<i>In Vivo</i> Characterization of the Toxicological Properties of DPhP, One of the Main Degradation Products of Aryl Phosphate Esters

Name: Work Video:
Duration: 3 min 30 s
Samia Selmi‐Ruby; Jesús Marín‐Sáez; Aurélie Fildier; Audrey Buleté; Myriam Abdallah; Jessica Garcia; Julie Deverchère; Loïc Spinner; Barbara Giroud; Sébastien Ibanez; Thierry Granjon; Claire Bardel; Alain Puisieux; Béatrice Fervers; Emmanuelle Vulliet; Léa Payen; Arnaud Vigneron
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4411], 'with': [682, 855, 858, 949, 1265, 1360, 1503, 1555, 1646, 1695, 2045, 2118, 2198, 2245, 2379, 2661, 2706, 2750, 2789, 2896, 2908, 3006, 3113, 3144, 3182, 3195, 3207, 3243, 3270, 3293, 3382, 3452, 3485, 3779, 3850, 3928, 3944, 4047, 4128, 4328, 4448], 'these': [683, 1317, 1326, 1422, 1449, 1504, 1662, 1834, 1848, 1899, 1927, 2098, 2142, 2762], 'compounds': [684, 1187, 3597, 3602, 4369, 4422], 'remain': [685], 'largely': [686, 1047, 1162], 'unknown': [687], 'effects': [690, 734, 812, 921, 1334, 1354, 2093], 'diphenyl': [692, 1020, 1036, 2189], '(DPhP),': [694], 'one': [695, 757, 2554], 'their': [697, 726, 1181, 1255, 1314, 1338, 1425, 2108, 2781, 3612], 'most': [698, 1445, 1749], 'frequent': [699], 'derivatives,': [700], 'poorly': [702], 'characterized.Objective:Our': [703], 'aim': [704, 2149, 2422], 'was': [705, 796, 863, 887, 1370, 2150, 2261, 2356, 2424, 2510, 2522, 2583, 2620, 2686, 2709, 2887, 2929, 2957, 3091, 3097, 3111, 3130, 3148, 3218, 3241, 3263, 3267, 3280, 3313, 3360, 3368, 3395, 3409, 3426, 3476, 3495, 3522, 3534, 3548, 3561, 3590, 3631, 3675, 3695, 3728, 3734, 3742, 3784, 3790, 3806, 3829, 3835, 3839, 3901, 3914, 3938, 3982, 4006, 4015, 4034, 4045, 4396, 4418], 'investigate': [707], 'whether': [708], 'DPhP': [709, 751, 779, 852, 909, 960, 1009, 1044, 1336, 1369, 1442, 1477, 1485, 1523, 1556, 1584, 1613, 1635, 1753, 1912, 1948, 1960, 2024, 2038, 2070, 2159, 2254, 2380, 2405, 2432, 2505, 2579, 2660, 2667, 2805, 3503], 'per': [710, 2632, 2649, 2652, 2753], 'se': [711], 'may': [712, 1453, 1538, 1731], 'represent': [713, 4023], 'a': [714, 817, 833, 897, 902, 929, 985, 1000, 1365, 1497, 1506, 1880, 1933, 2157, 2181, 2199, 2246, 2412, 2525, 2586, 2646, 2893, 2909, 2970, 3059, 3065, 3072, 3138, 3141, 3285, 3316, 3351, 3374, 3399, 3410, 3453, 3479, 3549, 3565, 3575, 3661, 3772, 3842, 3917, 3929, 3973, 4024, 4048, 4055, 4372], 'more': [715, 1366, 2061], 'relevant': [716, 748, 2158, 2386, 2429, 4312], 'marker': [717], 'exposure': [719, 780, 924, 990, 1258, 1342, 1361, 1606, 1674, 1910, 1946, 1974, 2260, 2444, 2694, 2730, 2873], 'APEs': [721, 1081, 1102, 1363, 1459, 1470, 1696, 1884], 'than': [722, 889, 2026, 2083, 2202, 2249, 2512], 'direct': [723, 1093, 1332, 1721], 'assessment': [724], 'concentration': [727, 2848, 3226], 'determine': [729, 788, 4311], 'its': [730, 759, 1076, 1092, 1216, 1226, 1494, 1743], 'potential': [731], 'deleterious': [732], 'biological': [733, 811, 1333, 1995, 2154, 2409, 4425], 'chronically': [736, 745], 'exposed': [737, 746, 850, 867, 1619, 2066, 2085], 'mice.Methods:Conventional': [738], 'animals': [739, 1900, 2378, 2722, 2752, 2776, 2853, 3015, 4250], '(FVB': [740], 'mice)': [741], 'were': [742, 764, 781, 1406, 1640, 1778, 1836, 1961, 2194, 2238, 2275, 2287, 2306, 2312, 2339, 2374, 2388, 2482, 2496, 2536, 2543, 2561, 2597, 2723, 2747, 2759, 2777, 2808, 2827, 2854, 2906, 2922, 2948, 2965, 2987, 3002, 3028, 3052, 3135, 3159, 3180, 3345, 3466, 3618, 3864, 3999, 4075, 4103, 4126, 4251, 4274, 4298, 4338, 4348, 4382, 4454], 'acutely': [743], 'doses': [749, 1704, 1787, 1835, 1889, 1944, 1958, 1975, 2047], 'triphenyl': [754, 997, 2187, 2192], '(TPhP),': [756, 999], 'main': [760, 986, 1401, 1560], 'precursors.': [761, 4072], 'Both': [762], 'molecules': [763, 1665, 2050, 2100, 2143, 2826], 'measured': [765, 2788], 'blood': [767, 1601, 2041, 2431, 2886, 2899, 2983, 3240], 'other': [769, 1154, 1268, 2119, 2518, 3601], 'tissues': [770, 2964], 'by': [771, 881, 1380, 1478, 1782, 1809, 2330, 2695, 2701, 2711, 2889, 2925, 3030, 3036, 3122, 3248, 4008, 4165], 'liquid': [772, 2933, 2992], 'chromatography–mass': [773], 'spectrometry': [774], '(LC-MS).': [775], 'Effects': [776], 'chronic': [778, 923, 2557, 2742, 2882], 'addressed': [782], 'through': [783, 1602, 1622, 1720, 1756, 2086, 2101, 2446, 2507, 2516, 2569], 'liver': [784, 940, 1379, 1467, 3095, 3110], 'multi-omics': [785], 'analysis': [786, 806, 895, 3191, 3203, 3913, 3937, 4264, 4284, 4316], 'corresponding': [790], 'metabolic': [791, 967], 'profile.': [792], 'Deep': [793], 'statistical': [794, 3233], 'exploration': [795], 'performed': [797, 2760, 3003, 3098, 3915, 4046, 4127], 'extract': [799, 3279], 'correlated': [800, 1645], 'information,': [801], 'guiding': [802], 'further': [803, 976], 'physiological': [804], 'analyses.Results:Multi-omics': [805], 'confirmed': [807], 'existence': [809], 'even': [815, 927], 