Repression of Irs2 by let‐7 mi <scp>RNA</scp> s is essential for homeostasis of the telencephalic neuroepithelium

Name: Work Video:
Duration: 3 min 30 s
Virginia Fernández; Maria Ángeles Martínez‐Martínez; Anna Prieto‐Colomina; Adrián Cárdenas; Rafael Soler; Martina Dori; Ugo Tomasello; Yuki Nomura; José P. López‐Atalaya; Federico Calegari; Vı́ctor Borrell
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'article': [702], 'text': [703], 'main': [705], 'figures.': [706], 'Peer': [707], 'ReviewDownload': [708], 'a': [709, 842, 988, 1012, 1060, 1079, 1084, 1384, 1506, 1606, 1678, 1748, 1885, 1956, 2036, 2043, 2249, 2586, 3003, 3467, 3495, 3500, 3732, 4229, 4251, 4264], 'summary': [710], 'editorial': [713, 717], 'decision': [714, 718], 'including': [716, 1285, 2865, 3516], 'letters,': [719], 'reviewer': [720], 'comments': [721], 'responses': [724], 'to': [725, 728, 823, 914, 941, 978, 1129, 1164, 1167, 1218, 1307, 1314, 1359, 1469, 1551, 1692, 1703, 1833, 1837, 1857, 1896, 1970, 2180, 2199, 2271, 2296, 2389, 2735, 2873, 2949, 3494, 3786, 4062], 'feedback.': [726], 'ToolsAdd': [727], 'favoritesDownload': [729], 'CitationsTrack': [730], 'CitationsPermissions': [731], 'ShareFacebookTwitterLinked': [732], 'InMendeleyWechatReddit': [733], 'Figures': [734], 'Info': [736], 'Abstract': [737], 'Structural': [738], 'integrity': [739, 830, 1185, 1266, 1363], 'cellular': [741, 826, 1181], 'embryonic': [745, 792, 957, 1424, 1556, 1561, 1578, 1629, 1765, 2430, 2493, 2875, 2979, 3550], 'stem': [746], 'cell': [747, 765, 772, 1143, 1198, 1287, 1428, 1463, 1756, 2836, 2863, 3054, 3075, 3371, 3799, 3806], 'niche': [748, 1369], 'are': [749, 821, 912, 1121, 1242, 1380, 1406, 1431, 1451, 2436, 2529, 2947, 3130, 3346, 3845, 4156], 'critical': [750, 811, 913, 2948], 'normal': [752, 1280, 2715, 3936, 4243], 'tissue': [753, 1860], 'development.': [754, 1579, 4244], 'In': [755, 1237, 1422, 2234, 2895, 3492, 4003], 'neuroepithelium,': [758, 927, 1884], 'controlled': [761], 'in': [762, 790, 815, 868, 884, 896, 904, 923, 954, 1005, 1011, 1023, 1030, 1066, 1104, 1158, 1320, 1333, 1414, 1510, 1528, 1545, 1576, 1591, 1698, 1705, 1764, 1779, 1790, 1807, 1819, 1829, 1847, 1941, 1958, 1965, 2028, 2071, 2080, 2124, 2132, 2167, 2245, 2264, 2291, 2299, 2304, 2323, 2332, 2355, 2362, 2377, 2381, 2397, 2420, 2434, 2437, 2486, 2512, 2524, 2527, 2604, 2619, 2652, 2664, 2704, 2713, 2722, 2730, 2748, 2774, 2796, 2842, 2848, 2851, 2866, 2902, 2924, 2932, 2952, 2957, 2974, 3037, 3082, 3093, 3118, 3156, 3200, 3243, 3256, 3326, 3353, 3366, 3380, 3404, 3418, 3448, 3460, 3472, 3513, 3552, 3561, 3571, 3585, 3589, 3606, 3630, 3670, 3811, 3843, 3929, 3953, 3969, 3991, 4072, 4105, 4171, 4242, 4289], 'part': [763, 4294], 'adhesion': [766, 936], 'molecules': [767], 'regulators': [769, 796, 1409], 'progenitor': [771, 938, 968, 1052, 1208, 1244, 1286, 1473, 2020, 3074, 3388, 3569, 3716, 3805, 4255, 4267], 'lineage,': [773], 'but': [774, 1354, 1687, 1890, 1951, 2930, 2956, 3532, 4108], 'specific': [776, 2122], 'orchestration': [777], 'these': [779, 872, 1672, 2239, 2349, 4274], 'processes': [780, 1127, 1417], 'remains': [781, 1514], 'unknown.': [782, 1516], 'Here,': [783, 1782], 'we': [784, 807, 1783, 2084, 2578, 3295, 3408, 3498], 'studied': [785, 1785], 'role': [787, 1061, 1761, 1787], 'microRNAs': [789, 911], 'telencephalon': [793, 958, 1077, 1812, 1850, 2182, 2282, 2367, 2400, 2622, 2657, 2667, 2693, 2980, 3084, 3121, 3356, 3403, 3512, 3560, 3633, 3646, 3894, 3956, 3972, 4084, 4124], 'as': [794, 1109, 1960, 2172, 2174, 2192, 2418, 3910, 3957, 3973, 3983, 3997, 4115], 'key': [795, 1087], 'gene': [798, 1357, 1411, 1733], 'expression.': [799, 1001], 'By': [800], 'using': [801, 1795, 2095, 2585], 'early': [803, 816, 897, 925, 956, 1024, 1511, 1552, 1577, 1583, 1639, 1791, 1852, 2055, 2081, 2173, 2240, 2636, 3426, 3549], 'recombiner': [804], 'Rx-Cre': [805, 1797, 2096, 2152, 2356, 2402, 2484, 2677, 2982], 'mouse,': [806, 1238], 'identify': [808, 1693, 3967], 'novel': [809], 'roles': [812, 1695, 2077], 'brain': [817, 906, 1318, 1378, 2056, 2425, 2608, 3779], 'development,': [818, 899, 1593, 2083], 'demonstrating': [819], 'they': [820], 'preserve': [824, 1360], 'structural': [829, 1184], 'neuroepithelium.': [834], 