, 91, 103, 117, 138, 157, 203, 214, 233, 249, 273, 292, 313], 'hemizygous': [64], '(PS1+/‐)': [65], 'homozygous': [67], '(PS1‐/‐)': [68], 'knockout': [69], '(KO)': [70], 'mouse': [71], 'embryos': [72], 'were': [73, 141, 282], 'used': [74, 87, 142], 'examine': [76], 'the': [77, 106, 114, 145, 159, 180, 184, 190, 328], 'on': [81, 120], 'NMDAR‐FR': [82], 'complex': [83], 'formation.': [84], 'We': [85], 'also': [86, 178, 283], 'two': [88], 'independently': [89], 'constructed': [90], 'FAD': [92, 100, 109, 118, 139, 215, 234, 250, 274, 293, 314, 332], 'mutant': [93, 101], 'knock‐in': [94], '(KI)': [95], 'mice,': [96], 'one': [97], 'expressing': [98, 108, 202, 213, 291], 'human': [99, 135, 151], 'allele': [102, 110], 'M146V': [104], 'other': [107], 'I213T,': [111], 'test': [113, 144], 'effects': [115, 330], 'mutants': [119, 140, 216, 315, 333], 'Factors‐dependent': [121], 'neuroprotection,': [122], 'NMDAR': [123, 130], 'FR': [126], 'PS1,': [128], 'EPSCs.': [131], 'In': [132], 'addition,': [133], 'postmortem': [134, 286], 'brains': [136, 212, 252, 287], 'carrying': [137], 'relevance': [146], 'our': [148, 297], 'study': [149], 'disease': [152, 206], 'mechanism.': [153], 'Result': [154], 'Absence': [155], 'reduces': [158], 'survival': [162, 176, 196], 'abolishes': [165], 'neuroprotection.': [166, 182], 'EphB2‐': [167], 'NMDAR‐derived': [169], 'peptides': [170], 'designed': [171], 'disrupt': [173], 'decrease': [179, 198, 317], 'Strikingly,': [183], 'neuroprotective': [185, 303], 'effect': [186], 'Factors': [188], 'levels': [191, 278], 'dramatically': [199], 'neurons': [201, 210, 236, 244, 247, 260], 'Familial': [204], 'Alzheimer': [205], '(FAD)': [207], 'mutants.': [208, 275, 294], 'Mouse': [209], 'contain': [217], 'increased': [218], 'amounts': [219], 'constitutive': [221, 228], 'PS1‐NMDAR': [222, 229, 280], 'complexes.': [223], 'Additional': [224], 'evidence': [225], 'indicate': [226, 308], 'formed': [231, 241], 'mutant‐expressing': [235, 251], 'may': [237, 316], 'differ': [238], 'those': [240], 'WT': [243, 262], 'more': [254], 'vulnerable': [255], 'cerebral': [257], 'ischemia': [258], 'than': [259], 'brains.': [263], 'Furthermore,': [264], 'NMDAR‐mediated': [265], 'EPSCs': [266], 'at': [267], 'CA1': [268], 'synapses': [269], 'altered': [271], 'Importantly,': [276], 'high': [277], 'found': [284], 'AD': [289], 'patients': [290], 'Conclusion': [295], 'Together,': [296], 'data': [298], 'identify': [299], 'novel': [301], 'PS1‐dependent': [302], 'mechanism': [304], 'pathway': [310], 'Factor‐depended': [318], 'toxic': [321], 'insults.': [322], 'These': [323], 'findings': [324], 'have': [325], 'implications': [326], 'for': [327], 'pathogenic': [329], 'therapeutic': [335], 'strategies.': [336]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3112221891', 'counts_by_year': [], 'updated_date': '2024-12-10T19:20:10.040069', 'created_date': '2020-12-21'}