'at': [816, 928, 1886, 2622, 2783, 2822, 2937, 2996, 3168, 3176, 3289, 3378, 3468, 3620, 3669, 3697, 3906, 3984, 3988, 3992, 4242, 4354], 'very': [818, 1608, 1702], 'low': [819, 930, 2363, 4068], 'dose': [820, 1739, 2387, 2913], '0.1mg/mL': [822], 'drinking': [824, 2102, 2470, 2492, 2508, 2534, 2570, 2576, 2617, 2670, 2850, 2879], 'water.': [825, 2851], 'Chemical': [826], 'structural': [827], 'homology': [828], 'pathway': [830], 'mapping': [831], 'demonstrated': [832, 1313, 1576], 'clear': [834], 'reduction': [835], 'fatty': [838], 'acid': [839, 936, 2217, 2237, 2282, 3431, 3642, 3654, 3751, 3765], 'catabolic': [840, 877], 'processes': [841, 878], 'centered': [842], 'on': [843, 952, 961, 1322, 1823, 1844, 1868, 1926, 2171, 2761, 3011, 4037, 4371], 'acylcarnitine': [844], 'mitochondrial': [846], 'β-oxidation': [847], 'mice': [849, 866, 1714, 2043, 2111, 2297, 2495, 2560, 2905, 2921], 'comparison': [854, 2117], 'those': [856, 1951, 2436], 'treated': [857, 2044, 2563, 2691], 'vehicle.': [859], 'An': [860, 1417], 'interesting': [861], 'finding': [862, 1419, 1452], 'that': [864, 890, 917, 1237, 1399, 1421, 1456, 1469, 1510, 1592, 1769, 1785, 1909, 2058, 2490, 2542, 3603], 'mRNA,': [870], 'expression': [871], 'genes': [873], 'involved': [874], 'lipid': [876], 'regulated': [880], 'peroxisome': [882, 1795], 'proliferator–activated': [883, 1796], 'receptor': [884, 1797], 'alpha': [885], '(PPARα)': [886], 'lower': [888, 1887], 'vehicle-treated': [892], 'mice.': [893, 2145], 'Immunohistochemistry': [894], 'showed': [896, 1509], 'specific': [898], 'down-regulation': [899], 'HMGCS2,': [901], 'kernel': [903], 'target': [904], 'gene': [905], 'PPARα.': [907], 'Overall,': [908], 'absorption': [910, 2096], 'disrupted': [911], 'body': [912, 1894], 'weight–gain': [913], 'processes.Conclusions:Our': [914], 'results': [915, 1849, 2541, 2682], 'suggest': [916], 'mice,': [919, 1938], 'dose,': [931, 2430], 'not': [933, 1189, 1235, 1461, 2598, 3608], 'negligible.': [934], 'Fatty': [935], 'metabolism': [937, 1547, 1918], 'is': [941, 1046, 1211, 1223, 1234, 1420, 1607], 'essential': [942], 'controlling': [944], 'fast': [945], 'feast': [947], 'periods,': [948], 'adverse': [950], 'consequences': [951, 2155], 'overall': [954], 'physiology.': [955, 1852], 'Therefore,': [956], 'impact': [958], 'circulating': [962], 'fat,': [963], 'cardiovascular': [964], 'pathologies': [965], 'disease': [968], 'incidence': [969], 'deserves,': [970], 'light': [972], 'our': [974, 2020, 2032, 2148, 4308], 'results,': [975], 'investigations.': [977], 'https://doi.org/10.1289/EHP6826IntroductionDiphenyl': [978], '(DPhP)': [980], 'has': [981, 1311, 1548, 1771], 'been': [982, 1243, 1431, 1549], 'as': [984, 1105, 1136, 1164, 1476, 1496, 1680, 1698, 2125, 2178, 2180, 2390, 4021], 'biomarker': [987], 'assessing': [989], 'aryl': [992, 1383], '(APEs),': [995], 'especially': [996], 'molecule': [1001], 'suspected': [1002], 'presenting': [1004], 'human': [1005, 1251, 1434, 1466, 1574, 1667, 1851, 1972, 4433], 'health': [1006], 'hazards.': [1007], 'However,': [1008, 1389], 'can': [1010, 1197, 1677], 'be': [1011, 1246, 1346, 1373, 1490, 1643, 2064], 'produced': [1012, 1374], 'from': [1013, 1079, 1225, 1375, 1393, 1404, 1585, 1963, 1976, 2175, 2196, 2240, 2264, 2277, 2289, 2302, 2358, 2396, 2411, 2427, 2564, 2628, 2960, 3220, 3403, 3421, 3455, 3483, 4259, 4383, 4424, 4440], 'degradation': [1014, 1457], 'several': [1016], 'APEs,': [1017], 'including': [1018], 'ethylhexyl': [1019], '(EHDPhP)': [1022], 'resorcinol': [1025], 'bis(diphenyl': [1026], 'phosphate)': [1027], '(RDP)': [1028], '(Ballesteros-Gómez': [1029], 'al.': [1031, 1041, 1055, 1059, 1063, 1071, 1084, 1088, 1099, 1205, 1231, 1280, 1290, 1298, 1303, 1309, 1387, 1415, 1439, 1528, 1568, 1589, 1632, 1656, 1717, 1729, 1802, 1806, 1830, 1877, 1924, 1981, 1985, 2000, 2004, 2008, 2012, 2016], '2015a,': [1032], '2015b)': [1033], 'tert-butylphenyl': [1035], '(BPDP)': [1038], '(Heitkamp': [1039], '1985).': [1042], 'Moreover,': [1043, 1152, 1879, 3935], 'itself': [1045], 'environment': [1051, 1202, 1253, 1488, 1534, 1639, 1653, 1978], 'worldwide': [1052], '(Björnsdotter': [1053, 1288, 1654, 1998], '2018;': [1056, 1068, 1291, 2001], 'Fu': [1057], '2017;': [1060, 1085], 'Li': [1061], '2019b;': [1064, 1281, 1982], 'Wang': [1065, 1069, 1282], 'Kannan': [1067, 1284], '2019),': [1072, 1440, 1590], 'either': [1073, 1455, 1869, 2445], 'owing': [1074, 2071], 'spontaneous/microorganism': [1077], 'production': [1078, 1521], 'known': [1080, 1989], '(Fu': [1082], 'Su': [1086], '2016),': [1089], 'use': [1094], 'industry': [1096], '(Mitchell': [1097], '2019).': [1100, 1569, 2017], 'Most': [1101], 'flame': [1106, 1155, 1269], 'retardants.': [1107, 1270], 'They': [1108, 3027], 'added': [1110, 3346], 'consumer': [1112], 'products': [1113], 'raw': [1115], 'materials': [1116, 1195], 'delay': [1118], 'combustion': [1119], 'meet': [1121], 