'We': [835, 3453], 'show': [836, 870], 'that': [837, 871, 1107, 1728, 1876, 1924, 2033, 2352, 2855, 2945, 2991, 3022, 3039, 3297, 3314, 3342, 3384, 3441, 3478, 3581], 'Rx-Cre;DicerF/F': [838, 2072, 2624, 2731, 2749, 2908], 'mouse': [839, 1440, 1548, 1611, 1799, 2141, 2357, 2589, 2716, 2751, 3613], 'embryos': [840, 1824, 1967, 2073, 2358, 2422, 2761, 2910, 3166, 3210, 3242, 3329, 3345, 3406, 3450, 3817, 4088], 'have': [841, 987, 1339, 1622, 1784, 3602], 'severe': [843, 1315, 1859], 'disruption': [844, 1305, 1730], 'apical': [848, 1095, 1151, 1272, 1335, 1900, 2785, 3179, 3223, 3244, 3318, 3744, 3750, 3828, 3874, 3882, 4173, 4191, 4258], 'junction': [849, 1274], 'belt,': [850], 'followed': [851, 2544], 'invagination': [853, 1880], 'ventricular': [856, 1131, 1147, 1156, 1214], 'surface': [857, 1157, 1215, 3745], 'formation': [859, 943, 980, 1029, 1865, 1938, 1973, 1979, 4069, 4100], 'hyperproliferative': [861, 983, 1981], 'rosettes.': [862, 984, 1071, 3726], 'Transcriptome': [863], 'analyses': [864, 1874, 2350, 2989], 'functional': [866, 2728], 'experiments': [867, 4284], 'vivo': [869, 2849], 'defects': [873, 1461, 1554, 1828], 'result': [874], 'from': [875, 1212, 1892, 1913, 1955, 2197, 2269, 2339, 2913, 3734], 'upregulation': [876], 'upon': [879, 1729, 1983, 2483, 2676], 'loss': [880, 934, 970, 990, 1444, 1542, 1853, 1898, 1948, 1957, 1997, 2008, 2067, 2640, 2726, 2742, 2839, 3079, 3545], 'an': [885, 891, 1159, 2699, 3099, 3565, 3735, 3775, 3896, 4126], 'apoptosis-independent': [886], 'manner.': [887, 1014], 'Our': [888, 2040], 'results': [889, 2041, 3340], 'reveal': [890, 3787], 'unprecedented': [892], 'relevance': [893, 2045], 'forebrain': [898, 2488], 'with': [900, 1059, 1069, 1091, 1141, 1605, 1671, 1888, 2155, 2218, 2277, 2315, 2334, 2670, 2940, 2967, 3033, 3542, 3748, 3803, 3819, 4117, 4131, 4148, 4185, 4233], 'potential': [901], 'mechanistic': [902], 'implications': [903], 'pediatric': [905, 949, 1067], 'cancer.': [907], 'Synopsis': [908], 'Dicer1-dependent': [909], 'repress': [915], 'p53': [916, 997, 1004, 1929], 'pathway': [917], 'activity': [918, 1022], 'expression': [921, 1017, 1358, 1374, 1412, 1640, 1710, 1921, 2123, 2189, 2237, 2290, 2311, 2412, 2675, 2723, 2768, 2792, 3939], 'levels': [922, 1711, 1740, 1915, 2212, 2227, 2263, 2287, 2689, 2861, 2921, 3030, 3301, 3417], 'which': [928, 1162, 1210, 1527, 1569, 1594, 1805, 1870, 2002, 2098, 3475], 'otherwise': [929], 'enters': [930], 'into': [931, 1524], 'hyperproliferation': [932], 'cells,': [939, 969, 1209], 'leading': [940, 977, 1467], 'true': [945, 982, 1070], 'rosettes': [946, 1877, 1940, 1982, 3591, 3601, 3629, 3788, 3821, 3871, 3908, 3928, 3952, 3968, 3982, 4071, 4103, 4287], 'reminiscent': [947, 4236], 'cancers.': [950], 'Loss': [951, 1002], 'Rx-Cre;Dicer1flox': [960], 'mutant': [961, 1823, 2750, 2760, 2909, 3102, 3125, 3165, 3209, 3241, 3328, 3344, 3428, 3612, 3652, 3710, 3738, 3777, 3899, 4087], 'mice': [962, 1621, 2153, 2403, 2983], 'produces': [963], 'massive': [964, 1470, 1864, 3053, 3350, 3370], 'transient': [965, 2835], 'apoptosis': [966, 1471, 1889, 1926, 2923, 2951, 2992, 3076, 3303, 3351], 'adherens': [972, 1171, 1273, 1901], 'junctions': [973, 1902], 'increased': [975, 996, 1834, 1904, 1920, 2267], 'proliferation,': [976, 2021], 'Rx-Dicer': [985, 1006, 1942, 2758, 3086, 3101, 3124, 3164, 3208, 3327, 3343, 3381, 3405, 3427, 3436, 3514, 3562, 3635, 3651, 3677, 3709, 3737, 3776, 3823, 3898, 3931, 4086], 'mutants': [986, 1007, 1448, 1943, 2625, 2857, 3087, 3437, 3563, 3636, 4074], 'significant': [989, 1679, 1694, 3234], 'family': [993], 'microRNAs,': [994, 1405], 'signaling': [998, 1064, 1930], 'rescues': [1008], 'their': [1009, 1638, 2616, 2629], 'phenotype': [1010, 1911], 'partially-penetrant': [1013], 'Increased': [1015], 'or': [1018, 1206, 1310, 1465, 1751], 'blockade': [1019], 'wild-type': [1025, 1966, 4128], 'embryos,': [1026, 2142, 3474], 'induce': [1027, 1971], 'rosette': [1028, 1972, 3733, 3993], 'rostral': [1032, 1849, 1883, 2306, 2364, 2621, 2654, 2844, 2926, 2976, 3083, 3094, 3120, 3158, 3202, 3355, 3420, 3530, 3559, 3632, 3645, 3813, 3820, 3893, 4107, 4140, 4291], 'telencephalon,': [1033, 1140, 1284, 2187, 2929, 2955], 'rescued': [1034, 1987, 2005], 'overexpression': [1036, 