Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2102870106', 'doi': 'https://doi.org/10.1016/s0006-8993(97)00449-6', 'title': '17β-Estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors', 'display_name': '17β-Estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors', 'publication_year': 1997, 'publication_date': '1997-07-01', 'ids': {'openalex': 'https://openalex.org/W2102870106', 'doi': 'https://doi.org/10.1016/s0006-8993(97)00449-6', 'mag': '2102870106', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9252035'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0006-8993(97)00449-6', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S96638545', 'display_name': 'Brain Research', 'issn_l': '0006-8993', 'issn': ['0006-8993', '1872-6240'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/s0006-8993(97)00449-6', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5059312315', 'display_name': 'Charles E. Weaver', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I111088046', 'display_name': 'Boston University', 'ror': 'https://ror.org/05qwgg493', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I111088046']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Charles E. Weaver', 'raw_affiliation_strings': ['Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, MA 02118-2394, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, MA 02118-2394, USA.', 'institution_ids': ['https://openalex.org/I111088046']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049457911', 'display_name': 'Mijeong Park-Chung', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I111088046', 'display_name': 'Boston University', 'ror': 'https://ror.org/05qwgg493', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I111088046']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mijeong Park-Chung', 'raw_affiliation_strings': ['Laboratory of Molecular Neurobiology, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, 80 East Concord Street Boston, MA 02118-2394, USA'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular Neurobiology, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, 80 East Concord Street Boston, MA 02118-2394, USA', 'institution_ids': ['https://openalex.org/I111088046']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004250684', 'display_name': 'Terrell T. Gibbs', 'orcid': 'https://orcid.org/0000-0001-5022-6049'}, 'institutions': [{'id': 'https://openalex.org/I111088046', 'display_name': 'Boston University', 'ror': 'https://ror.org/05qwgg493', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I111088046']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Terrell T. Gibbs', 'raw_affiliation_strings': ['Laboratory of Molecular Neurobiology, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, 80 East Concord Street Boston, MA 02118-2394, USA'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular Neurobiology, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, 80 East Concord Street Boston, MA 02118-2394, USA', 'institution_ids': ['https://openalex.org/I111088046']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5000768396', 'display_name': 'David H. Farb', 'orcid': 'https://orcid.org/0000-0002-9050-6480'}, 'institutions': [{'id': 'https://openalex.org/I111088046', 'display_name': 'Boston University', 'ror': 'https://ror.org/05qwgg493', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I111088046']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David H. Farb', 'raw_affiliation_strings': ['Laboratory of Molecular Neurobiology, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, 80 East Concord Street Boston, MA 02118-2394, USA'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular Neurobiology, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, 80 East Concord Street Boston, MA 02118-2394, USA', 'institution_ids': ['https://openalex.org/I111088046']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3080, 'currency': 'USD', 'value_usd': 3080, 'provenance': 'doaj'}, 'apc_paid': {'value': 3080, 'currency': 'USD', 'value_usd': 3080, 'provenance': 'doaj'}, 'fwci': 12.502, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 278, 'citation_normalized_percentile': {'value': 0.955858, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '761', 'issue': '2', 'first_page': '338', 'last_page': '341'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10694', 'display_name': 'Menopause: Health Impacts and Treatments', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10694', 'display_name': 'Menopause: Health Impacts and Treatments', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10529', 'display_name': 'Stress Responses and Cortisol', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/2802', 'display_name': 'Behavioral Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9906, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/excitotoxicity', 'display_name': 'Excitotoxicity', 'score': 0.935958}], 'concepts': [{'id': 'https://openalex.org/C25498285', 'wikidata': 'https://www.wikidata.org/wiki/Q1981368', 'display_name': 'Neuroprotection', 'level': 2, 'score': 0.9638056}, {'id': 'https://openalex.org/C2781012912', 'wikidata': 'https://www.wikidata.org/wiki/Q901117', 'display_name': 'Excitotoxicity', 'level': 4, 'score': 0.935958}, {'id': 'https://openalex.org/C67018056', 'wikidata': 'https://www.wikidata.org/wiki/Q414896', 'display_name': 'NMDA receptor', 'level': 3, 'score': 0.901965}, {'id': 