'flammability': [1122], 'standards': [1123, 2206], '(e.g.,': [1124], 'Fire': [1125, 1129, 1139, 1145], 'initiation': [1126], 'growth,': [1128], 'containment,': [1130], 'Non-combustibility': [1132], 'test': [1133], 'standards),': [1134], 'such': [1135, 1697, 2124], 'ISO/TC92': [1138], 'Safety': [1140], 'code,': [1141], 'TC89': [1144], 'Hazard': [1146], 'Testing': [1147], 'code': [1148], 'existing': [1149], 'Europe.': [1151], 'unlike': [1153], 'retardants,': [1156], 'TPhP': [1157, 1210, 1238, 1272, 1341, 1376, 1405, 1412, 1516, 1586, 1596, 1621, 1647, 1706, 1741, 1770, 1790, 1813, 1867, 1914, 2027, 2068, 2076, 2256, 2403, 2807, 3505], 'EHDPhP': [1159, 1240, 1274, 1428, 1518], 'also': [1161, 1212, 2262, 2949, 3591], 'plasticizers': [1165], 'lubricants': [1167], 'hydraulic': [1169], 'fluids,': [1170], 'rubber,': [1171], 'paints,': [1172], 'textile': [1173], 'coatings,': [1174], 'food': [1175, 1277], 'packaging,': [1176], 'PVC,': [1178], 'drastically': [1179], 'increasing': [1180, 1903], 'presence': [1182, 1315, 1483, 2074], 'These': [1186, 1759, 1776, 2825], 'usually': [1190], 'covalently': [1191], 'linked': [1192], 'plastic': [1194], 'easily': [1198], 'leach': [1199], 'into': [1200, 1563, 3162, 3315, 3347], '(Jamarani': [1203], '2018).High': [1206], 'vapor': [1207], 'pressure': [1208, 3876], 'likely': [1213, 2062], 'facilitate': [1215], 'release': [1217], 'air': [1220, 1306, 2079], 'once': [1221, 2977], 'it': [1222, 2521, 3560, 3667], 'freed': [1224], 'original': [1227], 'material': [1228], '(Meeker': [1229], '2013).': [1232, 1878], 'It': [1233, 3789, 4044], 'surprising': [1236], 'have': [1241, 1429, 1763, 2089, 2162, 3564], 'thus': [1242, 1343, 1746, 2090, 2644], 'shown': [1244, 1550], 'ubiquitous': [1247], 'components': [1248, 4297], 'indoor': [1252], 'where': [1254, 2494], 'sources': [1256], 'pathways': [1259], 'quite': [1261], 'diverse': [1262], 'heterogeneous': [1264], 'regard': [1266], 'Indeed,': [1271], 'quantification': [1275, 3501], '(Li': [1278, 1301, 1979], '2018),': [1285, 1657], 'house': [1286], 'dust': [1287], 'Meeker': [1292, 1296, 2002], 'Stapleton': [1294], '2010;': [1295], '2013),': [1299], 'water': [1300, 2103, 2338, 2471, 2509, 2535, 2571, 2577, 2609, 2618, 2671, 2815, 2831, 2865, 2870, 2880, 2980, 3440, 3743], '2019a),': [1304], '(Wei': [1307], '2015)': [1310, 1718, 1986], 'systematically': [1312], 'different': [1318, 2052, 2664, 2688, 3049, 3613, 4350, 4384], 'matrices,': [1319, 3057], 'raising': [1320, 1659], 'awareness': [1321], 'safety': [1324], 'compounds.': [1327], 'A': [1328, 3580, 3673, 3684, 3710, 3891], 'study': [1329, 1508, 1935], 'characterizing': [1330], 'relationship': [1339], 'appeared': [1344], 'particular': [1348], 'relevance': [1349, 1683, 1846], 'better': [1351], 'define': [1352], 'mechanisms': [1356], 'action': [1358], 'comprehensive': [1367], 'way.Historically,': [1368], 'believed': [1371], 'oxidase': [1381], 'esterase': [1384], '(Sasaki': [1385], '1984).': [1388], 'recent': [1390, 1507, 1906], 'analyses': [1391, 2165, 2398, 2758, 4228], 'obtained': [1392, 2174, 2239, 2263, 2357, 4439], 'vitro': [1395, 1686, 1781], 'cultured': [1396], 'hepatocytes': [1397, 1827], 'revealed': [1398], 'metabolites': [1402, 1423], 'derived': [1403], 'hydroxylated': [1407, 1744], 'glucuronated': [1409], 'forms': [1410], '(Su': [1413, 1828], '2014).': [1416, 1831], 'important': [1418], 'equivalents': [1426], 'recently': [1430], 'detected': [1432, 4206], 'urine': [1435, 1615], 'samples': [1436, 1616, 3179, 3222, 3994, 4074, 4231, 4245], '(Zhao': [1437], 'although': [1441], 'remained': [1443], 'abundant': [1446], 'metabolite': [1447, 1561, 2940, 2999], 'samples.': [1450], 'This': [1451, 3265, 4394], 'indicate': [1454], 'does': [1460], 'primarily': [1462], 'occur': [1463], 'rapidly': [1472], 'degraded': [1473], 'absorbed': [1475], 'Finally,': [1481, 1634, 2146, 2553, 3150], 'could': [1489, 1915, 1949], 'directly': [1491], 'due': [1492, 3610], 'importance': [1495], 'catalyst': [1498], 'polymerization': [1500], 'processes.In': [1501], 'line': [1502], 'hypotheses,': [1505], 'serum': [1511], 'hydrolase': [1512], 'significantly': [1513, 4349], 'contributed': [1514], 'clearance': [1519], '(Van': [1524], 'den': [1525], 'Eede': [1526], '2016).': [1529, 1633], 'Bacteria': [1530], 'microbiota': [1537], 'participate': [1539], 'this': [1541, 1603, 1628, 3698], 'type': [1542, 4261], 'transformation': [1544, 2109], 'because': [1545, 2147, 2538, 2559, 3559], 'bacterial': [1546], 'fully': [1552], 'degrade': [1553], 'TPhP,': [1554], 'initially': [1557], 'being': [1558], 'released': [1562], 'biofilm': [1565], '(Hou': [1566], 'Similarly,': [1570, 1905], 'microsomal': [1571], 'preparation': [1572], 'skin': [1575], 'ability': [1578, 1811], 'carboxylesterases': [1580], 'efficiently': [1582], 'generate': [1583], '(Abdallah': [1587], 'indicating': [1591], 'likelihood': [1594], 'reaching': [1597, 