1961, 1985, 1989, 4077], 'downregulation': [1040], 'Irs-2,': [1042], 'respectively.': [1043, 1936], 'Let-7': [1044], 'downregulate': [1046], 'amplification': [1048], 'human': [1050, 2029], 'cortical': [1051], 'cells': [1053, 1098, 1102, 1245, 1474, 1746, 3035, 3092, 3117, 3129, 3154, 3389, 3471, 3570, 3583, 3717, 3994, 4256, 4268], 'repressing': [1055], 'expression,': [1057], 'consistent': [1058, 2669, 2939, 2966, 3541], 'axis': [1065], 'cancers': [1068], 'Introduction': [1072], 'development': [1074, 1106, 1281, 1319, 1379, 1513, 1630, 1701, 1767, 1793, 2057, 2193], 'highly': [1080, 1122, 1867, 2037, 2602], 'complex': [1081, 3875], 'involving': [1083], 'sequence': [1085], 'events.': [1088], 'Neurogenesis': [1089], 'onsets': [1090], 'emergence': [1093, 2051], 'radial': [1096], 'glia': [1097], '(aRGCs),': [1099], 'specialized': [1100], 'neuroepithelial': [1101, 1368], 'serve': [1108], 'neural': [1110, 2135], 'progenitors': [1111, 1241], 'guide': [1113], 'migration': [1116, 1291], 'newborn': [1118], 'neurons.': [1119, 4002], 'aRGCs': [1120, 1166, 1178, 1200, 1338, 2996, 3305], 'polarized': [1123], 'extend': [1125], 'thin': [1126], 'attached': [1128], '(apical)': [1132], 'pial': [1134], '(basal)': [1135], 'surfaces': [1136], 'developing': [1139, 2126, 2606, 2868, 2954], 'bodies': [1144], 'forming': [1145, 1225], 'zone': [1148], '(VZ).': [1149], 'Their': [1150], 'terminates': [1153], 'at': [1154, 1454, 1479, 1774, 1813, 2216, 2238, 2329, 2368, 2428, 2491, 2519, 2626, 2687, 2762, 2816, 2825, 2871, 2960, 3028, 3031, 3167, 3211, 3394, 3438, 3548, 3809, 4089], 'end': [1160], 'foot,': [1161], 'serves': [1163], 'anchor': [1165], 'each': [1168, 2520, 4154], 'other': [1169, 2060], 'via': [1170], 'junctions.': [1172], 'This': [1173, 1457, 1726, 1992, 2937, 3596], 'maintains': [1174], 'polarity': [1176], 'VZ': [1188, 1269], '(Gotz': [1189, 1342], 'Huttner,': [1191, 1344], '2005;': [1192, 1345], 'Marthiens': [1193], 'et': [1194, 1229, 1233, 1254, 1258, 1262, 1293, 1297, 1301, 1323, 1327, 1347, 1351, 1390, 1394, 1398, 1436, 1486, 1490, 1494, 1498, 1502, 1566, 1614, 1647, 1653, 1657, 1661, 1665, 1684, 1717, 1723, 1802, 1843, 2115, 2149, 2161, 2878, 2882, 2886, 2892, 3616, 3622], 'al,': [1195, 1230, 1234, 1255, 1259, 1263, 1294, 1298, 1302, 1324, 1328, 1348, 1352, 1391, 1395, 1399, 1437, 1487, 1491, 1495, 1499, 1503, 1567, 1615, 1648, 1654, 1658, 1662, 1666, 1685, 1718, 1724, 1803, 1844, 2116, 2150, 2162, 2879, 2883, 2887, 2893, 3617, 3623], '2010).': [1196], 'Upon': [1197], 'division,': [1199], 'generate': [1201], 'either': [1202], 'additional': [1203], 'aRGCs,': [1204], 'neurons,': [1205, 4189], 'basal': [1207, 1220, 1240, 2207, 2320, 2447, 2497, 2661, 3174, 3218, 3246, 3320, 3755, 3766, 3834, 4193, 4270], 'delaminate': [1211], 'migrate': [1217], 'side': [1221], 'VZ,': [1224], 'SVZ': [1227], '(Miyata': [1228], '2004;': [1231, 1256], 'Noctor': [1232], '2004,': [1235], '2008).': [1236, 1725, 1845, 2894, 3624], 'most': [1239, 2360, 2601], 'intermediate': [1243, 2872], '(IPCs),': [1246], 'producing': [1247], 'majority': [1249], 'excitatory': [1251], 'neurons': [1252, 1477, 3008, 3138, 3198, 3721, 3760, 3886, 3919, 4170, 4279], '(Haubensak': [1253], 'Kowalczyk': [1257], '2009;': [1260], 'Taverna': [1261, 1300], '2014).': [1264, 1303, 1438], 'its': [1271, 2121, 2382, 2719, 3534], 'belt': [1275], 'proliferation': [1288, 1464, 2841, 3081], 'neuron': [1290], '(Cappello': [1292], '2006;': [1295, 1349, 1719, 3618], 'Rasin': [1296, 1350], '2007;': [1299, 2880, 2884], 'Its': [1304], 'due': [1306, 1895], 'developmental': [1308, 1416, 1481, 1553, 1827, 2637], 'insult': [1309], 'genetic': [1311], 'mutation': [1312], 'leads': [1313, 1550], 'malformations': [1316, 2053], 'humans': [1321], '(Barkovich': [1322], '2012;': [1325, 1496, 1500], 'Fernandez': [1326], '2016).': [1329, 1400], 'Molecular': [1330], 'mechanisms': [1331, 1355, 1388], 'involved': [1332, 1413, 2993, 3564], 'anchoring': [1336], 'been': [1340, 1623, 3604], 'identified': [1341], 'Cappello': [1346], '2007),': [1353], 'regulating': [1356], 'global': [1362, 3078], 'remain': [1370, 1741], 'largely': [1371, 1515, 1742, 3352, 3486], 'unexplored.': [1372], 'Gene': [1373], 'function': [1376, 1509, 1587, 2010], 'during': [1377], 