'https://openalex.org/C61174792', 'wikidata': 'https://www.wikidata.org/wiki/Q420510', 'display_name': 'Glutamate receptor', 'level': 3, 'score': 0.6081578}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.5833774}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.46843442}, {'id': 'https://openalex.org/C84606932', 'wikidata': 'https://www.wikidata.org/wiki/Q416496', 'display_name': 'Estrogen receptor', 'level': 4, 'score': 0.4523332}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.44376966}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.41250774}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.39117223}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.257918}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.20508063}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004958', 'descriptor_name': 'Estradiol', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D018696', 'descriptor_name': 'Neuroprotective Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D016194', 'descriptor_name': 'Receptors, N-Methyl-D-Aspartate', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002642', 'descriptor_name': 'Chick Embryo', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004958', 'descriptor_name': 'Estradiol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018690', 'descriptor_name': 'Excitatory Amino Acid Agonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006624', 'descriptor_name': 'Hippocampus', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D006624', 'descriptor_name': 'Hippocampus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016202', 'descriptor_name': 'N-Methylaspartate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018696', 'descriptor_name': 'Neuroprotective Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009498', 'descriptor_name': 'Neurotoxins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009498', 'descriptor_name': 'Neurotoxins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018408', 'descriptor_name': 'Patch-Clamp Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016194', 'descriptor_name': 'Receptors, N-Methyl-D-Aspartate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0006-8993(97)00449-6', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S96638545', 'display_name': 'Brain Research', 'issn_l': '0006-8993', 'issn': ['0006-8993', '1872-6240'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9252035', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0006-8993(97)00449-6', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S96638545', 'display_name': 'Brain Research', 'issn_l': '0006-8993', 'issn': ['0006-8993', '1872-6240'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.8}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 30, 'referenced_works': ['https://openalex.org/W1255054588', 'https://openalex.org/W1516762603', 'https://openalex.org/W1818239859', 'https://openalex.org/W1843854943', 'https://openalex.org/W1860838330', 'https://openalex.org/W1881159824', 'https://openalex.org/W1896045165', 'https://openalex.org/W1912224219', 'https://openalex.org/W1947395210', 'https://openalex.org/W1960543132', 'https://openalex.org/W1967330359', 'https://openalex.org/W1981475053', 'https://openalex.org/W1998164097', 'https://openalex.org/W2009667219', 'https://openalex.org/W2010926499', 'https://openalex.org/W2016597337', 'https://openalex.org/W2019267922', 'https://openalex.org/W2028541653', 'https://openalex.org/W2029545906', 'https://openalex.org/W2032218732', 'https://openalex.org/W2049312278', 'https://openalex.org/W2066168019', 'https://openalex.org/W2082648762', 'https://openalex.org/W2091097006', 'https://openalex.org/W2104877311', 'https://openalex.org/W2115142708', 'https://openalex.org/W2139748951', 'https://openalex.org/W2152110038', 'https://openalex.org/W2158239158', 'https://openalex.org/W2285071408'], 'related_works': ['https://openalex.org/W3146544726', 'https://openalex.org/W2920924601', 'https://openalex.org/W2766430282', 'https://openalex.org/W2417959095', 'https://openalex.org/W2110168561', 'https://openalex.org/W2084167126', 'https://openalex.org/W2057359585', 'https://openalex.org/W2022062858', 'https://openalex.org/W2014967627', 'https://openalex.org/W1991512531'], 'abstract_inverted_index': {'Several': [0], 'lines': [1], 'of': [2, 15, 37], 'evidence': [3], 'suggest': [4], 'that': [5], '17β-estradiol': [6], '(βE2)': [7], 'has': [8, 42], 'neuroprotective': [9, 56], 'properties.': [10], 'The': [11], 'risk': [12], 'and': [13, 26], 'severity': [14], 'dementia': [16], 'are': [17], 'decreased': [18], 'in': [19, 30], 'women': [20], 'who': [21], 'have': [22], 'received': [23], 'estrogen': [24], 'therapy,': [25], 'βE2': [27, 41, 59], 'protects': [28, 60], 'neurons': [29], 'vitro': [31], 'against': [32, 61], 'death': [33, 64], 'from': [34], 'a': [35], 'variety': [36], 'stressors.': [38], 'Neuroprotection': [39], 'by': [40, 65], 'been': [43], 'suggested': [44], 'to': [45, 48], 'be': [46], 'due': [47], 'free': [49], 'radical': [50], 'scavenging.': [51], 'We': [52], 'demonstrate': [53], 'an': [54], 'additional': [55], 'mechanism': [57], 'whereby': [58], 'NMDA-induced': [62], 'neuronal': [63], 'directly': [66], 'inhibiting': [67], 'the': [68], 'NMDA': [69], 'receptor.': [70]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2102870106', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 11}], 'updated_date': '2024-12-10T11:00:24.407078', 'created_date': '2016-06-24'}