3688], 'subcutaneous': [1598, 1722], 'fat': [1599, 2947, 3076, 3309], 'route': [1604, 1751], 'low.': [1609], 'Rapid': [1610], 'detection': [1611], 'women': [1618], 'nail': [1623], 'polish': [1624], 'tends': [1625], 'confirm': [1627, 1861, 3594], 'hypothesis': [1629], '(Mendelsohn': [1630], 'concentrations': [1636, 1997, 2039, 2417, 2433, 2532, 2595, 2665], 'reported': [1641, 2679, 3562], 'strongly': [1644], 'levels': [1648, 2364], 'same': [1652, 2858, 3094], 'hence': [1658], 'concerns': [1660], 'about': [1661], 'potentially': [1663], 'hazardous': [1664], 'health.The': [1668], 'complexity': [1669], 'routes': [1672, 1942, 2053], 'described': [1675, 2736], 'above': [1676], 'cast': [1678], 'doubts': [1679, 1843], 'vivo': [1689], 'studies': [1690, 1783], 'describing': [1691], 'toxicities': [1693], 'TPhP.': [1699, 2382], 'For': [1700, 2741, 3080, 3214, 3323], 'instance,': [1701], 'high': [1703, 1786, 4070], 'administered': [1707, 1885, 2531, 2596, 3225], 'via': [1708, 2051, 2104, 2533], 'oral': [1709, 2126, 2458, 2548, 2739, 2840], 'gavage': [1710, 2127, 2459, 2549, 2841], '(300mg/kg/d)': [1711], 'adult': [1713], '(Chen': [1715], 'injection': [1723, 2448, 2844, 3732, 3833], '(∼200μg/kg/d)': [1724], 'embryos/pups': [1726], '(Wang': [1727, 1922], '2018)': [1730], 'artificially': [1732], 'expose': [1733], 'organism': [1735], 'an': [1737, 1772, 1964, 2499, 2702, 2790, 2812, 3083, 3538, 4280], 'irrelevant': [1738], 'forms,': [1745], 'misrepresenting': [1747], 'common': [1750], 'exposure,': [1754, 2160, 2558, 2743], 'i.e.,': [1755, 3058], 'types': [1760], 'protocols': [1762], 'mainly': [1764], 'led': [1765], 'conclusion': [1768], 'obesogenic': [1773], 'endocrine-disrupting': [1774], 'activity.': [1775], 'findings': [1777], 'reinforced': [1779], 'showing': [1784], '(10–100μM)': [1788], 'disturb': [1791], 'activity': [1793, 1818], 'gamma': [1798], '(PPARγ)': [1799], '(Belcher': [1800], '2014;': [1803], 'Tung': [1804], '2017),': [1807], 'enhance': [1815], 'lipogenic': [1817], 'thyroid': [1821], 'hormone': [1822], 'isolated': [1824], 'chicken': [1825], 'embryo': [1826], 'Of': [1832], 'note,': [1833], 'highly': [1837], 'toxic': [1838], 'mammalian': [1840], 'cells,': [1841], 'casting': [1842], 'In': [1853], 'addition,': [1854], 'cell-based': [1855], 'transactivation': [1856], 'assays': [1857], 'somehow': [1858], 'failed': [1859], 'agonistic': [1862], 'antagonistic': [1864], 'activities': [1865], 'PPAR': [1870], 'TR': [1872], 'nuclear': [1873], 'receptors': [1874], '(Kojima': [1875], 'treatment': [1881], 'combining': [1882, 2166], 'four': [1883, 2721, 3056, 4227, 4296], 'individual': [1888], '1mg/kg/d': [1891], 'decreased': [1892, 3686, 3792], 'weight': [1895, 2602, 2696, 2782], '(BW)': [1896], 'gain': [1897, 2603, 2685], 'instead': [1901], 'it.': [1904], 'reports': [1907], 'indicated': [1908, 2391, 2835, 2847], 'disrupt': [1916], 'opposite': [1920], 'manners': [1921], '2018).Based': [1925], 'controversial': [1928], 'findings,': [1929], 'we': [1930, 2035, 2161, 4320, 4366], 'herein': [1931], 'large': [1934], 'conducted': [1936, 2163, 3219, 4035], 'which': [1940, 4346], 'mimic': [1950], 'found': [1952, 2406, 2437, 4429], 'humans.': [1954, 2439], 'Environmentally-': [1955], 'human-relevant': [1957], 'established': [1962], 'extensive': [1965], 'review': [1966], 'literature': [1969], 'estimating': [1970], 'mean': [1973, 2647], 'Wei': [1983, 2010], 'correlation': [1990], 'between': [1991, 2345, 2634, 2689, 4058, 4336, 4351], 'environmental': [1992], 'measurements': [1993], 'fluid': [1996], '2013;': [2005], 'Pouech': [2006], '2015;': [2009, 2013], 'Zhao': [2014], 'To': [2018], 'validate': [2019], 'choice': [2021], 'using': [2023, 2892, 3398, 3537, 4285, 4357, 4398], 'rather': [2025, 2082], 'another': [2029, 3801], 'APE': [2030, 3101], 'toxicity': [2033], 'study,': [2034], 'first': [2036, 2809, 2958, 4295], 'analyzed': [2037, 2091, 4076], 'various': [2046], 'both': [2049, 4100, 4269], 'exposure.': [2055, 2501], 'We': [2056, 2088, 2131, 2643], 'hypothesized': [2057], 'humans': [2059], 'continuously/chronically': [2065], 'dust,': [2081], 'temporarily/acutely': [2084], 'nutrition.': [2087], 'continuous': [2095], 'two': [2099, 3163, 4244], 'kinetic': [2105], 'measurement': [2106, 2170, 3102], '(bioaccumulation': [2112], 'tissue': [2114, 2172], 'distribution),': [2115], 'acute': [2120, 2443, 2547, 2729, 2872], 'modes': [2121], 'administration': [2123], 'tail-vein': [2129], 'injection.': [2130, 2552, 3723], 'then': [2132, 2828, 2988, 3685, 3791, 4455], 'data': [2135, 3527, 3530, 4093, 4116, 4122, 4225], 'reporting': [2136], 'bioaccumulation': [2138], 'distribution': [2140], 'analyze': [2152], 'dual-omics': [2164], 'metabolomics': [2167, 3104, 4263], 'transcriptomic': [2169, 2757], 'extracts': [2173, 3153], 'independent': [2176, 2745, 2765], 'experiments,': [2177, 2766], 'well': [2179], 'histological': [2182], 