'finely': [1381], 'tuned': [1382], 'number': [1385], 'regulatory': [1387, 2106], '(Bae': [1389], '2015;': [1392, 1396], 'Nord': [1393], 'Yao': [1397], 'Non-coding': [1401], 'RNAs,': [1402], 'particularly': [1404, 2380, 2870], 'major': [1407, 2720], 'post-transcriptional': [1408], 'many': [1415, 1427], '(Aprea': [1418], 'Calegari,': [1420], '2015).': [1421, 1667], 'cerebral': [1425, 1633, 2030], 'cortex,': [1426, 1634], 'cycle-related': [1429], 'proteins': [1430, 3876], 'targets': [1432, 1923], '(Arcila': [1435], 'Previous': [1439, 2847], 'models': [1441], 'miRNA': [1443, 1508, 1739, 2047], 'consistently': [1445], 'used': [1446, 1625], 'conditional': [1447, 1602, 2587], 'where': [1449, 2310], 'depleted': [1452], 'only': [1453, 1478, 3002, 3057], 'mid-late': [1455], 'corticogenesis.': [1456], 'caused': [1458], 'very': [1459, 1582, 1858, 2243], 'limited': [1460], 'on': [1462, 1531, 2018, 2049, 4158], 'neurogenesis,': [1466], 'instead': [1468], 'postmitotic': [1476], 'late': [1480, 2874], 'stages': [1482, 1777, 2241, 2494, 2876, 3551], '(De': [1483, 1840], 'Pietri': [1484, 1651, 1721, 1841, 2890, 3620], 'Tonelli': [1485, 1652, 1722, 1842, 2891, 3621], '2008;': [1488, 1655, 2888], 'Kawase-Koga': [1489, 1656], '2010;': [1492, 1659], 'McLoughlin': [1493], 'Nigro': [1497], 'Saurat': [1501, 1660], '2013).': [1504], 'As': [1505], 'result,': [1507], 'Biogenesis': [1517], 'requires': [1520, 1598], 'processing': [1521], 'pre-miRNAs': [1523], 'mature': [1525], 'miRNAs,': [1526], 'turn': [1529], 'depends': [1530], 'action': [1533], 'RNase': [1536], 'enzyme': [1537], 'Dicer1': [1538, 1544, 2770], '(Bartel,': [1539], '2018).': [1540], 'Complete': [1541], 'full': [1546, 2568], 'knockout': [1547], 'zygotes': [1549], 'arrest': [1557], 'after': [1558], 'gastrulation,': [1559], 'around': [1560], 'day': [1562, 2201], '7.5': [1563], '(E7.5)': [1564], '(Bernstein': [1565], '2003),': [1568], 'evidences': [1570], 'fundamental': [1572], 'importance': [1573], 'Given': [1580, 2707], 'lethality,': [1584], 'understanding': [1585], 'Dicer-dependent': [1589, 2583], 'occurs': [1595], 'much': [1596, 1775, 2649, 2961, 3445], 'later,': [1597], 'use': [1600], 'knockouts,': [1603], 'crossed': [1604, 2154], 'variety': [1607, 1680], 'Cre': [1609, 1673, 2091, 2100, 2165, 2254, 2353, 2972], 'recombinase-expressing': [1610], 'lines': [1612, 1675, 2093, 3614, 3826, 3832], '(Harfe': [1613], '2005).': [1616], 'Emx1-Cre,': [1617], 'Nestin-Cre,': [1618], 'hGFAP-Cre': [1620], 'widely': [1624], 'studies': [1627, 1690, 2853], 'taking': [1635], 'advantage': [1636], '(E9.5,': [1641], 'E10.5,': [1642], 'E13.5,': [1644, 1704], 'respectively)': [1645], '(Zimmerman': [1646], '1994;': [1649], 'De': [1650, 1720, 2889, 3619], '2013;': [1663], 'Zhang': [1664], 'Elimination': [1668], 'Dicer': [1670, 1736, 1773, 1855, 2594, 2642, 2681, 2703, 2729, 2745, 2789, 2856, 3611, 4073], 'driver': [1674, 1798, 2092], 'has': [1676], 'produced': [1677], 'phenotypes': [1682], '(Kawase-Koga': [1683], '2009),': [1686], 'surprisingly,': [1688], 'those': [1689], 'failed': [1691], 'dorsal': [1699, 2399, 2666, 2692, 3959, 4011], 'prior': [1702], 'spite': [1706, 3367], 'high': [1709, 2709, 2860, 2920, 3029, 3300, 3415, 3903], 'since': [1714], 'E10.5': [1715, 3331], '(Kloosterman': [1716, 3615], 'suggests': [1727], 'locus,': [1734], 'both': [1735], 'protein': [1737], 'unchanged': [1743], 'within': [1744], 'targeted': [1745], 'long': [1749], 'time,': [1750], 'until': [1752], 'diluted': [1753], 'over': [1754], 'consecutive': [1755], 'cycles.': [1757], 'Thus,': [1758], 'elucidating': [1759], 'may': [1768, 3390], 'require': [1769], 'removal': [1771], 'earlier': [1776, 1817, 2145, 2962], 'than': [1778, 1818, 2146, 2663, 3397, 3447], 'previous': [1780, 1820, 1838, 2090, 2942, 3610], 'studies.': [1781], 'line': [1800, 2159, 2505, 2590, 2783, 3172, 3216, 3763, 4017], '(Swindell': [1801, 2114], '2006),': [1804], 'recombines': [1806], 'primordium': [1809, 2846, 2906, 3047, 3160, 3204, 3422], 'E7.5,': [1814], '3': [1815, 2143, 3143, 3183, 3857], 'days': [1816, 2144], 'models.': [1821], 'Rx-Cre;DicerF/F(Rx-Dicer)': [1822], 'displayed': [1825], 'mild': [1826], 'neocortex': [1831, 2266, 2293, 2780, 2934, 3519, 3656, 4181], 'related': [1832], 'apoptosis,': [1835, 1959], 'similar': [1836, 2226], 'reports': [1839, 2943], 'However,': [1846, 3310], 'led': [1856], 'disorganization': [1861, 3504, 3556], 'proliferative': [1868, 3590, 3600, 4102, 4163], 'rosettes,': [1869, 4164], 'grew': [1871], 'caudally.': [1872], 'Time-course': [1873], 'revealed': [1875, 2915, 3021, 3477, 3580, 3911], 'formed': [1878], 'concomitant': [1887], 'independent': [1891, 1954], 'it,': [1893], 'proliferation.': [1905, 3309], 'These': [1906, 3525], 'two': [1907], 'aspects': [1908], 'emerged': [1912], 'decreased': [1914], 'promote': [1925], 'and/or': [1927], 'proliferation:': [1928], 'insulin': [1932], 'receptor': [1933], 'substrate-2': [1934], '(Irs2),': [1935], 'was': [1944, 1953, 1968, 1986, 1993, 2003, 2242, 2326, 2645, 2938, 3322, 3444, 3485, 3597, 4248, 4261], 'prevented': [1945], 'p53,': [1950], 'alone': [1964], 'sufficient': [1969], 'without': [1974, 2838, 3077], 'massively': [1975], 'increasing': [1976, 2196], 'apoptosis.': [1977], 'let-7.': [1991], 'phenocopied': [1994, 2027], 'endogenous': [1999], 'alone,': [2001], 'then': [2004], 'Irs2.': [2012], 'positive': [2014], 'effects': [2015], 'negative': [2023], 'let-7,': [2025], 'were': [2026, 2684, 2793, 3236, 3584, 4275], 'organoids,': [2031], 'indicating': [2032, 2248, 2698], 'conserved': [2038], 'mechanism.': [2039], 'suggest': [2042], 'general': [2044, 3501], 'dysregulation': [2048], 'and,': [2058], 'potentially,': [2059], 'tissues': [2061], 'ectodermal': [2063], 'origin.': [2064], 'Results': [2065], 'Early': [2066, 2395, 2741], 'To': [2074], 'investigate': [2075], 'circumvented': [2085], 'timing': [2087], 'limitation': [2088], 'mice,': [2097], 'express': [2099], 'under': [2101, 2414], 'control': [2103, 2755, 3162, 3206, 3239, 3449, 3649, 3675, 3707, 3816], 'sequences': [2107], 'transcription': [2110, 3937], 'factor': [2111, 3938], 'Rax': [2112], '(Rx)': [2113], '2006).': [2117], 'Best': [2118], 'known': [2119], 'retina,': [2127], 'Rx': [2128], 'first': [2130], 'expressed': [2131, 2209, 2603, 2686], 'anterior': [2134], 'fold': [2136], '(prospective': [2137, 3423], 'forebrain)': [2138], 'E7.5': [2140], 'Emx1': [2147], '(Furukawa': [2148], '1997).': [2151], 'Rosa26-tdTomato': [2157], 'reporter': [2158], '(Madisen': [2160], '2010)': [2163], 'demonstrated': [2164, 2615, 2854, 3313], 'recombination': [2166, 2255, 2354, 2396, 2485, 2678, 2701, 2973], 'emerging': [2169], 'vesicles': [2171], 'E8.5,': [2175], 'later': [2176], 'becoming': [2177], 'distinctively': [2178], 'restricted': [2179], '(Fig': [2183, 2230, 2256, 2283, 2345, 2633, 2696, 2935, 3048, 3067, 3334, 3451, 3488, 3523, 3537, 3575, 3592, 4280], 'EV1A).': [2184], 'Within': [2185], 'tdTomato': [2188, 2214, 2236, 2289], 'level': [2190, 2252, 2508, 2970], 'changed': [2191], 'progressed,': [2194], 'gradually': [2195, 2268], 'E11.5': [2198, 2369, 2904, 3059, 3100, 3359], 'E17.5/postnatal': [2200], '1': [2202, 2820], '(P1;': [2203], 'Fig': [2204, 3013], 'EV1B–D).': [2205], 'ganglia': [2208], 'highest': [2211, 2303], 'already': [2215], 'E11.5,': [2217, 3032], 'olfactory': [2220, 2456, 2502, 2776, 3107, 3659, 4204], 'bulb': [2221, 2777, 3660], '(OB)': [2222, 2778], 'septum': [2224, 3522], 'reaching': [2225, 2274], 'E12.5': [2229, 2270, 2763, 3123], 'EV1C': [2231, 2257], 'D).': [2233], 'contrast,': [2235, 2896], 'low': [2244], 'neocortex,': [2247, 2307, 2379, 2869, 3531, 4146], 'significantly': [2250, 2375, 3324], 'lower': [2251, 2376], 'D,': [2259, 3147, 4045], 'Table': [2260, 2564], 'EV1).': [2261], 'TdTomato': [2262, 2322, 2411, 2674], 'E17.5,': [2272, 3810], 'when': [2273], 'statistical': [2275, 2571], 'similarity': [2276, 2314], 'rest': [2279], 'EV1D).': [2284, 2346], 'Nevertheless,': [2285], 'always': [2294], 'tended': [2295], 'be': [2297], 'lowest': [2298], 'caudal': [2301, 2385], 'area': [2309], 'reached': [2312], 'greater': [2313, 2969, 3544], 'OB,': [2317, 2455, 2501, 3106, 3497, 4203], 'septum,': [2318, 2659], 'ganglia.': [2321], 'thalamus': [2325], 'virtually': [2327], 'absent': [2328], 'all': [2330, 2814, 2823], 'ages,': [2331], 'agreement': [2333], 'region': [2336, 3509, 3536, 4155], 'not': [2337, 2549, 2931, 3136, 3323, 3533, 4109], 'deriving': [2338], 'lineage': [2341], 'Rx+': [2343], 'territories': [2344], 