'validation.MethodsReagents': [2183], 'ChemicalsDiphenyl': [2185], 'phosphate,': [2186, 2188], 'phosphate-D10': [2190], 'phosphate-D15': [2193], 'purchased': [2195, 2276, 2288], 'Merck': [2197], 'purity': [2200, 2247], 'higher': [2201, 2248, 2511], '98%.': [2203], 'The': [2204, 2502, 2530, 2594, 3093, 3178, 3277, 3406, 3423, 3464, 3473, 3490, 3517, 3545, 3616, 3657, 3680, 3693, 3724, 3731, 3768, 3804, 3825, 3832, 3861, 3912, 3979, 4029, 4073, 4144, 4193, 4294, 4379, 4462], 'confirmation': [2205, 4458], 'carnitine,': [2208], 'acetylcarnitine,': [2209], 'palmitoylcarnitine,': [2210], 'lauroylcarnitine,': [2211], 'decanoylcarnitine,': [2212], 'hexanoylcarnitine,': [2213], 'stearic': [2214], 'acid,': [2215, 2220, 2227, 2229, 2231, 2233], 'oleic': [2216], 'linoleic': [2219], '7-ketocholesterol,': [2221], '3β-hydroxy-5-cholestene-7-one,': [2222], 'Hypoxanthine,': [2223], 'Ethyl': [2224], 'oleate,': [2225], 'cis-11-Eicosenoic': [2226], 'cis-11,14-Eicosadienoic': [2228], '(R)-3-hydroxybutyric': [2230], 'Taurocholic': [2232], 'Taurodeoxycholate,': [2234], 'Taurochenodeoxycholate,': [2235], 'Tauroursodeoxycholic': [2236], 'Merck,': [2241], 'all': [2242, 2309, 2803, 2884, 3151, 4230], 'them': [2244], '97%.': [2250], 'Corn': [2251], 'oil': [2252, 2818, 2863], 'resuspension': [2257], 'animal': [2259, 2327], 'Merck.Acetonitrile': [2265], 'heptane': [2267, 3129, 3358], 'LC-MS': [2269, 2286], 'quality': [2270, 2283, 3996, 4306], 'grade': [2271, 2284], 'ammonium': [2273, 3637, 3649, 3746, 3760], 'formate': [2274, 3638, 3650, 3747, 3761, 3895], 'BioSolve.': [2278], 'Water': [2279], 'formic': [2281, 3430, 3641, 3653, 3750, 3764], 'optima': [2285], 'Fisher': [2290], 'Scientific.Animal': [2291], 'Experiments': [2292, 2481], 'Animal': [2294], 'CareFemale': [2295], 'FVB': [2296], '(5': [2298], 'wk': [2299, 2568, 2797], 'old;': [2300], '15.2–18.7g)': [2301], 'Charles': [2303], 'River': [2304], 'Laboratories': [2305], 'experiments.': [2310, 2677], 'Animals': [2311], 'housed': [2313], '(from': [2314], '4': [2315, 3701, 3809], 'wk)': [2316], 'ANICAN': [2319], '(Center': [2320], 'Recherche': [2322], 'en': [2323], 'Cancérologie': [2324], 'Lyon)': [2326], 'facilities': [2328], 'accredited': [2329], 'French': [2332, 3007, 3024, 3038], 'Ministry': [2333, 3039], 'Agriculture.': [2335], 'provided': [2340, 2540], 'ad': [2341], 'libitum': [2342], '(lights': [2343], 'on:': [2344], '8': [2346, 2349], 'pm': [2347], 'am;': [2350], 'temperature:': [2351], '22°C±1°C;': [2352], 'humidity:': [2353], '55%±10%).': [2354], 'Safe': [2359], '(150-SP-25)': [2360], 'contained': [2362, 4196], 'phytoestrogens': [2366], 'isoflavones': [2368], '(no': [2369], 'soybean': [2370], 'alfalfa).Four': [2372], 'procedures': [2373, 2441], 'treat': [2377], 'Minimal': [2383], 'maximal': [2385], 'estimated': [2389, 3983], 'introduction': [2394], 'preliminary': [2397], 'measuring': [2399, 4304], 'quantity': [2401, 2836], 'mouse': [2408, 2633, 2653], 'fluids': [2410], 'wide': [2413], 'range': [2414, 3923], 'tested': [2416, 4299, 4456], '(0.01μg': [2418], '100μg).': [2420], 'Our': [2421], 'here': [2423], 'obtain,': [2426], 'environmentally': [2428], 'close': [2434], 'Three': [2440], 'mimicked': [2442, 2556], 'vein-tail': [2447, 2551, 2843], '(TPhP=0.1,': [2449, 2460], '10,': [2451, 2462], '100μg': [2453], 'DPhP=0.1': [2455, 2466], '1μg),': [2457, 2468], '100μg,': [2464], '[TPhP': [2472], 'DPhP=0.1mg/L': [2474], '(C1),': [2475], '1mg/L': [2476], '(C2),': [2477], '10mg/L': [2479], '(C3)].': [2480], 'stopped': [2483], '1': [2484, 2796, 3444, 3678, 3933, 3950], 'h': [2485], 'after': [2486, 2498, 2904, 2952], 'treatment,': [2487], 'except': [2488], 'involving': [2491], 'water,': [2493, 3329], 'euthanized': [2497, 2924], 'overnight': [2500], 'amount': [2503, 2514, 2607, 2859], 'ingested': [2506, 2515], 'routes,': [2519], 'though': [2520], 'spread': [2523], 'over': [2524, 3920], 'longer': [2526], 'period': [2527], 'time.': [2529], 'retained': [2537], 'they': [2539], 'similar': [2544], 'procedure': [2555, 4223], 'continuously': [2562], '5': [2565, 3635, 3647, 3744, 3758, 3963, 3977, 4377], '17': [2567], '(DPhP=C1,': [2572], 'C2,': [2573], 'C3).': [2574], 'Here,': [2575], 'containing': [2578, 2814, 3319], 'vehicle': [2582], 'changed': [2584], 'twice': [2585, 2968, 3269, 4036], 'week': [2587], 'until': [2588, 3687], 'end': [2590, 2639, 3870], 'treatment.': [2593], 'adapted': [2599], 'nor': [2604], 'ingested/d/mouse.': [2610], 'During': [2611], 'course': [2613], 'experiment,': [2616], 'consumption': [2619, 2648], 'verified': [2621], 'group': [2624, 2727, 4164, 4248, 4352], 'level': [2625], 'fluctuated': [2627], '4–5mL': [2629], '6–7mL': [2631], 'start': [2636, 2800], 'experiment.': [2642], 'calculated': [2645, 4321], 'day': [2650], '0.4–0.7μg,': [2655], '4–7μg,': [2656], '40–70μg': [2658], 'three': [2663, 3123, 3320], 'along': [2672], 'duration': [2674], 'As': [2678], 'section,': [2683], 'BW': [2684], 'slightly': [2687], 'groups;': [2692], 'therefore': [2693], 'during': [2697, 2795, 3170, 3470, 3622, 3822], 'experiment': [2699], 'increased': [2700], 'average': [2703], '13%': [2705], 'C3': [2707], 'reduced': [2710], '4%': [2712], '7%': [2714], 'C2': [2716], 'C1,': [2718], 'respectively.At': [2719], 'least': [2720, 4243, 4355], 'each': [2726, 2732, 3081, 3224, 3910, 4012, 4217, 4247, 4260], 'series': [2733], 'experiments': [2735, 2746, 3001], '(five': [2737], 'gavage).': [2740], '2': [2744, 3462, 3787, 3802, 4059], 'carried': [2748, 3396, 3535, 3939], 'out': [2749, 3397, 3536, 3940, 4254], '10': [2751, 2823, 3691, 3823], 'group.': [2754], 'Metabolomics': [2755], 'separate': [2763], 'reinforcing': [2767], 'strength': [2769], 'correlations': [2772], 'observed.': [2773], 'Between': [2774], 'groups,': [2775], 'randomized': [2778], 'according': [2779], 'time': [2785, 3727, 3828, 4050, 4169], 'reception': [2787], 'electronic': [2791], 'balance': [2792], 'acclimated': [2794], 'before': [2798, 2939, 2998], 'experiments.For': [2802], 'exposures,': [2804], 'solubilized': [2810], 'emulsion': [2813], 'corn': [2817, 2862], '(Merck)': [2819], '(1:1': [2820], 'v/v)': [2821], 'mg/L.': [2824], 'diluted': [2829, 2861], 'obtain': [2833, 3228, 4041], '100μL': [2838, 2868, 3333], 'Control': [2852], 'always': [2855], 'given': [2856, 4419], '(5μL': [2866], '500μL': [2875, 3260, 3294, 3330], '1L': [2877], 'exposure).For': [2883], 'conditions,': [2885], 'collected': [2888], 'cardiac': [2890], 'puncture': [2891], 'syringe': [2894], 'prefilled': [2895], 'heparin': [2897], '(arterial': [2898], 'collection': [2900], 'syringe,': [2901], 'BD': [2902], 'Preset)': [2903], 'anesthetized': [2907], 'mix': [2910], 'lethal': [2912], 'ketamine': [2915], '(100mg/kg)': [2916], 'xylazine': [2918], '(10mg/kg).': [2919], 'All': [2920, 2963, 4446], 'finally': [2923, 3705], 'cervical': [2926, 2953], 'dislocation.': [2927, 2954], 'Blood': [2928], 'immediately': [2930, 2951, 2989], 'frozen': [2931, 2990], 'nitrogen': [2934, 2993, 3288, 3377], 'store': [2936, 2995], '−80°C': [2938, 2997], 'extraction.': [2941], 'Liver,': [2942], 'mammary': [2943, 3078, 3311], 'glands,': [2944], 'visceral': [2946, 3075, 3308], 'harvested': [2950], 'Gall': [2955], 'bladder': [2956], 'removed': [2959], 'liver.': [2962], 'briefly': [2966], 'rinsed': [2967], 'bath': [2971], 'NaCl': [2973], 'solution': [2974, 3086, 3672, 3683, 3892], '(0.9%)': [2975], 'distilled': [2979, 3296, 3385, 3438, 3448], 'remove': [2982], 'bile.': [2985], 'Organs': [2986], 'extraction.Animal': [3000], 'compliance': [3005], 'European': [3009], 'regulations': [3010], 'protection': [3013], 'scientific': [3018], 'purposes': [3019], '(EC': [3020], 'Directive': [3021], '2010/63/EU': [3022], 'Decree': [3025], '2013–118).': [3026], 'approved': [3029], 'Ethics': [3032], 'Committee': [3033], 'authorized': [3035], '(APAFIS#3,680-2016010509529577v5).Sample': [3042], 'Preparation': [3043], 'Targeted': [3045], 'Analysis': [3046, 4219], 'MetabolomicsThree': [3048], 'extraction': [3050, 3061, 3096, 3143, 3217, 3266], 'methods': [3051], 'solid–liquid': [3060], 'liver,': [3064], 'liquid–liquid': [3066], 'microextraction': [3067], 'whole': [3069, 3239], 'blood,': [3070, 4434], 'derived-QuEChERS': [3073], 'glands.': [3079], 'extraction,': [3082, 3326], 'internal': [3084], 'standard': [3085], 'DPP-d10': [3088], 'TPP-d15': [3090], 'used.': [3092], 'targeted': [3100, 3211, 3301, 3388, 3392], 'analyses.A': [3105], 'mass': [3106, 3304, 3844, 3922, 4172, 4373], '20mg': [3108], 'extracted': [3112, 3242], '1mL': [3114, 3145, 3274], 'acetonitrile': [3116, 3134, 3147, 3646], '0.5mL': [3118], 'heptane,': [3120, 3335], 'assisted': [3121, 3247], 'zirconium': [3124, 3250, 3321], 'balls.': [3125, 3322], 'After': [3126, 3258, 3350], 'centrifugation,': [3127, 3259, 3356], 'discarded,': [3131], '750μL': [3132], 'transferred': [3136], 'vial,': [3139], 'second': [3142], 'conducted.': [3149], '(total': [3154], '1.5mL': [3156], 'acetonitrile)': [3158], 'pooled,': [3160], 'split': [3161], 'portions': [3164], '750μL,': [3166], 'evaporated': [3167, 3281, 3370], '35°C': [3169], 'approximately': [3171], '90': [3172], 'min,': [3173], 'stored': [3175], '−20°C.': [3177], 'reconstituted': [3181, 3292, 3381], '75μL': [3183, 3196], 'water/acetonitrile': [3185, 3632], '90:10': [3186], '(v/v),': [3187], 'prior': [3188, 3703], 'UHPLC-HRMS': [3190, 3202], 'reverse': [3192], 'phase': [3193, 3359, 3367, 3425, 3630, 3741], 'chromatography,': [3194], 'acetonitrile/water': [3198], '95:5': [3199], '(v/v)': [3200, 3634, 3757], 'HILIC': [3204, 3582, 3737], 'chromatography': [3205], '150μL': [3208], 'MeOH': [3209, 3386, 3449], 'UHPLC-MS/MS': [3212, 3302, 3389], 'analysis.': [3213, 3472], 'metabolomics,': [3215, 3532], 'eight': [3221], 'suitable,': [3229], 'reliable,': [3230], 'reproducible': [3232], 'results.A': [3234], 