'Taken': [2347], 'together,': [2348], 'showed': [2351, 2990, 3440, 4285], 'prevalent': [2361], 'ventral': [2366, 2656, 2928, 2978, 3096, 3971, 3975, 4013, 4293], 'E12.5,': [2371, 2627, 3061, 3361], 'while': [2372], 'it': [2373], 'medial': [2383, 2688, 4030, 4200], 'aspects.': [2386], 'Click': [2387, 2733, 4060], 'here': [2388, 2734, 4061], 'expand': [2390, 2736, 4063], 'figure.': [2392, 2738, 4065], 'Figure': [2393, 2739, 3071, 3625, 4066], 'EV1.': [2394], 'A,': [2404, 4078], 'B.': [2405, 3664, 4079], 'Bright': [2406], 'field': [2407], '(top': [2408], 'row)': [2409], '(red)': [2413], 'Rx3': [2416], 'promoter': [2417], 'seen': [2419], 'whole': [2421], '(A)': [2423], 'sections': [2426, 2753, 3431, 3642, 4081], '(B)': [2427, 2435], 'ages': [2431, 4092], 'indicated.': [2432, 2495], 'Sections': [2433], 'coronal': [2438], '(upper': [2439], 'panels)': [2440], 'sagittal': [2442, 3641], 'plane': [2443], '(bottom': [2444], 'panels).': [2445], 'BG,': [2446, 2496], 'ganglia;': [2448, 2498], 'di,': [2449], 'diencephalon;': [2450], 'H,': [2451, 2805, 4197], 'hippocampus;': [2452, 2806, 4198], 'NCx,': [2453, 2499, 3104], 'neocortex;': [2454, 2500, 3105], 'bulb;': [2457, 3108, 4205], 'ov,': [2458], 'optic': [2459], 'vesicle;': [2460], 'St,': [2461, 2803], 'striatum;': [2462, 2804], 'Th,': [2463, 2807, 4208], 'thalamus;': [2464], 'tv,': [2465], 'vesicle.': [2467], 'Scale': [2468, 2809, 3278, 4039, 4210], 'bars,': [2469, 3279, 4040, 4211], '500': [2470, 4041, 4215], 'μm': [2471, 2474, 2812, 3281, 3284, 3287, 4042, 4048, 4054, 4213, 4216, 4220], '(A),': [2472, 3282, 4214], '300': [2473], '(B).': [2475], 'C,': [2476, 3790], 'D.': [2477, 3703], 'Quantification': [2478, 3680], 'Tomato': [2480, 2510], 'fluorescence': [2481, 2511], 'intensity': [2482], 'areas': [2489, 2518], 'bulb.': [2503], 'Dashed': [2504, 3762], 'indicates': [2506, 3173, 3217, 3764, 4018], 'average': [2507], 'Basal': [2513], 'Ganglia.': [2514], 'Comparison': [2515], 'across': [2516, 4137], 'stage': [2521], 'shown': [2523, 4157], '(D).': [2525], 'Data': [2526, 3248, 3842, 4037, 4195], 'histograms': [2528, 3844], 'mean': [2530, 3252, 3846], '±': [2531, 3253, 3685, 3847], 'SEM,': [2532, 3848], 'symbols': [2533, 3255, 3687, 3849], 'indicate': [2534, 3258, 3688, 3725, 3827, 3833, 3839, 3850, 4007, 4162, 4167], 'individual': [2535, 3261, 3691, 3853], 'values;': [2536], 'n': [2537, 3855], '=': [2538, 3142, 3182, 3226, 3698], '3–8': [2539], 'replicates': [2540, 3144, 3184, 3228, 3700], 'per': [2541, 3145, 3185, 3229, 3701], 'age.': [2542, 3188, 3232], 'ANOVA': [2543], "Tukey's": [2546], 'test;': [2547], 'ns,': [2548], 'significant;': [2550], '*P': [2551, 3269, 3861], '<': [2552, 2555, 2558, 2561, 3270, 3273, 3276, 3695, 3862, 3865], '0.05,': [2553, 3271, 3863], '**P': [2554, 3272], '0.01,': [2556, 3274], '***P': [2557, 3275, 3694, 3864], '0.001,': [2559], '****P': [2560], '0.0001.': [2562], 'See': [2563], 'EV1': [2565, 2985], 'set': [2569], 'results.': [2572], 'Download': [2573, 2575, 2829, 2831, 3290, 3292, 4056, 4058, 4223, 4225], 'figure': [2574, 2830, 3291, 4057, 4224], 'PowerPoint': [2576, 2832, 3293, 4059, 4226], 'Next,': [2577, 3294, 3407], 'tested': [2579], 'elimination': [2581], 'Dicerflox/flox': [2588], '(DicerF/F).': [2591], 'ISH': [2592, 3463], 'against': [2593, 3873], 'miR9,': [2596], 'one': [2597], 'vertebrate': [2607], '(Radhakrishnan': [2609], 'Alwin': [2611], 'Prem': [2612], 'Anand,': [2613], '2016),': [2614], 'substantial': [2617], 'reduction': [2618, 2721, 3459], 'absence': [2630, 3988], 'E17.5': [2632, 2695, 2765, 3439, 3473, 3648, 3706, 3736, 3778], 'EV2).': [2634, 2987], 'At': [2635], 'stages,': [2638, 2963], 'miR9': [2644, 2683, 2712, 2791], 'almost': [2646], 'complete': [2647], 'prominent': [2651], '(OB,': [2658], 'ganglia)': [2662], '(neocortex),': [2668], 'pattern': [2672, 3666], 'described': [2679], 'above.': [2680], 'still': [2685], 'EV2),': [2697], 'incomplete': [2700], 'territory.': [2706], 'abundance': [2710, 3151, 3193, 3904], 'embryo': [2717, 3739, 3900, 4129], 'brain,': [2718], 'confirmed': [2724, 3454], 'embryos.': [2732, 3126, 3429], 'EV2.': [2740], 'embryosSagittal': [2752], '(DicerF/F)': [2756], '(Rx-Cre;DicerF/F)': [2759], 'showing': [2766, 2944, 3654, 3712, 4098], 'mRNA': [2771, 3669], 'miR-9': [2773], '(NCx).': [2781], 'Dashes': [2782], 'surface.': [2786, 3180, 3224], 'Levels': [2787], 'dramatically': [2794, 2919, 3299], 'reduced': [2795], 'OB': [2798, 3443, 3456, 3484, 3671, 3682], 'subpallium': [2800], 'mutants.': [2802, 3678, 3824, 3932], 'thalamus.': [2808, 4209], 'bar,': [2810], '100': [2811, 4219], '(E12.5,': [2813], 'images': [2815, 2824], 'same': [2818, 2827], 'scale),': [2819], 'mm': [2821], '(E17.5,': [2822], 'scale).': [2828], 'Massive': [2833, 3073], 'death': [2837, 3055], 'vitro': [2852], 'typically': [2858], 'exhibit': [2859], 'death,': [2864, 3372], '(Mott': [2877], 'Raver-Shapira': [2881], 'Davis': [2885], 'our': [2897, 3339], 'analysis': [2898, 3020, 3114, 3802], 'Casp3': [2900], 'stains': [2901, 3312, 3464], '(Rx-Dicer': [2911], 'mutants,': [2912, 3382, 3515], 'hereon)': [2914], 'occurrence': [2917], '1A).': [2936], 'prevent': [2950], 'case': [2959], 'also': [2965, 3476, 3527], '(Figs': [2984], 'Marker': [2988, 3113], 'mostly': [2994, 3363], 'Pax6+': [2995, 3131], '(67%': [2997], 'Casp+': [2999, 3011], 'cells)': [3000], 'small': [3004], 'minority': [3005], 'Tbr1+': [3007, 3137], '(8.6%': [3009], 'cells;': [3012], '1B': [3014], 'C).': [3016, 3491], 'A': [3017, 3577], 'detailed': [3018], 'time-course': [3019], 'apoptotic': [3023, 3034, 3128, 3153, 3416], 'events': [3024, 3377], 'started': [3025], 'suddenly': [3026, 3063], 'arranged': [3036, 3588], 'columns': [3038], 'spun': [3040], 'entire': [3042, 3507, 4139], 'thickness': [3043], '1D': [3049, 3068], 'E).': [3051, 3070], 'Remarkably,': [3052, 3365], 'lasted': [3056], 'between': [3058, 3238, 3330, 3358, 4010], 'decreasing': [3062], 'again': [3064], 'E13.5': [3066, 3333], '1.': [3072], 'A.': [3088, 3637], 'Distribution': [3089, 3149, 3191], 'Casp3+': [3091, 3116], 'domains': [3097], 'embryo.': [3103], 'Spt,': [3109, 4206], 'septum.': [3110, 3728], 'B,': [3111, 4044], 'C.': [3112, 3679, 4119], 'Most': [3127], 'RGCs': [3132], '(solid': [3133], 'arrowheads)': [3134], '(open': [3139], 'arrowheads).': [3140], 'N': [3141, 3181, 3225, 3697], 'marker.': [3146], 'E.': [3148, 3729], '(Casp3+)': [3155], 'indicated': [3169, 3213, 3341, 4091, 4096, 4116, 4150], 'ages.': [3170, 3214], 'Dotted': [3171, 3215, 3825], 'surface,': [3175, 3219, 3829], 'dashed': [3177, 3221, 3662, 3831], 'line,': [3178, 3222], 'genotype': [3186, 3230], 'F,': [3189], 'G.': [3190], 'mitoses': [3195, 3321, 3751, 3883, 3916], '(PH3+)': [3196], '(Tuj1)': [3199], '3–4': [3227], 'No': [3233], 'differences': [3235], 'found': [3237], 'nor': [3245], 'mitoses.': [3247, 4194], 'information:': [3249, 4038, 4196], 'Histograms': [3250], 'represent': [3251], 'SEM;': [3254, 3686], 'plots': [3257], 'values': [3259, 3689, 3851], 'embryos;': [3262, 3854, 3858], 'chi-square': [3263, 3859], 'test': [3264], '(C),': [3265], 't-test': [3266], '(E,': [3267, 4049], 'G);': [3268], '0.001.': [3277, 3696, 3866], '200': [3280, 4053], '40': [3283], '(B),': [3285], '25': [3286, 4047], '(D,': [3288], 'F).': [3289, 3595], 'reasoned': [3296], 'among': [3304], 'would': [3306], 'strongly': [3307], 'decrease': [3308], 'anti-PH3': [3311], 'density': [3316, 3374], 'altered': [3325], '1F': [3335], 'G).': [3337], 'Together,': [3338], 'severely': [3347], 'affected': [3348, 3528], 'affecting': [3362], 'aRGCs.': [3364], 'mitotic': [3376], 'remained': [3378, 4183], 'unaltered': [3379], 'suggesting': [3383], 'remaining': [3386], 'non-apoptotic': [3387], 'proliferate': [3391], 'self-renew': [3393], 'rates': [3395], 'higher': [3396], 'normal.': [3398], 'Disorganization': [3399], 'rostro-ventral': [3402], 'investigated': [3409], 'long-term': [3411], 'consequences': [3412], 'OB)': [3424], 'Sagittal': [3430, 4080, 4120], 'through': [3432, 3643, 3891, 4082, 4122], 'brains': [3434, 3711], 'smaller': [3446, 3496], '2A–C).': [3452], 'identity': [3457, 3926, 3960, 3976], 'size': [3461], 'Grm1,': [3466], 'marker': [3468, 3807], 'mitral': [3470], 'laminar': [3480, 4231], 'organization': [3481, 4232], 'preserved': [3487], '2B': [3489], 'addition': [3493], 'observed': [3499], 'profound': [3503], 'rostral–ventral': [3508], 'prefrontal': [3518], '2D).': [3524, 3576], 'alterations': [3526], 'parietal': [3535, 4111, 4142, 4180], 'EV3A': [3538], 'B),': [3540], 