'volume': [3235, 3733, 3834], '250μL': [3237], '950μL': [3244], 'ACN,': [3246, 3332], 'six': [3249], 'beads': [3251], 'microtube': [3253], 'homogenization': [3254], 'cell': [3256], 'lysis.': [3257], 'supernatant': [3262, 3365], 'recovered.': [3264], 'repeated': [3268], 'recovery': [3271], 'volumes': [3272], 'supernatant.': [3276], 'combined': [3278, 4275], 'dryness': [3283, 3372], 'under': [3284, 3373], 'stream': [3286, 3375], '40°C': [3290], 'mono(2-ethyl-5-oxohexyl)': [3297], 'phthalate': [3298], '(MeOH)': [3299], 'analysis.A': [3303], '25mg': [3306], 'glands': [3312], 'introduced': [3314], 'centrifugation': [3317], 'tube': [3318], 'QuEChERS': [3325], '500mL': [3327], '100mg': [3336], 'sodium': [3338, 3894], 'acetate,': [3339], '400mg': [3341], 'magnesium': [3343], 'sulfate': [3344], 'tube.': [3349], 'vigorous': [3352], 'manual': [3353], 'agitation': [3354], 'removed,': [3361], '400μL': [3363], 'ACN': [3366], 'recovered,': [3369], 'ambient,': [3379], '125μL': [3383], 'analysis.UHPLC-ESI-MS/MS': [3390], 'AnalysisFor': [3391], 'analysis,': [3393], 'separation': [3394, 3533], '1200': [3400], 'HPLC': [3401], 'system': [3402, 3475, 3542, 3838], 'Agilent': [3404], 'Technologies.': [3405], 'chosen': [3407, 3546], 'column': [3408, 3414, 3547, 3583, 3606, 3627, 3719], 'Kinetex': [3411], 'XB': [3412], 'C18': [3413, 3553, 3605, 3626, 4267], '(50×2.1mm': [3415], 'ID,': [3416], '1.7μm': [3417], 'porosity,': [3418], '100': [3419], 'Å)': [3420], 'Phenomenex.': [3422], 'mobile': [3424, 3629, 3740], 'composed': [3427], '0.01%': [3429, 3640, 3652, 3749, 3763], '(FA)': [3432], '0.1': [3434, 3818], 'mM': [3435, 3445, 3636, 3648, 3745, 3759], 'AmAc': [3436, 3446], 'pure': [3439], '(solution': [3441, 3450, 3459, 3643, 3655, 3752, 3766], 'A)': [3442, 3644, 3753], 'B)': [3451, 3460], 'gradient': [3454, 3658, 3694, 3770], '5%': [3456], '100%': [3458, 3670, 3708], 'min.': [3463, 3679, 3692, 3730, 3788, 3803, 3824, 3831], 'columns': [3465, 3617], 'maintained': [3467, 3619, 3676], '60°C': [3469], 'chromatographic': [3474, 3837, 4101], 'coupled': [3477, 3840], 'triple-stage': [3480], '5500': [3481], 'QTRAP®': [3482], 'ABSciex': [3484], 'electrospray': [3486, 3851], 'ionization': [3487, 3852], 'interface': [3488, 3853], '(ESI).': [3489], 'multiple': [3491], 'reaction': [3492], 'mode': [3493, 3943, 4033, 4098, 4186], 'monitoring': [3494], 'identification': [3499], '(limit': [3506], 'detection,': [3508], 'LODDPhP=0.3': [3509], 'ng/mL,': [3510, 3512, 3514], 'LOQDPhP=0.5': [3511], 'LODTPhP=0.7': [3513], 'LOQTPhP=1': [3515], 'ng/mL).': [3516], 'Analyst': [3518], 'software': [3519, 4085], '(version': [3520], '1.6.2)': [3521], 'instrument': [3525, 3980, 4088], 'control,': [3526], 'acquisition,': [3528], 'processing.For': [3531], 'UltiMate': [3539], '3000': [3540], 'UHPLC': [3541], '(Thermo': [3543], 'Scientific).': [3544], 'Luna': [3550], 'Omega': [3551], 'polar': [3552, 3569, 3614], '(100×2.1mm,': [3554, 3584], '1.6μm': [3555], 'particle': [3556, 3586], 'size)': [3557, 3587], '(Phenomenex),': [3558], 'greater': [3566], 'affinity': [3567], 'compounds,': [3570], 'detect': [3572, 3600], 'quantify': [3574], 'larger': [3576], 'number': [3577], 'metabolites.': [3579], 'nucleodur': [3581], '3μm': [3585], '(Macherey': [3588], 'Nagel)': [3589], 'identified': [3596], 'did': [3607], 'highlight': [3609], 'affinities.': [3615], '30°C': [3621], 'analysis.With': [3624], '90/10': [3633], 'B).': [3656, 3767], 'elution': [3659, 3769], 'had': [3660, 3771], 'flow': [3662, 3773], 'rate': [3663, 3774, 3931, 4057], '0.3mL/min,': [3665], 'started': [3668, 3778], 'percentage': [3681, 3699, 3805, 3816], '0%': [3689], 'within': [3690], 'held': [3696, 3712, 3785, 3807], 'min': [3702, 3715, 3797, 3810, 3819], 'returning': [3706], '3': [3714, 3878, 4052], 'condition': [3717], 'next': [3722, 4460], 'total': [3725, 3826], 'running': [3726, 3827], '18': [3729], '5μL.For': [3735], 'column,': [3738], 'acetonitrile:water': [3755], '95/5': [3756], '0.4mL/min': [3776], '95%': [3780], 'B': [3782], '70%': [3794], '7': [3796, 3968], '50%': [3799], 'return': [3812], 'initial': [3815], 'equilibrated': [3821], '25': [3830], '5μL.The': [3836], 'QTOF': [3843], 'spectrometer': [3845], '(Maxis': [3846], 'Plus,': [3847], 'Bruker': [3848], 'Daltonics®)': [3849], '(ESI)': [3854], 'operating': [3855], 'positive': [3857, 4095, 4185, 4272], 'negative': [3859, 4097, 4270], 'mode.': [3860, 4004], 'following': [3862, 3946], 'settings': [3863], 'used:': [3865], 'capillary': [3866], 'voltage': [3867], '3600V,': [3869], 'plate': [3871], 'offset': [3872], '500V,': [3874], 'nebulizer': [3875], 'bar': [3879], '(N2),': [3880, 3885], 'drying': [3881, 3887], 'gas': [3882], '9L/min': [3884], 'temperature': [3888], '200°C.': [3890], 'acetate': [3897], '(10': [3898], 'mM)': [3899], 'clusters': [3900], 'external': [3904], 'calibration': [3905], 'beginning': [3908], 'run.': [3911], 