'former.': [3554], 'overabundance': [3566], 'Ki67+': [3568, 3582], 'germinal': [3573, 4240], 'zones': [3574], 'closer': [3578], 'examination': [3579], 'fact': [3586], 'exquisitely': [3587], '2E': [3593], 'striking': [3598], 'because': [3599], 'never': [3603], 'reported': [3605], 'any': [3607], '2.': [3626], 'Formation': [3627], 'DAPI': [3638], 'stain': [3639], 'littermates': [3653], '(NCx)': [3657, 4182], '(OB;': [3661], 'line).': [3663], 'Expression': [3665, 3945], 'Grm1': [3668], '(dotted': [3672, 3746], 'line)': [3673, 3747], 'perimeter': [3683], '(mean': [3684], 'embryos);': [3692], 't-test,': [3693], '14': [3699], 'genotype.': [3702], 'Immunostains': [3704], 'distribution': [3714, 3914], '(Ki67,': [3718], 'red)': [3719], '(Tuj1,': [3722], 'green).': [3723], 'Arrowheads': [3724, 3838], 'Sp,': [3727], 'Detail': [3730], 'displaying': [3740], 'typical': [3741], 'features:': [3742], 'closed': [3743], 'PH3+': [3749], '(white': [3752], 'arrowhead)': [3753], 'mitoses,': [3756, 4271], 'surrounded': [3757, 4262], 'Tuj1+': [3759, 4169, 4278], '(green).': [3761], 'border': [3767, 3835, 4009, 4021, 4174], 'rosette.': [3770], 'F.': [3771], 'Rostral': [3772], 'half': [3773], 'immunostained': [3780, 3872], 'Pax6,': [3782], 'clarified,': [3783], 'segmented': [3785], '(yellow).': [3789], 'caudal;': [3791], 'R,': [3792], 'rostral.': [3793], 'G,': [3794, 4050], 'H.': [3795], 'BrdU': [3796], 'incorporation': [3797], 'cycle': [3800], 're-entry': [3801], 'Ki67': [3808], 'cortex': [3814], 'compared': [3818], 'VZ.': [3837, 4177], 'double-positive': [3840], 'cells.': [3841], '≥': [3856], 'test,': [3860], 'I.': [3867], 'Apical': [3868], 'lumen': [3869, 4247], '(Par3,': [3877], 'β-catenin),': [3878], 'primary': [3879], 'cilia': [3880], '(Arl13b),': [3881], '(PhVim),': [3884], '(Tuj1).': [3887, 3920], 'J.': [3888], 'Coronal': [3889], 'section': [3890, 4121], 'E14.5': [3897, 3930, 4127], 'illustrating': [3901], 'location': [3906], '(arrows),': [3909], '(PH3)': [3917], 'K–S.': [3921], 'Analysis': [3922], 'regional': [3925, 3943], '(K)': [3933], 'Schema': [3934], 'patterns': [3940], 'defining': [3941], 'identity.': [3944], 'Ngn2,': [3947], 'Tbr2,': [3948], 'Pax6': [3950], 'identifies': [3951, 3980, 3995], 'rostro-dorsal': [3955], 'having': [3958, 3974], '(L–N,': [3961], 'P);': [3962], 'Gsx2,': [3963], 'Dlx2,': [3964], 'Dlx5': [3966], '(O,': [3977], 'Q);': [3978], 'Nkx2.1': [3979], 'MGE': [3981], 'being': [3984], 'normotopic': [3985], '(R);': [3986], 'Gsx2': [3990], 'LGE': [3992], 'them': [3996], 'ectopic': [3998, 4168], '(S).': [3999], 'Tuj1': [4000], 'labels': [4001], '(L,': [4004], 'M),': [4005], 'arrowheads': [4006, 4166], 'territories,': [4014], 'dotted': [4016], 'outer': [4020], 'telencephalon.': [4024], 'LGE,': [4025], 'lateral': [4026], 'ganglionic': [4027, 4031, 4201], 'eminence;': [4028, 4032, 4202], 'MGE,': [4029, 4199], 'P,': [4033], 'pallium;': [4034], 'SP,': [4035], 'subpallium.': [4036], '(A,': [4043], 'F),': [4046], 'I,': [4051], 'P–S),': [4052], '(J–O).': [4055], 'EV3.': [4067], 'Regionalized': [4068], 'stained': [4093, 4147], 'markers,': [4097], 'selectively': [4104], '(or': [4112], 'caudal)': [4113], 'regions,': [4114], 'brackets.': [4118], 'electroporated': [4130, 4179], '+': [4133], 'Gfp': [4134], 'encoding': [4135], 'plasmids': [4136], 'regions': [4143], 'markers.': [4151], 'Details': [4152], 'right.': [4160], 'Arrows': [4161], 'unaffected,': [4184], 'perfect': [4186], 'layering': [4187], 'septum;': [4207], '150': [4212], '(B,': [4217], 'C),': [4218], '(C,': [4221], 'details).': [4222], 'Rosettes': [4227], 'had': [4228], 'distinct': [4230], 'apical–basal': [4234], 'polarity,': [4235], 'layers': [4241], 'An': [4245], 'inner': [4246], 'delimited': [4249], 'pseudostratified': [4252], 'layer': [4253], 'undergoing': [4257, 4269], 'mitosis,': [4259], 'band': [4265], 'finally,': [4273], 'enclosed': [4276], '2E).': [4281], 'Brain': [4282], 'clarification': [4283], 'numerous': [4286], 'located': [4288], 'th': [4296]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3088723365', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 4}], 'updated_date': '2024-12-10T08:35:58.812642', 'created_date': '2020-10-01'}
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