'full': [3918], 'scan': [3919, 3930], '50–1,000': [3925], 'daltons': [3926], '(Da)': [3927], 'Hz.': [3934], 'profile': [3942], 'transfer': [3947], 'parameters:': [3948], 'funnel': [3949], 'RF': [3951, 3956], '200': [3953], 'Vpp,': [3954, 3959], 'multipole': [3955], '50': [3958], 'quadrupole': [3960], 'energy': [3961, 3966], 'eV,': [3964, 3969], 'collision': [3965, 4166], 'stepping': [3970], 'basic,': [3971], 'pre-pulse': [3974], 'storage': [3975], 'ms.': [3978], 'resolution': [3981], '21,244': [3985], '(full': [3986], 'width': [3987], 'half': [3989], 'maximum,': [3990], 'FWHM)': [3991], 'm/z=415.211.All': [3993], 'controls': [3997], '(QCs)': [3998], 'injected': [4000, 4016], 'MS': [4003], 'QC': [4005, 4039], 'prepared': [4007], 'mixing': [4009], '5μL': [4010], 'sample': [4013, 4301, 4318], 'every': [4017], '13': [4018], 'samples,': [4019], 'so': [4020], 'ratio': [4025], 'sample/QC': [4026], '10%.': [4028], 'data-dependent': [4030], 'acquisition': [4031], '(DDA)': [4032], 'MS/MS': [4042, 4162, 4208, 4452], 'spectra.': [4043], 'cycle': [4049], 's': [4053], 'spectral': [4056], 'Hz': [4060, 4063], '16': [4062], 'order': [4065], 'record': [4067], 'intensity': [4071, 4213], 'randomly': [4077], 'ensure': [4079], 'representativeness': [4081], 'results.The': [4084], 'control': [4089, 4105], 'acquire': [4092], 'platforms': [4102], 'OTOF': [4104], '4.1,': [4106], 'Hystar': [4107], '4.1': [4108], '(Bruker': [4109, 4142], 'Daltonics®),': [4110], 'Data': [4112, 4257], 'Analysis®': [4113], '4.4.': [4114], 'Preprocessing': [4115], '(including': [4117], 'bucketing,': [4118], 'filtering,': [4119], 'scaling,': [4120], 'normalization)': [4123], 'alignment': [4125], 'algorithm': [4130], 'Time': [4131], 'aligned': [4132], 'Region': [4133], 'complete': [4134], 'eXtraction': [4135], '3D': [4136], '(T-Rex': [4137], '3D)': [4138], 'Metaboscape': [4140], '4.0': [4141, 4406], 'Daltonics®).': [4143], 'principal': [4145, 4282], 'parameters': [4146], 'create': [4149], 'bucket': [4151, 4194], 'tables': [4152, 4195], 'were:': [4153], 'Intensity': [4154], 'threshold=5,000': [4155], 'counts;': [4156], 'minimum': [4157], 'peak': [4158, 4212], 'length=7': [4159], 'spectra;': [4160], 'perform': [4161, 4279], 'import,': [4163], 'energy;': [4167], 'retention': [4168, 4199], 'window': [4170, 4173], '(min)=0.4–15;': [4171], '(m/z)=60–1,000;': [4174], 'electron': [4175], 'ion': [4176, 4201], 'collider': [4177], '(EIC)=0.8;': [4178], 'Ions=H+,': [4179], 'Na+,': [4180], 'K+,': [4181], 'NH4+,': [4182], '−H2O+H+': [4183], 'Ions=H−,': [4188], '2H−,': [4189], '2H−+Na+,': [4190], 'Cl−,': [4191], 'H−+HCOOH.': [4192], 'information': [4197], 'regarding': [4198], 'time,': [4200], 'm/z': [4202], 'ratio,': [4203], 'neutral': [4204], 'mass,': [4205], 'ions,': [4207], 'spectrum,': [4209], 'relative': [4211], 'features': [4215, 4313, 4347, 4447], 'sample.Untargeted': [4218], 'Annotation': [4221], 'WorkflowMultivariate': [4222], 'QCs.': [4234], 'Features': [4235], 'simultaneously': [4237], 'QCs': [4239], 'conserved': [4252], '(7,744': [4253], '11,168).': [4256], 'retrieved': [4258], '(HILIC': [4265], 'mode)': [4273], 'unsupervised': [4281], 'component': [4283], 'R': [4287, 4359], 'package': [4288, 4360], 'ade4': [4289], '(R': [4290], 'Development': [4291], 'Core': [4292], 'Team).': [4293], 'discrimination': [4302], 'analytical': [4309], 'procedure.To': [4310], 'discrimination,': [4319], 'adjusted': [4322], 'p-value': [4323, 4335], '(false': [4324], 'discovery': [4325], 'rate,': [4326], 'FDR)': [4327], 'Benjamini-Hochberg': [4330], 'method.': [4331], 'Fold': [4332], 'change': [4333], 'groups': [4337], 'build': [4341], 'volcano': [4342], 'plot': [4343], 'represented': [4345], '(FDR': [4353], '<0.05)': [4356], 'EnhanceVolcano': [4361], '(Blighe': [4362], '2018).For': [4363], 'compound': [4364, 4400], 'annotations,': [4365], 'selected': [4367], 'putative': [4368, 4449], 'based': [4370], 'deviation': [4374], 'inferior': [4375], 'ppm.': [4378], 'discovered': [4380], 'formulas': [4381], 'databases': [4385, 4426], '(analyte': [4386], 'DB,': [4387], 'ChEBI,': [4388, 4442], 'ChemSpider,': [4389], 'PubChem,': [4390], 'HMDB,': [4391, 4441], 'LIPID': [4392, 4444], 'MAPS®).': [4393, 4445], 'process': [4395], 'done': [4397], 'crawler': [4401], 'tool,': [4402], 'included': [4403], 'MetaboScape': [4405], 'search': [4409], 'tools': [4410], 'HMDB': [4413], 'LipidMaps': [4415], 'website.': [4416], 'Priority': [4417], 'arising': [4423], 'previously': [4428], 'quantified': [4431], 'urine,': [4435], 'feces': [4437], '(Data': [4438], 'annotations': [4450], 'spectra': [4453], '(see': [4459], 'section).': [4461], 'selection': [4463]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3103094267', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 5}], 'updated_date': '2024-12-24T08:19:04.333982', 'created_date': '2020-11-23'}
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